| Revision as of 21:46, 29 March 2004 editJfdwolff (talk | contribs)Administrators81,547 edits Started | Revision as of 14:12, 17 June 2004 edit undoPFHLai (talk | contribs)Administrators82,398 edits merging with GM-CSFNext edit → | ||
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| '''Granulocyte- |
'''Granulocyte-Colony Stimulating Factor''' ('''G-CSF''') is a ] produced by a number of different ] to stimulate the ] to produce ]s. | ||
| G-CSF is also known as '''Granulocyte-Macrophage Colony Stimulating Factor''' ('''GM-CSF''') and '''Colony-Stimulating Factor 3''' ('''CSF 3'''). | |||
| == Biological function == | == Biological function == | ||
| G-CSF is produced, amongst others, by ], ]s and a number of other ] cells. It is a 177-180 ]-long ]. The ], G-CSF-receptor, is present on ] |
G-CSF is produced, amongst others, by ], ]s and a number of other ] cells. It is a 177-180 ]-long ]. | ||
| The ], G-CSF-receptor, is present on precursor cells in the ] that, in response to stimulation by G-CSF, proliferate and differentiate into mature ]s. | |||
| ==Genetics== | ==Genetics== | ||
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| == Therapeutic use == | == Therapeutic use == | ||
| In ] and ], a ] form of G-CSF is used to accellerate recovery from ]. ] can cause ] and unacceptably low levels of ]s, making patients prone for ]s and ]. Filgrastim (Neupogen®) and PEG-filgrastim (Neulasta®) are two commercially available forms of rhG-CSF (recombinant human G-CSF). The PEG (]) form has a much longer ], reducing the necessity of daily injections. | In ] and ], a ] form of G-CSF is used to accellerate recovery from ]. ] can cause ] and unacceptably low levels of ]s, making patients prone for ]s and ]. | ||
| "Filgrastim" (Neupogen®) and "PEG-filgrastim" (Neulasta®) are two commercially available forms of rhG-CSF (recombinant human G-CSF) given to stimulate the production of various types of white blood cells, especially granulocytes and macrophages, following chemotherapy. The PEG (]) form has a much longer ], reducing the necessity of daily injections. Recombinant G-CSF is also marketed under the names "Leukine" and "Sargramostim". | |||
| == External links == | == External links == | ||
Revision as of 14:12, 17 June 2004
Granulocyte-Colony Stimulating Factor (G-CSF) is a growth factor produced by a number of different tissues to stimulate the bone marrow to produce granulocytes.
G-CSF is also known as Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Colony-Stimulating Factor 3 (CSF 3).
Biological function
G-CSF is produced, amongst others, by endothelium, macrophages and a number of other immune cells. It is a 177-180 amino acid-long protein.
The receptor, G-CSF-receptor, is present on precursor cells in the bone marrow that, in response to stimulation by G-CSF, proliferate and differentiate into mature granulocytes.
Genetics
The gene for G-CSF is located on chromosome 17, locus q11.2-q12.
Therapeutic use
In oncology and hematology, a recombinant form of G-CSF is used to accellerate recovery from neutropenia. Chemotherapy can cause myelosuppression and unacceptably low levels of white blood cells, making patients prone for infections and sepsis.
"Filgrastim" (Neupogen®) and "PEG-filgrastim" (Neulasta®) are two commercially available forms of rhG-CSF (recombinant human G-CSF) given to stimulate the production of various types of white blood cells, especially granulocytes and macrophages, following chemotherapy. The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections. Recombinant G-CSF is also marketed under the names "Leukine" and "Sargramostim".