Melatonin receptor 1C: Difference between revisions

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	'''Melatonin receptor 1C''', also known as '''MTNR1C''', is a ] that is encoded by the ''Mtnr1c'' ]. This ] has been identified in fish, ], and birds, but not in ]s.<ref name="Sugden_2004">{{cite journal \| author = Sugden D, Davidson K, Hough KA, Teh MT \|title = Melatonin, melatonin receptors and melanophores: a moving story \| journal = Pigment Cell Res. \| volume = 17 \| issue = 5 \| pages = 454–60 \| year = 2004 \| pmid = 15357831 \| doi = 10.1111/j.1600-0749.2004.00185.x }}</ref>		'''Melatonin receptor 1C''', also known as '''MTNR1C''', is a ] that is encoded by the ''Mtnr1c'' ]. This ] has been identified in fish, ], and birds, but not in ]s.<ref name="Sugden_2004">{{cite journal \| author = Sugden D, Davidson K, Hough KA, Teh MT \|title = Melatonin, melatonin receptors and melanophores: a moving story \| journal = Pigment Cell Res. \| volume = 17 \| issue = 5 \| pages = 454–60 \| year = 2004 \| pmid = 15357831 \| doi = 10.1111/j.1600-0749.2004.00185.x }}</ref>

⚫	== See also ==
⚫	* ]

	== References ==		== References ==
	{{Reflist\|2}}		{{Reflist\|2}}

			==Further reading==
			{{refbegin \| 2}}
			{{PBB_Further_reading
			\| citations =
			*{{cite journal \| author=Brzezinski A \| last2=Brzezinski \| first2=Amnon \|title=Melatonin in humans \|journal=N. Engl. J. Med. \|volume=336 \|issue= 3 \|pages= 186–95 \|year= 1997 \|pmid= 8988899 \|doi=10.1056/NEJM199701163360306 }}
			*{{cite journal \| author=Reppert SM, Weaver DR, Ebisawa T, ''et al.'' \|title=Cloning of a melatonin-related receptor from human pituitary \|journal=FEBS Lett. \|volume=386 \|issue= 2–3 \|pages= 219–24 \|year= 1996 \|pmid= 8647286 \|doi=10.1016/0014-5793(96)00437-1 }}
			*{{cite journal \| author=Niles LP, Wang J, Shen L, ''et al.'' \|title=Melatonin receptor mRNA expression in human granulosa cells \|journal=Mol. Cell. Endocrinol. \|volume=156 \|issue= 1–2 \|pages= 107–10 \|year= 2000 \|pmid= 10612428 \|doi=10.1016/S0303-7207(99)00135-5 }}
			*{{cite journal \| author=Roy D, Angelini NL, Fujieda H, ''et al.'' \|title=Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin \|journal=Endocrinology \|volume=142 \|issue= 11 \|pages= 4711–20 \|year= 2001 \|pmid= 11606436 \|doi=10.1210/en.142.11.4711 }}
			*{{cite journal \| author=Ayoub MA, Couturier C, Lucas-Meunier E, ''et al.'' \|title=Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer \|journal=J. Biol. Chem. \|volume=277 \|issue= 24 \|pages= 21522–8 \|year= 2002 \|pmid= 11940583 \|doi= 10.1074/jbc.M200729200 }}
			*{{cite journal \| author=Yuan L, Collins AR, Dai J, ''et al.'' \|title=MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells \|journal=Mol. Cell. Endocrinol. \|volume=192 \|issue= 1–2 \|pages= 147–56 \|year= 2003 \|pmid= 12088876 \|doi=10.1016/S0303-7207(02)00029-1 }}
			*{{cite journal \| author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' \|title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences \|journal=Proc. Natl. Acad. Sci. U.S.A. \|volume=99 \|issue= 26 \|pages= 16899–903 \|year= 2003 \|pmid= 12477932 \|doi= 10.1073/pnas.242603899 \| pmc=139241 }}
			*{{cite journal \| author=Slominski A, Pisarchik A, Zbytek B, ''et al.'' \|title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin \|journal=J. Cell. Physiol. \|volume=196 \|issue= 1 \|pages= 144–53 \|year= 2003 \|pmid= 12767050 \|doi= 10.1002/jcp.10287 }}
			*{{cite journal \| author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' \|title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) \|journal=Genome Res. \|volume=14 \|issue= 10B \|pages= 2121–7 \|year= 2004 \|pmid= 15489334 \|doi= 10.1101/gr.2596504 \| pmc=528928 }}
			*{{cite journal \| author=Suzuki S, Masui Y, Ohnuki M, ''et al.'' \|title=Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines \|journal=Biol. Pharm. Bull. \|volume=30 \|issue= 4 \|pages= 791–4 \|year= 2007 \|pmid= 17409522 \|doi=10.1248/bpb.30.791 }}
			}}
			{{refend}}

		⚫	== See also ==
		⚫	* ]
	{{G protein-coupled receptors}}		{{G protein-coupled receptors}}
	{{Melatonergics}}		{{Melatonergics}}



	{{transmembranereceptor-stub}}		{{transmembranereceptor-stub}}

Revision as of 06:31, 24 July 2012

Melatonin receptor 1C

Identifiers

Symbol

Mtnr1c

Search for
Structures	Swiss-model
Domains	InterPro

Melatonin receptor 1C, also known as MTNR1C, is a protein that is encoded by the Mtnr1c gene. This receptor has been identified in fish, amphibia, and birds, but not in humans.

References

Sugden D, Davidson K, Hough KA, Teh MT (2004). "Melatonin, melatonin receptors and melanophores: a moving story". Pigment Cell Res. 17 (5): 454–60. doi:10.1111/j.1600-0749.2004.00185.x. PMID 15357831.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

v t e Melatonin receptor modulators
MT₁Tooltip Melatonin receptor 1	Agonists: 2-Iodomelatonin 6-Hydroxymelatonin Agomelatine Fabomotizole (afobazole) GR-196,429 Melatonin N-Acetylserotonin (normelatonin) Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole
MT₂Tooltip Melatonin receptor 2	Agonists: 2-Iodomelatonin 6-Hydroxymelatonin Agomelatine GR-196,429 Melatonin N-Acetylserotonin (normelatonin) Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole
Unsorted	Agonists: 2-Phenylmelatonin 5-Methoxyluzindole 6-Chloromelatonin 6-Fluoromelatonin 6-Methoxymelatonin 6,7-Dichloro-2-methylmelatonin 8-M-PDOT AMMTC GR-135,531 (of MT₃Tooltip melatonin receptor 1C) N-Acetyltryptamine N-Butanoylmelatonin N-Propionylmelatonin S-24268 S-25150 Antagonists: 4-P-ADOT 4-P-PDOT DH-97 N-Acetyltryptamine (of MT₃) Prazosin (of MT₃) S-20928 S-22153 S-24601 S-25567 S-26131
See also: Receptor/signaling modulators Adrenergics Dopaminergics Serotonergics Monoamine metabolism modulators

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Revision as of 06:31, 24 July 2012

References

Further reading

See also