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Duloxetine: Difference between revisions

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Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours.

Duloxentine is also approved by the FDA for the treatment of diabetic neuropathy.


==External links== ==External links==

Revision as of 16:24, 27 August 2005

Duloxetine chemical structure of duloxetine
Duloxetine

IUPAC chemical name
CAS number
 ? 		ATC code
 ?
Chemical formula ?
Molecular weight ?
Bioavailability ?
Metabolism ?
Elimination half-life 10-15 hours
Excretion ?
Pregnancy category ?
Legal status ?
Routes of administration ?

Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.

Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.

Duloxentine is also approved by the FDA for the treatment of diabetic neuropathy.

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