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Vitamin C has been listed as one of the Natural sciences good articles under the good article criteria. If you can improve it further, please do so. If it no longer meets these criteria, you can reassess it.

Article milestones Date Process Result December 3, 2004 Featured article candidate Not promoted February 21, 2007 Good article nominee Listed March 24, 2007 Peer review Reviewed February 26, 2010 Good article reassessment Delisted November 27, 2017 Good article nominee Listed A fact from this article appeared on Misplaced Pages's Main Page in the "Did you know?" column on January 11, 2018.The text of the entry was: Did you know ... that in 1934 vitamin C was the first synthetic vitamin to be trademarked (as Redoxon) and marketed? Current status: Good article

This article has not yet been rated on Misplaced Pages's content assessment scale. It is of interest to multiple WikiProjects.

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Ideal sources for Misplaced Pages's health content are defined in the guideline Misplaced Pages:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Vitamin C. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC

Dispute over need for a reference

On 9 April 2021 a sentence was added by User:Magnovvig to the Food additives subsection: "It may be used as a flour treatment agent used in breadmaking." Two references were included. My opinion is that the second, from the Federation of Bakers, is sufficient, and that the first, a link to an article in the Independent titled "THE SHOCKING TRUTH" that is a lengthy screed against all bread ingredients not organic, containing a short mention about vitamin C being an ingredient, is not needed. I deleted the first reference. Magnovvig restored it. I hold by my opinion that the Independent ref is not needed to support the very simple factual sentence that is supported by the other reference. I would appreciate hearing from others on this dispute. David notMD (talk) 21:04, 11 April 2021 (UTC)

Agree. The first reference is not needed: the second is sufficient. Jrfw51 (talk) 21:16, 11 April 2021 (UTC)

I had notified Magnovvig on 9 April. No reply. Deleted the ref again on 13 April. David notMD (talk) 15:45, 13 April 2021 (UTC)

Citations needed

Cleared some citations needed. One remains in first paragraph of Chemistry. David notMD (talk) 06:23, 16 April 2021 (UTC)

Historical anecdote about scurvy in Richard Dana's Two Years Before the Mast

There is a great historical anecdote about scurvy in Richard Dana's Two Years Before the Mast, i.e. https://en.wikipedia.org/Two_Years_Before_the_Mast, where the author recounts a crew member falling sick and the symptoms--poking his arms made an indentation in the flesh, which did not spring back, as it had lost its elasticity. The brig hails another ship seeking provisions, fresh potatoes and onions. The sick crew member made a mush out of the onions and rubbed it on his gums. He was up in the shrouds within a couple hours. Might be a good addition. FYI. Cheers.

Feels a bit too obscure. Scurvy at sea is covered in the article in context of Lind's research, circa 1753. Dana's book is circa 1840. David notMD (talk) 01:08, 17 May 2021 (UTC)

Other diseases - Covid

Umm, quackery...? Just a sprinkle of research on efficacy in Covid and lowering the mortality:

• https://www.frontiersin.org/articles/10.3389/fimmu.2021.674681/full
• https://www.aging-us.com/article/202557/text
• https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00792-3

This article needs some serious updating.

REPLY: Misplaced Pages guidelines do not accept individual clinical trials as evidence. See WP:MEDRS. Any content about treating (or preventing) COVID requires review refs, preferably meta-analysis. The three hyperlinks provided above are to three trials, one oral, two IV, with mixed results. In my opinion it is premature to make any mention of COVID in the article. See Vitamin D as an example of more evidence and heated dispute. David notMD (talk) 11:23, 12 November 2021 (UTC)

MORE: Supplementation with micronutrients, including vitamin C, has been suggested as part of the supportive management of COVID-19, as levels of vitamin C in serum and leukocytes are depleted in the acute stage of infection owing to increased metabolic demands. The use of high-dose intravenous vitamin C has been studied. According to ClinicalTrials.gov, there are 50 completed or ongoing clinical trials including vitamin C, which have completed or are recruiting people, hospitalized and severely ill with COVID‑19.

There is a much more recent meta-analysis of RCT of Vitamin C in Covid-19 which should be included. This meets WP:MEDRS standards. Overall results are negative. Jrfw51 (talk) 17:14, 12 November 2021 (UTC)

Content added to article, using the Rawat reference. David notMD (talk) 11:49, 13 November 2021 (UTC)

References

1. ^ Abobaker A, Alzwi A, Alraied AH (December 2020). "Overview of the possible role of vitamin C in management of COVID-19". Pharmacological Reports. 72 (6): 1517–28. doi:10.1007/s43440-020-00176-1. PMC 7592143. PMID 33113146.
2. "Search of: vitamin C | Recruiting, Completed Studies | COVID-19". clinicaltrials.gov. Retrieved 27 February 2021.
3. Rawat D, Roy A, Maitra S, Gulati A, Khanna P, Baidya DK (October 2021). "Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials". Diabetes & Metabolic Syndrome. 15 (6): 102324. doi:10.1016/j.dsx.2021.102324. PMC 8552785. PMID 34739908.

Mistake in scheme describing ascorbate synthesis is mammals.

I removed the picture illustrating the synthesis of Ascorbic acid in mammals for the moment. (https://upload.wikimedia.org/wikipedia/commons/3/35/Vitamin_C_Biosynthesis_in_Vertebrates.svg)

As the article and the sources of that section state correctly the synthesis goes via Gulonate, not Gluconate, as the image showed. Unfortunately I do not have a correct scheme at hand at the moment. — Preceding unsigned comment added by Alpha ScorpiiA (talk • contribs) 17:36, 15 November 2021 (UTC)

water soluble or fat soluble?

I can to the page looking to find out if this is one of the water soluble vitamins or one of the fat soluble ones. I would have thought that's a fairly basic and commonly needed piece of information since it affects how you take the in and how you should consume supliments. I couldn't find the information I was looking for, instead I got bogged down and confused by much more complicated chemistry. 209.93.48.118 (talk) 10:18, 29 January 2022 (UTC)

"water-soluble" added to first sentenc of LEad. It was buried way down in the article. David notMD (talk) 11:53, 29 January 2022 (UTC)

Treatment for exercise-induced bronchoconstriction

A meta-analysis shows positive results for using vitamin C to treat exercise-induced asthma. However, if I were to interpret this study in the way that the anti-fringe zealots want me to, the only statement this study could possibly back up is "there is no good evidence of vitamin C for treating exercise-induced asthma", given the wording in the conclusion. Of course, they would only apply this impossibly high standard of evidence when the study goes against the "approved conclusions" the anti-fringe cabal has selected. MarshallKe (talk) 20:59, 13 March 2022 (UTC)

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