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'''Bromsulfthalein''' (also known as '''bromsulphthalein''', '''bromosulfophthalein''', and '''BSP''') is a ] used in ] function tests. Determining the rate of removal of the dye from the ] gives a measure of ].<ref>{{cite journal | doi = 10.1001/jama.1925.02660410020008| title = Clinical Application of the Bromsulphalein Test for Hepatic Function| journal = JAMA: The Journal of the American Medical Association| volume = 84| issue = 15| pages = 1112| year = 1925| last1 = Rosenthal| first1 = Sanford M.}}</ref> '''Bromsulfthalein''' (also known as '''bromsulphthalein''', '''bromosulfophthalein''', and '''BSP''') is a ] used in ] function tests. Determining the rate of removal of the dye from the ] gives a measure of ].<ref>{{cite journal | doi = 10.1001/jama.1925.02660410020008| title = Clinical Application of the Bromsulphalein Test for Hepatic Function| journal = JAMA: The Journal of the American Medical Association| volume = 84| issue = 15| pages = 1112| year = 1925| last1 = Rosenthal| first1 = Sanford M.}}</ref> The mechanism by which the liver detoxifies BSP is to attach it to glutathione which is the body’s master antioxidant.


==References== ==References==

Latest revision as of 20:19, 25 August 2024

Bromsulfthalein
Names
Preferred IUPAC name Disodium 3,3′-(4,5,6,7-tetrabromo-3-oxo-2-benzofuran-1,1(3H)-diyl)bis(6-hydroxybenzene-1-sulfonate)
Other names Bromsulphthalein; Bromosulfophthalein; Bromosulphophthalein; BSP; Sulfobromophthalein
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.005.498 Edit this at Wikidata
IUPHAR/BPS
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C20H10Br4O10S2.2Na/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;/q;2*+1/p-2Key: GHAFORRTMVIXHS-UHFFFAOYSA-L
  • InChI=1/C20H10Br4O10S2.2Na/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;/q;2*+1/p-2Key: GHAFORRTMVIXHS-NUQVWONBAX
SMILES
  • ..S(=O)(=O)c1c(O)ccc(c1)C3(OC(=O)c2c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S()(=O)=O
Properties
Chemical formula C20H8Br4Na2O10S2
Molar mass 837.99 g·mol
Pharmacology
ATC code V04CE02 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Bromsulfthalein (also known as bromsulphthalein, bromosulfophthalein, and BSP) is a phthalein dye used in liver function tests. Determining the rate of removal of the dye from the blood stream gives a measure of liver function. The mechanism by which the liver detoxifies BSP is to attach it to glutathione which is the body’s master antioxidant.

References

  1. Rosenthal, Sanford M. (1925). "Clinical Application of the Bromsulphalein Test for Hepatic Function". JAMA: The Journal of the American Medical Association. 84 (15): 1112. doi:10.1001/jama.1925.02660410020008.
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