| Revision as of 17:08, 10 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChemSpiderID', 'StdInChI', 'StdInChIKey', 'CASNo').← Previous edit | Revision as of 17:09, 10 November 2011 edit undoBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChemSpiderID', 'StdInChI', 'StdInChIKey').Next edit → | ||
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| |Section1={{Chembox Identifiers | |Section1={{Chembox Identifiers | ||
| | CASNo |
| CASNo=10389-08-9 | ||
| | ChemSpiderID = 14508512 | | ChemSpiderID = 14508512 | ||
| | StdInChI = 1S/C2H8NO4P.Ca/c3-1-2-7-8(4,5)6;/h1-3H2,(H2,4,5,6);/q;+2/p-2 | | StdInChI = 1S/C2H8NO4P.Ca/c3-1-2-7-8(4,5)6;/h1-3H2,(H2,4,5,6);/q;+2/p-2 | ||
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| Names | |
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| IUPAC name Calcium 2-aminoethyl phosphate | |
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| Properties | |
| Chemical formula | C2H6CaNO4P |
| Molar mass | 179.13 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
 Y verify (what is ?)
Infobox references
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Calcium 2-aminoethylphosphate (Ca-AEP or Ca-2AEP) is a vital component in the structure of cell membranes in the human body. It is the calcium salt of phosphorylethanolamine. It was discovered by the eminent biochemist Erwin Chargaff in 1941. Ca-AEP has been shown to help maintain cell membrane integrity and improve cellular functions. It was patented by Dr. Hans Alfred Nieper and Franz Kohler
Terminology and glossary
Calcium 2-amino ethyl phosphoric acid (Ca-AEP or Ca-2AEP) is also called calcium ethylamino-phosphate (calcium EAP), calcium colamine phosphate, calcium 2-aminoethyl ester of phosphoric acid, and calcium 2-amino ethanol phosphate
2-AEP plays a role as a component in the cell membrane and at the same time has the property to form complexes with minerals. This mineral transporter goes into the outer layer of the outer cell membrane where it releases its associated mineral and is itself metabolized with the structure of the cell membrane. The effect here is an increase of the electrical condenser function of cell membranes to resist toxins and viruses which may otherwise enter the cell and cause cellular degeneration. Calcium 2-AEP is said to be effective for repairing cell membrane damage. In Germany, calcium, potassium and magnesium 2-AEP are officially declared as the only active substances for the treatment of multiple sclerosis.
History, treatments, uses, and risks
CA-AEP was discovered by Erwin Chargaff, best known for his work that eventually led to the discovery of the double helix structure of DNA, in 1941. His findings were largely ignored for the first two decades but studies over the last 30 years have shown that Ca-AEP plays a vital role in maintaining cell membrane integrity and improving cellular functions. People have been using this to treat a host of ailments including multiple sclerosis, diabetes, asthma and immune disorders.
The first trial applications of Ca-AEP were for the treatment of multiple sclerosis (MS). In 1967 the German Health Authority approved the use of Ca-AEP for MS. MS, an inflammatory demyelinating condition, is one of the most common diseases of the central nervous system (brain and spinal cord). Myelin, the fatty material that surrounds nerves, acts as an insulator, much like the covering of an electric wire. An analysis of more than 2,000 patients who were treated with colamine salts in Germany over the course of 24 years revealed greater efficacy from Ca-AEP treatments than other known treatments. In 1986, Dr. George Morrissette conducted a retrospective poll of patients in the USA who originally had begun Ca-AEP treatment in Germany for MS. 82% of the almost 300 patients that entered the study showed a positive benefit from Ca-AEP therapy. And when treatment began in the early stages of MS, positive results rose to 92%.
After 30 years of Ca-AEP and calcium orotate therapies with over 3,500 patients with multiple sclerosis, the risk of bone fractures was drastically reduced. Furthermore, surgeons in six surgical centers located in USA and Europe reported finding extremely solid bone when implanting new joints in patients who were taking Ca-AEP combined with calcium and magnesium orotate for at least four years prior to their surgeries.
In 1967, the German Health Authority approved calcium 2-AEP as an official treatment for multiple sclerosis. In fact, 2-AEP is the only natural official MS treatment reimbursed by the German equivalent of the US Social Security System.
The U.S. National Multiple Sclerosis Society states that “calcium EAP protocol is not recommended by the Medical Advisory Board of the National MS Society.” The National MS Society warns of side effects and risk, but they do not list any on their website for this treatment. They do state that it “may include a powerful drug that suppresses the immune system” but they do not mention what this drug is.
Calcium 2-AEP is actually manufactured by numerous nutraceutical companies and is sold online and in health food stores.
References
- Membrane Integrity Factor Aids Treatment of Multiple Sclerosis, Asthma and Osteoporosis, Ward Dean, M.D. and Jim English (June 1999)
- Let’s Live Magazine “Mineral Transporters” Hans Nieper, M.D. (1992) Reproduced by the Brewer Science Library with permission from Let's Live magazine
- The MS Information SourceBook, National MS Society (Feb 2006)