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| first used in the ]. They are named after the drugs' molecular structure, which contains three rings of atoms (compare ]). The term 'tricyclic antidepressant' is sometimes abbreviated to '''TCA''. | first used in the ]. They are named after the drugs' molecular structure, which contains three rings of atoms (compare ]). The term 'tricyclic antidepressant' is sometimes abbreviated to '''TCA''. | ||
| Most tricylic antidepressants work by by preventing the re-absorption of neurotransmitters ] and ] back into the nerve cells. They are not considered addictive and have many fewer side-effects and restrictions than the ]. For many years they were the first choice for pharmacological treatment of depression. Although they remain effective, they have been increasingly replaced by ] and other newer drugs. These newer antidepressants are thought to have less ]s and are also thought to be less effective if used in a ] attempt, as the treatment and lethal doses are much further apart than with the tricyclic antidepressants. | |||
| The side effects of tricyclic antidepressant may include drowsiness, ], restlessness, dry mouth, constipation, urinary retention or difficulty with urination, cognitive and ] difficulties, weight gain, sweating, dizziness, decrease in sexual ability and desire, ] twitches, weakness, nausea, increased heart rate and irregular heart rhythms (rare). | The side effects of tricyclic antidepressant may include drowsiness, ], restlessness, dry mouth, constipation, urinary retention or difficulty with urination, cognitive and ] difficulties, weight gain, sweating, dizziness, decrease in sexual ability and desire, ] twitches, weakness, nausea, increased heart rate and irregular heart rhythms (rare). | ||
Revision as of 07:15, 23 July 2004
Structure of amitriptyline
Chemical structure of the tricyclic
antidepressent amitriptyline
Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. They are named after the drugs' molecular structure, which contains three rings of atoms (compare tetracyclic antidepressant). The term 'tricyclic antidepressant' is sometimes abbreviated to 'TCA.
Most tricylic antidepressants work by by preventing the re-absorption of neurotransmitters noradrenaline and serotonin back into the nerve cells. They are not considered addictive and have many fewer side-effects and restrictions than the MAOIs. For many years they were the first choice for pharmacological treatment of depression. Although they remain effective, they have been increasingly replaced by SSRIs and other newer drugs. These newer antidepressants are thought to have less side effects and are also thought to be less effective if used in a suicide attempt, as the treatment and lethal doses are much further apart than with the tricyclic antidepressants.
The side effects of tricyclic antidepressant may include drowsiness, anxiety, restlessness, dry mouth, constipation, urinary retention or difficulty with urination, cognitive and memory difficulties, weight gain, sweating, dizziness, decrease in sexual ability and desire, muscle twitches, weakness, nausea, increased heart rate and irregular heart rhythms (rare).
It is worth noting that many people suffer few, if any, side effects from taking tricyclic antidepressants. However, as with any medication, it is always worth reporting any problems you encounter to your health care provider.
Antidepressant drugs in the tricyclic drug group include:
- amitriptyline (Elavil®, Endep®)
- amoxapine (Asendin®)
- clomipramine (Anafranil®)
- desipramine (Norpramin®, Pertofrane®)
- dothiepin hydrochloride (Prothiaden®, Thaden®)
- doxepin (Adapin®, Sinequan®)
- imipramine (Tofranil®)
- nortryptyline (Pamelor®)
- protriptyline (Vivactil®)
- trimipramine (Surmontil®)