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Revision as of 16:10, 18 March 2023 editSmokefoot (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers74,550 edits Allantoin← Previous edit Latest revision as of 16:16, 18 March 2023 edit undoSmokefoot (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers74,550 edits replace obsolete ref 
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'''5-Hydroxyisourate''' is an ] that is produced by the ] of ]. The conversion is a major pathway in the antioxidant properties of urate. The conversion is catalysed by ].<ref>{{cite book |author =Perry A. Frey,Dexter B. Northrop | title =Enzymatic Mechanisms | date =1999 | publisher = IOS Press | isbn = 978-9051994322 }}</ref><ref>{{cite book | author =Richard B. Silverman | title =The organic chemistry of enzyme-catalyzed reactions | date =2002 | publisher = Academic Press | isbn = 978-0-12-643731-7}}</ref><ref>{{cite journal |doi=10.1007/s00253-010-2455-0|title=Cofactor-independent oxidases and oxygenases |year=2010 |last1=Fetzner |first1=Susanne |last2=Steiner |first2=Roberto A. |journal=Applied Microbiology and Biotechnology |volume=86 |issue=3 |pages=791–804 |pmid=20157809 |s2cid=25377247 }}</ref> '''5-Hydroxyisourate''' is an ] that is produced by the ] of ]. The conversion is a major pathway in the antioxidant properties of urate. The conversion is catalysed by ].<ref>{{cite journal | vauthors = Oksanen E, Blakeley MP, El-Hajji M, Ryde U, Budayova-Spano M | title = The Neutron Structure of Urate Oxidase Resolves a Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation | journal = PLOS ONE | volume = 9 | issue = 1 | pages = e86651 | date = 2014-01-23 | pmid = 24466188 | pmc = 3900588 | doi = 10.1371/journal.pone.0086651 | bibcode = 2014PLoSO...986651O | doi-access = free }}</ref><ref>{{cite journal |doi=10.1007/s00253-010-2455-0|title=Cofactor-independent oxidases and oxygenases |year=2010 |last1=Fetzner |first1=Susanne |last2=Steiner |first2=Roberto A. |journal=Applied Microbiology and Biotechnology |volume=86 |issue=3 |pages=791–804 |pmid=20157809 |s2cid=25377247 }}</ref>
] ]
5-Hydroxyisourate rearranges to ]. 5-Hydroxyisourate rearranges to ].


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==References== ==References==
{{reflist}} {{reflist}}

Latest revision as of 16:16, 18 March 2023

5-Hydroxyisourate
Names
IUPAC name 5-hydroxy-3,7-dihydropurine-2,6,8-trione
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
KEGG
MeSH 5-Hydroxyisourate
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)Key: LTQYPAVLAYVKTK-UHFFFAOYSA-N
  • InChI=1/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)Key: LTQYPAVLAYVKTK-UHFFFAOYAS
SMILES
  • C12=NC(=O)NC1(C(=O)NC(=O)N2)O
  • O=C1NC(=O)N/C2=N/C(=O)NC12O
Properties
Chemical formula C5H4N4O4
Molar mass 184.11 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

5-Hydroxyisourate is an organic compound that is produced by the oxidation of uric acid. The conversion is a major pathway in the antioxidant properties of urate. The conversion is catalysed by urate oxidase.

sequence of oxidation of ureate.

5-Hydroxyisourate rearranges to allantoin.

References

  1. Oksanen E, Blakeley MP, El-Hajji M, Ryde U, Budayova-Spano M (2014-01-23). "The Neutron Structure of Urate Oxidase Resolves a Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation". PLOS ONE. 9 (1): e86651. Bibcode:2014PLoSO...986651O. doi:10.1371/journal.pone.0086651. PMC 3900588. PMID 24466188.
  2. Fetzner, Susanne; Steiner, Roberto A. (2010). "Cofactor-independent oxidases and oxygenases". Applied Microbiology and Biotechnology. 86 (3): 791–804. doi:10.1007/s00253-010-2455-0. PMID 20157809. S2CID 25377247.

See also

Nucleotide metabolic intermediates
purine
metabolism
anabolism
R5P→IMP:
IMP→AMP:Adenylosuccinate
IMP→GMP:Xanthosine monophosphate
catabolism
pyrimidine
metabolism
anabolism
catabolism
uracil:
thymine:



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