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| '''Kynuramine''' is a chemical compound with the molecular formula {{chem2|C9H12N2O}}. It is the prototypical member of the class of ]s known collectively as kynuramines.<ref name=Hardeland>{{cite journal | doi = 10.1111/j.1600-079X.2009.00701.x }}</ref> Kynuramine is produced by the ] of ]<ref name=Hardeland/> and is a metabolite of ].<ref>{{cite journal | doi = 10.1017/S1462399406000068 }}</ref> | '''Kynuramine''' is a chemical compound with the molecular formula {{chem2|C9H12N2O}}. It is the prototypical member of the class of ]s known collectively as kynuramines.<ref name=Hardeland>{{cite journal | doi = 10.1111/j.1600-079X.2009.00701.x | title = Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines | date = 2009 | last1 = Hardeland | first1 = Rüdiger | last2 = Tan | first2 = Dun-Xian | last3 = Reiter | first3 = Russel J. | journal = Journal of Pineal Research | volume = 47 | issue = 2 | pages = 109–126 | pmid = 19573038 }}</ref> Kynuramine is produced by the ] of ]<ref name=Hardeland/> and is a metabolite of ].<ref>{{cite journal | doi = 10.1017/S1462399406000068 | title = Tryptophan metabolism in the central nervous system: Medical implications | date = 2006 | last1 = Ruddick | first1 = Jon P. | last2 = Evans | first2 = Andrew K. | last3 = Nutt | first3 = David J. | last4 = Lightman | first4 = Stafford L. | last5 = Rook | first5 = Graham A.W. | last6 = Lowry | first6 = Christopher A. | journal = Expert Reviews in Molecular Medicine | volume = 8 | issue = 20 | pages = 1–27 | pmid = 16942634 }}</ref> | ||
| Kynuramine is an ] inhibitor.<ref>{{cite journal | doi = 10.1016/0014-2999(81)90574-4 }}</ref> | Kynuramine is an ] inhibitor.<ref>{{cite journal | doi = 10.1016/0014-2999(81)90574-4 | title = An α-adrenoceptor inhibitory action of kynuramine | date = 1981 | last1 = Johnson | first1 = Thomas D. | last2 = Clarke | first2 = David E. | journal = European Journal of Pharmacology | volume = 72 | issue = 4 | pages = 351–356 | pmid = 6115758 }}</ref> | ||
| In biochemistry, kynuramine has been used as a substrate in assays used to measure ] activity.<ref>{{cite journal | doi = 10.1016/S0021-9258(17)40939-2 }}</ref><ref>{{cite journal | doi = 10.1016/S0009-9120(85)80094-1 }}</ref> | In biochemistry, kynuramine has been used as a substrate in assays used to measure ] activity.<ref>{{cite journal | doi = 10.1016/S0021-9258(17)40939-2 | doi-access = free | title = Kynuramine, a fluorescent substrate and probe of plasma amine oxidase | date = 1977 | last1 = Massey | first1 = J.B. | last2 = Churchich | first2 = J.E. | journal = Journal of Biological Chemistry | volume = 252 | issue = 22 | pages = 8081–8084 | pmid = 562342 }}</ref><ref>{{cite journal | doi = 10.1016/S0009-9120(85)80094-1 | title = A sensitive fluorometric assay for serum monoamine oxidase with kynuramine as substrate | date = 1985 | last1 = Matsumoto | first1 = T. | last2 = Suzuki | first2 = O. | last3 = Furuta | first3 = T. | last4 = Asai | first4 = M. | last5 = Kurokawa | first5 = Y. | last6 = Nimura | first6 = Y. | last7 = Katsumata | first7 = Y. | last8 = Takahashi | first8 = I. | journal = Clinical Biochemistry | volume = 18 | issue = 2 | pages = 126–129 | pmid = 4017223 }}</ref> | ||
| ==References== | ==References== | ||
Revision as of 16:02, 24 December 2024
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| Names | |
|---|---|
| IUPAC name 3-Amino-1-(2-aminophenyl)propan-1-one | |
| Other names Diaminopropiophenone | |
| Identifiers | |
| CAS Number | |
| 3D model (JSmol) | |
| PubChem CID | |
| CompTox Dashboard (EPA) | |
SMILES
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| Properties | |
| Chemical formula | C9H12N2O |
| Molar mass | 164.208 g·mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references | |
Kynuramine is a chemical compound with the molecular formula C9H12N2O. It is the prototypical member of the class of biogenic amines known collectively as kynuramines. Kynuramine is produced by the decarboxylation of kynurenine and is a metabolite of tryptophan.
Kynuramine is an α-adrenoceptor inhibitor.
In biochemistry, kynuramine has been used as a substrate in assays used to measure amine oxidase activity.
References
- ^ Hardeland, Rüdiger; Tan, Dun-Xian; Reiter, Russel J. (2009). "Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines". Journal of Pineal Research. 47 (2): 109–126. doi:10.1111/j.1600-079X.2009.00701.x. PMID 19573038.
- Ruddick, Jon P.; Evans, Andrew K.; Nutt, David J.; Lightman, Stafford L.; Rook, Graham A.W.; Lowry, Christopher A. (2006). "Tryptophan metabolism in the central nervous system: Medical implications". Expert Reviews in Molecular Medicine. 8 (20): 1–27. doi:10.1017/S1462399406000068. PMID 16942634.
- Johnson, Thomas D.; Clarke, David E. (1981). "An α-adrenoceptor inhibitory action of kynuramine". European Journal of Pharmacology. 72 (4): 351–356. doi:10.1016/0014-2999(81)90574-4. PMID 6115758.
- Massey, J.B.; Churchich, J.E. (1977). "Kynuramine, a fluorescent substrate and probe of plasma amine oxidase". Journal of Biological Chemistry. 252 (22): 8081–8084. doi:10.1016/S0021-9258(17)40939-2. PMID 562342.
- Matsumoto, T.; Suzuki, O.; Furuta, T.; Asai, M.; Kurokawa, Y.; Nimura, Y.; Katsumata, Y.; Takahashi, I. (1985). "A sensitive fluorometric assay for serum monoamine oxidase with kynuramine as substrate". Clinical Biochemistry. 18 (2): 126–129. doi:10.1016/S0009-9120(85)80094-1. PMID 4017223.