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Revision as of 09:23, 23 February 2011 editAnypodetos (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers39,350 editsm Sufficient refs for the contents of this stub← Previous edit Revision as of 07:58, 30 August 2011 edit undoBogBot (talk | contribs)Bots53,132 edits populated new fields in {{drugbox}} and reordered per bot approval. Report errors and suggestions to User_talk:BogBotNext edit →
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| Watchedfields = changed | Watchedfields = changed
| verifiedrevid = 398777189 | verifiedrevid = 398777189
⚫ | image = Amlodipine.svg
⚫ | type = combo
| image = Amlodipine.svg | image2 = Benazepril.svg

⚫ | image2 = Benazepril.svg
<!--Combo data-->
⚫ | component1 = Amlodipine
⚫ | type = combo
⚫ | class1 = ]
| component1 = Amlodipine
| component2 = Benazepril
⚫ | class1 = ]
⚫ | class2 = ]
⚫ | component2 = Benazepril
⚫ | class2 = ]

<!--Clinical data-->
| tradename =
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = D
⚫ | pregnancy_category =
⚫ | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫ | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫ | legal_US = Rx-only
⚫ | legal_status =
⚫ | routes_of_administration = Oral

<!--Identifiers-->
⚫ | CAS_number =
⚫ | ATC_prefix = None
⚫ | ATC_suffix =
⚫ | PubChem = 5746247
⚫ | DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4676979 | ChemSpiderID = 4676979

⚫ | InChI = 1/C24H28N2O5.C20H25ClN2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);5-8,17,23H,4,9-11,22H2,1-3H3/t19-,20-;/m0./s1
<!--Chemical data-->
| smiles = Clc1ccccc1C2C(\C(=O)OC)=C(/N\C(=C2\C(=O)OCC)COCCN)C.O=C(OCC)(N2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3 | smiles = Clc1ccccc1C2C(\C(=O)OC)=C(/N\C(=C2\C(=O)OCC)COCCN)C.O=C(OCC)(N2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3
⚫ | InChI = 1/C24H28N2O5.C20H25ClN2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);5-8,17,23H,4,9-11,22H2,1-3H3/t19-,20-;/m0./s1
| InChIKey = SRTZYSFUFGOMFR-FKLPMGAJBV | InChIKey = SRTZYSFUFGOMFR-FKLPMGAJBV
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
Line 18: Line 41:
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = SRTZYSFUFGOMFR-FKLPMGAJSA-N | StdInChIKey = SRTZYSFUFGOMFR-FKLPMGAJSA-N
⚫ | CAS_number =
⚫ | ATC_prefix = None
⚫ | ATC_suffix =
⚫ | PubChem = 5746247
⚫ | DrugBank =
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = D
⚫ | pregnancy_category=
⚫ | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫ | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫ | legal_US = Rx-only
⚫ | legal_status =
⚫ | routes_of_administration = Oral
}} }}
'''Amlodipine/benazepril''', marketed in the U.S. as '''Lotrel''' by ] and manufactured as a ] by ] and ], is an ] medication which combines a ] (] besilate) with an ] (]).<ref></ref> This drug, like similar combinations, is prescribed when either agent alone is not sufficient to bring a person's blood pressure down to target range. As a combination agent, Lotrel shares the ] profile of both of its individual parts.<ref>Drugs.com: </ref><ref>RxList.com: </ref> '''Amlodipine/benazepril''', marketed in the U.S. as '''Lotrel''' by ] and manufactured as a ] by ] and ], is an ] medication which combines a ] (] besilate) with an ] (]).<ref></ref> This drug, like similar combinations, is prescribed when either agent alone is not sufficient to bring a person's blood pressure down to target range. As a combination agent, Lotrel shares the ] profile of both of its individual parts.<ref>Drugs.com: </ref><ref>RxList.com: </ref>

Revision as of 07:58, 30 August 2011

Pharmaceutical compound
Amlodipine/benazepril
Combination of
AmlodipineCalcium channel blocker
BenazeprilACE inhibitor
Clinical data
Routes of
administration		Oral
ATC code
  • None
Legal status
Legal status
Identifiers
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
3D model (JSmol)
SMILES
  • Clc1ccccc1C2C(\C(=O)OC)=C(/N\C(=C2\C(=O)OCC)COCCN)C.O=C(OCC)(N2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3
InChI
  • InChI=1S/C24H28N2O5.C20H25ClN2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);5-8,17,23H,4,9-11,22H2,1-3H3/t19-,20-;/m0./s1
  • Key:SRTZYSFUFGOMFR-FKLPMGAJSA-N
  (verify)

Amlodipine/benazepril, marketed in the U.S. as Lotrel by Novartis and manufactured as a generic drug by Teva and Sandoz, is an antihypertensive medication which combines a calcium channel blocker (amlodipine besilate) with an angiotensin converting enzyme inhibitor (benazepril). This drug, like similar combinations, is prescribed when either agent alone is not sufficient to bring a person's blood pressure down to target range. As a combination agent, Lotrel shares the adverse reaction profile of both of its individual parts.

See also

References

  1. Lotrel Prescribing Information
  2. Drugs.com: Lotrel
  3. RxList.com: Lotrel

External links

Ion channel modulators
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
See also: Receptor/signaling modulators • Transient receptor potential channel modulators
Antihypertensive drugs acting on the renin–angiotensin system (C09)
ACE inhibitors
("-pril")
AIIRAs
("-sartan")
Renin inhibitors
("-kiren")
Dual ACE/NEP inhibitors
Neprilysin inhibitors
Other


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