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| '''CPCCOEt''' is a drug used in scientific research, which acts as a non-competitive ] at the ] subtype ], with high selectivity although only moderate ].<ref name="pmid10051528">{{cite journal |vauthors=Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R |title=CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding |journal=Molecular Pharmacology |volume=55 |issue=3 |pages=453–61 |date=March 1999 |pmid=10051528 }}</ref><ref name="pmid11087567">{{cite journal |vauthors=Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F |title=Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropanaphthalene-7a-carboxylic acid ethyl ester |journal=Journal of Medicinal Chemistry |volume=43 |issue=23 |pages=4428–36 |date=November 2000 |pmid=11087567 |doi= 10.1021/jm0009944}}</ref> It is used mainly in basic research into the function of the mGluR<sub>1</sub> receptor,<ref name="pmid17045308">{{cite journal |vauthors=Fukunaga I, Yeo CH, Batchelor AM |title=The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors |journal=Neuropharmacology |volume=52 |issue=2 |pages=450–8 |date=February 2007 |pmid=17045308 |doi=10.1016/j.neuropharm.2006.08.014 }}</ref><ref name="pmid18279362">{{cite journal |vauthors=Sugiyama Y, Kawaguchi SY, Hirano T |title=mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron |journal=The European Journal of Neuroscience |volume=27 |issue=4 |pages=884–96 |date=February 2008 |pmid=18279362 |doi=10.1111/j.1460-9568.2008.06063.x }}</ref> including the study of behavioural effects in animals including effects on memory and addiction.<ref name="pmid16697125">{{cite journal |vauthors=Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK |title=Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties |journal=Drug and Alcohol Dependence |volume=85 |issue=2 |pages=142–56 |date=November 2006 |pmid=16697125 |doi=10.1016/j.drugalcdep.2006.04.003 }}</ref><ref name="pmid17292864">{{cite journal |vauthors=Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S |title=Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction |journal=Biochemical and Biophysical Research Communications |volume=355 |issue=1 |pages=188–93 |date=March 2007 |pmid=17292864 |doi=10.1016/j.bbrc.2007.01.125 }}</ref> | '''CPCCOEt''' is a drug used in scientific research, which acts as a non-competitive ] at the ] subtype ], with high selectivity although only moderate ].<ref name="pmid10051528">{{cite journal |vauthors=Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R |title=CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding |journal=Molecular Pharmacology |volume=55 |issue=3 |pages=453–61 |date=March 1999 |pmid=10051528 }}</ref><ref name="pmid11087567">{{cite journal |vauthors=Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F |title=Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropanaphthalene-7a-carboxylic acid ethyl ester |journal=Journal of Medicinal Chemistry |volume=43 |issue=23 |pages=4428–36 |date=November 2000 |pmid=11087567 |doi= 10.1021/jm0009944}}</ref> It is used mainly in basic research into the function of the mGluR<sub>1</sub> receptor,<ref name="pmid17045308">{{cite journal |vauthors=Fukunaga I, Yeo CH, Batchelor AM |title=The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors |journal=Neuropharmacology |volume=52 |issue=2 |pages=450–8 |date=February 2007 |pmid=17045308 |doi=10.1016/j.neuropharm.2006.08.014 |s2cid=40361285 }}</ref><ref name="pmid18279362">{{cite journal |vauthors=Sugiyama Y, Kawaguchi SY, Hirano T |title=mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron |journal=The European Journal of Neuroscience |volume=27 |issue=4 |pages=884–96 |date=February 2008 |pmid=18279362 |doi=10.1111/j.1460-9568.2008.06063.x |s2cid=25581416 }}</ref> including the study of behavioural effects in animals including effects on memory and addiction.<ref name="pmid16697125">{{cite journal |vauthors=Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK |title=Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties |journal=Drug and Alcohol Dependence |volume=85 |issue=2 |pages=142–56 |date=November 2006 |pmid=16697125 |doi=10.1016/j.drugalcdep.2006.04.003 }}</ref><ref name="pmid17292864">{{cite journal |vauthors=Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S |title=Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction |journal=Biochemical and Biophysical Research Communications |volume=355 |issue=1 |pages=188–93 |date=March 2007 |pmid=17292864 |doi=10.1016/j.bbrc.2007.01.125 }}</ref> | ||
| ==See also== | ==See also== | ||
Revision as of 08:06, 23 September 2021
Pharmaceutical compound | |
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| Formula | C13H13NO4 |
| Molar mass | 247.250 g·mol |
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| (what is this?) (verify) | |
CPCCOEt is a drug used in scientific research, which acts as a non-competitive antagonist at the metabotropic glutamate receptor subtype mGluR1, with high selectivity although only moderate binding affinity. It is used mainly in basic research into the function of the mGluR1 receptor, including the study of behavioural effects in animals including effects on memory and addiction.
See also
References
- Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R (March 1999). "CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding". Molecular Pharmacology. 55 (3): 453–61. PMID 10051528.
- Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F (November 2000). "Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropanaphthalene-7a-carboxylic acid ethyl ester". Journal of Medicinal Chemistry. 43 (23): 4428–36. doi:10.1021/jm0009944. PMID 11087567.
- Fukunaga I, Yeo CH, Batchelor AM (February 2007). "The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors". Neuropharmacology. 52 (2): 450–8. doi:10.1016/j.neuropharm.2006.08.014. PMID 17045308. S2CID 40361285.
- Sugiyama Y, Kawaguchi SY, Hirano T (February 2008). "mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron". The European Journal of Neuroscience. 27 (4): 884–96. doi:10.1111/j.1460-9568.2008.06063.x. PMID 18279362. S2CID 25581416.
- Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK (November 2006). "Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties". Drug and Alcohol Dependence. 85 (2): 142–56. doi:10.1016/j.drugalcdep.2006.04.003. PMID 16697125.
- Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S (March 2007). "Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction". Biochemical and Biophysical Research Communications. 355 (1): 188–93. doi:10.1016/j.bbrc.2007.01.125. PMID 17292864.
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