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Revision as of 20:38, 10 August 2011 editCheMoBot (talk \| contribs)Bots141,565 edits Updating {{chembox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per [[Misplaced Pages:WikiProject Chemicals/Chem← Previous edit		Revision as of 19:24, 7 October 2011 edit undoRjwilmsi (talk \| contribs)Extended confirmed users, Pending changes reviewers, Rollbackers932,007 editsm Journal cites:, added 1 DOI, using AWB (7844)Next edit →
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	'''Tangeritin''' is an O-] that is found in ] and other ] peels. Tangeritin strengthens the cell wall and protects it from invasion {{Citation needed\|date=January 2008}}.		'''Tangeritin''' is an O-] that is found in ] and other ] peels. Tangeritin strengthens the cell wall and protects it from invasion {{Citation needed\|date=January 2008}}.

	Although few oj, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent<ref>{{cite journal \|author=Kurowska EM, Manthey JA \|title=Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia \|journal=J. Agric. Food Chem. \|volume=52 \|issue=10 \|pages=2879–86 \|year=2004 \|month=May \|pmid=15137829 \|doi=10.1021/jf035354z }}</ref>. A hamster study showed potential protective effects against ]<ref>{{cite journal \|author=Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT \|title=Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease \|journal=Neuroreport \|volume=12 \|issue=17 \|pages=3871–5 \|year=2001 \|month=December \|pmid=11726811 \|doi=10.1097/00001756-200112040-00053 }}</ref>. Tangeritin shows potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin induced ] in leukemia cells while sparing normal cells<ref>{{cite journal \|author=Hirano T, Abe K, Gotoh M, Oka K \|title=Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes \|journal=Br. J. Cancer \|volume=72 \|issue=6 \|pages=1380–8 \|year=1995 \|month=December \|pmid=8519648 \|pmc=2034105 }}</ref>. It counteracts tumor suppression of ] ]<ref>{{cite journal \|author=Chaumontet C, Droumaguet C, Bex V, Heberden C, Gaillard-Sanchez I, Martel P \|title=Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells \|journal=Cancer Lett. \|volume=114 \|issue=1-2 \|pages=207–10 \|year=1997 \|month=March \|pmid=9103293 \|doi=10.1016/S0304-3835(97)04664-8 }}</ref>. It acts to freeze cancer cells in phase ] of the cell cycle, preventing replication. In summary, ''in vitro'' studies show antimutagenic<ref>{{cite journal \|author=Calomme M, Pieters L, Vlietinck A, Vanden Berghe D \|title=Inhibition of bacterial mutagenesis by Citrus flavonoids \|journal=Planta Med. \|volume=62 \|issue=3 \|pages=222–6 \|year=1996 \|month=June \|pmid=8693033 \|doi=10.1055/s-2006-957864 }}</ref>, antiinvasive<ref>{{cite journal \|author=Bracke ME, Vyncke BM, Van Larebeke NA, ''et al.'' \|title=The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro \|journal=Clin. Exp. Metastasis \|volume=7 \|issue=3 \|pages=283–300 \|year=1989 \|pmid=2924447 \|doi=10.1007/BF01753681 }}</ref> and antiproliferative<ref>{{cite journal \|author=Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E \|title=Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro \|journal=Cancer Lett. \|volume=56 \|issue=2 \|pages=147–52 \|year=1991 \|month=February \|pmid=1998943 \|doi=10.1016/0304-3835(91)90089-Z }}</ref> effects. One caveat is that tangeritin appears to counteract the anticancer drug ] and to suppress the activity of natural killer cells<ref>{{cite journal \|author=Depypere HT, Bracke ME, Boterberg T, ''et al.'' \|title=Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer \|journal=Eur. J. Cancer \|volume=36 \|issue=Suppl 4\|pages=S73 \|year=2000 \|month=September \|pmid=11056327 \|doi=10.1016/S0959-8049(00)00234-3 }}</ref>.		Although few oj, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent<ref>{{cite journal \|author=Kurowska EM, Manthey JA \|title=Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia \|journal=J. Agric. Food Chem. \|volume=52 \|issue=10 \|pages=2879–86 \|year=2004 \|month=May \|pmid=15137829 \|doi=10.1021/jf035354z }}</ref>. A hamster study showed potential protective effects against ]<ref>{{cite journal \|author=Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT \|title=Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease \|journal=Neuroreport \|volume=12 \|issue=17 \|pages=3871–5 \|year=2001 \|month=December \|pmid=11726811 \|doi=10.1097/00001756-200112040-00053 }}</ref>. Tangeritin shows potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin induced ] in leukemia cells while sparing normal cells<ref>{{cite journal \|author=Hirano T, Abe K, Gotoh M, Oka K \|title=Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes \|journal=Br. J. Cancer \|volume=72 \|issue=6 \|pages=1380–8 \|year=1995 \|month=December \|pmid=8519648 \|pmc=2034105 \|doi=10.1038/bjc.1995.518}}</ref>. It counteracts tumor suppression of ] ]<ref>{{cite journal \|author=Chaumontet C, Droumaguet C, Bex V, Heberden C, Gaillard-Sanchez I, Martel P \|title=Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells \|journal=Cancer Lett. \|volume=114 \|issue=1-2 \|pages=207–10 \|year=1997 \|month=March \|pmid=9103293 \|doi=10.1016/S0304-3835(97)04664-8 }}</ref>. It acts to freeze cancer cells in phase ] of the cell cycle, preventing replication. In summary, ''in vitro'' studies show antimutagenic<ref>{{cite journal \|author=Calomme M, Pieters L, Vlietinck A, Vanden Berghe D \|title=Inhibition of bacterial mutagenesis by Citrus flavonoids \|journal=Planta Med. \|volume=62 \|issue=3 \|pages=222–6 \|year=1996 \|month=June \|pmid=8693033 \|doi=10.1055/s-2006-957864 }}</ref>, antiinvasive<ref>{{cite journal \|author=Bracke ME, Vyncke BM, Van Larebeke NA, ''et al.'' \|title=The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro \|journal=Clin. Exp. Metastasis \|volume=7 \|issue=3 \|pages=283–300 \|year=1989 \|pmid=2924447 \|doi=10.1007/BF01753681 }}</ref> and antiproliferative<ref>{{cite journal \|author=Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E \|title=Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro \|journal=Cancer Lett. \|volume=56 \|issue=2 \|pages=147–52 \|year=1991 \|month=February \|pmid=1998943 \|doi=10.1016/0304-3835(91)90089-Z }}</ref> effects. One caveat is that tangeritin appears to counteract the anticancer drug ] and to suppress the activity of natural killer cells<ref>{{cite journal \|author=Depypere HT, Bracke ME, Boterberg T, ''et al.'' \|title=Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer \|journal=Eur. J. Cancer \|volume=36 \|issue=Suppl 4\|pages=S73 \|year=2000 \|month=September \|pmid=11056327 \|doi=10.1016/S0959-8049(00)00234-3 }}</ref>.

	Tangeritin is commercially available as a dietary supplement.		Tangeritin is commercially available as a dietary supplement.

Revision as of 19:24, 7 October 2011

Tangeritin
Names

IUPAC names 5,6,7,8-tetramethoxy-2- (4-methoxyphenyl)-4H- 1-benzopyran-4-one
Identifiers
CAS Number	481-53-8
3D model (JSmol)	Interactive image
ECHA InfoCard	100.006.883
UNII	I4TLA1DLX6
CompTox Dashboard (EPA)	DTXSID30197417
SMILES O=C2C1=C(OC)C(OC)=C(OC)C(OC) =C1OC(C3=CC=C(OC)C=C3)=C2
Properties
Chemical formula	C₂₀H₂₀O₇
Molar mass	372.37 g/mol
Melting point	155-156 °C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is ?) Infobox references

Chemical compound

Tangeritin is an O-polymethoxylated flavone that is found in tangerine and other citrus peels. Tangeritin strengthens the cell wall and protects it from invasion .

Although few oj, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent. A hamster study showed potential protective effects against Parkinson's disease. Tangeritin shows potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin induced apoptosis in leukemia cells while sparing normal cells. It counteracts tumor suppression of gap junction intercellular signaling. It acts to freeze cancer cells in phase G1 of the cell cycle, preventing replication. In summary, in vitro studies show antimutagenic, antiinvasive and antiproliferative effects. One caveat is that tangeritin appears to counteract the anticancer drug tamoxifen and to suppress the activity of natural killer cells.

Tangeritin is commercially available as a dietary supplement.

References

Kurowska EM, Manthey JA (2004). "Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia". J. Agric. Food Chem. 52 (10): 2879–86. doi:10.1021/jf035354z. PMID 15137829. {{cite journal}}: Unknown parameter |month= ignored (help)
Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT (2001). "Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease". Neuroreport. 12 (17): 3871–5. doi:10.1097/00001756-200112040-00053. PMID 11726811. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Hirano T, Abe K, Gotoh M, Oka K (1995). "Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes". Br. J. Cancer. 72 (6): 1380–8. doi:10.1038/bjc.1995.518. PMC 2034105. PMID 8519648. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Chaumontet C, Droumaguet C, Bex V, Heberden C, Gaillard-Sanchez I, Martel P (1997). "Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells". Cancer Lett. 114 (1–2): 207–10. doi:10.1016/S0304-3835(97)04664-8. PMID 9103293. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Calomme M, Pieters L, Vlietinck A, Vanden Berghe D (1996). "Inhibition of bacterial mutagenesis by Citrus flavonoids". Planta Med. 62 (3): 222–6. doi:10.1055/s-2006-957864. PMID 8693033. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Bracke ME, Vyncke BM, Van Larebeke NA; et al. (1989). "The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro". Clin. Exp. Metastasis. 7 (3): 283–300. doi:10.1007/BF01753681. PMID 2924447. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E (1991). "Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro". Cancer Lett. 56 (2): 147–52. doi:10.1016/0304-3835(91)90089-Z. PMID 1998943. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Depypere HT, Bracke ME, Boterberg T; et al. (2000). "Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer". Eur. J. Cancer. 36 (Suppl 4): S73. doi:10.1016/S0959-8049(00)00234-3. PMID 11056327. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Flavones and their conjugates

Aglycones

Monohydroxyflavone	3-Hydroxyflavone 6-Hydroxyflavone
Dihydroxyflavones	Chrysin 4',7-Dihydroxyflavone 7,8-Dihydroxyflavone
Trihydroxyflavones	Apigenin Baicalein Galangin Norwogonin 7,8,3'-Trihydroxyflavone 6,7,4'-Trihydroxyflavone
Tetrahydroxyflavones	Fisetin Kaempferol Isoscutellarein Luteolin Norartocarpetin Scutellarein
Pentahydroxyflavones	Herbacetin Morin Quercetin Nortangeretin 6-Hydroxyluteolin Norwightin Hypolaetin Tricetin
O-methylated flavones	4',7-Dihydroxy-6-methoxyflavone Acacetin Alnetin Artocarpetin Chrysoeriol Cirsilineol Cirsiliol Cirsimaritin Diosmetin Eupatilin Genkwanin Hispidulin Nepetin Nobiletin Oroxylin A Pratol Salvigenin Sinensetin Tangeretin Techtochrysin Tricin Wogonin Zapotin

Glycosides

of apigenin	Apiin Apigetrin Isovitexin Rhoifolin Saponarin Schaftoside Vicenin-2 Vitexin
of baicalein	Baicalin Tetuin
of hypolaetin	Hypolaetin 8-glucoside Hypolaetin 8-glucuronide
of luteolin	Cynaroside Isoorientin Orientin Veronicastroside Luteolin-7-O-glucuronide

Acetylated

Artocarpetin A

Artoindonesianin P

Sulfated glycosides

Theograndin I and II

Polymers

Drugs

Categories:

Revision as of 20:38, 10 August 2011 editCheMoBot (talk \| contribs)Bots141,565 edits Updating {{chembox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per [[Misplaced Pages:WikiProject Chemicals/Chem← Previous edit		Revision as of 19:24, 7 October 2011 edit undoRjwilmsi (talk \| contribs)Extended confirmed users, Pending changes reviewers, Rollbackers932,007 editsm Journal cites:, added 1 DOI, using AWB (7844)Next edit →
Line 21:		Line 21:
	'''Tangeritin''' is an O-] that is found in ] and other ] peels. Tangeritin strengthens the cell wall and protects it from invasion {{Citation needed\|date=January 2008}}.		'''Tangeritin''' is an O-] that is found in ] and other ] peels. Tangeritin strengthens the cell wall and protects it from invasion {{Citation needed\|date=January 2008}}.

	Although few oj, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent<ref>{{cite journal \|author=Kurowska EM, Manthey JA \|title=Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia \|journal=J. Agric. Food Chem. \|volume=52 \|issue=10 \|pages=2879–86 \|year=2004 \|month=May \|pmid=15137829 \|doi=10.1021/jf035354z }}</ref>. A hamster study showed potential protective effects against ]<ref>{{cite journal \|author=Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT \|title=Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease \|journal=Neuroreport \|volume=12 \|issue=17 \|pages=3871–5 \|year=2001 \|month=December \|pmid=11726811 \|doi=10.1097/00001756-200112040-00053 }}</ref>. Tangeritin shows potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin induced ] in leukemia cells while sparing normal cells<ref>{{cite journal \|author=Hirano T, Abe K, Gotoh M, Oka K \|title=Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes \|journal=Br. J. Cancer \|volume=72 \|issue=6 \|pages=1380–8 \|year=1995 \|month=December \|pmid=8519648 \|pmc=2034105 }}</ref>. It counteracts tumor suppression of ] ]<ref>{{cite journal \|author=Chaumontet C, Droumaguet C, Bex V, Heberden C, Gaillard-Sanchez I, Martel P \|title=Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells \|journal=Cancer Lett. \|volume=114 \|issue=1-2 \|pages=207–10 \|year=1997 \|month=March \|pmid=9103293 \|doi=10.1016/S0304-3835(97)04664-8 }}</ref>. It acts to freeze cancer cells in phase ] of the cell cycle, preventing replication. In summary, ''in vitro'' studies show antimutagenic<ref>{{cite journal \|author=Calomme M, Pieters L, Vlietinck A, Vanden Berghe D \|title=Inhibition of bacterial mutagenesis by Citrus flavonoids \|journal=Planta Med. \|volume=62 \|issue=3 \|pages=222–6 \|year=1996 \|month=June \|pmid=8693033 \|doi=10.1055/s-2006-957864 }}</ref>, antiinvasive<ref>{{cite journal \|author=Bracke ME, Vyncke BM, Van Larebeke NA, ''et al.'' \|title=The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro \|journal=Clin. Exp. Metastasis \|volume=7 \|issue=3 \|pages=283–300 \|year=1989 \|pmid=2924447 \|doi=10.1007/BF01753681 }}</ref> and antiproliferative<ref>{{cite journal \|author=Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E \|title=Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro \|journal=Cancer Lett. \|volume=56 \|issue=2 \|pages=147–52 \|year=1991 \|month=February \|pmid=1998943 \|doi=10.1016/0304-3835(91)90089-Z }}</ref> effects. One caveat is that tangeritin appears to counteract the anticancer drug ] and to suppress the activity of natural killer cells<ref>{{cite journal \|author=Depypere HT, Bracke ME, Boterberg T, ''et al.'' \|title=Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer \|journal=Eur. J. Cancer \|volume=36 \|issue=Suppl 4\|pages=S73 \|year=2000 \|month=September \|pmid=11056327 \|doi=10.1016/S0959-8049(00)00234-3 }}</ref>.		Although few oj, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent<ref>{{cite journal \|author=Kurowska EM, Manthey JA \|title=Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia \|journal=J. Agric. Food Chem. \|volume=52 \|issue=10 \|pages=2879–86 \|year=2004 \|month=May \|pmid=15137829 \|doi=10.1021/jf035354z }}</ref>. A hamster study showed potential protective effects against ]<ref>{{cite journal \|author=Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT \|title=Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease \|journal=Neuroreport \|volume=12 \|issue=17 \|pages=3871–5 \|year=2001 \|month=December \|pmid=11726811 \|doi=10.1097/00001756-200112040-00053 }}</ref>. Tangeritin shows potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin induced ] in leukemia cells while sparing normal cells<ref>{{cite journal \|author=Hirano T, Abe K, Gotoh M, Oka K \|title=Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes \|journal=Br. J. Cancer \|volume=72 \|issue=6 \|pages=1380–8 \|year=1995 \|month=December \|pmid=8519648 \|pmc=2034105 \|doi=10.1038/bjc.1995.518}}</ref>. It counteracts tumor suppression of ] ]<ref>{{cite journal \|author=Chaumontet C, Droumaguet C, Bex V, Heberden C, Gaillard-Sanchez I, Martel P \|title=Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells \|journal=Cancer Lett. \|volume=114 \|issue=1-2 \|pages=207–10 \|year=1997 \|month=March \|pmid=9103293 \|doi=10.1016/S0304-3835(97)04664-8 }}</ref>. It acts to freeze cancer cells in phase ] of the cell cycle, preventing replication. In summary, ''in vitro'' studies show antimutagenic<ref>{{cite journal \|author=Calomme M, Pieters L, Vlietinck A, Vanden Berghe D \|title=Inhibition of bacterial mutagenesis by Citrus flavonoids \|journal=Planta Med. \|volume=62 \|issue=3 \|pages=222–6 \|year=1996 \|month=June \|pmid=8693033 \|doi=10.1055/s-2006-957864 }}</ref>, antiinvasive<ref>{{cite journal \|author=Bracke ME, Vyncke BM, Van Larebeke NA, ''et al.'' \|title=The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro \|journal=Clin. Exp. Metastasis \|volume=7 \|issue=3 \|pages=283–300 \|year=1989 \|pmid=2924447 \|doi=10.1007/BF01753681 }}</ref> and antiproliferative<ref>{{cite journal \|author=Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E \|title=Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro \|journal=Cancer Lett. \|volume=56 \|issue=2 \|pages=147–52 \|year=1991 \|month=February \|pmid=1998943 \|doi=10.1016/0304-3835(91)90089-Z }}</ref> effects. One caveat is that tangeritin appears to counteract the anticancer drug ] and to suppress the activity of natural killer cells<ref>{{cite journal \|author=Depypere HT, Bracke ME, Boterberg T, ''et al.'' \|title=Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer \|journal=Eur. J. Cancer \|volume=36 \|issue=Suppl 4\|pages=S73 \|year=2000 \|month=September \|pmid=11056327 \|doi=10.1016/S0959-8049(00)00234-3 }}</ref>.

	Tangeritin is commercially available as a dietary supplement.		Tangeritin is commercially available as a dietary supplement.