User talk:Andrew73: Difference between revisions

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			'''THIS USER IS A COMPLETE ARSEHOLE WHO IS NOT FIT TO ADD ANYTHING '''
	'''Welcome!'''

			'''UNFORTUNATELY HE IS SO DELUDED THAT HE THINKS THAT HE IS'''
	] to Misplaced Pages, Andrew73! My name is Ryan, aka ]. I noticed that you were new and haven't received any messages yet. I just wanted to see how you were doing. Misplaced Pages can be a little intimidating at first, since it uses different formatting than other sites that use ] and ]. In the long run, though, you'll find that the WikiSyntax is a lot easier and faster than those other ways. Here are a few links to get you started:

			'''WHICH EMOTIONAL INADEQUACY COMPELS PEOPLE LIKE THIS TO IMPOSE THEIR IGNORANCE ON OTHER PEOPLE ???'''
	*]
	*]
	*]
	*]

			'''General Tojo'''
	There are a lot of policies and guides to read, but I highly recommend reading over those first. If you have any questions, feel free to leave me a message on my ]. Please be sure to ] using four tildes (~~~~) to produce your name and the current date, along with a link to your user page. This way, others know when you left a message and how to find you. It's easier than having to type out your name, right? :)

	I hope you enjoy contributing to Misplaced Pages. We can use all the help we can get! Have a nice day.
	Sincerely, ]]<sup><font color=FF8247>]</font></sup> 22:05, September 5, 2005 (UTC)

	==Maze v maze==

	Andrew,

	I added the bit about the Maze procedure to the atrial fibrillation page. Both capitalizations have been used. Cox, who developed the procedure, prefers Maze in his recent publications:

	* Cox JL. Tex Heart Inst J. 2004; 31(3): 257–265. PMID 15562846

	I think that he actually intends it to be a proper noun, like "Kleenex", to distinguish it from other (lesser) "Maze-like" procedures. I'd rather not go around and around on this, but I'd prefer the Maze capitalization so that it is internally consistent, in agreement with Cox, and consistent with the other wikipedia subject that I wrote, ]. There I have been very careful to use what I believe to be the proper capitalizations.

	So I intend to change the capitalizations back to Maze where appropriate unless you plan to change them back again to maze.

	] 20:15, 2 January 2006 (UTC)
	: Thanks. I responded on ]. ] 21:07, 2 January 2006 (UTC)

	== Medic? ==

	Hi Andrew, your contribs suggest a medical background. Would you like to join ]? Please have a look. ] \| ] 07:10, 6 September 2005 (UTC)

	:You a hematologist then? ] \| ] 17:02, 22 September 2005 (UTC)

	:: Training to become a hematologist! ] 00:43, 11 October 2005 (UTC)


	=== Paid Editing Project ===

	Hi: My name is Tess and I work for a global independent research firm in New York. I am interested in hiring you for a Misplaced Pages editing project, based on your technology and medical experience and expertise. I attempted to email you through your user page. If you received it, please read it over and contact me with any questions. If you did not receive this email, please let me know and I would be more than happy to tell you more about this project. (You can call 512-651-1797 or email tfurman@glgroup.com). Thank you and I hope to hear from you soon! ] 18:41, 28 September 2005 (UTC)

	== Erythromelalgia ==

	I'm not sure if you're right about it not being a disease. OMIM seems to be happy to classify it as a clinical entity. ] \| ] 21:45, 8 October 2005 (UTC)

	: Good point. In the the ] section, ] was referring to the symptoms of erythromelalgia as secondary to e.g. ], rather than primary erythromelalgia in and of itself. ] 21:52, 8 October 2005 (UTC)

	== Bone marrow biopsy ==

	Hi,

	I dewikified aspirate in this article as it's redirecting to aspiration (phonetics) which seems completely irrelevant. There's also aspiration (medicine) but that doesn't seem to fit with what the article says either (could be wrong - I'm not a medic). If not, could you mention what an aspirate is in the article? Thanks, ] 23:23, 10 October 2005 (UTC)

	:: Embarrassingly, I didn't see your prior edit! I created a disambiguation page for ] and removed the redirect to ]. I now wikified aspirate to the page describing ] 00:43, 11 October 2005 (UTC)

	== The ] is a general medical journal ==

	See the .
	The short of the long of it is the ''Annals of Internal Medicine'' is an internal medicine journal.

	The article says: "It is considered to be one of the top five '''general''' medical journals..."

	''Annals of Internal Medicine'' isn't a general medical journal. ] 00:55, 15 October 2005 (UTC)

	: Interestingly, if you go to the ISI Web of Knowledge, Journal Citation Reports, where the impact factors are calculated and the journals are ranked, the category is "medicine, general & internal," so general medical and internal medicine journals are actually lumped together! So in the actual ranking scheme, it's #8. ] 12:58, 15 October 2005 (UTC)

	== PE ==

	I'm curious if you are aware of any historical accounts on the recognition of PE as a clinical entity. The article now mentions some classical papers, but not when the signs and symptoms (and etiology) of VTE/PE were first recognised.

	You're closer to Dr Goldhaber than me - he may be the person to ask :-) ] \| ] 06:51, 16 October 2005 (UTC)

	: I'll look into those classical papers later today! ] 12:12, 16 October 2005 (UTC)

	==Re:Heparin-Induced Thrombocytopenia==
	Makes sense...I don't have any problem with your removal. I was veiwing that page as a drug-induced thrombocytopenia page with heparin being the classical example, but I now agree that their inclusion was out of place. Later.--] 20:05, 16 October 2005 (UTC)

	== MDS ==

	Thanks for adding that to the page. It's much better now imo. ] 23:15, 17 October 2005 (UTC)

	== Blood (journal) ==

	I've started ]. I could not find a good historical account about the journal. Are you aware of any good resource for this purpose? ] \| ] 03:39, 21 October 2005 (UTC)
	: Well the first issue is available online as a pdf, though it does not offer any additional information! ] 11:31, 21 October 2005 (UTC)

	Do you have an URL? Can't find it. And Dr Damashek must have written ''something'' quotable? Heck, this guy and ] were the grand men of US haematology! ] \| ] 22:15, 22 October 2005 (UTC)
	: The url is . (It turns out that all of the issues of ''Blood'' are available online!). I can e-mail you the pdf if you don't have access to it. ] 23:07, 22 October 2005 (UTC)

	I just wrote up Max Wintrobe. Would you mind having a look? ] \| ] 01:30, 23 October 2005 (UTC)
	: Very impressed! ]

	== Who are you? ==

	? Just a guess...heme/onc, updating MGH and Harvard Medical School websites...probably born in 1973. If not and you are at MGH, I probably still know you! ] 02:31, 23 October 2005 (UTC)
	: Your detective work serves you well! Now do I know you?! ] 02:45, 23 October 2005 (UTC)
	::Probably not, though I've met you before. I'm a third year med/peds at MGH, . I've used your eponyms program since med school. It should be a wiki! ] 03:24, 23 October 2005 (UTC)
	::: Of course I know you ! We've had patients together! ] 14:34, 23 October 2005 (UTC)

	:Andrew, do you indeed have an eponyms program? Would you licence its contents under the GFDL? I've meant to approach Ole Daniel Enersen, the webmaster of http://www.whonamedit.com, about the copyright status of his site. ] \| ] 11:11, 23 October 2005 (UTC)
	:: Yes I do indeed have an for the Palm OS. At this time though, I'd like to decline the invitation to wiki its contents...perhaps this is out of a quixotic hope to do something more with it in the future! ] 14:34, 23 October 2005 (UTC)

	== Extra period in PMID converter? ==

	Happy to hear you like the converter. :-) Actually, the converter isn't adding the period; it's just that ] always adds a period to titles and in your case the title has already got a period of its own (see ). I've tweaked the converter so it removes trailing periods in titles, but this won't solve the larger issue of using ] et al to reference articles whose titles have trailing punctuation. For example, "Long-term potentiation--A decade of progress?" would still render pretty oddly. To solve this the right way would require lots of updates to existing wiki articles using it, but ] should probably let the user provide their own trailing punctuation in journal article titles. --] \| ] 16:01, 28 October 2005 (UTC)
	: Thanks. I've actually taken the liberty of removing the period from the template, and now the articles display correctly! ] 14:50, 29 October 2005 (UTC)



	== ] ==

	The above article is likely to be selected as next weeks choice at ] if it receives a few more
	votes. It is of interest to Wikipedians in general, and would improve the profile of medical-related topics on Misplaced Pages. To vote, click on WP:AID and sign your name in the '''Emergency department''' section.--] 18:48, 14 November 2005 (UTC)
	== ] ==
	<div style="text-align: center; margin: 0 10%;">
	{\| class="notice noprint" id="{{{id}}}" style="background: #5959AB; border: 1px solid #aaa; margin: 0 auto;"
	\|-
	\| ]
	\| <font color="white">Thank you for your support of the ''']</span>'''.<br><font color="white">This week ''']''' <font color="white">was selected to be improved to ] ].<br><font color="white">Hope you can help…
	\|}
	</div>
	Many thanks for your support!--] 23:48, 23 November 2005 (UTC)

	== COMMENT ON MUMPS PAGE BY USER MIDGELEY ==

	Why did you restore a comment that was deleted because it was invalid? The introduction of MMR in 1988 was planned and known about before 1988. The comment added is therefore incorrect and disruptive. It is not an assertion that events in 1988 caused events in 1987. As a BMA member User Midgeley knows that is the case.

	Is this not taking things to an unusual level?

	] 14:23, 20 December 2005 (UTC)

	: I restored the comment (invalid or valid) because it's on a discussion page, not the actual article. ] 14:26, 20 December 2005 (UTC)

	::Not clear what the point is here. Can you elucidate please?
	::] 14:44, 20 December 2005 (UTC)
	::: Since it's a ''discussion'' page, comments should be left in place for the sake of discussion, even if it's incorrect or disruptive. Perhaps you could add a comment to argue your point. ] 15:24, 20 December 2005 (UTC)

	== Breast Cancer Adjuvant external link ==

	If you feel the ''Adjuvant'' external link is especially necessary on the ] page, can you add a brief explanation of it? There are hundreds of "good" cancer resources out there, and this page shouldn't be just a listing of them. If that one, in particular, is unusually notable (which it might be -- I don't know enough about it), it'd be helpful to at least let a reader know what it is or why she should click. ] 19:32, 24 December 2005 (UTC)

	: I agree, the external link section has the potential to be populated with trivial or commercial links. But Adjuvant! is actually used in clinical practice, it's referenced further on PMID 11181660 In any event, I expanded its description on the article. ] 19:39, 24 December 2005 (UTC)

	== Quack ==

	] 00:29, 26 December 2005 (UTC).]]


	== RfC on See also ==
	I started an RfC on the vaccine/autism '''See Also''' sections at ] ] 05:42, 2 January 2006 (UTC)

	==Polio edits==
	Will you stop removing my links . ] 13:51, 2 January 2006 (UTC)
	: ], the link to Jim West was a non sequitur in the ] article. Why not discuss his relevance in the text of the article rather than a link that is out of the blue? ] 15:30, 2 January 2006 (UTC)

	== Thanks for vigilance against vandalism. ==

	Hello,

	I noticed that you caught the vandalism to the article on ]. Thanks for catching that! ]<sup>]</sup>

	== Biographies ==

	and ad hominem etc etc...
	I see you picked out some continuing adverse editing on Mumps.

	I think the ] article has the potential to be both interesting and good, if it is not disrupted. The scatter of failed biogrpahies of people whose only noticeable trait is to have been against vaccination doesn't help anything, and I wonder if we can do an effort to roll the whole damn lot up into paragprahs in the one article, unless any of them actually did interesti ng things as well. mendelsohn might make it I think, none of the others.

	I think it would be tedious if all the medical biographies got a line "he was in favour of vaccination and called people who were not idiots" - it would do for Osler... but it would not be encyclopedic there, and therefore its obverse is not encyclopedic in a (non-)biography.

	Advice? ] 23:04, 28 January 2006 (UTC)

	: Personally, I'm not too opposed to keeping their biographies as separate articles, even if their biographies aren't too notable. I do agree with your efforts with the ] article! In the end, I don't think there's a great solution. If there was one, I don't think this anti-vaccine controvery would still be an issue for over a century! ] 23:25, 28 January 2006 (UTC)

	== Vaccine injury ==

	Well done on balancing the POV in ]. ] \| ] 02:54, 7 February 2006 (UTC)

	== Equal signs ==

	If you use two equal signs, it will turn the text into a first-level section heading. In principle, the single equal sign would produce the equivalent of a page heading, which by definition every page already has (and should be unique). ''If'' you use <nowiki>==</nowiki> and you get a subsection of something else, it's because that "something" has been tagged (wrongly) with a single equal sign. See ] for details. --] <span style="font-size: 80%">(])</span> 15:24, 8 February 2006 (UTC)

	==Vandalism fighters can make mistakes==

	You deleted this () from the external links section of ]. I put it back. It is an online book with research level quality information and I highly recommend it.

	Here is a sample:

	:In order to gain infectivity, influenza A virions must incorporate HA proteins which have been endoproteolytically processed from a HA0 precursor to a disulphide-linked HA1,2 dimer (Chen 1998). The newly created N-terminus of the HA2 subunit harbours a fusogenic peptide, composed of a highly lipophilic domain (Skehel 2001). This domain is vitally required during the fusion process of viral and lysosomal membranes because it initiates the penetration process of viral genomic segments into the host cell cytoplasm. The cleavage site of the HA of low pathogenic viruses is composed of two basic amino acids at positions -1/-4 (H5) and -1/-3 (H7) (Wood 1993). These sites are accessible to tissue-speciﬁc trypsin-like proteases which are preferentially expressed at the surface of respiratory and gastrointestinal epithelia. Therefore, efﬁcient replication of LPAIVs is believed to be largely confined to these sites, at least in their natural hosts. In contrast, the cleavage site of HPAI viruses generally contains additional basic amino acids (arginine and/or lysine) which renders it processible for subtilysin-like endoproteases speciﬁc for a minimal consensus sequence of -R-X-K/R-R- (Horimoto 1994, Rott 1995). Proteases of this type (e.g. furin, proprotein-convertases) are active in virtually every tissue throughout the body. Therefore, viruses carrying these mutations have an advantage for replicating unrestrictedly in a systemic manner. This process has been documented in the field on several occasions. In Italy, for example, an LPAI H7N1 virus circulated for several months in the turkey and chicken population before, in December 1999, an HPAI H7N1 virus, distinguishable from its precursor only by its polybasic cleavage site, sprang up and caused devastating disease (Capua 2000).

	:It has been hypothesised that the HA gene of the H5 and H7 subtypes harbour distinct secondary RNA structures which favour insertional mutations (codon duplications) by a re-copying mechanism of the viral polymerase unit at a purine-rich sequence stretch encoding the endoproteolytic cleavage site of these HA proteins (Garcia 1996, Perdue 1997). This, and probably other mechanisms too, such as nucleotide substitutions or intersegmental recombination (Suarez 2004, Pasick 2005), may lead to the incorporation of additional basic amino acid residues. The latter has been experimentally proven by the generation of HPAIV from LPAIV precursors following repeated passaging in vitro and in vivo by site-directed mutagenesis (Li 1990, Walker and Kawaoka 1993, Horimoto and Kawaoka 1995, Ito 2001). Conversely, removal by reverse genetics of the polybasic cleavage site attenuates the HPAI phenotype (Tian 2005).

	:There are, however, viral strains in which the nucleotide sequence encoding the HA cleavage site and the pheno-/pathotype did not match in the predicted way: a Chilean H7N3 HPAIV which arose by intersegmental recombination displayed basic amino acid residues only at positions -1, -4 and -6 (Suarez 2004). Comparable examples exist for the H5 lineage (Kawaoka 1984). On the other hand, an H5N2 isolate from Texas was shown to harbour the HPAIV cleavage site consensus sequence, yet was clinically classiﬁed as LPAI (Lee 2005). These data re-emphasise the polygenic and intricate nature of influenza virus pathogenicity.

	:Fortunately, nascency of HPAI phenotypes in the field appears to be a rare event. During the last ﬁfty years, only 24 primary HPAI outbreaks caused by HPAIV, which likely arose de novo in this way in the field, have been reported world-wide (Table 1).

	:In addition, HPAIV have been shown to be able to infect mammals, and humans in particular. This has especially been observed for the Asian lineage H5N1 (WHO 2006). Host-dependent pathogenicity of HPAIV H5N1 for mammals has been studied in several model species: mice (Lu 1999, Li 2005a), ferrets (Zitzow 2002, Govorkova 2005), cynomolgous monkeys (Rimmelzwaan 2001) and pigs (Choi 2005). The outcome of infection was dependent on the viral strain and species of host. Ferrets appeared to mirror pathogenicity in humans better than mice (Maines 2005).

	:A number of genetic markers believed to be involved in pathogenicity have been located in different segments of the Z genotype of H5N1 (Table 2). Among these, mechanisms of interference with ﬁrst-line defence mechanisms of the host, such as the interferon system, through the NS-1 gene product have received marked interest. Experimentally, it has been demonstrated using reverse genetics, that NS-1 proteins of some H5N1 strains carrying glutamic acid at position 92 are capable of circumventing the antiviral effects of interferon and tumour necrosis factor-alpha, eventually leading to enhanced replication in, and reduced clearance from, the infected host (Seo 2002+2004). In addition, immune-mediated damage resulting from NS-1-mediated disruption of cytokine networks may account for parts of the lung lesions (Cheung 2002, Lipatov 2005). However, none of the mutations (Table 2) on its own represents a true prerequisite for pathogenicity in mammals (Lipatov 2003). Therefore, optimal gene constellations, to a large extent, appear to drive pathotype speciﬁcities in a host-dependent manner in mammals (Lipatov 2004).

	Thanks for helping make Misplaced Pages better. ] 14:09, 15 February 2006 (UTC)

	:: Thanks for catching this! ] 14:20, 15 February 2006 (UTC)

	== Ficoll ==

	Andrew73,

	Thanks for the correction on my entry about using Ficoll to separate islets from pancreatic tissue.

	Mouselady

	== Invitation ==

	Please weigh in on and see ]. Thanks in advance, and feel free to spread the word. --] 17:25, 1 March 2006 (UTC)

	== ] ==

	Left a note for you there. - ]] <sup>]</sup> 03:08, 31 March 2006 (UTC)

	== “Medicine” on MCOTW ==

	After a bit of inactivity, ] has been selected as the new ]. I am taking the unusual step of informing all participants, not just those who voted for it, since I feel that it is important that this highest-level topic for our collaboration be extremely well-written. In addition, it is a ] for ] and serves as the introduction to our other articles. Yet general articles are the ones that are most difficult for individuals to write, which is why I have invited all participants. I hope it isn't an intrusion; I don't make plan to make a habit of sending out these messages. — ] ] 02:16, 16 April 2006 (UTC)

	== An article you edited ==

	]. By ] ] 19:14, 16 April 2006 (UTC)

	== Arbitration on Biological psychiatry ==
	Andrew73, first of all, thanks for your expert help with the ] article. Our goal is to make it scholarly and encyclopedic in tone and content. However we have a major problem in that ] and ] are aggresively pushing ]-style content into the article. That of course isn't consistent with an encyclopedia.

	I asked ] and ] for mediation or arbitration. They didn't respond so regretfully we must proceed. Without mediation, we go straight to arbitration. If you're willing to support this, please read the below. I'll file the request later today, unless you suggest otherwise. ] 19:37, 19 April 2006 (UTC)

	*]
	*
	*
	*]
	*] - Recommended reading: A guide to presenting effective Arbitration cases.

	: I haven't been too active a participant with this article, but I'll see how I can help. Off the bat, this may be more of a content dispute than a behavioral issue per se. ] 22:37, 19 April 2006 (UTC)

	==Whale's RfC==
	I would appreciate your best efforts to help me with this --] 11:58, 20 April 2006 (UTC)

	==Attacks on WP editors==
	Thought I should draw your attention to http://www.vaccination. org.uk/vaccine/propaganda3.html] 12:06, 25 April 2006 (UTC)
	: Thanks...I think that was imported from the whale.to site. I'm not sure if I should be flattered or mortified! ] 12:17, 25 April 2006 (UTC)
	::Well, go with flattered.] 17:31, 25 April 2006 (UTC)

	==Princeton Undergrad Theses==
	I don't believe that this link is non-notable. It is one of the only colleges in the US, and I'm pretty sure in the world, where there entire undergraduate student body graduates with a thesis complete. Teach for america was founded by a studend during their involvement in the program, and there were many other notable contributions. I am reverting, please discuss. {{unsigned\|Danielfong}}
	: Have responded here ] 11:47, 1 May 2006 (UTC)

	==]==
	Hello,

	An Arbitration case involving you has been opened: ]. Please add evidence to the evidence sub-page, ]. You may also contribute to the case on the workshop sub-page, ].

	On behalf of the Arbitration Committee, ] \| ] 09:33, 1 May 2006 (UTC)

	:Andrew73, please read this section closely and make any comments you think appropriate under the "comment by parties" headings: ]. ] 17:17, 20 May 2006 (UTC)

	==MMR Vaccine==

	I reverted your edit that removed trademarks. For one thing, registered trademarks must be noted under the U.S. law.

	What's more important is that "Attenuvax®", ]®, etc. are ''products'' that Merck sells. Merck wants the trademark symbol on them, just like any good capitalist company. The wikipedia needs to reflect this actual fact in order to maintain NPOV. If you find some WP:style_bullshit that says trademarks are out, fine. Otherwise, I'm putting them back in incessantly. ] 15:55, 3 May 2006 (UTC)
	: I've responded in ]. ] 22:19, 3 May 2006 (UTC)

	== You and Midgley ==
	That was a darn fast reply. Do you watch Midgley's user page? More urgently, your edit made my user talk page completely weird. Please go see. It looks like a wikipedia bug. ] 19:34, 24 May 2006 (UTC)
	: I do watch Midgley's user page, as some of the commentary and exchanges tend to be amusing. I can't figure out though why my edit ended up looking like that, it does seem like a bug of some sort. ] 19:38, 24 May 2006 (UTC)
	:: I reverted it for the sake of getting back to a usable state. I am impressed at how broken that effect was; weird. ] 22:18, 24 May 2006 (UTC)

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	==]==
	This arbitration case is closed and the final decision has been published at the link above.

	Delivered for the arbitration committee as a clerk (I don't take part in making these decisions). --]

	== General Tojo's comments ==

	Hi FYI, I removed General Tojo's comments since a blocked/banned user should not be editing, not even with a sock account. Anyway, other than that I do not care if the comments are included or not. Happy editing -- ] \| ] 16:18, 27 June 2006 (UTC)

	'''It's good you do that, as being banned he won't be able to add to Misplaced Pages again. However, on the other hand, if you check your user pages you might just find that he has. General Tojo'''

Revision as of 21:08, 30 June 2006

THIS USER IS A COMPLETE ARSEHOLE WHO IS NOT FIT TO ADD ANYTHING

UNFORTUNATELY HE IS SO DELUDED THAT HE THINKS THAT HE IS

WHICH EMOTIONAL INADEQUACY COMPELS PEOPLE LIKE THIS TO IMPOSE THEIR IGNORANCE ON OTHER PEOPLE ???

General Tojo