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Revision as of 15:03, 27 December 2024 editBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,644 edits created drug stubTag: nowiki added  Latest revision as of 16:37, 27 December 2024 edit undoIdoghor Melody (talk | contribs)Autopatrolled, Event coordinators, Extended confirmed users, Page movers, IP block exemptions, New page reviewers, Pending changes reviewers32,603 editsm clean up, added orphan tagTag: AWB 
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Latest revision as of 16:37, 27 December 2024

This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions. (December 2024)

Pharmaceutical compound
Imocitrelvir
Clinical data
Other namesAG-7404, V-7404
Identifiers
IUPAC name
  • ethyl (E,4S)-4--2-oxopyridin-1-yl]pent-4-ynoyl]amino]-5-pent-2-enoate
CAS Number
PubChem CID
IUPHAR/BPS
UNII
ChEMBL
Chemical and physical data
FormulaC26H29N5O7
Molar mass523.546 g·mol
3D model (JSmol)
SMILES
  • CCOC(=O)/C=C/(C1CCNC1=O)NC(=O)(CC#C)N2C=CC=C(C2=O)NC(=O)C3=NOC(=C3)C
InChI
  • InChI=InChI=1S/C26H29N5O7/c1-4-7-21(31-13-6-8-19(26(31)36)29-24(34)20-14-16(3)38-30-20)25(35)28-18(9-10-22(32)37-5-2)15-17-11-12-27-23(17)33/h1,6,8-10,13-14,17-18,21H,5,7,11-12,15H2,2-3H3,(H,27,33)(H,28,35)(H,29,34)/b10-9+/t17-,18+,21-/m0/s1
  • Key:QCUZOJBYWQPLIN-BNMFZAHFSA-N

Imocitrelvir is an investigational new drug that is being evaluated for the treatment of viral infections. It is a 3C protease inhibitor in picornaviruses. Originally developed by Pfizer for treating human rhinovirus infections, this small molecule has shown promise against a broader range of viruses, including polioviruses.

References

  1. "Imocitrelvir". PatSnap.
  2. Xie H, Rhoden EE, Liu HM, Ogunsemowo F, Mainou BA, Burke RM, et al. (November 2024). "Antiviral Development for the Polio Endgame: Current Progress and Future Directions". Pathogens. 13 (11). Basel, Switzerland: 969. doi:10.3390/pathogens13110969. PMC 11597170. PMID 39599522.
  3. Bandyopadhyay AS, Burke RM, Hawes KM (June 2024). "Polio Eradication: Status, Struggles and Strategies". The Pediatric Infectious Disease Journal. 43 (6): e207-211. doi:10.1097/INF.0000000000004330. PMID 38564755.


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