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Revision as of 18:01, 2 November 2012 edit98.202.20.79 (talk) Define Redox Signaling, with citations← Previous edit Revision as of 05:34, 4 November 2012 edit undoNucleophilic (talk | contribs)1,364 edits Undid revision 521084605 by 98.202.20.79 (talk)Flatly-stated, wrong. In any case,should be discussed first-- see talk pageNext edit →
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] is a shortened form for ]-]. It is, “a reversible chemical reaction in which one reaction is an oxidation and the reverse is a reduction.” <ref>http://www.thefreedictionary.com/redox</ref>

] is an act of communication. It is, “a detectable physical quantity or impulse ( as a voltage, current, or magnetic field strength) by which messages or information can be transmitted.” <ref>http://www.merriam-webster.com/dictionary/signaling</ref>

By this definition, Redox Signaling is a process of communication within, and between the cells of living things, that is triggered, controlled or mediated by a reduction-oxidation reaction.

Reduction-oxidation reactions are very common within the body. They are generated by many chemical and metabolic processes. Some of these processes involve damage, such as damage by ], while others are just electro-chemical processes. Redox signaling is one of the means by which the body controls processes and responds to stresses and damage.

'''Redox signaling''' is cellular ], ] and electrochemically active oxides of nitrogen such as ] acting as biological messengers. Examples of reactive oxygen species include ] and ]. Arguably, ]<ref>Jerzy Bełtowski and Anna Jamroz-Wiśniewska, Modulation of H2S Metabolism by Statins: A New Aspect of Cardiovascular Pharmacology . Antioxidants & Redox Signaling. July 1, 2012, 17(1): 81-94. doi:10.1089/ars.2011.4358.</ref> and ] also mediate redox signaling. Similarly, modulation of charge-transfer processes and electronic conduction in macromolecules is also redox signaling. For a review, see Forman.<ref>{{cite pmid|19735727}}</ref>. For example, ] likely play a key role in fibrocyte activation<ref>{{cite pmid|16297593}}</ref><ref>{{cite pmid|11134893}}</ref> and thus scar formation. '''Redox signaling''' is cellular ], ] and electrochemically active oxides of nitrogen such as ] acting as biological messengers. Examples of reactive oxygen species include ] and ]. Arguably, ]<ref>Jerzy Bełtowski and Anna Jamroz-Wiśniewska, Modulation of H2S Metabolism by Statins: A New Aspect of Cardiovascular Pharmacology . Antioxidants & Redox Signaling. July 1, 2012, 17(1): 81-94. doi:10.1089/ars.2011.4358.</ref> and ] also mediate redox signaling. Similarly, modulation of charge-transfer processes and electronic conduction in macromolecules is also redox signaling. For a review, see Forman.<ref>{{cite pmid|19735727}}</ref>. For example, ] likely play a key role in fibrocyte activation<ref>{{cite pmid|16297593}}</ref><ref>{{cite pmid|11134893}}</ref> and thus scar formation.

Revision as of 05:34, 4 November 2012

Redox signaling is cellular free radicals, reactive oxygen species and electrochemically active oxides of nitrogen such as nitric oxide acting as biological messengers. Examples of reactive oxygen species include hydrogen peroxide and superoxide radical. Arguably, hydrogen sulfide and carbon monoxide also mediate redox signaling. Similarly, modulation of charge-transfer processes and electronic conduction in macromolecules is also redox signaling. For a review, see Forman.. For example, reactive oxygen species likely play a key role in fibrocyte activation and thus scar formation.

History

In a series of papers beginning in 1941, Szent-Gyorgyi proposed that modulation of electronic processes in semiconductive macromolecules plays a key role in biological function and in diseases such as cancer. Hush reviews the history of such molecular electronics.

Similarly, the first modern statement of the "ROS are messengers" component of redox signaling appears to be that of Proctor,. At a 1979 congress of free radical investigators he further generalized this concept to suggest that " ....active oxygen metabolites act as specific intermediary transmitter substances for a variety of biological processes including inflammation, fibrosis, and possibly, neurotransmission.." and " One explanation for this data is that various active oxygen species ( or such products as hydroperoxides ) may act as specific transmitter substances....". After initial opposition, this global concept was published in a 1984 review. The next reference seems to be Bochner and coworkers., reporting increased synthesis of "alarmome" adenylylated nucleotides as a specific response to oxidative stress in bacteria.

Electronic conduction in redox signaling

Hush credits Mcginness and coworkers . with the first experimental confirmation of Szent-Gyorgyi's theories concerning semiconductor mechanisms in cellular signaling. Priel and coworkers postulate active electrochemical mechanisms in modulation of cellular processes by microtubules. Bettinger and Bao review recent work on biomaterial-based organic electronic devices. Such may play a role in control of cellular function.

Reactive oxygen species as messengers

The formation of ROS such as hydrogen peroxide underlies much biotic and abiotic stress signaling. For example, as signaling molecules, hydrogen peroxide and other ROS post- translationally modify target proteins by oxidizing thiol groups, thus forming disulfide bonds that reversibly alter protein structure and function. Specificity is achieved by localized production, concatenate hormone or calcium signaling, with targeted secondary oxidation occurring via glutaredoxins or thioredoxins. Target proteins containing reduction-oxidation (redox) sensitive thiol groups include i) signal transduction pathway proteins, such as phosphatases and mitogen-activated protein kinases, ii) embryogenesis regulating proteins iii) many transcription factors, iv) RNA-binding proteins that direct DNA methylation, and v) proteins involved in histone acetylation, deacetylation or methylation.

Similarly, the tyrosine-specific Protein Tyrosine Phosphatases are intracellular activities lacking disulfide bonds, but they might sense intracellular redox potential through the conserved cysteine in their active sites An intracellular oscillation of oxidant levels has been experimentally linked to maintenance of the rate of cell proliferation.

As an example, when chelating redox-active iron is present in the endosomal/lysosomal compartment of cultured epithelial cell line HeLa with the iron chelator desferrioxamine, cell proliferation is inhibited.

Thioredoxin (Trx) signaling Is also important in Cancer, as are other aspects of redox signaling.

References

  1. Jerzy Bełtowski and Anna Jamroz-Wiśniewska, Modulation of H2S Metabolism by Statins: A New Aspect of Cardiovascular Pharmacology . Antioxidants & Redox Signaling. July 1, 2012, 17(1): 81-94. doi:10.1089/ars.2011.4358.
  2. Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19735727, please use {{cite journal}} with |pmid=19735727 instead.
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  4. Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11134893, please use {{cite journal}} with |pmid=11134893 instead.
  5. Szent-Gyorgyi, A., 1941b. The study of energy-levels in biochemistry. Nature 148 (3745), 157–159. Szent-Gyorgyi, A., 1957. Bioenergetics. Academic Press, New York. Szent-Gyorgyi, A., 1960. Introduction to a Submolecular Biology. Academic Press, New York. Szent-Gyorgyi, A., 1968. Bioelectronics. Academic Press, New York. Szent-Gyorgyi, A., 1976. Electronic Biology and Cancer. Marcel Dekker, Inc., New York. Szent-Gyorgyi, A., 1978. The Living State and Cancer. Marcel Dekker, Inc., New York.
  6. Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 14976006, please use {{cite journal}} with |pmid= 14976006 instead.
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  8. Proctor, P.; McGinness, J.E. (1970). "Levodopa side-effects and the Lesch-Nyhan syndrome". Lancet 2: 1367
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  22. "Tyrosine specific protein phosphatases at PROSITE"Template:Inconsistent citations{{cite web}}: CS1 maint: postscript (link)
  23. "Interpro record for Tyrosine specific protein phosphatases"Template:Inconsistent citations{{cite web}}: CS1 maint: postscript (link)
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  26. http://www.mdanderson.org/education-and-research/departments-programs-and-labs/labs/powis-laboratory/current-research/index.html
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Further reading

External links

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