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| '''Duloxetine hydrochloride''' (brand name |
'''Duloxetine hydrochloride''' (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Chemically known as LY248686, -N-methyl-3-(1-napthalenyloxy)-2-thiophene-propanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. | ||
| Furthermore, duloxentine HCI lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours. | |||
Revision as of 21:28, 3 April 2004
Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Chemically known as LY248686, -N-methyl-3-(1-napthalenyloxy)-2-thiophene-propanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.
Furthermore, duloxentine HCI lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.