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'''Brain-specific angiogenesis inhibitor 3''' is a ] that in humans is encoded by the ''BAI3'' ].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenet Cell Genet | volume = 79 | issue = 1–2 | pages = 103–8 |date=Apr 1998 | pmid = 9533023 | doi =10.1159/000134693 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577}}</ref> |
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'''Brain-specific angiogenesis inhibitor 3''' is a ] that in humans is encoded by the ''BAI3'' ].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenet Cell Genet | volume = 79 | issue = 1–2 | pages = 103–8 |date=Apr 1998 | pmid = 9533023 | doi =10.1159/000134693 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577}}</ref> |
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BAI1, a p53-target gene, encodes brain-specific ] inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez" /> The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons. <ref>{{cite journal | first1 = V | last1 = Lanoue |first2 = A |last2 = Usardi |first3 = S M |last3=Sigoillot | first4 = M | last4= Talleur |first5= K | last5 = Iyer | first6 = J |last6=Mariani| first7=P |last7=Isope| first8=G |last8 = Vodjdani |last9= Heintz| first9=N |last10=Selimi| first10=F | title = The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons | journal = Molecular Psychiatry | volume = 18 |pages = 943--950 | date = 2013 | doi= }}</ref> |
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BAI1, a p53-target gene, encodes brain-specific ] inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez" /> The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.<ref>{{cite journal | first1 = V | last1 = Lanoue |first2 = A |last2 = Usardi |first3 = S M |last3=Sigoillot | first4 = M | last4= Talleur |first5= K | last5 = Iyer | first6 = J |last6=Mariani| first7=P |last7=Isope| first8=G |last8 = Vodjdani |last9= Heintz| first9=N |last10=Selimi| first10=F | title = The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons | journal = Molecular Psychiatry | volume = 18 |pages = 943--950 | date = 2013 | doi= }}</ref> |
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The adhesion GPCR BaI3 is an orphan receptor that has a long ] consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.<ref>{{cite journal | last1 = Bolliger | first1=Marc F. | last2 = Martinelli | first2= David C. | last3 = Südhof | first3 = Thomas C. | title = The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins | journal =PNAS |volume = 108 | issue=6 | pages = 2534-2539| date = 2011 | doi = 10.1073/pnas.1019577108}}</ref> BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses. |
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The adhesion GPCR BaI3 is an orphan receptor that has a long ] consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.<ref>{{cite journal | last1 = Bolliger | first1=Marc F. | last2 = Martinelli | first2= David C. | last3 = Südhof | first3 = Thomas C. | title = The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins | journal =PNAS |volume = 108 | issue=6 | pages = 2534-2539| date = 2011 | doi = 10.1073/pnas.1019577108}}</ref> BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses. |
