| Revision as of 15:22, 27 May 2022 editIra Leviton (talk | contribs)Extended confirmed users330,828 editsm Fixed a PMC parameter in a citation. Please see Category:CS1 maint: PMC format.← Previous edit |
Revision as of 17:19, 27 May 2022 edit undoBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,551 edits consistent citation formatting; removed further reading citations not specific to this geneNext edit → |
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{{Infobox_gene}} |
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{{Infobox_gene}} |
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'''Ubiquitin carboxyl-terminal hydrolase 1''' is an ] that in humans is encoded by the ''USP1'' ].<ref name="pmid12838346">{{cite journal | vauthors = Puente XS, Sanchez LM, Overall CM, Lopez-Otin C | title = Human and mouse proteases: a comparative genomic approach | journal = Nat Rev Genet | volume = 4 | issue = 7 | pages = 544–58 |date=Jul 2003 | pmid = 12838346 | doi = 10.1038/nrg1111 | s2cid = 2856065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USP1 ubiquitin specific peptidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7398}}</ref> |
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'''Ubiquitin carboxyl-terminal hydrolase 1''' is an ] that in humans is encoded by the ''USP1'' ].<ref name="pmid12838346">{{cite journal | vauthors = Puente XS, Sánchez LM, Overall CM, López-Otín C | title = Human and mouse proteases: a comparative genomic approach | journal = Nature Reviews. Genetics | volume = 4 | issue = 7 | pages = 544–558 | date = July 2003 | pmid = 12838346 | doi = 10.1038/nrg1111 | s2cid = 2856065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USP1 ubiquitin specific peptidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7398}}</ref> |
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This gene encodes a member of the ]-specific processing (UBP) family of proteases that is a ] (DUB) with His and Cys domains. This protein is located in the ] and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. |
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This gene encodes a member of the ]-specific processing (UBP) family of proteases that is a ] (DUB) with His and Cys domains. This protein is located in the ] and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. |
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== Therapy == |
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== Therapy == |
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USP1 expression is deregulated in certain types of human cancer. Recent findings indicated that USP1 inhibition may contribute to revert cisplatin resistance in an ''in vitro'' model of non-small cell lung cancer (NSCLC), which supports that USP1 can act as an effective target in cancer therapy. <ref>{{Cite journal |last=García-Santisteban |first=Iraia |last2=Peters |first2=Godefridus J. |last3=Giovannetti |first3=Elisa |last4=Rodríguez |first4=Jose Antonio |date=2013-08-10 |title=USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy |url=https://doi.org/10.1186/1476-4598-12-91 |journal=Molecular Cancer |volume=12 |issue=1 |pages=91 |doi=10.1186/1476-4598-12-91 |issn=1476-4598 |pmc=3750636 |pmid=23937906}}</ref> |
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USP1 expression is deregulated in certain types of human cancer. Recent findings indicated that USP1 inhibition may contribute to revert cisplatin resistance in an ''in vitro'' model of non-small cell lung cancer (NSCLC), which supports that USP1 can act as an effective target in cancer therapy. <ref>{{cite journal | vauthors = García-Santisteban I, Peters GJ, Giovannetti E, Rodríguez JA | title = USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy | journal = Molecular Cancer | volume = 12 | issue = 1 | pages = 91 | date = August 2013 | pmid = 23937906 | pmc = 3750636 | doi = 10.1186/1476-4598-12-91 }}</ref> |
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==References== |
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== References == |
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==Further reading== |
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== Further reading == |
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{{refbegin | 2}} |
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*{{cite journal | vauthors=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337–52 |year= 1999 |pmid= 9827704 |doi=10.1080/10409239891204251 }} |
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* {{cite journal | vauthors = D'Andrea A, Pellman D | title = Deubiquitinating enzymes: a new class of biological regulators | journal = Critical Reviews in Biochemistry and Molecular Biology | volume = 33 | issue = 5 | pages = 337–352 | year = 1999 | pmid = 9827704 | doi = 10.1080/10409239891204251 }} |
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*{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }} |
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* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }} |
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*{{cite journal |vauthors=Fujiwara T, Saito A, Suzuki M, etal |title=Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease |journal=Genomics |volume=54 |issue= 1 |pages= 155–8 |year= 1999 |pmid= 9806842 |doi=10.1006/geno.1998.5554 }} |
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* {{cite journal | vauthors = Fujiwara T, Saito A, Suzuki M, Shinomiya H, Suzuki T, Takahashi E, Tanigami A, Ichiyama A, Chung CH, Nakamura Y, Tanaka K | display-authors = 6 | title = Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease | journal = Genomics | volume = 54 | issue = 1 | pages = 155–158 | date = November 1998 | pmid = 9806842 | doi = 10.1006/geno.1998.5554 }} |
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*{{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }} |
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* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–1795 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }} |
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*{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }} |
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* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | display-authors = 6 | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–435 | date = March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }} |
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*{{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }} |
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* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–292 | date = September 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }} |
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*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |doi-access=free }} |
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* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | display-authors = 6 | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–2144 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }} |
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*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} |
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* {{cite journal | vauthors = Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R | title = The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway | journal = Molecular Cell | volume = 17 | issue = 3 | pages = 331–339 | date = February 2005 | pmid = 15694335 | doi = 10.1016/j.molcel.2005.01.008 | hdl-access = free | hdl = 1874/17796 }} |
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*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
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* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | display-authors = 6 | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-D418 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }} |
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*{{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }} |
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*{{cite journal |vauthors=Nijman SM, Huang TT, Dirac AM, etal |title=The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway |journal=Mol. Cell |volume=17 |issue= 3 |pages= 331–9 |year= 2005 |pmid= 15694335 |doi= 10.1016/j.molcel.2005.01.008 |hdl=1874/17796 |hdl-access=free }} |
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*{{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }} |
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{{refend}} |
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{{refend}} |
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USP1 expression is deregulated in certain types of human cancer. Recent findings indicated that USP1 inhibition may contribute to revert cisplatin resistance in an in vitro model of non-small cell lung cancer (NSCLC), which supports that USP1 can act as an effective target in cancer therapy.
