Uncoupling protein: Difference between revisions

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Revision as of 19:39, 27 February 2013

An uncoupling protein is a mitochondrial inner membrane protein that can dissipate the proton gradient before it can be used to provide the energy for oxidative phosphorylation.

There are five types known in mammals:

UCP1, also known as thermogenin
UCP2
UCP3
SLC25A27, also known as "UCP4"
SLC25A14, also known as "UCP5"

Uncoupling proteins play a role in normal physiology, as in hibernation, because the energy is used to generate heat (see thermogenesis) instead of producing ATP. However, other substances such as 2,4-Dinitrophenol and CCCP also serve the same uncoupling function, and are considered poisonous. Salicylic acid is also an uncoupling agent and will deplete the body of ATP and increase body temperature if taken in excess.

References

Nedergaard J, Ricquier D, Kozak LP (2005). "Uncoupling proteins: current status and therapeutic prospects". EMBO Rep. 6 (10): 917–21. doi:10.1038/sj.embor.7400532. PMC 1369193. PMID 16179945.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

Uncoupling+Agents at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Mitochondrial proteins

Outer membrane

fatty acid degradation	Carnitine palmitoyltransferase I Long-chain-fatty-acid—CoA ligase
tryptophan metabolism	Kynureninase
monoamine neurotransmitter metabolism	Monoamine oxidase

Intermembrane space

Inner membrane

oxidative phosphorylation	Coenzyme Q – cytochrome c reductase Cytochrome c NADH dehydrogenase Succinate dehydrogenase
pyrimidine metabolism	Dihydroorotate dehydrogenase
mitochondrial shuttle	Malate-aspartate shuttle Glycerol phosphate shuttle
steroidogenesis	Cholesterol side-chain cleavage enzyme Steroid 11-beta-hydroxylase Aldosterone synthase
other	Glutamate aspartate transporter Glycerol-3-phosphate dehydrogenase ATP synthase Carnitine palmitoyltransferase II Uncoupling protein

Matrix

citric acid cycle	Citrate synthase Aconitase Isocitrate dehydrogenase Oxoglutarate dehydrogenase complex Succinyl coenzyme A synthetase Fumarase Malate dehydrogenase
anaplerotic reactions	Aspartate transaminase Glutamate dehydrogenase Pyruvate dehydrogenase complex
urea cycle	Carbamoyl phosphate synthetase I Ornithine transcarbamylase N-Acetylglutamate synthase
alcohol metabolism	ALDH2
PMPCB

Other/to be sorted

Mitochondrial DNA

Complex I	MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND4L MT-ND5 MT-ND6
Complex III	MT-CYB
Complex IV	MT-CO1 MT-CO2 MT-CO3
ATP synthase	MT-ATP6 MT-ATP8
tRNA	MT-TA MT-TC MT-TD MT-TE MT-TF MT-TG MT-TH MT-TI MT-TK MT-TL1 MT-TL2 MT-TM MT-TN MT-TP MT-TQ MT-TR MT-TS1 MT-TS2 MT-TT MT-TV MT-TW MT-TY

see also mitochondrial diseases

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