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	== Image for "Helper T cells" subsection ==

	]s (APCs) present antigen on their Class II MHC molecules (]). Helper T cells recognize these, with the help of their expression of CD4 co-receptor (]). The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals (green arrows) that stimulate the activity of ]s, ] and ]s, the latter producing ]. The stimulation of B cells and macrophages succeeds a proliferation of T helper cells.]]
	This image is problematic for reasons I stated above in Image review. I'm tempted to create a diagram showing a CD4+ T cell at center, with an array of functions depicted around it - in the 4 corners, perhaps - cytotoxic ("killer") CD8+ T cell licensing, delayed type hypersensitivity using ] and granulomatous inflammation as a really important example (it's the basis of the ] for latent TB), B cell help in the germinal center reaction (the basis for ]s that have been so dramatically effective, and the ] role. I'll do my best to make it as simple/accessible as desired. Any thoughts? — ] (]) 02:16, 4 December 2020 (UTC)
	:Yes. Thanks. Are you considering something like this ? ] (]) 08:42, 4 December 2020 (UTC)
	::Yes, figure 2 in that paper is the sort of thing I was thinking of, but is a bit more detailed perhaps than we need for this article. — ] (]) 13:41, 4 December 2020 (UTC)
	:::Excellent. Thanks. ] (]) 18:33, 4 December 2020 (UTC)
	{{clear}}

	== Cell structure addition ==		== Cell structure addition ==

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OCLC 688486716, ISBN 9786130279011.

Cell structure addition

Graham Beards this appears to be a COI addition; is it needed, and is it in the right place? SandyGeorgia (Talk) 15:44, 15 December 2020 (UTC)

PS, if I am unable to decipher why this content is there, perhaps our readers won't either. And the last sentence is uncited, just as we are asking Wehwalt to have a look as to swapping this in to TFA ... and it's a one-paragraph section. SandyGeorgia (Talk) 15:51, 15 December 2020 (UTC)

It's WP:RECENT that can be deleted. I agree, it doesn't help the reader.Graham Beards (talk) 16:40, 15 December 2020 (UTC)

Concern raised at WP:ERRORS

Please see here. I'd be grateful if someone would post a response there, though much of it may be a matter for this talk page.--Wehwalt (talk) 13:21, 30 December 2020 (UTC)

I don't regard any of the concerns to be errors.

With regard to the use of the definite article, this is what our sources use; see for example: Sompayrac L (2019). How the immune system works. Hoboken, NJ: Wiley-Blackwell. ISBN 978-1-119-54212-4. OCLC 1083261548. (my emphasis).
As for the use of the word "diseases". The immune system is not only important in "infectious disease" and "damage", among others in plays a role in embryology. I think, for the Lead, it's ok to lack a little precision here.
It's not really a medical topic; it's biology.
"The figure legend contains no errors. But an improved legend could be proposed on the article's Talk Page.
The "other mechanisms that protect us from harm" have nothing at all to do with immunity. We draw the line where our sources do. Again see Sompayrac.
The article is stable, and has been for years. The improvements and updates that have been made for its second time as TFA, should not be regarded as symptom of instability.

Graham Beards (talk) 15:16, 30 December 2020 (UTC)

Organs

I came to this article looking for information on immune system organs such as lymph nodes and the spleen. I noticed this information is absent. A search of the article turns up "lymph node" one time, and spleen zero times. If you think it fits, consider adding a section or paragraph somewhere listing and describing the immune system organs. This might also be a good candidate for a diagram. Maybe something similar to this. –Novem Linguae (talk) 12:50, 10 May 2021 (UTC)

Did you miss "Organs of the lymphatic system" at the bottom? Graham Beards (talk) 14:05, 10 May 2021 (UTC)

I did miss it. Thanks for pointing it out. Perhaps it deserves more weight than a collapsed navbox, but up to you guys. –Novem Linguae (talk) 19:00, 10 May 2021 (UTC)

Vitamin D

Why does this article put a sharp focus on Vitamin D? And not on other hormones that regulate immune cells? In the paragraph 'Vitamin D', nothing is explained about how this vitamin mechanistically modulates T-cells, only that T-cells extend calcitriol receptors. To get the relevance across, it might be worthwhile to explain that vitamin D deficiency is associated with autoimmune diseases. Eosino (talk) 16:21, 31 March 2022 (UTC)

Agree that the previous content was both vague from in vitro research and outdated. I replaced the content and sources with this edit. Discussing vitamin D - even with inconclusive content to reflect the current state of science - seems reasonable, as there is plentiful attention in laboratory research to identify vitamin D effects on immune cells. However, no WP:MEDRS reviews exist to establish a cause-and-effect relationship between vitamin D and immune function. Zefr (talk) 17:17, 31 March 2022 (UTC)

Physical excercise

The following is from my Talk Page: I am planning to (at least partially) tackle the exercise article, which is in a rather abyssmal state. I noticed the amount of coverage medical sources have regarding the immune system and exercise, and upon glossing over immune system, there weren't any mentions of exercise, physical activity etc., which is very surprising. Wouldn't it be wise to have a section dedicated to the effects of exercise, perhaps below the "Sleep and rest" section? I've found some great systematic reviews on the topic, and a few umbrella reviews mentioning it. I'd be happy to help out with creating such a section. Any thoughts? Cheers - Wretchskull (talk) 09:57, 9 December 2022 (UTC)

Hi, yes you are right. It is a serious omission. May I suggest we collaborate on a section? Graham Beards (talk) 10:06, 9 December 2022 (UTC)

Excellent! I'm very busy today but I have plenty of time this weekend. I'll give you a notice when I'm ready! Search wherever you want and you'll stumble upon some great findings on this topic; Cochrane and PubMed seems like a good start, but I'm sure the refs you already used in immune system are also useful. Wretchskull (talk) 10:22, 9 December 2022 (UTC)

I'm looking forward to a fruitful collaboration. Graham Beards (talk) 10:29, 9 December 2022 (UTC)

Hello again! I've picked a few sources here, mostly from a journal specialized in this topic (Exercize Immunology Review). I was wondering what the structure of such a section should be. Do you think we should have a paragraph explaining the technical microscopic changes and a paragraph below for its studied effects on infections, inflammation, cancer, etc.? Wretchskull (talk) 09:18, 11 December 2022 (UTC)

Hi, it's best if we only use reviews as these are compliant with WP:MEDRS. From a quick glance , I think I spotted some primary studies. Perhaps we should move our conversation to the article's Talk Page? That way others can pitch in. With regard to the section's structure, I suggest the heading "Effect of physical excercise" ( I think the article uses UK English, but I will have to check), followed by a section on the effects on innate immunity, one on adaptive immunity and, as you said, effects on disease course (but we must avoid primary studies). Thoughts? Best regards, Graham Beards (talk) 11:32, 11 December 2022 (UTC)

Of course. I'll start working on its medical effects, but I would appreciate if you could help with innate/adaptive immunity as my knowledge in that topic is nowhere near as vast as an expert like yours. If I have any questions I'll use the article talk page from now on. By the way, regarding the sources, I was surprised when you said some were primary. I assume it's because it doesn't have the blue highlight with the word "review" on it (like this one)? The title of such sources contain the word "review", otherwise I wouldn't use them. All MEDRS sources I use are filtered by review, systematic review, or meta analysis. I might be missing something, though, and I'd be happy if you could correct me. Cheers - Wretchskull (talk) 13:47, 11 December 2022 (UTC)

I hadn't looked at them closely. Graham Beards (talk) 14:57, 11 December 2022 (UTC)

I have started the new section.Graham Beards (talk) 13:43, 12 December 2022 (UTC)

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