| Revision as of 14:36, 21 August 2003 editKosebamse (talk | contribs)Extended confirmed users, Rollbackers5,826 editsm copyedit← Previous edit | Revision as of 12:14, 29 August 2003 edit undoKosebamse (talk | contribs)Extended confirmed users, Rollbackers5,826 edits moreNext edit → | ||
| Line 5: | Line 5: | ||
| Sepsis is particulary common and dangerous in elderly, immunocompromised, and critically ill patients, where it is a major cause of death in intensive care units worldwide. In the ], sepsis is the leading cause of death in non-] ] patients, while recent 1998 data from the ] show that it is the 11th leading cause of death overall. Mortality rates ranging from 28 to 50% have been reported for sepsis. | Sepsis is particulary common and dangerous in elderly, immunocompromised, and critically ill patients, where it is a major cause of death in intensive care units worldwide. In the ], sepsis is the leading cause of death in non-] ] patients, while recent 1998 data from the ] show that it is the 11th leading cause of death overall. Mortality rates ranging from 28 to 50% have been reported for sepsis. | ||
| The therapy of sepsis relies on |
The therapy of sepsis relies on ] (and in some cases, surgical) treatment of the causating infection, fluid replacement, adequate nutrition (including ]), and appropriate support for organ dysfunction. This may include ] in renal failure, ] in pulmonary dysfunction, transfusion of ], ] and coagulation factors to stabilize blood ], and drug and fluid therapy for circulatory failure. Therapeutic strategies aimed at the inflammation process itself have largely failed to improve outcome. However, the infusion of activated Protein C, a coagulation factor, has recently been shown to improve survival in sepsis. Low dose ] also seems to be beneficial. | ||
Revision as of 12:14, 29 August 2003
Sepsis is a life-threatening condition caused by the immune response of an organism to severe infection. Sepsis is characterized by overwhelming systemic (i.e. not localised) inflammation. It is often associated with coagulation disorders and dysfunction of the circulatory system. Even under optimal treatment, dysfunction of many organ systems may progress to multiple organ failure and eventually death.
Sepsis is particulary common and dangerous in elderly, immunocompromised, and critically ill patients, where it is a major cause of death in intensive care units worldwide. In the United States, sepsis is the leading cause of death in non-coronary ICU patients, while recent 1998 data from the Centers for Disease Control show that it is the 11th leading cause of death overall. Mortality rates ranging from 28 to 50% have been reported for sepsis.
The therapy of sepsis relies on antibiotic (and in some cases, surgical) treatment of the causating infection, fluid replacement, adequate nutrition (including parenteral nutrition), and appropriate support for organ dysfunction. This may include hemodialysis in renal failure, mechanical ventilation in pulmonary dysfunction, transfusion of blood plasma, platelets and coagulation factors to stabilize blood coagulation, and drug and fluid therapy for circulatory failure. Therapeutic strategies aimed at the inflammation process itself have largely failed to improve outcome. However, the infusion of activated Protein C, a coagulation factor, has recently been shown to improve survival in sepsis. Low dose cortisol also seems to be beneficial.
Related conditions
- Septicemia (or bacteriemia) is the presence of bacteria in the bloodstream. Septicemia can occur in sepsis and other serious diseases such as infective endocarditis, but it may also be a harmless and transient condition.
- SIRS (Systemic inflammatory response syndrome) is associated with a variety of causes such as severe trauma, burns, or shock. In its clinical appearance SIRS may be indistinguishable from sepsis, but a causating infection is by definition not involved.