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| '''Human Germline Engineering''' is the process in which the genome of an individual is edited in such a way that the change is heritable. This is achieved through genetic alterations within the germinal cells, or the reproductive cells such as the ] and ].<ref>{{Cite book|url=https://books.google.com/books?hl=en&lr=&id=9VZ6EF_TUw8C&oi=fnd&pg=PR9&dq=germline+engineering&ots=lW9PFpp5A-&sig=fG0_muv_E5UZu5cVPEjMyYdNhPI#v=onepage&q=germline%20engineering&f=false|title=Engineering the Human Germline: An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children|last=Stock|first=Gregory|last2=Campbell|first2=John|date=2000-02-03|publisher=Oxford University Press|isbn=9780195350937|language=en}}</ref> | '''Human Germline Engineering''' is the process in which the genome of an individual is edited in such a way that the change is heritable. This is achieved through genetic alterations within the germinal cells, or the reproductive cells such as the ] and ].<ref>{{Cite book|url=https://books.google.com/books?hl=en&lr=&id=9VZ6EF_TUw8C&oi=fnd&pg=PR9&dq=germline+engineering&ots=lW9PFpp5A-&sig=fG0_muv_E5UZu5cVPEjMyYdNhPI#v=onepage&q=germline%20engineering&f=false|title=Engineering the Human Germline: An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children|last=Stock|first=Gregory|last2=Campbell|first2=John|date=2000-02-03|publisher=Oxford University Press|isbn=9780195350937|language=en}}</ref> The first attempt to edit the human germline was reported in 2015, where a group of Chinese scientists the gene editing technique ] to edit single celled, non-viable embryos to see the effectiveness of this technique.<ref>{{Cite journal|last=Cyranoski|first=David|last2=Reardon|first2=Sara|title=Chinese scientists genetically modify human embryos|url=http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378|journal=Nature|language=en|doi=10.1038/nature.2015.17378}}</ref> This attempt was rather unsuccessful; however, the non-viable embyros that were used contained an extra set of chromosomes, which may prove to be problematic. | ||
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Revision as of 15:38, 5 May 2017
Human Germline Engineering is the process in which the genome of an individual is edited in such a way that the change is heritable. This is achieved through genetic alterations within the germinal cells, or the reproductive cells such as the oocyte and spermatogonium. The first attempt to edit the human germline was reported in 2015, where a group of Chinese scientists the gene editing technique CRISPR/Cas9 to edit single celled, non-viable embryos to see the effectiveness of this technique. This attempt was rather unsuccessful; however, the non-viable embyros that were used contained an extra set of chromosomes, which may prove to be problematic.
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- Stock, Gregory; Campbell, John (2000-02-03). Engineering the Human Germline: An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children. Oxford University Press. ISBN 9780195350937.
- Cyranoski, David; Reardon, Sara. "Chinese scientists genetically modify human embryos". Nature. doi:10.1038/nature.2015.17378.