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David Henry Gorski
Nationality	American
Alma mater	Case Western Reserve University University of Michigan
Scientific career
Fields	Oncology Surgery
Institutions	Wayne State University School of Medicine Barbara Ann Karmanos Cancer Institute
Doctoral advisor	Kenneth Walsh

David H. Gorski is an American surgical oncologist, Professor of surgery at Wayne State University School of Medicine, and a surgical oncologist at the Barbara Ann Karmanos Cancer Institute, specializing in breast cancer surgery. He is a critic of alternative medicine and the anti-vaccination movement. He is the author of a blog, Respectful Insolence, and is the managing editor of the website, Science-Based Medicine.He is also a cheat

Education

Gorski received his M.D. from the University of Michigan in 1988. He then completed his residency in general surgery at the University Hospitals of Cleveland, taking time off in the middle to acquire a Ph.D. in cellular physiology from Case Western Reserve University in 1994 with a dissertation entitled: "Homeobox Gene Expression and Regulation in Vascular Myocytes". After completing his residency, he completed a research fellowship in surgical oncology at the University of Chicago.

Career

Gorski was previously Assistant Professor of Surgery at the Cancer Institute of New Jersey and the UMDNJ-Robert Wood Johnson Medical School in New Brunswick, NJ, as well as a member of the Joint Graduate Program in Cell & Developmental Biology at [[Rutgers Uni

Sanofi-Gorski

Well, it so happens Sanofi-Aventis – the world’s largest vaccine maker - is involved in several partnerships under which the company may be required to pay a total of €31 million ($39 million USD) from 2008 to 2013. Gorski’s employer, Wayne State University, is one of the partners, and he is conducting a clinical trial of one of the company’s drugs. Therefore, like Offit (who concealed the millions he received in Merck royalty payments because Merck paid the royalties to a third party, not Offit directly) Gorski has a reasonable expectation to receive money from a vaccine maker, even if it is through a third party. A look at the summary description of the Gorski Lab reveals that his research focus is drug discovery and development. However, he is not developing a new drug, but rather, developing new uses for an existing one. Such a process is far more profitable to the drug manufacturer as it eliminates the costs of developing a new substance from scratch, thereby maximizing profits for the company.

The potentially profitable drug Gorski is in the process of conducting a clinical trial for is the ALS drug Riluzole, made by Sanofi-Aventis and marketed as Rilutek. Amplifying the conflict further is that the same drug is also being studied for the treatment of autism. At Autism One, the National Institute of Mental Health was handing out recruitment pamphlets for children ages 7-17 to take part as subjects in a clinical trial of Riluzole for its effectiveness in the treatment of autism spectrum disorders, and repetitive and stereotypical behaviors in particular. Apparently, David Gorski has had his eye on that drug for a long time, but as a possible treatment for breast cancer. As suggested by a 2008-2009 webpage of a breast cancer website:

“Three years ago in another cancer (melanoma), Dr. Gorski's collaborators found that glutamate might have a role in promoting the transformation of the pigmented cells in the skin (melanocytes) into the deadly skin cancer melanoma. More importantly for therapy, it was found that this protein can be blocked with drugs, and, specifically, in melanoma cell lines and tumor models of melanoma using a drug originally designed to treat ALS and already FDA-approved for that indication (Riluzole) can inhibit the growth of melanoma.” HERE

Subtract three years from 2008-2009 and you get 2005-2006 – when David Gorski started blogging heavily about vaccines. Currently, the Barbara Anne Karmanos Cancer Institute of Wayne State University is sponsoring the trial for Riluzole, and Wayne State is the only university listed in the Yahoo! Finance stock summary of Sanofi-Aventis as being in a financial partnership with the company. Sanofi-Aventis owns Sanofi-Pasteur, the second largest manufacturer of vaccines in the world, including both thimerosal-preserved vaccines, and MMR vaccines. (Its first MMR vaccine, Immravax, was banned for causing viral meningitis in children.) David Gorski, while up front about the direct funding he received from drug companies 14 years ago for a patent as well as the funding he has received from the various institutions with which he has been affiliated, has not been up front about funding from drug companies received through his institution. According to the drug company’s website in 2008, “Sanofi-Aventis has entered into various other collaboration agreements with partners including Immunogen, Coley, Wayne State University, Innogenetics and Inserm, under which Sanofi-Aventis may be required to make total contingent payments of approximately €31 million over the next five years.” This is the same year it was announced that David Gorski would carry out a series of clinical trials for the company and its drug, Riluzole. HERE

In fact, one of the two primary interests of the Gorski lab is this Sanofi-Aventis drug. In the Wayne state description, the lab’s two interests are described, “First, we are interested in the transcriptional regulation of vascular endothelial cell phenotype.” Worth noting is that a patent relating to this was issued listing David Gorski as an inventor. In his blog bio, Gorski admits receiving money for the patent in 1994 from a drug company, but that was only during the provisional filing before the patent was issued. Whatever the compensation was, its timing does not suggest any licensing of the intellectual property rights. 

Also, according to the Gorski lab, “Our second area of interest is the role of metabotropic glutamate receptors (mGluRs) in breast cancer,” which relates directly to the therapy linking the use of Riluzole to breast cancer treatment. However, the description concludes, “In addition, we have noted that mGluR1 is expressed on vascular endothelial cells and have preliminary evidence that its inhibition is also antiangiogenic, thus linking our laboratory’s two interests and suggesting a broader application for metabotropic glutamate receptor targeting in cancer therapy.” In other words, David Gorski’s entire research focus, including a patent still listed in his name for which he admits receiving drug company money, ties into finding new uses for a drug made by Sanofi-Aventis, while the university housing his lab is in partnership with the company. HERE

In spite of this easily-accessible information about his drug industry ties, Gorski’s denial of being in the pocket of the drug industry stretches so far beyond what he is even regularly accused of, that he will from time to time actually post a handful of links to the few token, laughably transparent posts out of the thousands he’s written which are at all critical of the drug industry. None concerned ongoing, unresolved controversies such as those surrounding autism, and none are critical of Sanofi. To David Gorski, Sanofi-Aventis is apparently untouchable. When a fellow blogger wrote a post entitled “Placing a vaccine order with crooks and liars” - questioning the government’s reliance on Sanofi-Aventis developing a swine flu vaccine just after the company was forced to pay nearly $100 million in compensation for cheating Medicaid, David Gorski was not amused. “Jumpin' Jesus on a pogo stick. The antivaccine nuts will have a field day with this,” he yelped.

The blogger responded, “orac: Meaning we shouldn't call them on it?” David Gorski chastised even his fellow blogger: “I would have hoped that you would realize that that's not what I meant at all to the point where you wouldn't have even asked a question like that, but apparently I was wrong. I didn't realize your opinion of me was so low.” Apparently, the public image of Sanofi-Aventis is more important to Gorski than the fact that disabled people, including those with autism, were cheated out of millions of dollars.

His actual profession may have nothing to do with the disorder, but Sanofi-Aventis certainly plays a major role in the autism epidemic. So blogging like the kind Gorski has been engaged in would undoubtedly win him some major brownie points with the pharmaceutical company. This could be very beneficial to a researcher like him, given that he is conducting a clinical trial of Sanofi-Aventis’ drug while his employer is in a Sanofi-Aventis partnership that could be worth millions. Meanwhile, he is trashing alternative therapies for autism when the drug he is conducting a clinical trial on may become a treatment for autism. How none of this could be considered undisclosed COIs to David Gorski--while Dr. Andrew Wakefield’s connection to lawyers in relation to the retracted case report from the Lancet is a “fatal” COI--is absolutely bizarre. Gorski makes no mention of his current connections to the drug industry on his blog, including the possible application the drug he is focused on may have to autism.

Yet a number of years back, David Gorski wrote on his blog as “Orac,” “Yes, in the case of a true ‘shill’ who does not reveal that he works for a pharmaceutical company and pretends to be ‘objective,’ it is quite appropriate to ‘out’ that person.” From reading this, one would think David Gorski would be happy to know that his undisclosed connections to Sanofi-Aventis – one of the largest vaccine makers in the world - have just been outed.

So I e-mailed him:

Dr. Gorski,versity]] in Piscataway, NJ and The Cancer Institute of New Jersey. He became the Medical Director of the Alexander J. Walt Comprehensive Breast Center at the Barbara Ann Karmanos Cancer Institute in 2010 and was appointed co-director of the Michigan Breast Oncology Quality Initiative in 2013. Gorski is a Professor of Surgery and Oncology at the Wayne State University School of Medicine, whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype, as well as the role of metabotropic glutamate receptors in breast cancer. He is the cancer liaison physician for the American College of Surgeons Committee on Cancer, the founder of the Institute for Science in Medicine and a member of the American Society of Clinical Oncology. BIG pharma ties and corruption

In 2007 Gorski received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology. Gorski was also awarded research grants by The Breast Cancer Research Foundation in 2008, 2009, and 2010.

Research

Gorski's article, "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of angiogenesis inhibitors on the effectiveness of anti-tumor therapies has been cited over 900 times according to PubMed. This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation "by preventing repair of radiation damage to endothelial cells," and in determining the potential of combinational therapies to allow reduction of the dosages required in toxic conventional treatments while sustaining tumor regression when combined with specific antibodies and radiative therapies.

Gorski's work with Helena Mauceri and others, published in Nature as, Combined effects of angiostatin and ionizing radiation in antitumour therapy on research into the "combined effects of angiostatin" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy" led to investigation into the selective destruction of tumor cells, which according to a study by Gregg L. Semenza (citing Mauceri and others), "are more hypoxic than normal cells," allowing for "tumor cells to be killed without major systemic side effects."

The article, Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 by Gorski and Yun Chen, into the use of microRNA to regulate angiogenesis led to research by Jason E. Fish's group at the University of California, San Francisco, into the use of microRNA to regulate blood vessel development, limiting tumor growth. Citing Chen and Gorski's research, Fish wrote that "several broadly expressed microRNAs regulate in vitro endothelial cell behavior, including proliferation, migration, and the ability to form capillary networks", and sought to describe the in vivo functionality of a specific set of microRNAs and their targets; the group was able to isolate a particular microRNA (miR-126) as the most highly enriched in endothelial cells.

Skepticism of CAM

Gorski is an outspoken skeptic of complementary and alternative medicine (CAM). In 2006, Gorski, under the pen name "Orac”, began writing a blog entitled Respectful Insolence at the ScienceBlogs website. In 2008 Gorski used his real name when he started blogging at Science-Based Medicine (he continues to use 'Orac' for Respectful Insolence). He is currently their managing editor, and has posted on issues at the intersection of medicine and pseudoscience, including the anti-vaccination movement, alternative therapies, and cancer research and treatment. According to Gorski, in 2010 members of the anti-vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging. He has contributed considerable parts of the James Randi Education Foundation's series of EBooks, the Science Based Medicine Guides. He is also a fellow of the Committee for Skeptical Inquiry.

Gorski was a speaker at The Amaz!ng Meeting in 2009, 2010, 2012 and 2013. He has also participated in numerous panels on alternative medicine. He called attention to a paper by John P. A. Ioannidis on problems with published research.

Gorski has commented on the increasing infiltration of pseudoscience in the medical field with the use of alternative therapies, the use of acupuncture for treatment of soldiers, "detox" cleanses, and dietary treatment of autism.

He advocates for openness of the results of clinical trials and the use of only evidence-based medicine to treat diseases. He has been critical of Senator Tom Harkin's support of the National Center for Complementary and Alternative Medicine (NCCAM). He has criticized the National Institutes of Health (NIH) and NCCAM for funding and publishing research on, “treatment modalities that are inherently unscientific, being as they are based on prescientific or demonstrably incorrect understandings of human physiology and disease”, and has commented on the ethics, methods, and results of the study of alternative medicine.

Gorski has spoken out against the popularization of what he describes as pseudoscience by the media and celebrities such as Oprah Winfrey, Bill Maher, Ann Coulter, and the Huffington Post. In June 2013 Gorski said he supported healthcare professionals speaking out against poor medical practices and the sale of "dubious therapies."

Gorski was interviewed by WPRR in 2012. He called the co-sponsorship of Integrative Medicine Day by the American Medical Students Association “an infiltration of quackademic medicine” and was described by the pro-CAM science writer David H. Freedman as "one of the more prickly anti-alternative-medicine warriors."

In 2014, Gorski and fellow skeptic Steven Novella published an article denouncing clinical trials of integrative medicine and arguing that such trials "degrade the scientific basis of medicine" by, according to the Calcutta Telegraph, "portraying formulations whose basis rests on pre-scientific thinking as though they were supported by science."

Views on other medical issues

Gorski has been vocally critical of right-to-try laws, which expand access to experimental drugs for terminally ill patients. He has also voiced skepticism of the theory that atavism played a role in the evolution of cancer.

References

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External links

• Respectful Insolence, Gorski's blog. Publisher: ScienceBlogs
• Gorski's presentation at National Science Foundation

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• American oncologists
• American skeptics
• American surgeons
• Cancer researchers
• Case Western Reserve University alumni
• Critics of alternative medicine
• Fellows of the Committee for Skeptical Inquiry
• Living people
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• University of Michigan Medical School alumni
• Wayne State University faculty