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Taniborbactam

Clinical data
Other names	VNRX-5133, VNRX5133
Legal status
Legal status	Investigational
Identifiers
IUPAC name (3R)-3-acetyl]amino]-2-hydroxy-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid
CAS Number	1613267-49-4
PubChem CID	76902493
UNII	8IGQ156Z07
Chemical and physical data
Formula	C19H28BN3O5
Molar mass	389.26 g·mol
3D model (JSmol)	Interactive image
SMILES B1((CC2=C(O1)C(=CC=C2)C(=O)O)NC(=O)CC3CCC(CC3)NCCN)O

Taniborbactam (development code VNRX-5133) is a pharmaceutical drug that acts as a β-lactamase inhibitor. It inhibits the function of bacterial β-lactamases which impart resistance to β-lactam antibiotics. However, unlike other β-lactamase inhibitors that are used as pharmaceuticals, taniborbactam is effective against enzymes of the New Delhi metallo-beta-lactamase 1 group which are the most frequently identified sources of acquired antibiotic resistance worldwide.

Taniborbactam, in combination with cefepime, is in clinical trials for the treatment of bacterial infections, including urinary tract infection and pyelonephritis.

References

1. . doi:10.1021/acs.jmedchem.9b01518. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
2. . doi:10.1016/S1473-3099(23)00069-5. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
3. . doi:10.1056/NEJMoa2304748. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
4. "Cefepime/taniborbactam - VenatoRx Pharmaceuticals". AdisInsight.

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