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Phenindione

Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	AU: D Passes into breast milk
Routes of administration	Oral
ATC code	B01AA02 (WHO)
Pharmacokinetic data
Protein binding	88%
Elimination half-life	5 to 10 hours
Identifiers
IUPAC name 2-phenyl-1H-indene-1,3(2H)-dione
CAS Number	83-12-5
PubChem CID	4760
IUPHAR/BPS	6838
DrugBank	DB00498
ChemSpider	4596
UNII	5M7Y6274ZE
KEGG	D08354
ChEBI	CHEBI:8066
ChEMBL	ChEMBL711
CompTox Dashboard (EPA)	DTXSID5023453
ECHA InfoCard	100.001.323
Chemical and physical data
Formula	C15H10O2
Molar mass	222.243 g·mol
3D model (JSmol)	Interactive image
SMILES O=C2c1ccccc1C(=O)C2c3ccccc3
InChI InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H Key:NFBAXHOPROOJAW-UHFFFAOYSA-N
(verify)

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.

References

1. Naisbitt DJ, Farrell J, Chamberlain PJ, Hopkins JE, Berry NG, Pirmohamed M, Park BK (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". The Journal of Pharmacology and Experimental Therapeutics. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID 15743920. S2CID 17052792.
2. Sweetman SC, ed. (2009). Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. "Phenindione", p. 1369.

External links

• Diseases Database (DDB): 30536

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