Capreomycin: Difference between revisions

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	\| ATC_supplemental =		\| ATC_supplemental =
	\| PubChem = 3032400		\| PubChem = 3032400
	\| DrugBank = ~~DB00314~~		\| DrugBank = APRD00844
	\| ChemSpiderID = 21106276		\| ChemSpiderID = 21106276
	\| UNII_Ref = {{fdacite\|correct\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = 232HYX66HC		\| UNII = 232HYX66HC
	\| KEGG = ~~<!-- blanked - oldvalue:~~ D00135 ~~-->~~		\| KEGG = D00135
	\| ChEMBL_Ref = {{ebicite\|correct\|EBI}}		\| ChEMBL_Ref = {{ebicite\|correct\|EBI}}
	\| ChEMBL = ~~<!-- blanked - oldvalue:~~ 1201252 ~~-->~~		\| ChEMBL = 1201252

			<!--Chemical data-->
	\| C=25 \| H=44 \| N=14 \| O=8		\| C=25 \| H=44 \| N=14 \| O=8
	\| molecular_weight = 668.706 g/mol		\| molecular_weight = 668.706 g/mol

Revision as of 19:57, 10 November 2011

Pharmaceutical compound

Capreomycin
Clinical data


AHFS/Drugs.com	Monograph
MedlinePlus	a682860
ATC code	J04AB30 (WHO)
Identifiers
IUPAC name (3S)-3,6-diamino-N--8--2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide; (3S)-3,6-diamino-N--8--2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide
CAS Number	11003-38-6
PubChem CID	3032400
DrugBank	APRD00844
ChemSpider	21106276
UNII	232HYX66HC
KEGG	D00135
ChEMBL	ChEMBL1201252
CompTox Dashboard (EPA)	DTXSID8040989
Chemical and physical data
Formula	C₂₅H₄₄N₁₄O₈
Molar mass	668.706 g/mol g·mol
InChI InChI=1S/C25H44N14O8.C25H44N14O7/c26-4-1-2-11(27)6-17(41)32-8-14-20(43)35-15(9-34-25(30)47)21(44)39-18(13-3-5-31-24(29)38-13)23(46)33-7-12(28)19(42)37-16(10-40)22(45)36-14;1-11-19(41)36-15(9-32-17(40)7-12(27)3-2-5-26)21(43)37-16(10-34-25(30)46)22(44)39-18(14-4-6-31-24(29)38-14)23(45)33-8-13(28)20(42)35-11/h9,11-14,16,18,40H,1-8,10,26-28H2,(H,32,41)(H,33,46)(H,35,43)(H,36,45)(H,37,42)(H,39,44)(H3,29,31,38)(H3,30,34,47);10-15,18H,2-9,26-28H2,1H3,(H,32,40)(H,33,45)(H,35,42)(H,36,41)(H,37,43)(H,39,44)(H3,29,31,38)(H3,30,34,46)/b15-9-;16-10-/t11-,12?,13?,14+,16+,18?;11-,12+,13?,14?,15-,18?/m10/s1 Key:VCOPTHOUUNAYKQ-TWKMCICTSA-N

Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for tuberculosis. Adverse effects include nephrotoxicity and 8th cranial nerve toxicity.

The drug should not be given with streptomycin or other drugs that may damage the 8th nerve.

It is a cyclic peptide. Capreomycin is administered intramuscularly and shows bacteriostatic activity.

Rifamycins/ RNA polymerase inhibitor	Rifampicin Rifabutin Rifapentine Rifalazil
Antifolates/DSI	Dapsone Acedapsone Diucifon Promin Solasulfone Sulfoxone
ASA	4-Aminosalicylic acid (Calcium aminosalicylate Sodium aminosalicylate)
Topoisomerase inhibitors/ quinolones	Gatifloxacin Moxifloxacin

Aminoglycosides	Amikacin Kanamycin Streptomycin
Oxazolidone	Linezolid Sutezolid
Polypeptide antibiotics	Capreomycin

Other/unknown

Combinations

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