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| First described by Moersch and Woltman at the ] in 1956,{{ref|mws}} '''stiff person syndrome''' (SPS) is a rare ] disorder of unknown ]. Those with the illness experience progressive, fluctuating tonic contractions of all muscles, particularly the axial musculature. Inability to walk and ] quickly ensues; death usually occurs six to twelve months after diagnosis. | First described by Moersch and Woltman at the ] in 1956,{{ref|mws}} '''stiff person syndrome''' (SPS) is a rare ] disorder of unknown ]. Those with the illness experience progressive, fluctuating tonic contractions of all muscles, particularly the axial musculature. Inability to walk and ] quickly ensues; death usually occurs six to twelve months after diagnosis. | ||
| Treatment is mostly ] with muscle relaxants such as ], which lose their effectiveness as the illness progresses. Because many patients with SPS have circulating antibodies to ], an ] genesis to the disease has been postulated and some authorities recommend humane trials of ] therapy, ] or ] infusion owing to the absence of ], ]-controlled ] on treatment efficacy. | Treatment is mostly ] with muscle relaxants such as ], which lose their effectiveness as the illness progresses. Because many patients with SPS have circulating antibodies to ], an ] genesis to the disease has been postulated and some authorities recommend humane trials of ] therapy, ] or intravenous ] infusion owing to the absence of ], ]-controlled ] on treatment efficacy. | ||
| ==References== | ==References== | ||
Revision as of 08:08, 30 August 2005
First described by Moersch and Woltman at the Mayo Clinic in 1956, stiff person syndrome (SPS) is a rare neurologic disorder of unknown etiology. Those with the illness experience progressive, fluctuating tonic contractions of all muscles, particularly the axial musculature. Inability to walk and paralysis quickly ensues; death usually occurs six to twelve months after diagnosis.
Treatment is mostly palliative with muscle relaxants such as benzodiazepines, which lose their effectiveness as the illness progresses. Because many patients with SPS have circulating antibodies to glutamic acid decarboxylase, an autoimmune genesis to the disease has been postulated and some authorities recommend humane trials of immunosuppressive therapy, plasmapheresis or intravenous immunoglobulin infusion owing to the absence of double-blind, placebo-controlled class A trials on treatment efficacy.
References
Template:Journal reference issue PMID 13350379
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