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| | fields = {{ublist | ] }} | | fields = {{ublist | ] }} | ||
| | workplaces = {{ublist | ] | ] | ] }} | | workplaces = {{ublist | ] | ] | ] }} | ||
| | alma_mater = {{ublist | ] (]) |
| alma_mater = {{ublist | ] (]) }} | ||
| | doctoral_advisor = George P. Hess<br>Robert Lesh Baldwin | | doctoral_advisor = George P. Hess<br>Robert Lesh Baldwin | ||
| | doctoral_students = | | doctoral_students = | ||
| | known_for = Studies on ] | | known_for = Studies on ] | ||
| | awards = G. N. Ramachandran Gold Medal | |||
| | awards = 1996 Birla Biology Award<br>2000 ]<br>2011 ] Distinguished Alumnus Award<br>2011 ] G. N. Ramachandran Gold Medal | |||
| }} | }} | ||
| '''Jayant Bhalchandra Udgaonkar''' (born 1960) is a former ] and ] of ]<ref>{{Cite web |title=Jayant B. Udgaonkar - IISER Pune |url=https://www.iiserpune.ac.in/research/department/biology/people/faculty/regular-faculty/jayant-b-udgaonkar/348}}</ref> at the ]. Without any major scientific contribution, he has nevertheless established himself as a prominent protein-folding scientist amongst the local scientific community (for notable contributions in the field, see ]). In 2016, the ] published a retraction notice<ref> {{cite web |date= 7 December 2021 |title=Retraction Notice to: The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/biophysj/pdf/S0006-3495(21)00952-8.pdf |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref> citing evidence of manipulation via duplication, mirroring, and rescaling of identical data in one of his papers.<ref> {{cite web |date= 26 April 2016 |title=The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/action/showPdf?pii=S0006-3495%2816%2930068-6 |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref> | |||
| '''Jayant Bhalchandra Udgaonkar''' (born 1960) is an Indian biochemist, molecular biologist, and academic at the ]. He is the former Director of the ],<ref>{{cite news|last1=Nair|first1=Ardhra|title=New IISER director points at lack of funding for research|url=https://timesofindia.indiatimes.com/city/pune/new-iiser-director-points-at-lack-of-funding-for-research/articleshow/61426575.cms|access-date=1 November 2017|agency=The Times of India}}</ref><ref>{{cite news|title=Government clears appointment of top officials of four IIMs, IISER|url=http://www.hindustantimes.com/education/government-clears-appointment-of-top-officials-of-four-iims-iiser/story-Jp2JSglKUe8yOFgTcn1nVP.html|agency=Hindustan Times|date=19 September 2017}}</ref> and was previously a senior professor at the ].<ref name="Prof. Jayant B. Udgaonkar on NCBS">{{cite web | url=https://www.ncbs.res.in/faculty/student/133/1247 | title=Prof. Jayant B. Udgaonkar on NCBS | publisher=National Centre for Biological Sciences | date=2016 | access-date=15 October 2016}}</ref> A J.C. Bose National Fellow, he is known for his studies on ].<ref name="Brief Profile of the Awardee">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=95 | title=Brief Profile of the Awardee | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> He is an elected fellow of the ],<ref name="Fellow profile - Udgaonkar">{{cite web | url=http://www.ias.ac.in/describe/fellow/Udgaonkar,_Prof._Jayant_Bhalchandra | title=Fellow profile - Udgaonkar | publisher=Indian Academy of Sciences | date=2016 | access-date=6 October 2016}}</ref> ]<ref name="Indian fellow - Udgaonkar">{{cite web | url=http://insaindia.res.in/detail.php?id=P02-1326 | title=Indian fellow - Udgaonkar | publisher=Indian National Science Academy | date=2016 | access-date=11 October 2016}}</ref> and ].<ref name="TWAS fellow">{{cite web | url=http://twas.org/member/udgaonkar-jayant | title=TWAS fellow | publisher=TWAS | date=2016 | access-date=15 October 2016}}</ref> The ], the apex agency of the Government of India for scientific research, awarded him the ], one of the highest Indian science awards, in 2000, for his contributions to biological sciences.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=201 | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> He has received Vigyan Shri Award under ] scheme (2024). He is the son of noted scientist Padmabhushan ].<ref>{{cite book|last1=Phondke|first1=Bal|last2=Sheth|first2=Parul R.|last3=Naik-Satam|first3=Suhas|last4=Deshpande|first4=A.P.|title=B.M. Udgaonkar: Eminent Scientist and Educationist|date=2007|publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication|location=Mumbai|url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf}}</ref> | |||
| == Biography == | == Biography == | ||
| ].]] | ] (This is not Dr. Udgaonkar`s own result).]] | ||
| Jayant Udgaonkar, born on 22 March 1960 |
Jayant Udgaonkar, born on 22 March 1960, did his B.Sc. in chemistry from ]<ref name="Profile on NCBS">{{cite web |date=2016 |title=Profile on NCBS |url=https://www.ncbs.res.in/sites/default/files/ju_cvbrief_jan16.pdf |access-date=15 October 2016 |publisher=National Centre for Biological Sciences}}</ref>, and obtained his PhD from ]. He propounded the protein folding hypothesis that ''initial ]'' is the first stage in protein folding, which he demonstrated using a model protein and elucidated the various stages of protein folding and unfolding. His current work focuses on formation of ].<ref name="Jayant Udgaonkar on Google Scholar">{{cite web |date=2016 |title=Jayant Udgaonkar on Google Scholar |url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en |access-date=16 October 2016 |work=Author profile |publisher=Google Scholar}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web |date=2016 |title=Jayant Udgaonkar on ResearchGate |url=https://www.researchgate.net/profile/Jayant_Udgaonkar |access-date=16 October 2016 |work=Author profile}}</ref> | ||
| == Legacy == | == Legacy == | ||
| He is the son of noted scientist ].<ref>{{cite book|last1=Phondke|first1=Bal|last2=Sheth|first2=Parul R.|last3=Naik-Satam|first3=Suhas|last4=Deshpande|first4=A.P.|title=B.M. Udgaonkar: Eminent Scientist and Educationist|date=2007|publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication|location=Mumbai|url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf}}</ref> | |||
| During his doctoral studies at Cornell University, Udgaonkar is known to have developed a protocol for rapid chemical kinetic studies at the cell surface.<ref name="Indian fellow - Udgaonkar" /> Later, while pursuing his post-doctoral studies, he developed methodologies for hydrogen exchange using ] for exploring the ''intermediates populating ] pathways''. Furthering his Stanford studies on protein folding at NCBS, he propounded the theory that ''initial ]'' is the first stage in protein folding, which he demonstrated using a model protein ] and elucidated the various transition stages of protein folding and unfolding.<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | access-date=5 October 2016 | pages=34 | archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf | archive-date=4 March 2016 | url-status=dead }}</ref> He has also demonstrated that, contrary to the general understanding that a single dominant barrier slows down the protein folding, several distributed small barriers can also influence the reaction.<ref name="Indian fellow - Udgaonkar" /> His current work focuses on formation of ] ] and his research has shown multiple pathways of aggregation in the formation of amyloid fibrils of different morphologies.<ref name="Summary of Achievements">{{cite web | url=http://www.serb.gov.in/pdfs/research/Prof_Jayant_Udgaonkar.pdf | title=Summary of Achievements | publisher=SERB | date=2016 | access-date=16 October 2016}}</ref> | |||
| ⚫ | == Awards and Honors == | ||
| * Vigyan Shri Award under ] scheme (2024)<ref>{{cite web |title=Rashtriya Vigyan Puraskar (RVP) - 2024 : Final List of Awardees |url=https://awards.gov.in/Home/GoToIndex?filename=Award%2FCommunication%2F202488013634H24ZU2.pdf|website=awards.gov.in |publisher=CASU, Ministry of Home Affairs, Government of India |access-date=15 August 2024}}</ref><ref>{{cite news |title=Rashtriya Vigyan Puraskar: Chandrayaan-3 team and 32 others selected for first ever edition |url=https://economictimes.indiatimes.com/news/science/rashtriya-vigyan-puraskar-chandrayaan-3-team-and-32-others-selected-for-first-ever-edition-here-is-full-list/articleshow/112349033.cms?from=mdr |newspaper=The Economic Times | date=7 August 2024 |access-date=15 August 2024}}</ref> | |||
| Udgaonkar has published a number of articles in peer reviewed journals detailing his researches,{{Refn|group=note|Please see Selected bibliography section}} ] and ], two online repositories of scientific articles, have listed several of them.<ref name="Jayant Udgaonkar on Google Scholar">{{cite web | url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en | title=Jayant Udgaonkar on Google Scholar | publisher=Google Scholar | work=Author profile | date=2016 | access-date=16 October 2016}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web | url=https://www.researchgate.net/profile/Jayant_Udgaonkar | title=Jayant Udgaonkar on ResearchGate | work=Author profile | date=2016 | access-date=16 October 2016}}</ref> A former guest editor of the ] of ] (2013 and 2015) and a former editorial board member of ''Folding and Design'' (1996–98), he is an associate editor of the ] journal<ref name="Profile on NCBS" /> and a member of the editorial board of ''Protein Engineering, Design and Selection'' (since 2003), an Oxford journal.<ref name="Editorial Office">{{cite web | url=http://www.oxfordjournals.org/our_journals/proeng/for_authors/editorial_board.html | archive-url=https://web.archive.org/web/20160321195455/http://www.oxfordjournals.org/our_journals/proeng/for_authors/editorial_board.html | url-status=dead | archive-date=2016-03-21 | title=Editorial Office | publisher=Oxford Journals | date=2016 | access-date=16 October 2016}}</ref> He is also a member of the Asia-Pacific International Molecular Biology Network since 2001 and has mentored several scholars in their doctoral researches.<ref name="Indian fellow - Udgaonkar" /> | |||
| * Udgaonkar stood first in the BSc chemistry examinations of the ] in 1979 protein folding.<ref name="Profile on NCBS" /> | |||
| ⚫ | == Awards and |
||
| Udgaonkar, who stood first in the BSc chemistry examinations of the ] in 1979, received several scholarships and research fellowships including the National Merit Scholarship of the Government of India, Merit Scholarship of the Indian Institute of Technology, Madras, ] fellowship, Biotechnology Career Fellowship of ], Golden Jubilee Biotechnology fellowship of the ], Swarnajayanti fellowship of the ] and Senior Research fellowship of ] and is a J. C. Bose National Fellow of the ], the tenancy of the fellowship running from 2007 till 2017.<ref name="Profile on NCBS" /> He received the Birla Award in Biology in 1996 and the Indian Academy of Sciences elected him as a fellow in 1997.<ref name="Fellow profile - Udgaonkar" /> The ] awarded him the ], one of the highest Indian science awards, in 2000.<ref name="View Bhatnagar Awardees" /> He became an elected fellow of the ] in 2002 and ] elected him as a fellow in 2007.<ref name="TWAS fellow" />Vigyan Shri Award under ] scheme (2024). | |||
| == Selected bibliography == | == Selected bibliography == | ||
| * {{cite journal | |
* {{cite journal |title=Early folding intermediate of ribonuclease A. |author=Jayant B Udgaonkar, Robert L Baldwin |journal=Proceedings of the National Academy of Sciences |date=November 1990 |volume=87 |issue=21 |pages=8197–8201 |doi=10.1073/pnas.87.21.8197 |pmc=54922 |pmid=2236032 |bibcode=1990PNAS...87.8197U |doi-access=free}} | ||
| * {{cite journal | title=How cooperative are protein folding and unfolding transitions?: Cooperativity in protein folding/unfolding reactions | author=Pooja Malhotra, Jayant B Udgaonkar | journal=Protein Science | date=August 2016 | doi=10.1002/pro.3015 | volume=25 | issue=11 | pages=1924–1941| pmc=5079258 | pmid=27522064}} | |||
| * {{cite journal | title=Microsecond Rearrangements of Hydrophobic Clusters in an Initially Collapsed Globule Prime Structure Formation during the Folding of a Small Protein | author=Rama Reddy Goluguri, Jayant B Udgaonkar | journal=Journal of Molecular Biology | date=June 2016 | volume=428 | issue=15 | doi=10.1016/j.jmb.2016.06.015 | pages=3102–3117 | pmid=27370109}} | |||
| *{{Cite journal|last1=Singh|first1=Jogender|last2=Kumar|first2=Harish|last3=Sabareesan|first3=Ambadi T.|last4=Udgaonkar|first4=Jayant B.|date=2014-12-03|title=Rational Stabilization of Helix 2 of the Prion Protein Prevents Its Misfolding and Oligomerization|journal=Journal of the American Chemical Society|language=en|volume=136|issue=48|pages=16704–16707|doi=10.1021/ja510964t|pmid=25407394|issn=0002-7863}} | |||
| *{{Cite journal|last1=Zaidi|first1=Faisal N.|last2=Nath|first2=Utpal|last3=Udgaonkar|first3=Jayant B.|date=December 1997|title=Multiple intermediates and transition states during protein unfolding|journal=Nature Structural Biology|volume=4|issue=12|pages=1016–1024|doi=10.1038/nsb1297-1016|pmid=9406552|s2cid=1692527|issn=1072-8368}} | |||
| * {{cite journal | title=Thermodynamics of denaturation of barstar: evidence for cold denaturation and evaluation of the interaction with guanidine hydrochloride | author=Vishwas R Agashe, Jayant B Udgaonkar | journal=Biochemistry | date=March 1995 | volume=34 | issue=10 | pages=3286–99 | doi=10.1021/bi00010a019| pmid=7880824 }} | |||
| * {{cite journal | title=Equilibrium unfolding studies of barstar: evidence for an alternative conformation which resembles a molten globule | author=Ritu Khurana, Jayant B Udgaonkar | journal=Biochemistry | date=January 1994 | volume=33 | issue=1 | pages=106–115 | doi=10.1021/bi00167a014| pmid=8286327 }} | |||
| * {{cite journal | title=Early folding intermediate of ribonuclease A. | author=Jayant B Udgaonkar, Robert L Baldwin | journal=Proceedings of the National Academy of Sciences | date=November 1990 | volume=87 | issue=21 | pages=8197–8201 | doi=10.1073/pnas.87.21.8197| pmc=54922 | pmid=2236032| bibcode=1990PNAS...87.8197U | doi-access=free }} | |||
| == See also == | |||
| {{Div col}} | |||
| * ] | |||
| * ] | |||
| * ] | |||
| * ] | |||
| {{div col end}} | |||
| {{portal|India|Biology}} | |||
| == Notes == | |||
| {{reflist|group=note}} | |||
| == References == | == References == | ||
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Revision as of 16:15, 28 December 2024
Indian biochemist, molecular biologist (born 1960)
| Jayant B. Udgaonkar | |
|---|---|
 | |
| Born | (1960-03-22) 22 March 1960 (age 64) Maharashtra, India |
| Nationality | Indian |
| Alma mater | |
| Known for | Studies on Protein folding |
| Awards | G. N. Ramachandran Gold Medal |
| Scientific career | |
| Fields | |
| Institutions | |
| Doctoral advisor | George P. Hess Robert Lesh Baldwin |
Jayant Bhalchandra Udgaonkar (born 1960) is a former Director and Professor of Biology at the Indian Institute of Science Education and Research, Pune. Without any major scientific contribution, he has nevertheless established himself as a prominent protein-folding scientist amongst the local scientific community (for notable contributions in the field, see protein folding). In 2016, the Biophysical Journal published a retraction notice citing evidence of manipulation via duplication, mirroring, and rescaling of identical data in one of his papers.
Biography
Jayant Udgaonkar, born on 22 March 1960, did his B.Sc. in chemistry from St. Xavier's College, Mumbai, and obtained his PhD from Cornell University. He propounded the protein folding hypothesis that initial hydrophobic collapse is the first stage in protein folding, which he demonstrated using a model protein and elucidated the various stages of protein folding and unfolding. His current work focuses on formation of amyloid protein folding.
Legacy
He is the son of noted scientist Bhalchandra Udgaonkar.
Awards and Honors
- Vigyan Shri Award under Rashtriya Vigyan Puraskar scheme (2024)
- Udgaonkar stood first in the BSc chemistry examinations of the University of Mumbai in 1979 protein folding.
Selected bibliography
- Jayant B Udgaonkar, Robert L Baldwin (November 1990). "Early folding intermediate of ribonuclease A." Proceedings of the National Academy of Sciences. 87 (21): 8197–8201. Bibcode:1990PNAS...87.8197U. doi:10.1073/pnas.87.21.8197. PMC 54922. PMID 2236032.
References
- "Jayant B. Udgaonkar - IISER Pune".
- "Retraction Notice to: The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes" (PDF). Biophysical Society. 7 December 2021. Retrieved 24 September 2024.
- "The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes". Biophysical Society. 26 April 2016. Retrieved 24 September 2024.
- ^ "Profile on NCBS" (PDF). National Centre for Biological Sciences. 2016. Retrieved 15 October 2016.
- "Jayant Udgaonkar on Google Scholar". Author profile. Google Scholar. 2016. Retrieved 16 October 2016.
- "Jayant Udgaonkar on ResearchGate". Author profile. 2016. Retrieved 16 October 2016.
- Phondke, Bal; Sheth, Parul R.; Naik-Satam, Suhas; Deshpande, A.P. (2007). B.M. Udgaonkar: Eminent Scientist and Educationist (PDF). Mumbai: National Center for Science Communication; Homi Bhabha Centre for Science Communication.
- "Rashtriya Vigyan Puraskar (RVP) - 2024 : Final List of Awardees" (PDF). awards.gov.in. CASU, Ministry of Home Affairs, Government of India. Retrieved 15 August 2024.
- "Rashtriya Vigyan Puraskar: Chandrayaan-3 team and 32 others selected for first ever edition". The Economic Times. 7 August 2024. Retrieved 15 August 2024.
External links
- "Jayant Udgaonkar, Ph.D. on Chemistry Tree". Scientist profile. Chemistry Tree. 2016. Retrieved 16 October 2016.