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Revision as of 05:31, 14 November 2006 edit69.22.233.172 (talk) I introduced many points of caution consistent with the fact that this drug has not been approved by the US or any other governmental body,. This article itself is an example of public relations.← Previous edit Revision as of 06:07, 14 November 2006 edit undoNetscott (talk | contribs)Extended confirmed users22,834 edits rv, no original researchNext edit →
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'''Bremelanotide''' (formerly PT-141) is the generic term for a new ] that has been tested with rats and is currently proposed as useful in treating some aspects of ] in some men (] or ]) as well as possible sexual dysfunctions in some women (]). The promoters think of it as a ] ], but doubt has been cast on this category in general and there is no reliable evidence for the existence of this class of chemicals. Unlike ] and other related medications, Bremelanotide does not act upon the vascular system, but is alleged to affect the central nervous system, raising new questions about safety and efficacy. Side effects, long term effects, and efficacy in different populations are all open to question and further study at the moment. Bremelanotide is being tested not as a pill or injection, but as a nasal spray. '''Bremelanotide''' (formerly PT-141) is the generic term for a new ] for use in treating ] in men (] or ]) as well as sexual dysfunction in women (]). It is a ] ]. Unlike ] and other related medications, it does not act upon the vascular system, but directly increases sexual desire. Bremelanotide is a spray introduced nasally.


The manufacturers have said that originally, the ] ] that bremelanotide was developed from was tested as a sunless tanning agent. In initial testing, they report, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in eight out of the ten original male volunteer test subjects. Further information about the subjective aspects of the response or the long term impact is missing. In unpublished clinical studies that the manufacturer reports through press releases and at non-peer-reviewed conferences, bremelanotide has been shown to be effective in treating male sexual and erectile dysfunction as well as female sexual dysfunction in highly selected participants. It is currently being tested by ] who have not offered any indication of how they plan to market this product and prevent its abuse. Originally, the ] ] that bremelanotide was developed from was tested as a sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in eight out of the ten original male volunteer test subjects. In clinical studies, bremelanotide has been shown to be effective in treating male sexual and erectile dysfunction as well as female sexual dysfunction. It is currently being tested by ].


Bremelanotide is a cyclic hepta-] ] analog of ] (alpha-MSH) that activates the ]s ] and ] in the ]. It has the ] Ac-Nle-''cyclo''-OH or ''cyclo''-alpha-MSH-(4-10). PT-141 is a ] of ] that lacks the ] ] ]. Its molecular forumla is C<sub>50</sub>H<sub>68</sub>N<sub>14</sub>O<sub>10</sub> with a molecular weight of 1025.2. Bremelanotide is a cyclic hepta-] ] analog of ] (alpha-MSH) that activates the ]s ] and ] in the ]. It has the ] Ac-Nle-''cyclo''-OH or ''cyclo''-alpha-MSH-(4-10). PT-141 is a ] of ] that lacks the ] ] ]. Its molecular forumla is C<sub>50</sub>H<sub>68</sub>N<sub>14</sub>O<sub>10</sub> with a molecular weight of 1025.2.


In the ] it is currently in a ] ]. The utlimate usefulness of this drug cannot be predicted at the moment, since it has not been approved by the U.S. or any other government, nor is approval scheduled. The drug has received widespread publicity, indicating the strength of the public relations available to the manufacturer. In the ] it is currently in a ] ].


== External links == == External links ==

Revision as of 06:07, 14 November 2006

Chemical structure of Bremelanotide (formerly PT-141) CAS# 189691-06-3

Bremelanotide (formerly PT-141) is the generic term for a new medication for use in treating sexual dysfunction in men (erectile dysfunction or impotence) as well as sexual dysfunction in women (sexual arousal disorder). It is a synthetic aphrodisiac. Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire. Bremelanotide is a spray introduced nasally.

Originally, the peptide Melanotan II that bremelanotide was developed from was tested as a sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in eight out of the ten original male volunteer test subjects. In clinical studies, bremelanotide has been shown to be effective in treating male sexual and erectile dysfunction as well as female sexual dysfunction. It is currently being tested by Palatin Technologies.

Bremelanotide is a cyclic hepta-peptide lactam analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that activates the melanocortin receptors MC3-R and MC4-R in the central nervous system. It has the amino acid sequence Ac-Nle-cyclo-OH or cyclo-alpha-MSH-(4-10). PT-141 is a metabolite of Melanotan II that lacks the C-terminal amide function. Its molecular forumla is C50H68N14O10 with a molecular weight of 1025.2.

In the United States it is currently in a Phase III clinical trial.

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