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Members of the Alanine or Glycine:Cation Symporter (AGCS) Family (TC# 2.A.25) transport alanine and/or glycine in symport with Na and or H.

Structure and Function

Known proteins in the AGCS family are between 445 to 550 amino acyl residues in length and possess 8 to 12 putative transmembrane α-helical spanners. They may possess 11 transmembrane segments (TMSs) as seems to be true for DagA and AgcS, although Acp has only 8 TMSs, perhaps the result of truncation. At this time, there does not appear to be any 3D crystal structures available for members of the AGCS family. Members of the AGCS family have been found in bacteria and archaea. As of 2015, only three members of the family have been functionally characterized . These proteins show limited sequence similarity in the APC family (TC# 2.A.3), and homology has been established.

Transport Reaction

The generalized transport reaction catalyzed by the AGCS family is:

alanine or glycine (out) + Na or H (out) → alanine or glycine (in) + Na or H (in).

Proteins in the AGCS Family

There are currently 10 proteins belonging to the AGCS family. These proteins and their descriptions can be found in the Transporter Classification Database.

Further Reading

• Rodionov, DA; Hebbeln, P; Eudes, A; ter Beek, J; Rodionova, IA; Erkens, GB; Slotboom, DJ; Gelfand, MS; Osterman, AL; Hanson, AD; Eitinger, T (January 2009). "A novel class of modular transporters for vitamins in prokaryotes". Journal of Bacteriology. 191 (1): 42–51. doi:10.1128/JB.01208-08. PMID 18931129.
• Kamata, H; Akiyama, S; Morosawa, H; Ohta, T; Hamamoto, T; Kambe, T; Kagawa, Y; Hirata, H (October 25, 1992). "Primary structure of the alanine carrier protein of thermophilic bacterium PS3". Journal of Biological Chemistry. 267 (30): 21650–5. PMID 1400476.

References

1. Bualuang, A; Kageyama, H; Tanaka, Y; Incharoensakdi, A; Takabe, T (2015). "Functional characterization of a member of alanine or glycine: cation symporter family in halotolerant cyanobacterium Aphanothece halophytica". 79 (2): 230–5. doi:10.1080/09168451.2014.968091. PMID 25421789. {{cite journal}}: Cite journal requires |journal= (help)
2. ^ Saier, MH Jr. "2.A.25 The Alanine or Glycine:Cation Symporter (AGCS) Family". Transporter Classification Database. Saier Lab Bioinformatics Group / SDSC.