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| A '''tetracyclic antidepressant''' is an ] ] from the ]. The name tetracyclic is derived from the drug's molecular structure which consists of four ring-like structures in a ] (compare ]). | A '''tetracyclic antidepressant''' is an ] ] from the ]. The name tetracyclic is derived from the drug's molecular structure which consists of four ring-like structures in a ] (compare ]). | ||
| ] (trade named |
] (trade named Ludiomil), and ] (trade named Remeron in the USA, Remergil, Remeron and Zispin in Europe, and Avanza in Australia) are the only two drugs from this group widely used for the treatment of ]. ] was previously available internationally, however in it has been phased out in favor of mirtazapine in most markets. | ||
| Research on other tetracyclic antidepressant compounds (for example ]) have been reported in the scientific literature. These other tetracyclic antidepressants are not publicly available. | Research on other tetracyclic antidepressant compounds (for example ]) have been reported in the scientific literature. These other tetracyclic antidepressants are not publicly available. | ||
Revision as of 12:08, 28 April 2009
There are also several chemically unrelated tetracyclic antibiotics based on Tetracycline.
A tetracyclic antidepressant is an antidepressant drug from the tetracyclic drug group. The name tetracyclic is derived from the drug's molecular structure which consists of four ring-like structures in a T-shape (compare tricyclic antidepressant).
Maprotiline (trade named Ludiomil), and mirtazapine (trade named Remeron in the USA, Remergil, Remeron and Zispin in Europe, and Avanza in Australia) are the only two drugs from this group widely used for the treatment of clinical depression. Mianserin was previously available internationally, however in it has been phased out in favor of mirtazapine in most markets.
Research on other tetracyclic antidepressant compounds (for example setiptiline) have been reported in the scientific literature. These other tetracyclic antidepressants are not publicly available.
List of tetracyclic antidepressants
According to MeSH the tetracyclic antidepressants have the following effects:
| Adrenergic Uptake Inhibitor | Adrenergic Alpha-Receptor Antagonist | Dopamine Receptor Antagonist | Serotonin Uptake Inhibitor | Serotonin 5-HT2 Receptor Antagonist | Histamine H1 Receptor Antagonist | |
| Amoxapine | yes | - | yes | weak | yes | yes |
| Maprotiline | yes | yes | weak | - | yes | yes |
| Mianserin | - | yes | - | - | yes | yes |
| Mirtazapine | - | yes | - | - | yes | yes |