| Revision as of 11:15, 26 January 2005 editKarn (talk | contribs)Extended confirmed users2,783 edits add link to manufacturer website← Previous edit | Revision as of 20:47, 26 January 2005 edit undoMykhal (talk | contribs)Extended confirmed users5,566 editsm naphthalenyl -> naphthylNext edit → | ||
| Line 1: | Line 1: | ||
| ] | ] | ||
| '''Duloxetine hydrochloride''' (brand name: '''Cymbalta''') is a medically used drug that primarily targets major ] disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1- |
'''Duloxetine hydrochloride''' (brand name: '''Cymbalta''') is a medically used drug that primarily targets major ] disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of ] (5-hydroxytryptamine, 5-HT) and ] (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. | ||
| Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. | Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. | ||
Revision as of 20:47, 26 January 2005
Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.
Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.
External Links
This article is a stub. You can help Misplaced Pages by expanding it. |