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Hearing loss
Other names	Deaf or hard of hearing; anakusis or anacusis is total deafness
Specialty	Otorhinolaryngology, audiology
Symptoms	Decreased ability to hear
Complications	Social isolation, dementia
Types	Conductive, sensorineural, and mixed hearing loss, central auditory dysfunction
Causes	Genetics, aging, exposure to noise, some infections, birth complications, trauma to the ear, certain medications or toxins
Diagnostic method	Hearing tests
Prevention	Immunization, proper care around pregnancy, avoiding loud noise, avoiding certain medications
Treatment	Hearing aids, sign language, cochlear implants, closed captioning, subtitles
Frequency	1.33 billion / 18.5% (2015)

Hearing loss is a partial or total inability to hear. Hearing loss may be present at birth or acquired at any time afterwards. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to acquire spoken language, and in adults it can create difficulties with social interaction and at work. Hearing loss can be temporary or permanent. Hearing loss related to age usually affects both ears and is due to cochlear hair cell loss. In some people, particularly older people, hearing loss can result in loneliness.

Hearing loss may be caused by a number of factors, including: genetics, ageing, exposure to noise, some infections, birth complications, trauma to the ear, and certain medications or toxins. A common condition that results in hearing loss is chronic ear infections. Certain infections during pregnancy, such as cytomegalovirus, syphilis and rubella, may also cause hearing loss in the child. Hearing loss is diagnosed when hearing testing finds that a person is unable to hear 25 decibels in at least one ear. Testing for poor hearing is recommended for all newborns. Hearing loss can be categorized as mild (25 to 40 dB), moderate (41 to 55 dB), moderate-severe (56 to 70 dB), severe (71 to 90 dB), or profound (greater than 90 dB). There are three main types of hearing loss: conductive hearing loss, sensorineural hearing loss, and mixed hearing loss.

About half of hearing loss globally is preventable through public health measures. Such practices include immunization, proper care around pregnancy, avoiding loud noise, and avoiding certain medications. The World Health Organization recommends that young people limit exposure to loud sounds and the use of personal audio players to an hour a day in an effort to limit exposure to noise. Early identification and support are particularly important in children. For many, hearing aids, sign language, cochlear implants and subtitles are useful. Lip reading is another useful skill some develop. Access to hearing aids, however, is limited in many areas of the world.

As of 2013 hearing loss affects about 1.1 billion people to some degree. It causes disability in about 466 million people (5% of the global population), and moderate to severe disability in 124 million people. Of those with moderate to severe disability 108 million live in low and middle income countries. Of those with hearing loss, it began during childhood for 65 million. Those who use sign language and are members of Deaf culture may see themselves as having a difference rather than a disability. Many members of Deaf culture oppose attempts to cure deafness and some within this community view cochlear implants with concern as they have the potential to eliminate their culture.

Definition

• Hearing loss is defined as diminished acuity to sounds which would otherwise be heard normally. The terms hearing impaired or hard of hearing are usually reserved for people who have relative inability to hear sound in the speech frequencies. Hearing loss occurs when sound waves enter the ears and damage the sensitive tissues The severity of hearing loss is categorized according to the increase in intensity of sound above the usual level required for the listener to detect it.
• Deafness is defined as a degree of loss such that a person is unable to understand speech, even in the presence of amplification. In profound deafness, even the highest intensity sounds produced by an audiometer (an instrument used to measure hearing by producing pure tone sounds through a range of frequencies) may not be detected. In total deafness, no sounds at all, regardless of amplification or method of production, can be heard.
• Speech perception is another aspect of hearing which involves the perceived clarity of a word rather than the intensity of sound made by the word. In humans, this is usually measured with speech discrimination tests, which measure not only the ability to detect sound, but also the ability to understand speech. There are very rare types of hearing loss that affect speech discrimination alone. One example is auditory neuropathy, a variety of hearing loss in which the outer hair cells of the cochlea are intact and functioning, but sound information is not faithfully transmitted by the auditory nerve to the brain.

Use of the terms "hearing impaired", "deaf-mute", or "deaf and dumb" to describe deaf and hard of hearing people is discouraged by many in the deaf community as well as advocacy organizations, as they are offensive to many deaf and hard of hearing people.

Hearing standards

Human hearing extends in frequency from 20 to 20,000 Hz, and in intensity from 0 dB to 120 dB HL or more. 0 dB does not represent absence of sound, but rather the softest sound an average unimpaired human ear can hear; some people can hear down to −5 or even −10 dB. Sound is generally uncomfortably loud above 90 dB and 115 dB represents the threshold of pain. The ear does not hear all frequencies equally well: hearing sensitivity peaks around 3,000 Hz. There are many qualities of human hearing besides frequency range and intensity that cannot easily be measured quantitatively. However, for many practical purposes, normal hearing is defined by a frequency versus intensity graph, or audiogram, charting sensitivity thresholds of hearing at defined frequencies. Because of the cumulative impact of age and exposure to noise and other acoustic insults, 'typical' hearing may not be normal.

Signs and symptoms

• difficulty using the telephone
• loss of sound localization
• difficulty understanding speech, especially of children and women whose voices are of a higher frequency.
• difficulty understanding speech in the presence of background noise (cocktail party effect)
• sounds or speech sounding dull, muffled or attenuated
• need for increased volume on television, radio, music and other audio sources

Hearing loss is sensory, but may have accompanying symptoms:

• pain or pressure in the ears
• a blocked feeling

There may also be accompanying secondary symptoms:

• hyperacusis, heightened sensitivity with accompanying auditory pain to certain intensities and frequencies of sound, sometimes defined as "auditory recruitment"
• tinnitus, ringing, buzzing, hissing or other sounds in the ear when no external sound is present
• vertigo and disequilibrium
• tympanophonia, also known as autophonia, abnormal hearing of one's own voice and respiratory sounds, usually as a result of a patulous (a constantly open) eustachian tube or dehiscent superior semicircular canals
• disturbances of facial movement (indicating a possible tumour or stroke) or in persons with Bell's palsy

Complications

Hearing loss is associated with Alzheimer's disease and dementia. The risk increases with the hearing loss degree. There are several hypotheses including cognitive resources being redistributed to hearing and social isolation from hearing loss having a negative effect. According to preliminary data, hearing aid usage can slow down the decline in cognitive functions.

Hearing loss is responsible for causing thalamocortical dysrthymia in the brain which is a cause for several neurological disorders including tinnitus and visual snow syndrome.

Cognitive decline

Hearing loss is an increasing concern especially in aging populations. The prevalence of hearing loss increases about two-fold for each decade increase in age after age 40. While the secular trend might decrease individual level risk of developing hearing loss, the prevalence of hearing loss is expected to rise due to the aging population in the US. Another concern about aging process is cognitive decline, which may progress to mild cognitive impairment and eventually dementia. The association between hearing loss and cognitive decline has been studied in various research settings. Despite the variability in study design and protocols, the majority of these studies have found consistent association between age-related hearing loss and cognitive decline, cognitive impairment, and dementia. The association between age-related hearing loss and Alzheimer's disease was found to be nonsignificant, and this finding supports the hypothesis that hearing loss is associated with dementia independent of Alzheimer pathology. There are several hypotheses about the underlying causal mechanism for age-related hearing loss and cognitive decline. One hypothesis is that this association can be explained by common etiology or shared neurobiological pathology with decline in other physiological system. Another possible cognitive mechanism emphasize on individual's cognitive load. As people developing hearing loss in the process of aging, the cognitive load demanded by auditory perception increases, which may lead to change in brain structure and eventually to dementia. One other hypothesis suggests that the association between hearing loss and cognitive decline is mediated through various psychosocial factors, such as decrease in social contact and increase in social isolation. Findings on the association between hearing loss and dementia have significant public health implication, since about 9% of dementia cases are associated with hearing loss.

Falls

Falls have important health implications, especially for an aging population where they can lead to significant morbidity and mortality. Elderly people are particularly vulnerable to the consequences of injuries caused by falls, since older individuals typically have greater bone fragility and poorer protective reflexes. Fall-related injury can also lead to burdens on the financial and health care systems. In literature, age-related hearing loss is found to be significantly associated with incident falls. There is also a potential dose-response relationship between hearing loss and falls—greater severity of hearing loss is associated with increased difficulties in postural control and increased prevalence of falls. The underlying causal link between the association of hearing loss and falls is yet to be elucidated. There are several hypotheses that indicate that there may be a common process between decline in auditory system and increase in incident falls, driven by physiological, cognitive, and behavioral factors. This evidence suggests that treating hearing loss has potential to increase health-related quality of life in older adults.

Depression

Depression is one of the leading causes of morbidity and mortality worldwide. In older adults, the suicide rate is higher than it is for younger adults, and more suicide cases are attributable to depression. Different studies have been done to investigate potential risk factors that can give rise to depression in later life. Some chronic diseases are found to be significantly associated with risk of developing depression, such as coronary heart disease, pulmonary disease, vision loss and hearing loss. Hearing loss can attribute to decrease in health-related quality of life, increase in social isolation and decline in social engagement, which are all risk factors for increased risk of developing depression symptoms.

Spoken language ability

Post-lingual deafness is hearing loss that is sustained after the acquisition of language, which can occur due to disease, trauma, or as a side-effect of a medicine. Typically, hearing loss is gradual and often detected by family and friends of affected individuals long before the patients themselves will acknowledge the disability. Post-lingual deafness is far more common than pre-lingual deafness. Those who lose their hearing later in life, such as in late adolescence or adulthood, face their own challenges, living with the adaptations that allow them to live independently.

Prelingual deafness is profound hearing loss that is sustained before the acquisition of language, which can occur due to a congenital condition or through hearing loss before birth or in early infancy. Prelingual deafness impairs an individual's ability to acquire a spoken language in children, but deaf children can acquire spoken language through support from cochlear implants (sometimes combined with hearing aids). Non-signing (hearing) parents of deaf babies (90–95% of cases) usually go with oral approach without the support of sign language, as these families lack previous experience with sign language and cannot competently provide it to their children without learning it themselves. This may in some cases (late implantation or not sufficient benefit from cochlear implants) bring the risk of language deprivation for the deaf baby because the deaf baby would not have a sign language if the child is unable to acquire spoken language successfully. The 5–10% of cases of deaf babies born into signing families have the potential of age-appropriate development of language due to early exposure to a sign language by sign-competent parents, thus they have the potential to meet language milestones, in sign language in lieu of spoken language.

Causes

Hearing loss has multiple causes, including ageing, genetics, perinatal problems and acquired causes like noise and disease. For some kinds of hearing loss the cause may be classified as of unknown cause.

There is a progressive loss of ability to hear high frequencies with aging known as presbycusis. For men, this can start as early as 25 and women at 30. Although genetically variable, it is a normal concomitant of ageing and is distinct from hearing losses caused by noise exposure, toxins or disease agents. Common conditions that can increase the risk of hearing loss in elderly people are high blood pressure, diabetes (hearing loss in diabetes), or the use of certain medications harmful to the ear. While everyone loses hearing with age, the amount and type of hearing loss is variable.

Noise-induced hearing loss (NIHL), also known as acoustic trauma, typically manifests as elevated hearing thresholds (i.e. less sensitivity or muting). Noise exposure is the cause of approximately half of all cases of hearing loss, causing some degree of problems in 5% of the population globally. The majority of hearing loss is not due to age, but due to noise exposure. Various governmental, industry and standards organizations set noise standards. Many people are unaware of the presence of environmental sound at damaging levels, or of the level at which sound becomes harmful. Common sources of damaging noise levels include car stereos, children's toys, motor vehicles, crowds, lawn and maintenance equipment, power tools, gun use, musical instruments, and even hair dryers. Noise damage is cumulative; all sources of damage must be considered to assess risk. In the US, 12.5% of children aged 6–19 years have permanent hearing damage from excessive noise exposure. The World Health Organization estimates that half of those between 12 and 35 are at risk from using personal audio devices that are too loud. Hearing loss in adolescents may be caused by loud noise from toys, music by headphones, and concerts or events.

Hearing loss can be inherited. Around 75–80% of all these cases are inherited by recessive genes, 20–25% are inherited by dominant genes, 1–2% are inherited by X-linked patterns, and fewer than 1% are inherited by mitochondrial inheritance. Syndromic deafness occurs when there are other signs or medical problems aside from deafness in an individual, such as Usher syndrome, Stickler syndrome, Waardenburg syndrome, Alport's syndrome, and neurofibromatosis type 2. Nonsyndromic deafness occurs when there are no other signs or medical problems associated with the deafness in an individual.

Fetal alcohol spectrum disorders are reported to cause hearing loss in up to 64% of infants born to alcoholic mothers, from the ototoxic effect on the developing fetus plus malnutrition during pregnancy from the excess alcohol intake. Premature birth can be associated with sensorineural hearing loss because of an increased risk of hypoxia, hyperbilirubinaemia, ototoxic medication and infection as well as noise exposure in the neonatal units. Also, hearing loss in premature babies is often discovered far later than a similar hearing loss would be in a full-term baby because normally babies are given a hearing test within 48 hours of birth, but doctors must wait until the premature baby is medically stable before testing hearing, which can be months after birth. The risk of hearing loss is greatest for those weighing less than 1500 g at birth.

Disorders responsible for hearing loss include auditory neuropathy, Down syndrome, Charcot–Marie–Tooth disease variant 1E, autoimmune disease, multiple sclerosis, meningitis, cholesteatoma, otosclerosis, perilymph fistula, Ménière's disease, recurring ear infections, strokes, superior semicircular canal dehiscence, Pierre Robin, Treacher-Collins, Usher Syndrome, Pendred Syndrome, and Turner syndrome, syphilis, vestibular schwannoma, and viral infections such as measles, mumps, congenital rubella (also called German measles) syndrome, several varieties of herpes viruses, HIV/AIDS, and West Nile virus.

Some medications may reversibly affect hearing. These medications are considered ototoxic. This includes loop diuretics such as furosemide and bumetanide, non-steroidal anti-inflammatory drugs (NSAIDs) both over-the-counter (aspirin, ibuprofen, naproxen) as well as prescription (celecoxib, diclofenac, etc.), paracetamol, quinine, and macrolide antibiotics. Others may cause permanent hearing loss. The most important group is the aminoglycosides (main member gentamicin) and platinum based chemotherapeutics such as cisplatin and carboplatin.

In addition to medications, hearing loss can also result from specific chemicals in the environment: metals, such as lead; solvents, such as toluene (found in crude oil, gasoline and automobile exhaust, for example); and asphyxiants. Combined with noise, these ototoxic chemicals have an additive effect on a person's hearing loss. Hearing loss due to chemicals starts in the high frequency range and is irreversible. It damages the cochlea with lesions and degrades central portions of the auditory system. For some ototoxic chemical exposures, particularly styrene, the risk of hearing loss can be higher than being exposed to noise alone. The effects is greatest when the combined exposure include impulse noise. A 2018 informational bulletin by the US Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) introduces the issue, provides examples of ototoxic chemicals, lists the industries and occupations at risk and provides prevention information.

There can be damage either to the ear, whether the external or middle ear, to the cochlea, or to the brain centers that process the aural information conveyed by the ears. Damage to the middle ear may include fracture and discontinuity of the ossicular chain. Damage to the inner ear (cochlea) may be caused by temporal bone fracture. People who sustain head injury are especially vulnerable to hearing loss or tinnitus, either temporary or permanent.

Pathophysiology

Sound waves reach the outer ear and are conducted down the ear canal to the eardrum, causing it to vibrate. The vibrations are transferred by the 3 tiny ear bones of the middle ear to the fluid in the inner ear. The fluid moves hair cells (stereocilia), and their movement generates nerve impulses which are then taken to the brain by the cochlear nerve. The auditory nerve takes the impulses to the brainstem, which sends the impulses to the midbrain. Finally, the signal goes to the auditory cortex of the temporal lobe to be interpreted as sound.

Hearing loss is most commonly caused by long-term exposure to loud noises, from recreation or from work, that damage the hair cells, which do not grow back on their own.

Older people may lose their hearing from long exposure to noise, changes in the inner ear, changes in the middle ear, or from changes along the nerves from the ear to the brain.

Diagnosis

Identification of a hearing loss is usually conducted by a general practitioner medical doctor, otolaryngologist, certified and licensed audiologist, school or industrial audiometrist, or other audiometric technician. Diagnosis of the cause of a hearing loss is carried out by a specialist physician (audiovestibular physician) or otorhinolaryngologist.

Hearing loss is generally measured by playing generated or recorded sounds, and determining whether the person can hear them. Hearing sensitivity varies according to the frequency of sounds. To take this into account, hearing sensitivity can be measured for a range of frequencies and plotted on an audiogram. Other method for quantifying hearing loss is a hearing test using a mobile application or hearing aid application, which includes a hearing test. Hearing diagnosis using mobile application is similar to the audiometry procedure. Audiograms, obtained using mobile applications, can be used to adjust hearing aid applications. Another method for quantifying hearing loss is a speech-in-noise test. which gives an indication of how well one can understand speech in a noisy environment. Otoacoustic emissions test is an objective hearing test that may be administered to toddlers and children too young to cooperate in a conventional hearing test. Auditory brainstem response testing is an electrophysiological test used to test for hearing deficits caused by pathology within the ear, the cochlear nerve and also within the brainstem.

A case history (usually a written form, with questionnaire) can provide valuable information about the context of the hearing loss, and indicate what kind of diagnostic procedures to employ. Examinations include otoscopy, tympanometry, and differential testing with the Weber, Rinne, Bing and Schwabach tests. In case of infection or inflammation, blood or other body fluids may be submitted for laboratory analysis. MRI and CT scans can be useful to identify the pathology of many causes of hearing loss.

Hearing loss is categorized by severity, type, and configuration. Furthermore, a hearing loss may exist in only one ear (unilateral) or in both ears (bilateral). Hearing loss can be temporary or permanent, sudden or progressive. The severity of a hearing loss is ranked according to ranges of nominal thresholds in which a sound must be so it can be detected by an individual. It is measured in decibels of hearing loss, or dB HL. There are three main types of hearing loss: conductive hearing loss, sensorineural hearing loss, and mixed hearing loss. An additional problem which is increasingly recognised is auditory processing disorder which is not a hearing loss as such but a difficulty perceiving sound. The shape of an audiogram shows the relative configuration of the hearing loss, such as a Carhart notch for otosclerosis, 'noise' notch for noise-induced damage, high frequency rolloff for presbycusis, or a flat audiogram for conductive hearing loss. In conjunction with speech audiometry, it may indicate central auditory processing disorder, or the presence of a schwannoma or other tumor.

People with unilateral hearing loss or single-sided deafness (SSD) have difficulty in hearing conversation on their impaired side, localizing sound, and understanding speech in the presence of background noise. One reason for the hearing problems these patients often experience is due to the head shadow effect.

Idiopathic sudden hearing loss is a condition where a person as an immediate decrease in the sensitivity of their sensorineural hearing that does not have a known cause. This type of loss is usually only on one side (unilateral) and the severity of the loss varies. A common threshold of a "loss of at least 30 dB in three connected frequencies within 72 hours" is sometimes used, however there is no universal definition or international consensus for diagnosing idiopathic sudden hearing loss.

Prevention

It is estimated that half of cases of hearing loss are preventable. About 60% of hearing loss in children under the age of 15 can be avoided. There are a number of effective preventative strategies, including: immunization against rubella to prevent congenital rubella syndrome, immunization against H. influenza and S. pneumoniae to reduce cases of meningitis, and avoiding or protecting against excessive noise exposure. The World Health Organization also recommends immunization against measles, mumps, and meningitis, efforts to prevent premature birth, and avoidance of certain medication as prevention. World Hearing Day is a yearly event to promote actions to prevent hearing damage.

Avoiding exposure to loud noise can help prevent noise-induced hearing loss. 18% of adults exposed to loud noise at work for five years or more report hearing loss in both ears as compared to 5.5% of adults who were not exposed to loud noise at work. Different programs exist for specific populations such as school-age children, adolescents and workers. But the HPD (without individual selection, training and fit testing) does not significantly reduce the risk of hearing loss. The use of antioxidants is being studied for the prevention of noise-induced hearing loss, particularly for scenarios in which noise exposure cannot be reduced, such as during military operations.

Workplace noise regulation

Noise is widely recognized as an occupational hazard. In the United States, the National Institute for Occupational Safety and Health (NIOSH) and the Occupational Safety and Health Administration (OSHA) work together to provide standards and enforcement on workplace noise levels. The hierarchy of hazard controls demonstrates the different levels of controls to reduce or eliminate exposure to noise and prevent hearing loss, including engineering controls and personal protective equipment (PPE). Other programs and initiative have been created to prevent hearing loss in the workplace. For example, the Safe-in-Sound Award was created to recognize organizations that can demonstrate results of successful noise control and other interventions. Additionally, the Buy Quiet program was created to encourage employers to purchase quieter machinery and tools. By purchasing less noisy power tools like those found on the NIOSH Power Tools Database and limiting exposure to ototoxic chemicals, great strides can be made in preventing hearing loss.

Companies can also provide personal hearing protector devices tailored to both the worker and type of employment. Some hearing protectors universally block out all noise, and some allow for certain noises to be heard. Workers are more likely to wear hearing protector devices when they are properly fitted.

Often interventions to prevent noise-induced hearing loss have many components. A 2017 Cochrane review found that stricter legislation might reduce noise levels. Providing workers with information on their sound exposure levels was not shown to decrease exposure to noise. Ear protection, if used correctly, can reduce noise to safer levels, but often, providing them is not sufficient to prevent hearing loss. Engineering noise out and other solutions such as proper maintenance of equipment can lead to noise reduction, but further field studies on resulting noise exposures following such interventions are needed. Other possible solutions include improved enforcement of existing legislation and better implementation of well-designed prevention programmes, which have not yet been proven conclusively to be effective. The conclusion of the Cochrane Review was that further research could modify what is now regarding the effectiveness of the evaluated interventions.

The Institute for Occupational Safety and Health of the German Social Accident Insurance has created a hearing impairment calculator based on the ISO 1999 model for studying threshold shift in relatively homogeneous groups of people, such as workers with the same type of job. The ISO 1999 model estimates how much hearing impairment in a group can be ascribed to age and noise exposure. The result is calculated via an algebraic equation that uses the A-weighted sound exposure level, how many years the people were exposed to this noise, how old the people are, and their sex. The model's estimations are only useful for people without hearing loss due to non-job related exposure and can be used for prevention activities.

Screening

The United States Preventive Services Task Force recommends neonatal hearing screening for all newborns, as the first three years of life are believed to be the most important for language development. Universal neonatal hearing screenings have now been widely implemented across the U.S., with rates of newborn screening increasing from less than 3% in the early 1990s to 98% in 2009. Newborns whose screening reveals a high index of suspicion of hearing loss are referred for additional diagnostic testing with the goal of providing early intervention and access to language.

The American Academy of Pediatrics advises that children should have their hearing tested several times throughout their schooling:

• When they enter school
• At ages 6, 8, and 10
• At least once during middle school
• At least once during high school

While the American College of Physicians indicated that there is not enough evidence to determine the utility of screening in adults over 50 years old who do not have any symptoms, the American Language, Speech Pathology and Hearing Association recommends that adults should be screened at least every decade through age 50 and at three-year intervals thereafter, to minimize the detrimental effects of the untreated condition on quality of life. For the same reason, the US Office of Disease Prevention and Health Promotion included as one of Healthy People 2020 objectives: to increase the proportion of persons who have had a hearing examination.

Management

Management depends on the specific cause if known as well as the extent, type and configuration of the hearing loss. Sudden hearing loss due to an underlying nerve problem may be treated with corticosteroids.

Most hearing loss, that result from age and noise, is progressive and irreversible, and there are currently no approved or recommended treatments. A few specific kinds of hearing loss are amenable to surgical treatment. In other cases, treatment is addressed to underlying pathologies, but any hearing loss incurred may be permanent. Some management options include hearing aids, cochlear implants, middle ear implants, assistive technology, and closed captioning; in movie theaters, a Hearing Impaired (HI) audio track may be available via headphones to better hear dialog.

This choice depends on the level of hearing loss, type of hearing loss, and personal preference. Hearing aid applications are one of the options for hearing loss management. For people with bilateral hearing loss, it is not clear if bilateral hearing aids (hearing aids in both ears) are better than a unilateral hearing aid (hearing aid in one ear).

Idiopathic sudden hearing loss

For people with idiopathic sudden hearing loss, different treatment approaches have been suggested that are usually based on the suspected cause of the sudden hearing loss. Treatment approaches may include corticosteroid medications, rheological drugs, vasodilators, anesthetics, and other medications chosen based on the suspected underlying pathology that caused the sudden hearing loss. The evidence supporting most treatment options for idiopathic sudden hearing loss is very weak and adverse effects of these different medications is a consideration when deciding on a treatment approach.

Epidemiology

Globally, hearing loss affects about 10% of the population to some degree. It caused moderate to severe disability in 124.2 million people as of 2004 (107.9 million of whom are in low and middle income countries). Of these 65 million acquired the condition during childhood. At birth ~3 per 1000 in developed countries and more than 6 per 1000 in developing countries have hearing problems.

Hearing loss increases with age. In those between 20 and 35 rates of hearing loss are 3% while in those 44 to 55 it is 11% and in those 65 to 85 it is 43%.

A 2017 report by the World Health Organization estimated the costs of unaddressed hearing loss and the cost-effectiveness of interventions, for the health-care sector, for the education sector and as broad societal costs. Globally, the annual cost of unaddressed hearing loss was estimated to be in the range of $750–790 billion international dollars.

The International Organization for Standardization (ISO) developed the ISO 1999 standards for the estimation of hearing thresholds and noise-induced hearing impairment. They used data from two noise and hearing study databases, one presented by Burns and Robinson (Hearing and Noise in Industry, Her Majesty's Stationery Office, London, 1970) and by Passchier-Vermeer (1968). As race are some of the factors that can affect the expected distribution of pure-tone hearing thresholds several other national or regional datasets exist, from Sweden, Norway, South Korea, the United States and Spain.

In the United States hearing is one of the health outcomes measure by the National Health and Nutrition Examination Survey (NHANES), a survey research program conducted by the National Center for Health Statistics. It examines health and nutritional status of adults and children in the United States. Data from the United States in 2011–2012 found that rates of hearing loss has declined among adults aged 20 to 69 years, when compared with the results from an earlier time period (1999–2004). It also found that adult hearing loss is associated with increasing age, sex, ethnicity, educational level, and noise exposure. Nearly one in four adults had audiometric results suggesting noise-induced hearing loss. Almost one in four adults who reported excellent or good hearing had a similar pattern (5.5% on both sides and 18% on one side). Among people who reported exposure to loud noise at work, almost one third had such changes.

Social and cultural aspects

People with extreme hearing loss may communicate through sign languages. Sign languages convey meaning through manual communication and body language instead of acoustically conveyed sound patterns. This involves the simultaneous combination of hand shapes, orientation and movement of the hands, arms or body, and facial expressions to express a speaker's thoughts. "Sign languages are based on the idea that vision is the most useful tool a deaf person has to communicate and receive information".

Deaf culture refers to a tight-knit cultural group of people whose primary language is signed, and who practice social and cultural norms which are distinct from those of the surrounding hearing community. This community does not automatically include all those who are clinically or legally deaf, nor does it exclude every hearing person. According to Baker and Padden, it includes any person or persons who "identifies him/herself as a member of the Deaf community, and other members accept that person as a part of the community," an example being children of deaf adults with normal hearing ability. It includes the set of social beliefs, behaviors, art, literary traditions, history, values, and shared institutions of communities that are influenced by deafness and which use sign languages as the main means of communication. Members of the Deaf community tend to view deafness as a difference in human experience rather than a disability or disease. When used as a cultural label especially within the culture, the word deaf is often written with a capital D and referred to as "big D Deaf" in speech and sign. When used as a label for the audiological condition, it is written with a lower case d.

There also multiple educational institutions for both deaf and Deaf people, that usually use sign language as the main language of instruction. Famous institutions include Gallaudet University and the National Technical Institute for the Deaf in the US, and the National University Corporation of Tsukuba University of Technology in Japan.

Research

Stem cell transplant and gene therapy

A 2005 study achieved successful regrowth of cochlea cells in guinea pigs. However, the regrowth of cochlear hair cells does not imply the restoration of hearing sensitivity, as the sensory cells may or may not make connections with neurons that carry the signals from hair cells to the brain. A 2008 study has shown that gene therapy targeting Atoh1 can cause hair cell growth and attract neuronal processes in embryonic mice. Some hope that a similar treatment will one day ameliorate hearing loss in humans.

Recent research, reported in 2012 achieved growth of cochlear nerve cells resulting in hearing improvements in gerbils, using stem cells. Also reported in 2013 was regrowth of hair cells in deaf adult mice using a drug intervention resulting in hearing improvement. The Hearing Health Foundation in the US has embarked on a project called the Hearing Restoration Project. Also Action on Hearing Loss in the UK is also aiming to restore hearing.

Researchers reported in 2015 that genetically deaf mice which were treated with TMC1 gene therapy recovered some of their hearing. In 2017, additional studies were performed to treat Usher syndrome and here, a recombinant adeno-associated virus seemed to outperform the older vectors.

Audition

Besides research studies seeking to improve hearing, such as the ones listed above, research studies on the deaf have also been carried out in order to understand more about audition. Pijil and Shwarz (2005) conducted their study on the deaf who lost their hearing later in life and, hence, used cochlear implants to hear. They discovered further evidence for rate coding of pitch, a system that codes for information for frequencies by the rate that neurons fire in the auditory system, especially for lower frequencies as they are coded by the frequencies that neurons fire from the basilar membrane in a synchronous manner. Their results showed that the subjects could identify different pitches that were proportional to the frequency stimulated by a single electrode. The lower frequencies were detected when the basilar membrane was stimulated, providing even further evidence for rate coding.

See also

• Audiology
• Deaf hearing
• H.870
• Safe listening
• World Hearing Day

References

1. Elsevier. Dorland's Illustrated Medical Dictionary. Elsevier.
2. ^ "Deafness and hearing loss Fact sheet N°300". World Health Organization. March 2015. Archived from the original on 16 May 2015. Retrieved 23 May 2015.{{cite web}}: CS1 maint: unfit URL (link)
3. ^ Shearer AE, Hildebrand MS, Smith RJ (2014). "Deafness and Hereditary Hearing Loss Overview". In Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJ, Stephens K, Amemiya A (eds.). GeneReviews . Seattle: University of Washington. PMID 20301607.
4. Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, Carter A, Casey DC, Charlson FJ, Chen AZ, Coggeshall M, Cornaby L, Dandona L, Dicker DJ, Dilegge T, Erskine HE, Ferrari AJ, Fitzmaurice C, Fleming T, Forouzanfar MH, Fullman N, Gething PW, Goldberg EM, Graetz N, Haagsma JA, Hay SI, Johnson CO, Kassebaum NJ, Kawashima T, Kemmer L (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.
5. "Deafness". Encyclopædia Britannica Online. Encyclopædia Britannica Inc. 2011. Archived from the original on 2012-06-25. Retrieved 2012-02-22.
6. "Deafness and hearing loss". World Health Organization. 2020-03-01. Retrieved 2020-07-13.
7. "Hearing Loss at Birth (Congenital Hearing Loss)". American Speech-Language-Hearing Association. Retrieved 2020-07-13.
8. ^ Lasak JM, Allen P, McVay T, Lewis D (March 2014). "Hearing loss: diagnosis and management". Primary Care. 41 (1): 19–31. doi:10.1016/j.pop.2013.10.003. PMID 24439878.
9. ^ Schilder AG, Chong LY, Ftouh S, Burton MJ (2017). "Bilateral versus unilateral hearing aids for bilateral hearing impairment in adults". The Cochrane Database of Systematic Reviews. 2017 (12): CD012665. doi:10.1002/14651858.CD012665.pub2. ISSN 1469-493X. PMC 6486194. PMID 29256573.
10. Fowler KB (December 2013). "Congenital cytomegalovirus infection: audiologic outcome". Clinical Infectious Diseases. 57 Suppl 4 (suppl_4): S182–84. doi:10.1093/cid/cit609. PMC 3836573. PMID 24257423.
11. ^ "1.1 billion people at risk of hearing loss WHO highlights serious threat posed by exposure to recreational noise" (PDF). who.int. 27 February 2015. Archived (PDF) from the original on 1 May 2015. Retrieved 2 March 2015.
12. Vos T, Barber RM, Bell B, Bertozzi-Villa A, Biryukov S, Bolliger I, Charlson F, Davis A, Degenhardt L, Dicker D, Duan L, Erskine H, Feigin VL, Ferrari AJ, Fitzmaurice C, Fleming T, Graetz N, Guinovart C, Haagsma J, Hansen GM, Hanson SW, Heuton KR, Higashi H, Kassebaum N, Kyu H, Laurie E, Liang X, Lofgren K, Lozano R, MacIntyre MF (August 2015). "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 386 (9995): 743–800. doi:10.1016/s0140-6736(15)60692-4. PMC 4561509. PMID 26063472.
13. ^ The global burden of disease: 2004 update (PDF). Geneva: World Health Organization. 2008. p. 35. ISBN 9789241563710. Archived (PDF) from the original on 2013-06-24.
14. Olusanya BO, Neumann KJ, Saunders JE (May 2014). "The global burden of disabling hearing impairment: a call to action". Bulletin of the World Health Organization. 92 (5): 367–73. doi:10.2471/blt.13.128728. PMC 4007124. PMID 24839326.
15. ^ Elzouki AY (2012). Textbook of clinical pediatrics (2nd ed.). Berlin: Springer. p. 602. ISBN 9783642022012. Archived from the original on 2015-12-14.
16. "Community and Culture – Frequently Asked Questions". nad.org. National Association of the Deaf. Archived from the original on 27 December 2015. Retrieved 31 July 2014.
17. "Sound and Fury – Cochlear Implants – Essay". www.pbs.org. PBS. Archived from the original on 2015-07-06. Retrieved 2015-08-01.
18. "Understanding Deafness: Not Everyone Wants to Be 'Fixed'". www.theatlantic.com. The Atlantic. 2013-08-09. Archived from the original on 2015-07-30. Retrieved 2015-08-01.
19. Williams S (2012-09-13). "Why not all deaf people want to be cured". www.telegraph.co.uk. The Daily Telegraph. Archived from the original on 2015-09-24. Retrieved 2015-08-02.
20. Sparrow R (2005). "Defending Deaf Culture: The Case of Cochlear Implants" (PDF). The Journal of Political Philosophy. 13 (2): 135–52. doi:10.1111/j.1467-9760.2005.00217.x. S2CID 145727204. Retrieved 30 November 2014.
21. Mehmood A (2023-01-30). "What causes vision loss and hearing loss? Is it because of loud music or yelling?". militaryseoblog. Archived from the original on 2023-02-04. Retrieved 2023-02-04.
22. eBook: Current Diagnosis & Treatment in Otolaryngology: Head & Neck Surgery, Lalwani, Anil K. (Ed.) Chapter 44: Audiologic Testing by Brady M. Klaves, PhD, Jennifer McKee Bold, AuD, Access Medicine
23. Bennett R (May 2019). "Time for Change". The Hearing Journal. 72 (5): 16. doi:10.1097/01.HJ.0000559500.67179.7d.
24. "Community and Culture - Frequently Asked Questions". nad.org. National Association of the Deaf. Archived from the original on 2015-12-27. Retrieved 27 January 2016.
25. ANSI 7029:2000/BS 6951 Acoustics – Statistical distribution of hearing thresholds as a function of age
26. ANSI S3.5-1997 Speech Intelligibility Index (SII)
27. Hung SC (Aug 2015). "Hearing Loss is Associated With Risk of Alzheimer's Disease: A Case-Control Study in Older People". Journal of Epidemiology. 25 (8). Journal of Epidemiol: 517–521. doi:10.2188/jea.JE20140147. PMC 4517989. PMID 25986155.
28. Thomson RS, Auduong P, Miller AT, Gurgel RK (April 2017). "Hearing loss as a risk factor for dementia: A systematic review". Laryngoscope Investigative Otolaryngology. 2 (2): 69–79. doi:10.1002/lio2.65. PMC 5527366. PMID 28894825.
29. Hoppe U, Hesse G (2017-12-18). "Hearing aids: indications, technology, adaptation, and quality control". GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery. 16: Doc08. doi:10.3205/cto000147. PMC 5738937. PMID 29279726.
30. Lin FR, Niparko JK, Ferrucci L (November 2011). "Hearing loss prevalence in the United States". Archives of Internal Medicine. 171 (20): 1851–1852. doi:10.1001/archinternmed.2011.506. PMC 3564588. PMID 22083573.
31. Park HL, O'Connell JE, Thomson RG (December 2003). "A systematic review of cognitive decline in the general elderly population". International Journal of Geriatric Psychiatry. 18 (12): 1121–1134. doi:10.1002/gps.1023. PMID 14677145. S2CID 39164724.
32. ^ Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA (February 2018). "Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis". JAMA Otolaryngology–Head & Neck Surgery. 144 (2): 115–126. doi:10.1001/jamaoto.2017.2513. PMC 5824986. PMID 29222544.
33. ^ Thomson RS, Auduong P, Miller AT, Gurgel RK (April 2017). "Hearing loss as a risk factor for dementia: A systematic review". Laryngoscope Investigative Otolaryngology. 2 (2): 69–79. doi:10.1002/lio2.65. PMC 5527366. PMID 28894825.
34. Pichora-Fuller MK, Mick P, Reed M (August 2015). "Hearing, Cognition, and Healthy Aging: Social and Public Health Implications of the Links between Age-Related Declines in Hearing and Cognition". Seminars in Hearing. 36 (3): 122–139. doi:10.1055/s-0035-1555116. PMC 4906310. PMID 27516713.
35. Ford AH, Hankey GJ, Yeap BB, Golledge J, Flicker L, Almeida OP (June 2018). "Hearing loss and the risk of dementia in later life". Maturitas. 112: 1–11. doi:10.1016/j.maturitas.2018.03.004. PMID 29704910. S2CID 13998812.
36. ^ Dhital A, Pey T, Stanford MR (September 2010). "Visual loss and falls: a review". Eye. 24 (9): 1437–1446. doi:10.1038/eye.2010.60. PMID 20448666.
37. Jiam NT, Li C, Agrawal Y (November 2016). "Hearing loss and falls: A systematic review and meta-analysis". The Laryngoscope. 126 (11): 2587–2596. doi:10.1002/lary.25927. PMID 27010669. S2CID 28871762.
38. ^ Agmon M, Lavie L, Doumas M (June 2017). "The Association between Hearing Loss, Postural Control, and Mobility in Older Adults: A Systematic Review". Journal of the American Academy of Audiology. 28 (6): 575–588. doi:10.3766/jaaa.16044. PMID 28590900. S2CID 3744742.
39. Fiske A, Wetherell JL, Gatz M (April 2009). "Depression in older adults". Annual Review of Clinical Psychology. 5 (1): 363–389. doi:10.1146/annurev.clinpsy.032408.153621. PMC 2852580. PMID 19327033.
40. Huang CQ, Dong BR, Lu ZC, Yue JR, Liu QX (April 2010). "Chronic diseases and risk for depression in old age: a meta-analysis of published literature". Ageing Research Reviews. Microbes and Ageing. 9 (2): 131–141. doi:10.1016/j.arr.2009.05.005. PMID 19524072. S2CID 13637437.
41. Arlinger S (July 2003). "Negative consequences of uncorrected hearing loss – a review". International Journal of Audiology. 42 Suppl 2 (sup2): 2S17–20. doi:10.3109/14992020309074639. PMID 12918624. S2CID 14433959.
42. Meyer C, Scarinci N, Ryan B, Hickson L (December 2015). "'This Is a Partnership Between All of Us': Audiologists' Perceptions of Family Member Involvement in Hearing Rehabilitation". American Journal of Audiology. 24 (4): 536–548. doi:10.1044/2015_AJA-15-0026. PMID 26649683. S2CID 13091175.
43. Niparko JK, Tobey EA, Thal DJ, Eisenberg LS, Wang NY, Quittner AL, Fink NE (April 2010). "Spoken language development in children following cochlear implantation". JAMA. 303 (15): 1498–1506. doi:10.1001/jama.2010.451. PMC 3073449. PMID 20407059.
44. Kral A, O'Donoghue GM (October 2010). "Profound deafness in childhood". The New England Journal of Medicine. 363 (15): 1438–1450. doi:10.1056/NEJMra0911225. PMID 20925546. S2CID 13639137.
45. Hall WC (May 2017). "What You Don't Know Can Hurt You: The Risk of Language Deprivation by Impairing Sign Language Development in Deaf Children". Maternal and Child Health Journal. 21 (5): 961–965. doi:10.1007/s10995-017-2287-y. PMC 5392137. PMID 28185206.
46. Mayberry R (2007). "When timing is everything: Age of first-language acquisition effects on second-language learning". Applied Psycholinguistics. 28 (3): 537–549. doi:10.1017/s0142716407070294.
47. Robinson DW, Sutton GJ (1979). "Age effect in hearing – a comparative analysis of published threshold data". Audiology. 18 (4): 320–334. doi:10.3109/00206097909072634. PMID 475664.
48. Abraham AM, Jacob JJ, Varghese A (2023-09-28). "Should We Screen Patients with Type 2 Diabetes Mellitus for Hearing Loss?". Aging Medicine and Healthcare. 14 (3): 102–113. doi:10.33879/AMH.143.2022.01008.
49. Worrall L, Hickson LM (2003). "Communication activity limitations". In Worrall LE, Hickson LM (eds.). Communication disability in aging: from prevention to intervention. Clifton Park, NY: Delmar Learning. pp. 141–142.
50. Akinpelu OV, Mujica-Mota M, Daniel SJ (March 2014). "Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta-analysis". The Laryngoscope. 124 (3): 767–776. doi:10.1002/lary.24354. PMID 23945844. S2CID 25569962.
51. "Hearing Loss and Older Adults" (Last Updated June 3, 2016). National Institute on Deafness and Other Communication Disorders. 2016-01-26. Archived from the original on October 4, 2016. Retrieved September 11, 2016.
52. ^ Oishi N, Schacht J (June 2011). "Emerging treatments for noise-induced hearing loss". Expert Opinion on Emerging Drugs. 16 (2): 235–245. doi:10.1517/14728214.2011.552427. PMC 3102156. PMID 21247358.
53. "CDC – NIOSH Science Blog – A Story of Impact..." cdc.gov. 25 March 2015. Archived from the original on 2015-06-13.
54. In the United States, United States Environmental Protection Agency, Occupational Safety and Health Administration, National Institute for Occupational Safety and Health, Mine Safety and Health Administration, and numerous state government agencies among others, set noise standards.
55. ^ "Noise-Induced Hearing Loss: Promoting Hearing Health Among Youth". CDC Healthy Youth!. CDC. 2009-07-01. Archived from the original on 2009-12-21.
56. de Laat JA, van Deelen L, Wiefferink K (September 2016). "Hearing Screening and Prevention of Hearing Loss in Adolescents". The Journal of Adolescent Health. 59 (3): 243–245. doi:10.1016/j.jadohealth.2016.06.017. PMID 27562364.
57. Too Loud! For Too Long! Loud noises damage hearing U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Environmental Health. (6 January 2020).
58. ^ Rehm H. "The Genetics of Deafness; A Guide for Patients and Families" (PDF). Harvard Medical School Center For Hereditary Deafness. Harvard Medical School. Archived from the original (PDF) on 2013-10-19.
59. "Hearing Loss in Premature Babies". Salus Health. Pennsylvania Ear Institute. 2016. Retrieved 16 August 2020.
60. Starr A, Sininger YS, Pratt H (2011). "The varieties of auditory neuropathy". Journal of Basic and Clinical Physiology and Pharmacology. 11 (3): 215–230. doi:10.1515/JBCPP.2000.11.3.215. PMID 11041385. S2CID 31806057.
61. Starr A, Picton TW, Sininger Y, Hood LJ, Berlin CI (June 1996). "Auditory neuropathy". Brain. 119 ( Pt 3) (3): 741–753. doi:10.1093/brain/119.3.741. PMID 8673487.
62. Rodman R, Pine HS (June 2012). "The otolaryngologist's approach to the patient with Down syndrome". Otolaryngologic Clinics of North America. 45 (3): 599–629, vii–viii. doi:10.1016/j.otc.2012.03.010. PMID 22588039.
63. McKusick VA, Kniffen CL (30 January 2012). "# 118300 Charcot–Marie Tooth Disease and Deafness". Online Mendelian Inheritance in Man. Retrieved 2 March 2018.
64. Byl FM, Adour KK (March 1977). "Auditory symptoms associated with herpes zoster or idiopathic facial paralysis". The Laryngoscope. 87 (3): 372–379. doi:10.1288/00005537-197703000-00010. PMID 557156. S2CID 41226847.
65. Jos J. Eggermont (2017). Hearing Loss: Causes, Prevention, and Treatment. Elsevier Science. pp. 198–. ISBN 978-0-12-809349-8.
66. Araújo E, Zucki F, Corteletti LC, Lopes AC, Feniman MR, Alvarenga K (2012). "Hearing loss and acquired immune deficiency syndrome: systematic review". Jornal da Sociedade Brasileira de Fonoaudiologia. 24 (2): 188–192. doi:10.1590/s2179-64912012000200017. PMID 22832689.
67. Curhan SG, Shargorodsky J, Eavey R, Curhan GC (September 2012). "Analgesic use and the risk of hearing loss in women". American Journal of Epidemiology. 176 (6): 544–554. doi:10.1093/aje/kws146. PMC 3530351. PMID 22933387.
68. Cone B, Dorn P, Konrad-Martin D, Lister J, Ortiz C, Schairer K. "Ototoxic Medications (Medication Effects)". American Speech-Language-Hearing Association.
69. Rybak LP, Mukherjea D, Jajoo S, Ramkumar V (November 2009). "Cisplatin ototoxicity and protection: clinical and experimental studies". The Tohoku Journal of Experimental Medicine. 219 (3): 177–186. doi:10.1620/tjem.219.177. PMC 2927105. PMID 19851045.
70. Rybak LP, Ramkumar V (October 2007). "Ototoxicity". Kidney International. 72 (8): 931–935. doi:10.1038/sj.ki.5002434. PMID 17653135.
71. ^ "Tox Town – Toluene – Toxic chemicals and environmental health risks where you live and work – Text Version". toxtown.nlm.nih.gov. Archived from the original on 2010-06-09. Retrieved 2010-06-09.
72. ^ Morata TC. "Addressing the Risk for Hearing Loss from Industrial Chemicals". CDC. Archived from the original on 2009-01-22. Retrieved 2008-06-05.
73. Johnson AC (2008-09-09). "Occupational exposure to chemicals and hearing impairment – the need for a noise notation" (PDF). Karolinska Institutet: 1–48. Archived from the original (PDF) on 2012-09-06. Retrieved 2009-06-19.
74. Venet T, Campo P, Thomas A, Cour C, Rieger B, Cosnier F (March 2015). "The tonotopicity of styrene-induced hearing loss depends on the associated noise spectrum". Neurotoxicology and Teratology. 48: 56–63. Bibcode:2015NTxT...48...56V. doi:10.1016/j.ntt.2015.02.003. PMID 25689156.
75. Fuente A, Qiu W, Zhang M, Xie H, Kardous CA, Campo P, Morata TC (March 2018). "Use of the kurtosis statistic in an evaluation of the effects of noise and solvent exposures on the hearing thresholds of workers: An exploratory study" (PDF). The Journal of the Acoustical Society of America. 143 (3): 1704–1710. Bibcode:2018ASAJ..143.1704F. doi:10.1121/1.5028368. PMC 8588570. PMID 29604694.
76. "Preventing Hearing Loss Caused by Chemical (Ototoxicity) and Noise Exposure" (PDF). Retrieved 4 April 2018.
77. Hilal F, Liaw J, Cousins JP, Rivera AL, Nada A (2023-04-01). "Autoincudotomy as an uncommon etiology of conductive hearing loss: Case report and review of literature". Radiology Case Reports. 18 (4): 1461–1465. doi:10.1016/j.radcr.2022.10.097. ISSN 1930-0433. PMC 9925837. PMID 36798057.
78. Park K, Choung YH (2009-01-01). "Isolated congenital ossicular anomalies". Acta Oto-Laryngologica. 129 (4): 419–422. doi:10.1080/00016480802587846. ISSN 0001-6489. PMID 19116789. S2CID 205395847.
79. Oesterle EC (March 2013). "Changes in the adult vertebrate auditory sensory epithelium after trauma". Hearing Research. 297: 91–98. doi:10.1016/j.heares.2012.11.010. PMC 3637947. PMID 23178236.
80. Eggermont JJ (January 2017). "Acquired hearing loss and brain plasticity". Hearing Research. 343: 176–190. doi:10.1016/j.heares.2016.05.008. PMID 27233916. S2CID 3568426.
81. "How We Hear". American Speech-Language-Hearing Association. Retrieved 2 March 2018.
82. "How We Hear". Archived from the original on 1 May 2017.
83. "How Do We Hear?". NIDCD. January 3, 2018.
84. "What Is Noise-Induced Hearing Loss?". NIH – Noisy Planet. December 27, 2017.
85. "CDC – Noise and Hearing Loss Prevention – Preventing Hearing Loss, Risk Factors – NIOSH Workplace Safety and Health Topic". NIOSH/CDC. 5 February 2018. Retrieved 3 March 2018.
86. "Age-Related Hearing Loss". NIDCD. 18 August 2015.
87. ^ Shojaeemend H, Ayatollahi H (October 2018). "Automated Audiometry: A Review of the Implementation and Evaluation Methods". Healthcare Informatics Research. 24 (4): 263–275. doi:10.4258/hir.2018.24.4.263. PMC 6230538. PMID 30443414.
88. ^ Keidser G, Convery E (April 2016). "Self-Fitting Hearing Aids: Status Quo and Future Predictions". Trends in Hearing. 20: 233121651664328. doi:10.1177/2331216516643284. PMC 4871211. PMID 27072929.
89. Jansen S, Luts H, Dejonckere P, van Wieringen A, Wouters J (2013). "Efficient hearing screening in noise-exposed listeners using the digit triplet test" (PDF). Ear and Hearing. 34 (6): 773–778. doi:10.1097/AUD.0b013e318297920b. PMID 23782715. S2CID 11858630.
90. Lieu JE (May 2004). "Speech-language and educational consequences of unilateral hearing loss in children". Archives of Otolaryngology – Head & Neck Surgery. 130 (5): 524–530. doi:10.1001/archotol.130.5.524. PMID 15148171.
91. ^ Plontke SK, Meisner C, Agrawal S, Cayé-Thomasen P, Galbraith K, Mikulec AA, Parnes L, Premakumar Y, Reiber J, Schilder AG, Liebau A (2022-07-22). "Intratympanic corticosteroids for sudden sensorineural hearing loss". The Cochrane Database of Systematic Reviews. 2022 (7): CD008080. doi:10.1002/14651858.CD008080.pub2. ISSN 1469-493X. PMC 9307133. PMID 35867413.
92. Graham JM, Baguley DM (2009). Ballantyne's Deafness (7th ed.). Chichester: John Wiley & Sons. p. 16. ISBN 978-0-470-74441-3. Archived from the original on 2017-09-08.
93. "Hearing Loss in Children". U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities. October 29, 2021. Retrieved 17 March 2017.
94. "Childhood hearing loss: act now, here's how!" (PDF). WHO. 2016. p. 6. Archived (PDF) from the original on 6 March 2016. Retrieved 2 March 2016. Over 30% of childhood hearing loss is caused by diseases such as measles, mumps, rubella, meningitis and ear infections. These can be prevented through immunization and good hygiene practices. Another 17% of childhood hearing loss results from complications at birth, including prematurity, low birth weight, birth asphyxia and neonatal jaundice. Improved maternal and child health practices would help to prevent these complications. The use of ototoxic medicines in expectant mothers and newborns, which is responsible for 4% of childhood hearing loss, could potentially be avoided.
95. "Preventing Noise-Induced Hearing Loss". U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. 8 June 2020. Retrieved 13 July 2020.
96. "Quick Statistics About Hearing". NIH. National Institute on Deafness and Other Communication Disorders. 25 March 2021. Retrieved 27 October 2022.
97. Davis A, McMahon CM, Pichora-Fuller KM, Russ S, Lin F, Olusanya BO, Chadha S, Tremblay KL (April 2016). "Aging and Hearing Health: The Life-course Approach". The Gerontologist. 56 Suppl 2 (Suppl_2): S256–267. doi:10.1093/geront/gnw033. PMC 6283365. PMID 26994265.
98. Berger EH, Voix J (2018). "Chapter 11: Hearing Protection Devices". In D.K. Meinke, E.H. Berger, R. Neitzel, D.P. Driscoll, K. Bright (eds.). The Noise Manual (6th ed.). Falls Church, Virginia: American Industrial Hygiene Association. pp. 255–308. Retrieved 10 August 2022.
99. Groenewold M.R., Masterson E.A., Themann C.L., Davis R.R. (2014). "Do hearing protectors protect hearing?". American Journal of Industrial Medicine. 57 (9). Wiley Periodicals: 1001–1010. doi:10.1002/ajim.22323. ISSN 1097-0274. PMC 4671486. PMID 24700499. Retrieved 15 October 2022.
100. Stucken EZ, Hong RS (October 2014). "Noise-induced hearing loss: an occupational medicine perspective". Current Opinion in Otolaryngology & Head and Neck Surgery. 22 (5): 388–393. doi:10.1097/moo.0000000000000079. PMID 25188429. S2CID 22846225.
101. "Noise and Hearing Loss Prevention". Centers for Disease Control and Prevention: National Institute for Occupational Safety and Health. Archived from the original on July 9, 2016. Retrieved July 15, 2016.
102. "Safety and Health Topics: Occupational Noise Exposure". Occupational Safety and Health Administration. Archived from the original on May 6, 2016. Retrieved July 15, 2015.
103. "Controls for Noise Exposure". Centers for Disease Control and Prevention: National Institute for Occupational Safety and Health. Archived from the original on July 4, 2016. Retrieved July 15, 2016.
104. "Excellence in Hearing Loss Prevention Award". Safe-in-Sound. Archived from the original on May 27, 2016. Retrieved July 15, 2016.
105. "Buy Quiet". Centers for Disease Control and Prevention: National Institute for Occupational Safety and Health. Archived from the original on August 8, 2016. Retrieved July 15, 2016.
106. "PowerTools Database". Centers for Disease Control and Prevention: National Institute for Occupational Safety and Health. Archived from the original on June 30, 2016. Retrieved July 15, 2016.
107. "Occupationally-Induced Hearing Loss". Publication number 2010-136. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. 2010. doi:10.26616/NIOSHPUB2010136. Archived from the original on 2016-05-12.
108. ^ Tikka C, Verbeek JH, Kateman E, Morata TC, Dreschler WA, Ferrite S (July 2017). "Interventions to prevent occupational noise-induced hearing loss". The Cochrane Database of Systematic Reviews. 7 (7): CD006396. doi:10.1002/14651858.cd006396.pub4. PMC 6353150. PMID 28685503.
109. Institute for Occupational Safety and Health of the German Social Accident Insurance. "Hearing impairment calculator".
110. "Your Baby's Hearing Screening and Next Steps | NIDCD". www.nidcd.nih.gov. 2021-11-09. Retrieved 2023-06-21.
111. "Recommended Uniform Screening Panel | HRSA". www.hrsa.gov. Retrieved 2023-06-21.
112. Gaffney M, Eichwald J, Gaffney C, Alam S, Centers for Disease Control and Prevention (CDC) (2014-09-12). "Early hearing detection and intervention among infants – hearing screening and follow-up survey, United States, 2005–2006 and 2009–2010". MMWR Supplements. 63 (2): 20–26. ISSN 2380-8942. PMID 25208254.
113. Wilson JM, Jungner G, Organization WH (1968). "Principles and practice of screening for disease". Public Health Papers (34). hdl:10665/37650.
114. Moyer VA (2012-11-06). "Screening for Hearing Loss in Older Adults: U.S. Preventive Services Task Force Recommendation Statement". Annals of Internal Medicine. 157 (9). The American College of Physicians: 655–661. doi:10.7326/0003-4819-157-9-201211060-00526. PMID 22893115. S2CID 29265879. Archived from the original on 2012-10-27. Retrieved 2012-11-06.
115. "Who Should be Screened for Hearing Loss". www.asha.org. Archived from the original on 2017-03-17. Retrieved 2017-03-17.
116. "Hearing and Other Sensory or Communication Disorders | Healthy People 2020". www.healthypeople.gov. Archived from the original on 2017-03-18. Retrieved 2017-03-17.
117. Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, Poling GL, Roberts JK, Stachler RJ, Zeitler DM, Corrigan MD, Nnacheta LC, Satterfield L, Monjur TM (August 2019). "Clinical Practice Guideline: Sudden Hearing Loss (Update) Executive Summary". Otolaryngology–Head and Neck Surgery. 161 (2): 195–210. doi:10.1177/0194599819859883. PMID 31369349.
118. "Accessibility & The Audio Track File". Cinepedia. Retrieved 14 November 2023.
119. Koo M, Nguyen W, Lee JH, Oh SH, Kyun Park M (September 2022). "Behavioral Evaluation of 3 Smartphone-Based Hearing Aid Apps for Patients with Mild Hearing Loss: An Exploratory Pilot Study". The Journal of International Advanced Otology. 18 (5): 399–404. doi:10.5152/iao.2022.21469. ISSN 2148-3817. PMC 9524353. PMID 36063096.
120. World Health Organization W (2017). Global costs of unaddressed hearing loss and cost-effectiveness of interventions: a WHO report. Geneva: World Health Organization. pp. 5–10. ISBN 978-92-4-151204-6.
121. ISO IO (2013). Acoustics – Estimation of noise induced hearing loss. Geneva: International Organization for Standardization. p. 20.
122. Passchier-Vermeer W (1969). Hearing loss due to exposure to steady state broadband noise. Delft, Netherlands: TNO, Instituut voor gezondheidstechniek. pp. Report 35 Identifier 473589.
123. Johansson M, Arlinger S (2004-07-07). "Reference data for evaluation of occupationally noise-induced hearing loss". Noise & Health. 6 (24): 35–41. PMID 15703139.
124. Tambs K, Hoffman HJ, Borchgrevink HM, Holmen J, Engdahl B (May 2006). "Hearing loss induced by occupational and impulse noise: results on threshold shifts by frequencies, age and gender from the Nord-Trøndelag Hearing Loss Study". International Journal of Audiology. 45 (5): 309–317. doi:10.1080/14992020600582166. PMID 16717022. S2CID 35123521.
125. Jun HJ, Hwang SY, Lee SH, Lee JE, Song JJ, Chae S (March 2015). "The prevalence of hearing loss in South Korea: data from a population-based study". The Laryngoscope. 125 (3): 690–694. doi:10.1002/lary.24913. PMID 25216153. S2CID 11731976.
126. Flamme GA, Deiters K, Needham T (March 2011). "Distributions of pure-tone hearing threshold levels among adolescents and adults in the United States by gender, ethnicity, and age: Results from the US National Health and Nutrition Examination Survey". International Journal of Audiology. 50 (Suppl 1): S11–20. doi:10.3109/14992027.2010.540582. PMID 21288063. S2CID 3396617.
127. Rodríguez Valiente A, Roldán Fidalgo A, García Berrocal JR, Ramírez Camacho R (August 2015). "Hearing threshold levels for an otologically screened population in Spain". International Journal of Audiology. 54 (8): 499–506. doi:10.3109/14992027.2015.1009643. PMID 25832123. S2CID 143590528.
128. Hoffman HJ, Dobie RA, Losonczy KG, Themann CL, Flamme GA (March 2017). "Declining Prevalence of Hearing Loss in US Adults Aged 20 to 69 Years". JAMA Otolaryngology–Head & Neck Surgery. 143 (3): 274–285. doi:10.1001/jamaoto.2016.3527. PMC 5576493. PMID 27978564.
129. Carroll YI, Eichwald J, Scinicariello F, Hoffman HJ, Deitchman S, Radke MS, Themann CL, Breysse P (February 2017). "Vital Signs: Noise-Induced Hearing Loss Among Adults – United States 2011–2012". MMWR. Morbidity and Mortality Weekly Report. 66 (5): 139–144. doi:10.15585/mmwr.mm6605e3. PMC 5657963. PMID 28182600.
130. "American Sign Language". NIDCD. 2015-08-18. Archived from the original on 15 November 2016. Retrieved 17 November 2016.
131. Baker C, Carol Padden (1978). American Sign Language: A Look at Its Story, Structure and Community.
132. ^ Padden CA, Humphries T( (2005). Inside Deaf Culture. Cambridge, MA: Harvard University Press. p. 1. ISBN 978-0-674-01506-7.
133. ^ Jamie Berke (9 February 2010). "Deaf Culture - Big D Small D". About.com. Archived from the original on 4 March 2016. Retrieved 22 November 2013.
134. Ladd P (2003). Understanding Deaf Culture: In Search of Deafhood. Multilingual Matters. p. 502. ISBN 978-1-85359-545-5.
135. Lane HL, Richard Pillard, Ulf Hedberg (2011). The People of the Eye: Deaf Ethnicity and Ancestry. Oxford University Press. p. 269. ISBN 978-0-19-975929-3.
136. "Top Deaf universities and colleges". Healthy Hearing. Retrieved 2021-08-12.
137. "Tsukuba University of Technology Home". www.tsukuba-tech.ac.jp. Retrieved 2021-08-12.
138. Coghlan A (2005-02-14). "Gene therapy is first deafness 'cure'". NewScientist.com News Service. Archived from the original on 2008-09-14.
139. Gubbels SP, Woessner DW, Mitchell JC, Ricci AJ, Brigande JV (September 2008). "Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer". Nature. 455 (7212): 537–41. Bibcode:2008Natur.455..537G. doi:10.1038/nature07265. PMC 2925035. PMID 18754012.
140. Gewin V (2012-09-12). "Human embryonic stem cells restore gerbil hearing". Nature News. doi:10.1038/nature.2012.11402. S2CID 87417776. Archived from the original on 2012-12-14. Retrieved 2013-01-22.
141. Ander D. "Drug may reverse permanent deafness by regenerating cells of inner ear: Harvard study". National Post. Archived from the original on 2013-02-16.
142. "Hearing Health Foundation". HHF. Archived from the original on 2013-01-27. Retrieved 2013-01-22.
143. "Biomedical research – Action On Hearing Loss". RNID. Archived from the original on 2013-01-23. Retrieved 2013-01-22.
144. Gallacher J (9 July 2015). "Deafness could be treated by virus, say scientists". UK: BBC. Archived from the original on 9 July 2015. Retrieved 9 July 2015.
145. Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR (July 2015). "Tmc gene therapy restores auditory function in deaf mice". Science Translational Medicine. 7 (295): 295ra108. doi:10.1126/scitranslmed.aab1996. PMC 7298700. PMID 26157030.
146. Isgrig K, Shteamer JW, Belyantseva IA, Drummond MC, Fitzgerald TS, Vijayakumar S, Jones SM, Griffith AJ, Friedman TB, Cunningham LL, Chien WW (March 2017). "Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome". Molecular Therapy. 25 (3): 780–791. doi:10.1016/j.ymthe.2017.01.007. PMC 5363211. PMID 28254438.
147. Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH (March 2017). "A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear". Nature Biotechnology. 35 (3): 280–284. doi:10.1038/nbt.3781. PMC 5340646. PMID 28165475.
148. Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS (March 2017). "Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c". Nature Biotechnology. 35 (3): 264–272. doi:10.1038/nbt.3801. PMC 5340578. PMID 28165476.
149. Carlson NR (2010). Physiology of behavior (11th ed.). Upper Saddle River, New Jersey: Pearson Education, Inc.

External links

• WHO fact sheet on deafness and hearing loss
• Template:Curlie
• National Institute for the Prevention of Deafness and other Communication Disorders
• Global Costs of unaddressed hearing loss and cost-effectiveness of interventions World Health Organization. 2017. Internet archive on 12 May 2020.
• Occupational Noise and Hearing Loss Prevention U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. (6 February 2018).
• Global Audiology, International Society of Audiology
• International Ototoxicity Management Group

• Hearing loss
• Audiology
• Communication disorders
• Occupational safety and health
• Otorhinolaryngology
• Deafness