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The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" /> The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" />

== Therapy ==
USP1 expression is deregulated in certain types of human cancer. Recent findings indicated that USP1 inhibition may contribute to revert cisplatin resistance in an ''in vitro'' model of non-small cell lung cancer (NSCLC), which supports that USP1 can act as an effective target in cancer therapy. <ref>{{cite journal | vauthors = García-Santisteban I, Peters GJ, Giovannetti E, Rodríguez JA | title = USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy | journal = Molecular Cancer | volume = 12 | issue = 1 | pages = 91 | date = August 2013 | pmid = 23937906 | pmc = 3750636 | doi = 10.1186/1476-4598-12-91 }}</ref>


== References == == References ==

Revision as of 14:11, 27 January 2023

Protein-coding gene in the species Homo sapiens
USP1
Identifiers
AliasesUSP1, UBP, ubiquitin specific peptidase 1
External IDsOMIM: 603478; MGI: 2385198; HomoloGene: 2528; GeneCards: USP1; OMA:USP1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for USP1Genomic location for USP1
Band1p31.3Start62,436,297 bp
End62,451,804 bp
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)
Chromosome 4 (mouse)Genomic location for USP1Genomic location for USP1
Band4|4 C6Start98,812,047 bp
End98,823,780 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • ventricular zone

  • sperm

  • trabecular bone

  • ganglionic eminence

  • gonad

  • endothelial cell

  • germinal epithelium

  • cartilage tissue

  • tibia
Top expressed in
  • seminiferous tubule

  • gastrula

  • primitive streak

  • spermatid

  • spermatocyte

  • vas deferens

  • mandibular prominence

  • abdominal wall

  • ureter

  • maxillary prominence
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7398

230484

Ensembl

ENSG00000162607

ENSMUSG00000028560

UniProt

O94782

Q8BJQ2

RefSeq (mRNA)

NM_003368
NM_001017415
NM_001017416

NM_001301414
NM_146144
NM_001356424

RefSeq (protein)

NP_001017415
NP_001017416
NP_003359

NP_001288343
NP_666256
NP_001343353

Location (UCSC)Chr 1: 62.44 – 62.45 MbChr 4: 98.81 – 98.82 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000162607Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028560Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP1 ubiquitin specific peptidase 1".

Further reading


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