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Linus Carl Pauling (February 28, 1901 – August 19, 1994) was an American quantum chemist and biochemist, widely regarded as the premier chemist of the twentieth century. Pauling was a pioneer in the application of quantum mechanics to chemistry (quantum mechanics can, in principle, describe all of chemistry and molecular biology), and in 1954 was awarded the Nobel Prize in chemistry for his work describing the nature of chemical bonds. He also made important contributions to crystal and protein structure determination, and was one of the founders of molecular biology. Pauling is noted as a versatile scholar for his expertise in inorganic chemistry, organic chemistry, metallurgy, immunology, anesthesiology, psychology, debate, radioactive decay, and the aftermath of nuclear weapons, in addition to quantum mechanics and molecular biology.

Pauling received the Nobel Peace Prize in 1962 for his campaign against above-ground nuclear testing, becoming the only person in history to individually receive two Nobel Prizes (Marie Curie won Nobel Prizes in physics and chemistry, but shared the former and won the latter individually; John Bardeen won two Nobel Prizes in the field of physics, but both were shared; Frederick Sanger won two Nobel Prizes in chemistry, but one was shared).

Later in life, he became an advocate for regular consumption of massive doses of Vitamin C, which is still regarded as unorthodox by conventional medicine.

Early life

Pauling was born in Portland, Oregon to Herman Henry William Pauling (1876-1910) of Concordia, Missouri; and Lucy Isabelle Darling (1881-1926) of Lonerock, Oregon. Herman was an unsuccessful druggist who moved his family to and from a number of different cities in Oregon from 1903 to 1909, finally returning to Portland that year. Herman died in 1910 of a perforated ulcer, and Isabelle was left to care for Linus and two younger siblings: Pauline Pauling (1901-2003) who married Thomas Joseph Ney (1881-1963) of Millville, New Jersey; and Frances Lucille Pauling (1904-?).

Pauling was a voracious reader as a child, and at one point his father wrote a letter to a local paper inviting suggestions of additional books that would occupy his time. A friend, Lloyd Jeffress, had a small chemistry laboratory in his bedroom when Pauling was in grammar school, and Jeffress' laboratory experiments inspired Pauling to plan to become a chemical engineer.

In high school, Pauling continued to experiment in chemistry, borrowing much of the equipment and materials from an abandoned steel company near which his grandfather worked as a night watchman.

Pauling failed to take some required American history courses and did not qualify for his high school diploma. The school awarded him the diploma 45 years later only after he had won two Nobel Prizes.

College and university

In 1917, Pauling entered the Oregon Agricultural College (OAC) in Corvallis, now Oregon State University. Because of financial needs, he had to work full-time while attending a full schedule of classes. After his second year, he planned to take a job in Portland to help support his mother, but the college offered him a position teaching quantitative analysis (a course Pauling had just finished taking as a student). This allowed him to continue his studies at OAC.

In his last two years at OAC, Pauling became aware of the work of Gilbert N. Lewis and Irving Langmuir on the electronic structure of atoms and their bonding to form molecules. He decided to focus his research on how the physical and chemical properties of substances are related to the structure of the atoms of which they are composed, becoming one of the founders of the new science of quantum chemistry.

In 1922, Pauling graduated from OAC and went to graduate school at the California Institute of Technology ("Caltech") in Pasadena, California under the guidance of Roscoe Gilkey Dickinson. His graduate research involved the use of X-ray diffraction to determine crystal structure. He published seven papers on the crystal structure of minerals while he was at Caltech. He received his Ph. D. degree in physical chemistry, summa cum laude, in 1925.

Marriage

In his senior years Linus Pauling taught junior classes in "Chemistry for Home Economic Majors" . In one of these classes he met Ava Helen Miller, who he married her on June 17, 1923; they had three sons and a daughter.

Early scientific career

Pauling later traveled to Europe on a Guggenheim Fellowship to study under German physicist Arnold Sommerfeld in Munich, Danish physicist Niels Bohr in Copenhagen, and Austrian physicist Erwin Schrödinger in Zürich. All three were experts working in the new field of quantum mechanics and other branches of physics. While he was studying at the Oregon Agricultural College, Pauling was first exposed to the idea of quantum theory and quantum mechanics. He became interested in seeing how it might help in the understanding of his chosen field of interest, the electronic structure of atoms and molecules. In Europe, Pauling was also exposed to one of the first quantum mechanical analyses of bonding in the hydrogen molecule, done by Walter Heitler and Fritz London. Pauling devoted the two years of his European trip to this work and decided to make this the focus of his future research. He became one of the first scientists in the field of quantum chemistry and a pioneer in the application of quantum theory to the structure of molecules. In 1927, he took a new position as an assistant professor at Caltech in theoretical chemistry.

Pauling began his faculty career at Caltech with a very productive five years, both continuing with his X-ray crystal studies and performing quantum mechanical calculations on atoms and molecules. He published approximately fifty papers in those five years and created five rules now known as Pauling's Rules. In 1929, he was promoted to associate professor, and in 1930, to full professor. By 1931, the American Chemical Society awarded Pauling the Langmuir Prize for the most significant work in pure science by a person 30 years of age or younger. In 1932, Pauling published what he regarded as his most important paper, in which he first laid out the concept of hybridization of atomic orbitals and analyzed the tetravalency of the carbon atom.

At Caltech, Pauling struck a close friendship with theoretical physicist Robert Oppenheimer, who was spending part of his research and teaching schedule away from Berkeley at Caltech every year. The two men planned to mount a joint attack on the nature of the chemical bond; apparently Oppenheimer would supply the mathematics and Pauling would interpret the results. However, this relationship soured when Pauling began to suspect that Oppenheimer was probably becoming too close to Pauling's wife, Ava Helen. Once, when Pauling was at work, Oppenheimer had come to their place and blurted out an invitation to Ava Helen to join him on a tryst to Mexico. Although she flatly refused, she reported this incident to Pauling. This, and her apparent nonchalance about the incident, disquieted him, and he immediately cut off his relationship with the Berkeley professor, leading to a coolness between them that would last their lives, although Oppenheimer did invite Pauling to be the head of the Chemistry Division of the atomic bomb project. (Pauling refused, saying that he was a pacifist).

In the summer of 1930, Pauling made another European trip, learning about the use of electrons in diffraction studies similar to the ones he had performed with X-rays. With a student of his, L. O. Brockway, he built an electron diffraction instrument at Caltech and used it to study the molecular structure of a large number of chemical substances.

Linus Pauling introduced the concept of electronegativity in 1932. Using the various properties of molecules, such as the energy required to break bonds and the dipole moments of molecules, he established a scale and an associated numerical value for most of the elements, the Pauling Electronegativity Scale, which is useful in predicting the nature of bonds between atoms in molecules.

Work on the nature of the chemical bond

In the 1930s he began publishing papers on the nature of the chemical bond, leading to his famous textbook on the subject published in 1939. It is based primarily on his work in this area that he received the Nobel Prize in Chemistry in 1954 "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances". Pauling summarized his work on the chemical bond in The Nature of the Chemical Bond, one of the most influential chemistry books ever published. In the 30 years since its first edition was published in 1939, the book had been cited more than 16,000 times. Even today, many modern scientific papers and articles in important journals cite this work, more than half a century after first publication.

Part of Pauling's work on the nature of the chemical bond led to his introduction of the concept of orbital hybridization. While it is normal to think of the electrons in an atom as being described by orbitals of types such as s, p, etc., it turns out that in describing the bonding in molecules, it is better to construct functions that partake of some of the properties of each. Thus the one 2s and three 2p orbitals in a carbon atom can be combined to make four equivalent orbitals (called sp hybrid orbitals), which would be the appropriate orbitals to describe carbon compounds such as methane, or the 2s orbital may be combined with two of the 2p orbitals to make three equivalent orbitals (called sp hybrid orbitals), with the remaining 2p orbital unhybridized, which would be the appropriate orbitals to describe certain unsaturated carbon compounds such as ethylene. Other hybridization schemes are also found in other types of molecules.

Another area which he explored was the relationship between ionic bonding, where electrons are transferred between atoms, and covalent bonding where electrons are shared between atoms on an equal basis. Pauling showed that these were merely extremes, between which most actual cases of bonding fall. It was here especially that Pauling's electronegativity concept was particularly useful; the electronegativity difference between a pair of atoms will be the surest predictor of the degree of ionicity of the bond.

The third of the topics that Pauling attacked under the overall heading of "the nature of the chemical bond" was the accounting of the structure of aromatic hydrocarbons, particularly the prototype, benzene. The best description of benzene had been made by the German chemist Friedrich Kekulé. He had treated it as a rapid interconversion between two structures, each with alternating single and double bonds, but with the double bonds of one structure in the locations where the single bonds were in the other. Pauling showed that a proper description based on quantum mechanics was an intermediate structure containing some aspects of each. The structure was a superposition of structures rather than a rapid interconversion between them. The name "resonance" was later applied to this phenomenon. In a sense, this phenomenon resembles that of hybridization, described earlier, because it involves combining more than one electronic structure to achieve an intermediate result.

Work on structure of the atomic nucleus

On September 16, 1952, Linus Pauling opened a new research notebook with these words "I have decided to attack the problem of the structure of nuclei" (see his actual notes at Oregon State Special Collections). On October 15, 1965, Pauling published his Close-Packed Spheron Model of the atomic nucleus in two well respected journals, Science, and Proc. Natl. Acad. Sci. For nearly three decades, until his death in 1994, Pauling published numerous papers on his spheron cluster model.

No modern text books on nuclear physics discuss the Pauling Spheron Model of the Atomic Nucleus, yet it provides a unique perspective, well published in the leading journals of science, on how fundamental "clusters of nucleons" can form shell structure in agreement with recognized theory of quantum mechanics. Pauling was well versed in quantum mechanics--he coauthored one of the first textbooks on the subject (Introduction to Quantum Mechanics with Applications to Chemistry by Linus Pauling, E. Bright Wilson, 1935). The Pauling spheron nucleon clusters include the deuteron, helion , and triton .

Work on biological molecules

In the mid-1930s, Pauling decided to strike out into new areas of interest. Early in his career, he had mentioned a lack of interest in studying molecules of biological importance. But as Caltech was developing a new strength in biology, and Pauling interacted with such great biologists as Thomas Hunt Morgan, Theodosius Dobzhanski, Calvin Bridges, and Alfred Sturtevant, he started to become interested in studying biological molecules. His first work in this area involved the structure of hemoglobin. He was able to demonstrate that the hemoglobin molecule changes structure when it gains or loses an oxygen atom. As a result of this observation, he decided to make a more thorough study of protein structure in general. He returned to his earlier use of X-ray diffraction analysis. But protein structures were far less amenable to this technique than the crystalline minerals of his former work. The best X-ray pictures of proteins in the 1930s had been made by the British crystallographer William Astbury, but when Pauling tried, in 1937, to account for Astbury's observations quantum mechanically, he could not.

It took eleven years for Pauling to explain the problem: his mathematical analysis was correct, but Astbury's pictures were taken in such a way that the protein molecules were tilted from their expected positions. Pauling had formulated a model for the structure of hemoglobin in which atoms were arranged in a helical pattern, and applied this idea to proteins in general.

In 1951, based on the structures of amino acids and peptides and the planarity of the peptide bond, Pauling and colleagues correctly proposed the alpha helix and beta sheet as the primary structural motifs in protein secondary structure. This work exemplified his ability to think unconventionally; central to the structure was the unorthodox assumption that one turn of the helix may well contain a non-integral number of amino acid residues.

Pauling then suggested a helical structure for deoxyribonucleic acid (DNA) but in this structure he uncharacteristically made several basic mistakes, including making the phosphate group neutral, a fact which would no longer represent DNA as an acid. Sir Lawrence Bragg had been disappointed that Pauling had won the race to find the alpha helix. Bragg's team had made a fundamental error in making their models of protein by not recognizing the planar nature of the peptide bond. When it was learned at the Cavendish Laboratory that Pauling was working on molecular models of the structure of DNA, Watson and Crick were allowed to make a molecular model of DNA using unpublished data from Maurice Wilkins and Rosalind Franklin at King's College. Early in 1953 James D. Watson and Francis Crick proposed a correct structure for the DNA double helix. One of the impediments facing Pauling in this work was that he did not have access to the high quality X-ray diffraction photographs of DNA taken by Rosalind Franklin, which Watson and Crick had seen. He planned to attend a conference in England, where he might have been shown the photos, but he could not do so because his passport was withheld at the time by the State Department, on suspicions that he had Communist sympathies. This was at the start of the McCarthy period in the United States.

Pauling also studied enzyme reactions and was among the first ones to point out that enzymes bring about reactions by stabilizing the transition state of the reaction, a view which is central to understanding their mechanism of action. He was also among the first scientists to postulate that the binding of antibodies to antigens would be due to a complementarity between their structures. Along the same lines, with the physicist turned biologist Max Delbruck, he wrote an early paper arguing that DNA replication was likely to be due to complementarity, rather than similarity, as suggested by a few researchers. This was made clear in the model of the structure of DNA that Watson and Crick discovered.

Molecular genetics

In November 1949 Linus Pauling, Harvey Itano, S. J. Singer and Ibert Wells published in the journal Science the first proof that a human disease was associated with a change in a specific protein. Using electrophoresis, they demonstrated that individuals with sickle cell disease had a modified hemoglobin in their red blood cells, and that individuals with the sickle cell trait, upon electrophoresis, had both the normal and abnormal hemoglobin. This was the first demonstration of a specific protein associated with a human disease, and the Mendelian inheritance of a change in that specific protein - the dawn of molecular genetics.

It was Vernon Ingram and J. A. Hunt in 1956 who determined that the change in the hemoglobin molecule in sickle cell disease and trait was the substitution of the glutamic acid in position 6 of the β-chain of the normal protein by valine.

Activism

Pauling had been practically apolitical until World War II, but the war changed his life profoundly, and he became a peace activist. During the beginning of the Manhattan Project, Robert Oppenheimer invited him to be in charge of the Chemistry division of the project, but he declined, saying that he was a pacifist. In 1946 he joined the Emergency Committee of Atomic Scientists, chaired by Albert Einstein, whose mission was to warn the public of the dangers associated with the development of nuclear weapons. His political activism prompted the U.S. State Department to deny him a passport in 1952, when he was invited to speak at a scientific conference in London. His passport was restored in 1954, shortly before the ceremony in Stockholm where he received his first Nobel Prize. Joining Einstein, Bertrand Russell and 8 other leading scientists and intellectuals he signed the Russell-Einstein Manifesto in 1955.

In 1957, Pauling began a petition drive in cooperation with biologist Barry Commoner, who had studied radioactive strontium-90 in the baby teeth of children across North America and concluded that above-ground nuclear testing posed public health risks in the form of radioactive fallout. He also participated in a public debate with the atomic physicist Edward Teller about the actual probability of fallout causing mutations. In 1958, Pauling and his wife presented the United Nations with a petition signed by more than 11,000 scientists calling for an end to nuclear-weapon testing. Public pressure subsequently led to a moratorium on above-ground nuclear weapons testing, followed by the Partial Test Ban Treaty, signed in 1963 by John F. Kennedy and Nikita Khrushchev. On the day that the treaty went into force, the Nobel Prize Committee awarded Pauling the Peace Prize, describing him as "Linus Carl Pauling, who ever since 1946 has campaigned ceaselessly, not only against nuclear weapons tests, not only against the spread of these armaments, not only against their very use, but against all warfare as a means of solving international conflicts." Interestingly, the Caltech Chemistry Department, wary of his political views, did not even formally congratulate him. However, the Biology Department did throw him a small party, showing they were more appreciative and sympathetic toward his work on radiation mutation.

Many of Pauling's critics, including scientists who appreciated the contributions that he had made in chemistry, disagreed with his political positions and saw him as a naïve spokesman for Soviet communism. He was ordered to appear before the Senate Internal Security Subcommittee, which termed him "the number one scientific name in virtually every major activity of the Communist peace offensive in this country." An extraordinary headline in Life magazine characterized his 1962 Nobel Prize as "A Weird Insult from Norway." Pauling was awarded the International Lenin Peace Prize by the USSR in 1970.

Work in the development of the electric car

In the late 1950s, Pauling became concerned with the problem of air pollution - particularly with the growing smog problem in Los Angeles. At the time, most scientists believed that the smog was due to chemical plants and refineries - not gasoline engine exhaust. Pauling worked with Arie Haagen-Smit and others at Caltech to show that smog was a product of automobile pollution instead of factory pollution. Shortly after this discovery, Pauling began work to develop a practical and affordable electric car. He joined forces with the engineers at the Eureka Williams company in the development of the Henney Kilowatt - the first speed-controlled electric car. After researching the electrophysics underlying the initial Kilowatt propulsion system, Pauling determined that traditional lead-acid batteries would not provide the power necessary to give electric cars the performance necessary to rival traditional gasoline powered cars. Pauling accurately predicted that the low top speed and the short range of the Henney Kilowatt would make them impractical and unpopular. Pauling insisted on making the car more practical before releasing it to the public, and recommended that the project be discontinued until the appropriate battery was available commercially. Unfortunately, Eureka Williams Company insisted that the production plans for the car proceed - leading to dismal sales and an additional delay in the development of practical electric cars.

Work in alternative medicine

In 1941, at age 40, Pauling was diagnosed with a serious form of Bright’s disease, a fatal renal disease. Experts believed then that Bright's disease was untreatable. With the help of Dr. Thomas Addis at Stanford, Pauling was able to control the disease with Addis' then unusual, low protein, salt-free diet. Addis also prescribed vitamins and minerals for all his patients.

In the late 1950s, Pauling worked on the role of enzymes in brain function, believing that mental illness may be partly caused by enzyme dysfunction. It wasn't until he read "Niacin Therapy in Psychiatry" by Abram Hoffer in 1965 that he realized that vitamins might have important biochemical effects unrelated to their prevention of associated deficiency diseases. Pauling published a brief paper, "Orthomolecular Psychiatry", in the journal Science in 1968 (PMID 5641253) that gave name and principle to the popular but controversial megavitamin therapy movement of the 1970s. Pauling coined the term "orthomolecular" to refer to the practice of varying the concentration of substances normally present in the body to prevent and treat disease.

Pauling's work on vitamin C in his later years generated controversy and was regarded by some adversaries in the field of medicine as outright quackery. His ideas formed the basis of orthomolecular medicine, which is considered pseudoscience by some critics. The majority are often dismissive: "Scientific research has found no benefit from orthomolecular therapy for any disease."

He was first introduced to the concept of high-dose vitamin C by biochemist Irwin Stone in 1966 and began taking several grams every day to prevent colds. Excited by the results, he researched the clinical literature and published "Vitamin C and the Common Cold" in 1970. He began a long clinical collaboration with the British cancer surgeon, Ewan Cameron, in 1971 on the use of intravenous and oral vitamin C as cancer therapy for terminal patients. Cameron and Pauling wrote many technical papers and a popular book, "Cancer and Vitamin C", that discussed their observations. After three disputed trials at the Mayo Clinic, Pauling, known for his blunt precision and candor, pointedly denounced Moertel's conclusions and handling of the final study as "fraud and deliberate misrepresentation" , Pauling published critiques of the second Mayo-Moertel cancer trial's flaws over several years as he was able to slowly unearth some of the trial's undisclosed details. However, the wave of adverse publicity generated by Moertel and the media effectively undercut Pauling's credibility and his vitamin C work for a generation. Always precariously perched since his molecular biologically inspired crusade to stop atmospheric nuclear testing in the 1950s, the 1985 Mayo-Moertel confrontation left Pauling isolated from his institutional funding sources, academic support and a bemused public. He later collaborated with the Canadian physician, Abram Hoffer, on a micronutrient regimen, including high-dose vitamin C, as adjunctive cancer therapy.

As of 2005, some physicians have called for a more careful reassessment of vitamin C, especially intravenous vitamin C, in cancer treatment. The selective toxicity of vitamin C for cancer cells has been demonstrated repeatedly, . The Proceedings of the National Academy of Sciences recently published a paper demonstrating vitamin C killing cancer cells.

With two colleagues, Pauling founded the Institute of Orthomolecular Medicine in Menlo Park, California, in 1973, which was soon renamed the Linus Pauling Institute of Science and Medicine. Pauling directed research on vitamin C, but also continued his theoretical work in chemistry and physics until his death from prostate cancer in 1994. In his last years, he became especially interested in the possible role of vitamin C in preventing atherosclerosis and published three case reports on the use of lysine and vitamin C to relieve angina pectoris. In 1996, the Linus Pauling Institute moved from Palo Alto, California, to Corvallis, Oregon, to become part of Oregon State University, where it continues to conduct research on micronutrients, phytochemicals (chemicals from plants), and other constituents of the diet in preventing and treating disease.

Pauling's legacy

Pauling's contribution to science is held by many in the utmost regard. He was included in a list of the 20 greatest scientists of all time by the British magazine New Scientist, with Albert Einstein being the only other scientist from the twentieth century on the list. Gautam R. Desiraju, the author of the Millennium Essay in Nature (408: 407, 2000) claimed that Pauling was one of the greatest thinkers and visionaries of the millennium, along with Galileo, Newton, and Einstein (PMID 11100703). Pauling is also notable for the diversity of his interests: quantum mechanics, inorganic chemistry, organic chemistry, protein structure, molecular biology, and medicine. In all these fields, and especially on the boundaries between them, he made decisive contributions. His work on chemical bonding marks the beginning of modern quantum chemistry, and many of his contributions like hybridization and electronegativity have become part of standard chemistry textbooks. Although his valence bond approach fell short of accounting quantitatively for some of the characteristics of molecules, such as the paramagnetic nature of oxygen and the color of organometallic complexes, and would later be superseded by the Molecular Orbital Theory of Robert Mulliken, the strength of Pauling's theory has lain in its simplicity, and it has endured. Pauling's work on crystal structure contributed significantly to the prediction and elucidation of the structures of complex minerals and compounds. His discovery of the alpha helix and beta sheet is a fundamental foundation for the study of protein structure.

In his time, Pauling was frequently honored with the sobriquet "Father of molecular biology". His discovery of sickle cell anemia as a 'molecular disease' opened the way toward examining genetically acquired mutations at a molecular level.

Trivia

• Linus Pauling was a member of Delta Upsilon Fraternity.
• Linus Pauling was a member of the Alpha Chi Sigma professional chemistry fraternity.
• Linus Pauling was a member of Sigma Xi, The Scientific Research Society.
• There is a Houston, Texas, psych-rock band called the Linus Pauling Quartet.
• In Corvallis, Oregon, USA, Highland View Middle School was renamed Linus Pauling Middle School in 2003.

Works by Linus Pauling

• Pauling, L. The Nature of the Chemical Bond (Cornell University Press) ISBN 0801403332
• Pauling, L., and Wilson, E. B. Introduction to Quantum Mechanics with Applications to Chemistry (Dover Publications) ISBN 0486648710
• Cameron E. and Pauling, L. Cancer and Vitamin C: A Discussion of the Nature, Causes, Prevention, and Treatment of Cancer With Special Reference to the Value of Vitamin C (Camino Books) ISBN 094015921X
• Pauling, L. How to Live Longer and Feel Better (Avon Books) ISBN 0380702894
• Pauling, L. Linus Pauling On Peace - A Scientist Speaks Out on Humanism and World Survival (Rising Star Press) ISBN 0933670036
• Pauling, L. General Chemistry (Dover Publications) ISBN 0486656225
• A Lifelong Quest for Peace with Daisaku Ikeda

See also

• Pauling's rules
• Vitamin C
• 1920 US Census with Pauling in Portland, Oregon
• Alpha helix

Notes and references

Notes

1. Linus Pauling Biography, Nobelprize.org
2. The Dark Side of Linus Pauling's Legacy by Stephen Barrett
3. Cassileth BR. Alternative medicine handbook: the complete reference guide to alternative and complementary therapies. New York: W.W.Norton & Co., 1998:67.
4. "Vitamin Therapy, Megadose / Orthomolecular Therapy" British Columbia Provincial Health Services Authority 2000

References

• Hager, Thomas, "Force of Nature: The Life of Linus Pauling" Simon & Schuster (1995) ISBN 684809095.
• Hager, Tom, "Linus Pauling and the Chemistry of Life" Oxford University Press (1998) ISBN 0195139720.
• Mead, Clifford and Thomas Hager, "Linus Pauling: Scientist and Peacemaker" Oregon State University Press (2001) ISBN 0870714899.
• Marinacci, Barbara, and Ramesh Krishnamurthy, "Linus Pauling on Peace" Rising Star Press (1998) ISBN 0933670036.
• Goertzel, Ted and Ben Goertzel, "Linus Pauling: A Life in Science and Politics" Basic Books (1995) ISBN 0465006728
• Serafini, Anthony, "Linus Pauling: A Man and His Science" Paragon House (1989) ISBN 155778440X.

Quotes

• "A couple of days after my talk, there was a man in my office from the FBI saying-Who told you how much plutonium there is in an atomic bomb? And I said-Nobody told me, I figured it out."
• "I have always liked working in some scientific direction that nobody else is working in."

External links

• Academy of Achievement Profile http://www.achievement.org/autodoc/page/pau0pro-1
• Academy of Achievement Biography http://www.achievement.org/autodoc/page/pau0bio-1
• Academy of Achievement Interview http://www.achievement.org/autodoc/page/pau0int-1
• Academy of Achievement Photo Gallery http://www.achievement.org/autodoc/page/pau0gal-1
• Francis Crick: The Impact of Linus Pauling on Molecular Biology (from the 1995 Oregon State University symposium):
• The Ava Helen and Linus Pauling Papers at the Oregon State University Libraries
• Linus Pauling (1901-1994)
• National Academy of Sciences biography
• Caltech oral history interview
• Berkeley Conversations With History interview
• Scans of 46 of Pauling's notebooks from 1922 to 1994
• Linus Pauling and the Race for DNA
• Linus Pauling: The Nature of the Chemical Bond
• Linus Pauling, Hemoglobin and Sickle Cell Anemia: A Documentary History
• Linus Pauling's Honors, Awards and Medals
• Linus Pauling Centenary Exhibit
• Linus Pauling Investigates Vitamin C
• The Dark Side of Linus Pauling's Legacy
• The Linus Pauling Institute at Oregon State University
• The Many Lives of Linus Pauling: A Review of Reviews J. Chem. Educ.

v t e Laureates of the Nobel Prize in Chemistry
1901–1925	1901: Jacobus van 't Hoff 1902: Emil Fischer 1903: Svante Arrhenius 1904: William Ramsay 1905: Adolf von Baeyer 1906: Henri Moissan 1907: Eduard Buchner 1908: Ernest Rutherford 1909: Wilhelm Ostwald 1910: Otto Wallach 1911: Marie Curie 1912: Victor Grignard / Paul Sabatier 1913: Alfred Werner 1914: Theodore Richards 1915: Richard Willstätter 1916 1917 1918: Fritz Haber 1919 1920: Walther Nernst 1921: Frederick Soddy 1922: Francis Aston 1923: Fritz Pregl 1924 1925: Richard Zsigmondy
1926–1950	1926: Theodor Svedberg 1927: Heinrich Wieland 1928: Adolf Windaus 1929: Arthur Harden / Hans von Euler-Chelpin 1930: Hans Fischer 1931: Carl Bosch / Friedrich Bergius 1932: Irving Langmuir 1933 1934: Harold Urey 1935: Frédéric Joliot-Curie / Irène Joliot-Curie 1936: Peter Debye 1937: Norman Haworth / Paul Karrer 1938: Richard Kuhn 1939: Adolf Butenandt / Leopold Ružička 1940 1941 1942 1943: George de Hevesy 1944: Otto Hahn 1945: Artturi Virtanen 1946: James B. Sumner / John Northrop / Wendell Meredith Stanley 1947: Robert Robinson 1948: Arne Tiselius 1949: William Giauque 1950: Otto Diels / Kurt Alder
1951–1975	1951: Edwin McMillan / Glenn T. Seaborg 1952: Archer Martin / Richard Synge 1953: Hermann Staudinger 1954: Linus Pauling 1955: Vincent du Vigneaud 1956: Cyril Hinshelwood / Nikolay Semyonov 1957: Alexander Todd 1958: Frederick Sanger 1959: Jaroslav Heyrovský 1960: Willard Libby 1961: Melvin Calvin 1962: Max Perutz / John Kendrew 1963: Karl Ziegler / Giulio Natta 1964: Dorothy Hodgkin 1965: Robert Woodward 1966: Robert S. Mulliken 1967: Manfred Eigen / Ronald Norrish / George Porter 1968: Lars Onsager 1969: Derek Barton / Odd Hassel 1970: Luis Federico Leloir 1971: Gerhard Herzberg 1972: Christian B. Anfinsen / Stanford Moore / William Stein 1973: Ernst Otto Fischer / Geoffrey Wilkinson 1974: Paul Flory 1975: John Cornforth / Vladimir Prelog
1976–2000	1976: William Lipscomb 1977: Ilya Prigogine 1978: Peter D. Mitchell 1979: Herbert C. Brown / Georg Wittig 1980: Paul Berg / Walter Gilbert / Frederick Sanger 1981: Kenichi Fukui / Roald Hoffmann 1982: Aaron Klug 1983: Henry Taube 1984: Robert Merrifield 1985: Herbert A. Hauptman / Jerome Karle 1986: Dudley R. Herschbach / Yuan T. Lee / John Polanyi 1987: Donald J. Cram / Jean-Marie Lehn / Charles J. Pedersen 1988: Johann Deisenhofer / Robert Huber / Hartmut Michel 1989: Sidney Altman / Thomas Cech 1990: Elias Corey 1991: Richard R. Ernst 1992: Rudolph A. Marcus 1993: Kary Mullis / Michael Smith 1994: George Olah 1995: Paul J. Crutzen / Mario Molina / F. Sherwood Rowland 1996: Robert Curl / Harold Kroto / Richard Smalley 1997: Paul D. Boyer / John E. Walker / Jens Christian Skou 1998: Walter Kohn / John Pople 1999: Ahmed Zewail 2000: Alan J. Heeger / Alan MacDiarmid / Hideki Shirakawa
2001–present	2001: William Knowles / Ryoji Noyori / K. Barry Sharpless 2002: John B. Fenn / Koichi Tanaka / Kurt Wüthrich 2003: Peter Agre / Roderick MacKinnon 2004: Aaron Ciechanover / Avram Hershko / Irwin Rose 2005: Robert H. Grubbs / Richard R. Schrock / Yves Chauvin 2006: Roger D. Kornberg 2007: Gerhard Ertl 2008: Osamu Shimomura / Martin Chalfie / Roger Y. Tsien 2009: Venkatraman Ramakrishnan / Thomas A. Steitz / Ada E. Yonath 2010: Richard F. Heck / Akira Suzuki / Ei-ichi Negishi 2011: Dan Shechtman 2012: Robert Lefkowitz / Brian Kobilka 2013: Martin Karplus / Michael Levitt / Arieh Warshel 2014: Eric Betzig / Stefan Hell / William E. Moerner 2015: Tomas Lindahl / Paul L. Modrich / Aziz Sancar 2016: Jean-Pierre Sauvage / Fraser Stoddart / Ben Feringa 2017: Jacques Dubochet / Joachim Frank / Richard Henderson 2018: Frances Arnold / Gregory Winter / George Smith 2019: John B. Goodenough / M. Stanley Whittingham / Akira Yoshino 2020: Emmanuelle Charpentier / Jennifer Doudna 2021: David MacMillan / Benjamin List 2022: Carolyn R. Bertozzi / Morten P. Meldal / Karl Barry Sharpless 2023: Moungi G. Bawendi / Louis E. Brus / Alexei I. Ekimov 2024: David Baker / Demis Hassabis / John M. Jumper

v t e Laureates of the Nobel Peace Prize
1901–1925	1901: Henry Dunant / Frédéric Passy 1902: Élie Ducommun / Charles Gobat 1903: Randal Cremer 1904: Institut de Droit International 1905: Bertha von Suttner 1906: Theodore Roosevelt 1907: Ernesto Moneta / Louis Renault 1908: Klas Arnoldson / Fredrik Bajer 1909: A. M. F. Beernaert / Paul Estournelles de Constant 1910: International Peace Bureau 1911: Tobias Asser / Alfred Fried 1912: Elihu Root 1913: Henri La Fontaine 1914 1915 1916 1917: International Committee of the Red Cross 1918 1919: Woodrow Wilson 1920: Léon Bourgeois 1921: Hjalmar Branting / Christian Lange 1922: Fridtjof Nansen 1923 1924 1925: Austen Chamberlain / Charles Dawes
1926–1950	1926: Aristide Briand / Gustav Stresemann 1927: Ferdinand Buisson / Ludwig Quidde 1928 1929: Frank B. Kellogg 1930: Nathan Söderblom 1931: Jane Addams / Nicholas Butler 1932 1933: Norman Angell 1934: Arthur Henderson 1935: Carl von Ossietzky 1936: Carlos Saavedra Lamas 1937: Robert Cecil 1938: Nansen International Office for Refugees 1939 1940 1941 1942 1943 1944: International Committee of the Red Cross 1945: Cordell Hull 1946: Emily Balch / John Mott 1947: Friends Service Council / American Friends Service Committee 1948 1949: John Boyd Orr 1950: Ralph Bunche
1951–1975	1951: Léon Jouhaux 1952: Albert Schweitzer 1953: George C. Marshall 1954: United Nations High Commissioner for Refugees 1955 1956 1957: Lester B. Pearson 1958: Georges Pire 1959: Philip Noel-Baker 1960: Albert Luthuli 1961: Dag Hammarskjöld 1962: Linus Pauling 1963: International Committee of the Red Cross / League of Red Cross Societies 1964: Martin Luther King Jr. 1965: UNICEF 1966 1967 1968: René Cassin 1969: International Labour Organization 1970: Norman Borlaug 1971: Willy Brandt 1972 1973: Lê Đức Thọ (declined award) / Henry Kissinger 1974: Seán MacBride / Eisaku Satō 1975: Andrei Sakharov
1976–2000	1976: Betty Williams / Mairead Corrigan 1977: Amnesty International 1978: Anwar Sadat / Menachem Begin 1979: Mother Teresa 1980: Adolfo Pérez Esquivel 1981: United Nations High Commissioner for Refugees 1982: Alva Myrdal / Alfonso García Robles 1983: Lech Wałęsa 1984: Desmond Tutu 1985: International Physicians for the Prevention of Nuclear War 1986: Elie Wiesel 1987: Óscar Arias 1988: UN Peacekeeping Forces 1989: Tenzin Gyatso (14th Dalai Lama) 1990: Mikhail Gorbachev 1991: Aung San Suu Kyi 1992: Rigoberta Menchú 1993: Nelson Mandela / F. W. de Klerk 1994: Shimon Peres / Yitzhak Rabin / Yasser Arafat 1995: Pugwash Conferences / Joseph Rotblat 1996: Carlos Belo / José Ramos-Horta 1997: International Campaign to Ban Landmines / Jody Williams 1998: John Hume / David Trimble 1999: Médecins Sans Frontières 2000: Kim Dae-jung
2001–present	2001: United Nations / Kofi Annan 2002: Jimmy Carter 2003: Shirin Ebadi 2004: Wangari Maathai 2005: International Atomic Energy Agency / Mohamed ElBaradei 2006: Grameen Bank / Muhammad Yunus 2007: Al Gore / Intergovernmental Panel on Climate Change 2008: Martti Ahtisaari 2009: Barack Obama 2010: Liu Xiaobo 2011: Ellen Johnson Sirleaf / Leymah Gbowee / Tawakkol Karman 2012: European Union 2013: Organisation for the Prohibition of Chemical Weapons 2014: Kailash Satyarthi / Malala Yousafzai 2015: Tunisian National Dialogue Quartet 2016: Juan Manuel Santos 2017: International Campaign to Abolish Nuclear Weapons 2018: Denis Mukwege / Nadia Murad 2019: Abiy Ahmed 2020: World Food Programme 2021: Maria Ressa / Dmitry Muratov 2022: Ales Bialiatski / Memorial / Center for Civil Liberties 2023: Narges Mohammadi 2024: Nihon Hidankyo

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• 1901 births
• 1994 deaths
• American scientists
• American chemists
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• Prostate cancer deaths
• Nobel Peace Prize winners
• Nobel Prize in Chemistry winners
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• People from Portland, Oregon
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