Grapefruit seed extract: Difference between revisions

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	==Preparation==		==Preparation==
	GSE is prepared by grinding ~~grapefrute~~ seeds into a fine powder which is dissolved into purified water and ] to remove ] and ]. The distilled ] solution is spray-dried at a low temperature to form a grapefruit ] ] powder. The powder is then dissolved in vegetable ] and heated while food grade ] and ] are added. The mixture is pressure cooked, undergoing ] using ] and ]. This slurry is then cooled, filtered, and treated with ] light. Standardized GSE contains 60% grapefruit extract and 40% vegetable glycerin.{{fact}}		GSE is prepared by grinding grapefruit seeds into a fine powder which is dissolved into purified water and ] to remove ] and ]. The distilled ] solution is spray-dried at a low temperature to form a grapefruit ] ] powder. The powder is then dissolved in vegetable ] and heated, while food-grade ] and ] are added. The mixture is pressure cooked, undergoing ] using ] and ]. This slurry is then cooled, filtered, and treated with ] light. Standardized GSE contains 60% grapefruit extract and 40% vegetable glycerin.{{fact}}

	For most applications of GSE, 15 drops<!--when did a "drop" become an official measurement?--> in 8 oz of water is used.{{fact}}

	==Precautions and side effects==		==Precautions and side effects==

Revision as of 15:42, 7 September 2006

Grapefruit seed extract (GSE), also known as grapefruit pulp extract, is a liquid derived from the seeds, pulp, and white membranes of grapefruit. Although there has been no scientific demonstration of efficacy some practitioners of alternative medicine recommend this extract as an antibacterial, antiviral, and anti-fungal agent. It is also recommended by some nutritionists for the treatment of candidiasis, earache, throat infections, and diarrhea.

Preparation

GSE is prepared by grinding grapefruit seeds into a fine powder which is dissolved into purified water and distilled to remove fiber and pectin. The distilled aqueous solution is spray-dried at a low temperature to form a grapefruit bioflavonoid concentrate powder. The powder is then dissolved in vegetable glycerin and heated, while food-grade ammonium chloride and ascorbic acid are added. The mixture is pressure cooked, undergoing catalytic conversion using enzymes and hydrochloric acid. This slurry is then cooled, filtered, and treated with ultraviolet light. Standardized GSE contains 60% grapefruit extract and 40% vegetable glycerin.

Precautions and side effects

Generally GSE is very acidic, with a ph of 2, compared to the human body at a ph of 7.5 and water at 7. The acidity of GSE can irritate biological tissues if not diluted properly. GSE has been shown to be non-toxic in doses many times greater than recommended, and even when regularly overdosed, GSE seldom produces a noticable allergic reaction. However, people who are allergic to citrus fruits should exercise caution in consuming GSE.

Scientific research

Antimicrobial effects of grapefruit seed extract have been demonstrated in in vitro experiments such as the agar diffusion test. , , However, there is also strong evidence that the anti-microbial effect associated with grapefruit seed extract is attributable to the contamination or adulteration of commercial GSE preparations with synthetic antimicrobials or preservatives . Studies have shown that some commercial preparations contain the compound benzalkonium chloride, which is a synthetic antimicrobial commonly used in disinfectants and cleaning products, the related compound benzethonium chloride, the antibiotic triclosan, or the preservative methyl paraben. , , Some samples were shown to contain up to 22% benzalkonium chloride by weight, despite the known allergenicity and toxicity of the compound at higher doses. These chemicals were not present in grapefruit seed extracts prepared in the laboratory, and GSE preparations without the contaminants were found to possess no significant antimicrobial effect.

A study that examined the antiviral properties of GSE found that GSE had no efficacy as a disinfectant for feline calicivirus and feline parvovirus.

References

Sharamon, S., Baginski, B.J. The Healing Power of Grapefruit Seed. Lotus Press, Wisconsin. 1996. ISBN 0914955276
Sachs, A. The Authoritative Guide to Grapefruit Seed Extract : Stay Healthy Naturally: A Natural Alternative for Treating Colds, Infections, Herpes, Candida and Many Other Ailments. LifeRhythm, Medocino, California, 1997. ISBN 0940795175
Sakamoto, S., Sato, K., Maitani, T., Yamada, T. Analysis of components in natural food additive “grapefruit seed extract” by HPLC and LC/MS. Bull. Natl. Inst. Health Sci. 1996, 114:38–42.
von Woedtke, T., Schlüter, B., Pflegel, P., Lindequist, U.; Jülich, W.-D. Aspects of the antimicrobial efficacy of grapefruit seed extract and its relation to preservative substances contained. Pharmazie 1999 54:452–456.
Takeoka, G., Dao, L., Wong, R.Y., Lundin, R., Mahoney N. Identification of benzethonium chloride in commercial grapefruit seed extracts. J Agric Food Chem. 2001 49(7):3316–20
Takeoka, G.R., Dao, L.T., Wong, R.Y., Harden L.A. Identification of benzalkonium chloride in commercial grapefruit seed extracts. J Agric Food Chem. 2005 53(19):7630–6
Eleraky, N.Z., Potgieter, L.N., Kennedy, M.A. Virucidal efficacy of four new disinfectants. J Am Anim Hosp Assoc. 2002 38(3):231–4

Category:

Antifungals