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Revision as of 17:23, 20 March 2019

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USP1

Identifiers

Aliases

USP1, UBP, ubiquitin specific peptidase 1

External IDs

OMIM: 603478; MGI: 2385198; HomoloGene: 2528; GeneCards: USP1; OMA:USP1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p31.3	Start	62,436,297 bp
Band	1p31.3	End	62,451,804 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4\|4 C6	Start	98,812,047 bp
Band	4\|4 C6	End	98,823,780 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

ventricular zone

sperm

trabecular bone

ganglionic eminence

gonad

endothelial cell

germinal epithelium

cartilage tissue

tibia

Top expressed in

seminiferous tubule

gastrula

primitive streak

spermatid

spermatocyte

vas deferens

mandibular prominence

abdominal wall

ureter

maxillary prominence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cysteine-type peptidase activity protein binding hydrolase activity thiol-dependent deubiquitinase cysteine-type endopeptidase activity peptidase activity
Cellular component	nucleus nucleoplasm
Biological process	skeletal system development monoubiquitinated protein deubiquitination response to UV ubiquitin-dependent protein catabolic process proteolysis cellular response to DNA damage stimulus protein deubiquitination DNA repair regulation of DNA repair interstrand cross-link repair
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7398


230484

Ensembl


ENSG00000162607


ENSMUSG00000028560

UniProt


O94782


Q8BJQ2

RefSeq (mRNA)


NM_003368 NM_001017415 NM_001017416


NM_001301414 NM_146144 NM_001356424

RefSeq (protein)


NP_001017415 NP_001017416 NP_003359


NP_001288343 NP_666256 NP_001343353

Location (UCSC)

Chr 1: 62.44 – 62.45 Mb

Chr 4: 98.81 – 98.82 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.

Template:PBB Summary

References

^ GRCh38: Ensembl release 89: ENSG00000162607 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000028560 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
"Entrez Gene: USP1 ubiquitin specific peptidase 1".

Revision as of 17:23, 20 March 2019

References

Further reading