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| Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. | Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. | ||
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Revision as of 11:15, 26 January 2005
Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-napthalenyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.
Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.
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