Revision as of 14:14, 7 August 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report errors or [[u← Previous edit | Revision as of 23:59, 30 August 2011 edit undoBogBot (talk | contribs)Bots53,132 edits populated new fields in {{drugbox}} and reordered per bot approval. Report errors and suggestions to User_talk:BogBotNext edit → | ||
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{{Drugbox | ||
| verifiedrevid = 443509780 | | verifiedrevid = 443509780 | ||
| IUPAC_name = (6''R'',7''R'')-7-{<br>amino}-3-{<br>sulfanylmethyl}-8-oxo-5-thia-1-azabicyclo<br>oct-2-ene-2-carboxylic acid | | IUPAC_name = (6''R'',7''R'')-7-{<br>amino}-3-{<br>sulfanylmethyl}-8-oxo-5-thia-1-azabicyclo<br>oct-2-ene-2-carboxylic acid | ||
| image = Cefotiam.svg | | image = Cefotiam.svg | ||
| width = 250 | | width = 250 | ||
<!--Clinical data--> | |||
| tradename = | |||
| Drugs.com = {{drugs.com|international|cefotiam}} | |||
⚫ | | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | ||
⚫ | | pregnancy_US = <!-- A / B / C / D / X --> | ||
⚫ | | pregnancy_category = | ||
⚫ | | legal_AU = <!-- Unscheduled / S2 / S4 / S8 --> | ||
⚫ | | legal_UK = <!-- GSL / P / POM / CD --> | ||
⚫ | | legal_US = <!-- OTC / Rx-only --> | ||
⚫ | | legal_status = | ||
⚫ | | routes_of_administration = ], intramuscular | ||
<!--Pharmacokinetic data--> | |||
⚫ | | bioavailability = 60% (]) | ||
⚫ | | protein_bound = 40% | ||
⚫ | | metabolism = Nil | ||
⚫ | | elimination_half-life = Approximately 1 hour | ||
⚫ | | excretion = ] | ||
<!--Identifiers--> | |||
| CASNo_Ref = {{cascite|correct|CAS}} | | CASNo_Ref = {{cascite|correct|CAS}} | ||
⚫ | | CAS_number = 61622-34-2 | ||
⚫ | | ATC_prefix = J01 | ||
⚫ | | ATC_suffix = DC07 | ||
⚫ | | ATC_supplemental = | ||
⚫ | | PubChem = 43708 | ||
⚫ | | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ||
⚫ | | DrugBank = APRD00855 | ||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ||
| ChemSpiderID = 39831 | | ChemSpiderID = 39831 | ||
| UNII_Ref = {{fdacite|correct|FDA}} | | UNII_Ref = {{fdacite|correct|FDA}} | ||
| UNII = 91W6Z2N718 | | UNII = 91W6Z2N718 | ||
⚫ | | KEGG_Ref = {{keggcite|correct|kegg}} | ||
⚫ | | InChI = 1/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 | ||
⚫ | | KEGG = D07648 | ||
⚫ | | smiles = O=C2N1/C(=C(\CS12NC(=O)Cc3nc(sc3)N)CSc4nnnn4CCN(C)C)C(=O)O | ||
⚫ | | ChEBI_Ref = {{ebicite|correct|EBI}} | ||
⚫ | | InChIKey = QYQDKDWGWDOFFU-IUODEOHRBO | ||
⚫ | | ChEBI = 355510 | ||
| ChEMBL_Ref = {{ebicite|correct|EBI}} | | ChEMBL_Ref = {{ebicite|correct|EBI}} | ||
| ChEMBL = 1296 | | ChEMBL = 1296 | ||
<!--Chemical data--> | |||
⚫ | | C=18 | H=23 | N=9 | O=4 | S=3 | ||
⚫ | | molecular_weight = 525.631 g/mol | ||
⚫ | | smiles = O=C2N1/C(=C(\CS12NC(=O)Cc3nc(sc3)N)CSc4nnnn4CCN(C)C)C(=O)O | ||
⚫ | | InChI = 1/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 | ||
⚫ | | InChIKey = QYQDKDWGWDOFFU-IUODEOHRBO | ||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | ||
| StdInChI = 1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 | | StdInChI = 1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 | ||
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | ||
| StdInChIKey = QYQDKDWGWDOFFU-IUODEOHRSA-N | | StdInChIKey = QYQDKDWGWDOFFU-IUODEOHRSA-N | ||
⚫ | | CAS_number = 61622-34-2 | ||
⚫ | | ATC_prefix = J01 | ||
⚫ | | ATC_suffix = DC07 | ||
⚫ | | ATC_supplemental = | ||
⚫ | | ChEBI_Ref = {{ebicite|correct|EBI}} | ||
⚫ | | ChEBI = 355510 | ||
⚫ | | PubChem = 43708 | ||
⚫ | | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ||
⚫ | | DrugBank = APRD00855 | ||
⚫ | | KEGG_Ref = {{keggcite|correct|kegg}} | ||
⚫ | | KEGG = D07648 | ||
⚫ | | C |
||
⚫ | | molecular_weight = 525.631 g/mol | ||
⚫ | | bioavailability = 60% (]) | ||
⚫ | | protein_bound = 40% | ||
⚫ | | metabolism = Nil | ||
⚫ | | elimination_half-life = Approximately 1 hour | ||
⚫ | | excretion = ] | ||
⚫ | | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | ||
⚫ | | pregnancy_US = <!-- A / B / C / D / X --> | ||
⚫ | | pregnancy_category = | ||
⚫ | | legal_AU = <!-- Unscheduled / S2 / S4 / S8 --> | ||
⚫ | | legal_UK = <!-- GSL / P / POM / CD --> | ||
⚫ | | legal_US = <!-- OTC / Rx-only --> | ||
⚫ | | legal_status = | ||
⚫ | | routes_of_administration = ], intramuscular | ||
}} | }} | ||
'''Cefotiam''' is a second-generation ] ]. | '''Cefotiam''' is a second-generation ] ]. |
Revision as of 23:59, 30 August 2011
Pharmaceutical compoundClinical data | |
---|---|
AHFS/Drugs.com | International Drug Names |
Routes of administration | Intravenous, intramuscular |
ATC code | |
Pharmacokinetic data | |
Bioavailability | 60% (intramuscular) |
Protein binding | 40% |
Metabolism | Nil |
Elimination half-life | Approximately 1 hour |
Excretion | Renal |
Identifiers | |
IUPAC name
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.205.922 |
Chemical and physical data | |
Formula | C18H23N9O4S3 |
Molar mass | 525.631 g/mol g·mol |
3D model (JSmol) | |
SMILES
| |
InChI
| |
(verify) |
Cefotiam is a second-generation cephalosporin antibiotic.
External links
- Müller R, Böttger C, Wichmann G (2003). "Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients". Arzneimittelforschung. 53 (2): 126–32. PMID 12642969.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - Kolben M, Mandoki E, Ulm K, Freitag K (2001). "Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section". Eur J Clin Microbiol Infect Dis. 20 (1): 40–2. doi:10.1007/s100960000365. PMID 11245321.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - Shimizu S, Chen K, Miyakawa S (1996). "Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses". Dermatology. 192 (2): 174–6. doi:10.1159/000246352. PMID 8829507.
{{cite journal}}
: CS1 maint: multiple names: authors list (link)
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