Artemotil: Difference between revisions

Revision as of 13:53, 28 October 2011 editBeetstra (talk \| contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').← Previous edit		Revision as of 13:55, 28 October 2011 edit undoBeetstra (talk \| contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: '').Next edit →
Line 22:		Line 22:

	<!--Identifiers-->		<!--Identifiers-->
	\| CAS_number = ~~<!-- blanked - oldvalue:~~ 75887-54-6 ~~-->~~		\| CAS_number = 75887-54-6
	\| ATC_prefix = P01		\| ATC_prefix = P01
	\| ATC_suffix = BE04		\| ATC_suffix = BE04
Line 30:		Line 30:
	\| UNII_Ref = {{fdacite\|correct\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = XGL7GFB9YI		\| UNII = XGL7GFB9YI
	\| ChEMBL = ~~<!-- blanked - oldvalue:~~ 301267 ~~-->~~		\| ChEMBL = 301267

			<!--Chemical data-->
	\| C=17 \| H=28 \| O=5		\| C=17 \| H=28 \| O=5
	\| molecular_weight = 312.401 g/mol		\| molecular_weight = 312.401 g/mol

Revision as of 13:55, 28 October 2011

Pharmaceutical compound

Artemotil
Clinical data

AHFS/Drugs.com	International Drug Names
Pregnancy category	not available
Routes of administration	Intramuscular injection
ATC code	P01BE04 (WHO)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	20 hours
Identifiers
IUPAC name (5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxydioxepinoisochromene
CAS Number	75887-54-6
PubChem CID	72416
ChemSpider	16735673
UNII	XGL7GFB9YI
ChEMBL	ChEMBL301267
Chemical and physical data
Formula	C₁₇H₂₈O₅
Molar mass	312.401 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES C1CC3C42OO(C)(CC12)O4O(OCC)3C
InChI InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17?/m1/s1 Key:NLYNIRQVMRLPIQ-LCAQWSNOSA-N

Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.

Cryptosporidiosis	thiazolides (nitazoxanide)
Isosporiasis	trimethoprim/sulfamethoxazole
Toxoplasmosis	pyrimethamine sulfadiazine clindamycin atovaquone

Individual
agents

4-Methanolquinolines

Other

Co-formulation

Other

Combi-
nations

Fixed-dose (co-formulated) ACTs	artemether/lumefantrine arterolane/piperaquine artesunate/amodiaquine (ASAQ) artesunate/mefloquine (ASMQ) artesunate/pyronaridine piperaquine/dihydroartemisinin
Other combinations (not co-formulated)	artesunate/mefloquine artesunate/SP quinine/clindamycin quinine/doxycycline quinine/tetracycline

This antiinfective drug article is a stub. You can help Misplaced Pages by expanding it.