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2000 2000
; 56:27-33).</p> ; 56:27-33).</p>

SELECTED STUDIES GROUPED
BY APPARATUS AND DISORDER
Allergies
9 placebo-controlled clinical trials of a homeopathic medicine
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Rhinitis and
oculorhinitis
Rhinitis and
oculorhinitis
Rhinitis and
oculorhinitis
Rhinitis and
oculorhinitis
Rhinitis and
oculorhinitis
Rhinitis and
oculorhinitis
Rhinitis and
oculorhinitis
Allergic bronchial
asthma
Wiesenauer M.,
Haussler S.,
Gaus W.
Wiesenauer M.,
Gaus W.
Reilly D.T.,
Taylor M.A.
Reilly D.T.,
Taylor M.A.,
McSharry C.,
Aitchinson T.
Wiesenauer M.,
Gaus W.,
Haussler S.
Wiesenauer M.,
Ludtke R.
Taylor M.A.,
Reilly D.,
Llewellyn-Jones
R.H.,
McSharry C.,
Aitchinson T.C.
Campbell J.H.,
Taylor M.A.,
Beattie N.,
McSharry C.,
Aitchinson T.,
Carter R.,
Stevenson R.D.,
Reilly D.T.
The treatment of pollinosis
with Galphimia glauca.
Double-blind trial comparing
the effectiveness of the
homeopathic preparation
Galphimia potentisation D6,
Galphimia dilution 10-6 and
placebo on pollinosis.
Potent placebo or potency?
A proposed study model with
its initial findings using
homeopathically prepared
pollens in hayfever.
Is homeopathy a placebo
response? Controlled trial of
homeopathic potency, with
pollen in hayfever as model.
The treatment of pollinosis
with Galphimia glauca - dou-
ble-blind clinical trial.
The treatment of pollinosis
with Galphimia glauca D4 –
a randomised placebo-
controlled double-blind
clinical trial.
Randomized controlled trial
of homeopathy versus
placebo in perennial allergic
rhinitis with overview of four
trial series.
Is homeopathy a placebo
response? A controlled trial of
homeopathic immunotherapy
in atopic asthma.
Fortsch. Med.
,
1983
, 101:
811-814.
Arzneim.
Forsch./Drug Res.
,
1985
, 33:
1745-1747.
Br. Hom. J.
,
1985
,
74: 65-75.
Lancet
,
1986
, 2:
881-886.
Allergologie
,
1990
, 13:
359-363.
Phytomedicine
,
1995
, 2: 3-6.
British Medical
Journal
2000
Aug,
19-26; 321
(7259): 471-6.
Am. Rev. Resp.
Dis.
,
1990
, 141:
A24.
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
38
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Allergic bronchial
asthma
Reilly D.,
Taylor M.A.,
Beattie N.,
Campbell J.H.,
McSharry C.,
Aitchinson T.,
Carter R.,
Stevenson R.D.
Is evidence for homeopathy
reproducible?
Lancet
,
1994
,
344: 1601-1606.
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Allergic rhinitis and
oculorhinitis
Allergic rhinitis and
oculorhinitis
Weiser M.,
Gegenheimer
L.H.,
Klein P.
Matusiewicz R.
A randomized equivalence
trial comparing the efficacy
and safety of Luffa comp.-Heel
nasal spray with cromolyn-
sodium spray in the treatment
of seasonal allergic rhinitis.
The efficacy of Engystol in
cases of bronchial asthma
treated with corticosteroids.
Research in
Complementary
Medicine,
1999
/6.
Biologische
Medizin
,
1995
, 5;
242-246.
The homeopathic
medicine was not
therapeutically
inferior* to the
allopathic reference
drug
The homeopathic
medicine was not
therapeutically
inferior* to the
allopathic reference
drug
AUTHORS
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
2 clinical trials of a homeopathic medicine
vs the corresponding allopathic reference drug
39
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Muscle cramps (2
drugs vs. placebo
Rheumatoid
arthritis
Rheumatoid
arthritis
Rheumatoid
arthritis
Tibiotarsal sprain
(astragalus)
Fibromyositis
Trauma
Haemarthrosis
Mossinger P.
Gibson R.G.,
Gibson S.L.M.,
Mc Neil A.D.,
Gray G.H.,
Carson W.,
Buchanan
W.W.
Gibson R.G.,
Gibson S.L.M.,
Mc Neil A.D,
Buchanan
W.W.
Wiesenauer M.,
Gaus W.
Zell J.,
Connert W.D.,
Mau J.,
Feuerstake G.
Fisher P.,
Greenwood A.,
Huskisson E.C.,
Turner P.,
Belon P.
Gibson J.,
Haslam Y.,
Laurenson L.,
Newman P.,
Pit R.,
Robins M.
Thiel W.,
Borho B.
Demonstrations of efficacy.
Salicylates and homeopathy
in rheumatoid arthritis:
preliminary observations.
Homeopathic therapy in
rheumatoid arthritis:
evaluation by double-blind
clinical therapeutic trial.
Demonstration of efficacy of a
homeopathic medicine in
chronic polyarthritis.
Randomised double-blind
trial.
Treatment of acute sprains of
the ankle: A controlled
double-blind trial to test the
effectiveness of a
homeopathic ointment.
Effect of homeopathic
treatment on fibrositis
(primary fibromyalgia).
Double blind trial of Arnica in
acute trauma patients.
The treatment of recent
traumatic blood effusions of
the knee joint.
Allg. Hom.
Zeitung
,
1976
,
221: 26-31.
Br. J. Clin.
Pharmac.
,
1978
;
6: 391-395.
Br. J. Clin.
Pharmac.
,
1980
;
9: 453-459.
Akt Rheumatol.
,
1991
, 16: 1-9.
Forts. der Med.
,
1988
96/62-
100/70.
Brit. Med. J.
,
1989
, 299: 365-
366.
Homoeopathy
,
1991
, 41: 54-55.
Biol. Medizin
,
1991
, 20:
506-515.
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
Arthromyofascial apparatus
8 placebo-controlled clinical trials of a homeopathic medicine
40
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Osteoarthritis of the
knee
Osteoarthritis of the
knee
Osteoarthritis of the
knee
Backache
Nahler G.,
Metelmann H.,
Sperber H.
Maronna U.,
Weiser M.,
Klein P.
Van Haselen
R.A.
Stam C.,
Bonnet M.S.,
Van Haselen
R.A.
Treating osteoarthritis of the
knee with a homeopathic
preparation
Results of a
randomized, controlled,
clinical trial in comparison to
hyaluronic acid.
Oral treatment of
osteoarthritis of the knee with
Zeel S tablets.
A randomized controlled trial
comparing topical piroxican
gel with a homeopathic gel in
osteoarthritis of the knee.
The efficacy and safety of a
homeopathic gel in the
treatment of acute low back
pain: a multi-centre,
randomised, double-blind
comparative clinical trial.
Orthopädische
Praxis
,
1996
, 5.
Orthop
ä
dische
Praxis
,
2000
, 5.
Rheumatology
(Oxford)
,
2000
Jul,; 39 (7): 714-9.
Br. Homeopath. J.,
2001
Jan; 90(1):
21-8.
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
AUTHORS
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
4 clinical trials of a homeopathic medicine
vs the corresponding allopathic reference drug
41
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
AUTHORS
Coagulation and circulatory
disorders
5 placebo-controlled clinical trials of a homeopathic medicine
ORIGINAL/TRANSLATED
DISORDER
PUBLICATION EFFECT
Haemostasis
Doutremepuich
C., Pailley D.,
Anne M.C.,
De Seze O.,
Paccalin J.,
Quilichini R.
Template bleeding time after
ingestion of ultra low dosages
of acetylsalicylic acid in
healthy subjects. Preliminary
study.
Thrombosis Res.,
1987
, 48:
501-504.
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
AUTHORS
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
1 clinical trial of a homeopathic medicine vs
the corresponding allopathic reference drug
Haematoma
Haematoma
Varicose veins
Filariasis
Asymptomatic
filariasis
Bourgois J.C.
Amodeo C.,
Dorfman P.,
Ricciotti F.,
Tetau M.,
Veroux P.F.
Ernst E.,
Saradeth T.,
Resch K.L.
Subramanyam
V.R., Mishra N.,
Ray Y.,
Rakshit G.,
Pattnaik N.M.
Kumar A.,
Mishra N.
Protection of the venous
system in patients with
perfused breast cancer.
Double-blind clinical trial.
Evaluation of the action of
Arnica 5CH on vein disorders
after lengthy perfusion.
Complementary treatment of
varicose veins. A randomised,
placebo-controlled, double-
blind trial.
Homeopathic treatment of
filariasis. Experience in an
Indian rural setting.
Effect of homeopathic
treatment of filariasis. A
single-blind 69-months
follow-up study in an
endemic village in Orissa.
Universit
é
Paris
Nord (Thesis),
1983
.
Cahiers Biother.
,
1988
, 98: 77-82.
Phlebology
,
1990
,
5: 157-163.
Br. Hom. J.
,
1990
,
79: 157-160.
Br. Hom. J.
,
1994
,
83: 216-219.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
42
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Skin lesions
Skin lesions
Pyodermitis
Burns
Dermatosis
Plantar warts
Paterson J.
Balzarini A.,
Felisi E.,
Martini A.,
De Donno F.
Mossinger P.
Leaman A.M.,
Gorman D.
Schwab G.
Labrecque M.,
Audet D.,
Latulippe L.G.,
Drouin J.
Report on Mustard Gas
Experiment.
Efficacy of homeopathic
treatment of skin reaction
during radiotherapy for breast
cancer: a randomised,
double-blind clinical trial.
The therapeutic efficacy of
Hepar sulfuris calcareum D4
in pyodermitis and boils.
Cantharis in the early
treatment of minor burns.
Can the effect of homeopathic
substances in high potencies
be demonstrated
experimentally? A controlled,
cross-over double blind study
in patients with skin
conditions.
Homeopathic treatment of
plantar warts.
J. Am. Inst.
Homeopathy,
1944
, 37: 47-50,
88-92.
Br. Homeopath. J.
,
2000
Jan; 89 (1):
8-12.
Allg. Hom.
Zeitung
,
1980
,
225: 22-28.
Arch. Emerg.
Med.
,
1989
, 6:
259-261.
Proc. 45th LMHI
Congr., Barcelona,
Spain
,
1990
,
166-169.
Ca. Med. Assoc.
J.
,
1992
, 146:
1749-1753.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
Dermatology
6 placebo-controlled clinical trials of a homeopathic medicine
43
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Pharyngitis
Gastritis
Irritable colon
Cholecystitis
Anal fissures
Diarrhoea
(paediatric cases)
Diarrhoea
(paediatric cases)
Diarrhoea
(paediatric cases)
Mossinger P.
Ritter H.
Rahlfs V.W.,
Mossinger P.
Mossinger P.
Bignamini M.,
Saruggia M.,
Sansonetti G.
Jacobs J.,
Jimenez L.M.,
Gloyd S.S.,
Carares F.E.,
Gaitan M.P.,
Crothers D.
Jacobs J.,
Jimenez L.M.,
Gloyd S.S.,
Gale J.L.,
Crothers D.
Jacobs J.,
Jimenez L.M.,
Malthouse S.,
Chapman E.,
Crothers D.,
Masuk M.,
Jonas W.B.
The treatment of pharyngitis
with Phytolacca.
Double-blind
homeotherapeutic study and
the issues involved.
Asa foetida in the treatment of
irritable colon: double-blind
clinical trial.
Homeopathy and naturopathy.
How to overcome conflicts.
Homeopathic treatment of
anal fissures using nitricum
acidum.
Homeopathic treatment of
acute childhood diarrhoea.
A randomised clinical trial in
Nicaragua.
Treatment of acute childhood
diarrhoea. A randomised
clinical trial in Nicaragua.
Homeopathic treatment of
acute childhood diarrhoea:
results from a clinical trial in
Nepal.
Allg. Hom.
Zeitung
,
1973
;
218: 111-121.
Hippokrates
,
1966
, 12:
472-476.
Dtsch. Med.
Wschr.
,
1979
,
104: 140-143.
Hippokrates
(Stuttgart)
,
1984
,
165-169.
Berl. J. Res. Hom.
,
1991
, 1 (4/5):
286-287.
Br. Hom. J.
,
1993
,
82: 83-86.
Pediatrics
,
1994
,
93: 719-725.
J. Altern.
Complement.
Med.
,
2000
Apr; 6
(2): 131-9.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
Gastrointestinal apparatus
8 placebo-controlled clinical trials of a homeopathic medicine
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Vomiting
Stukalova E.N. Efficacy of homotoxicological
treatment in early toxaemia of
pregnancy.
B.T.
,
2000
, 4
(Ukrainian
edition)
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
AUTHORS
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
1 clinical trial of a homeopathic medicine
vs the corresponding allopathic reference drug
44
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Menopause
Leucorrhoea
Premenstrual
syndrome
Childbirth (pain)
Childbirth (pain)
Childbirth (labour)
Florid
condylomatosis
Gauthier J.E.
Carey H.
Lepaisant C.
Coudert M.
Dorfman P.,
Lasserre M.N.,
Tetau M.
Eid P.,
Felisi E.,
Sideri M.
Destro Castaniti
M.
Comparative therapeutic
study of the action of
clonidine and Lachesis muta
in the treatment of hot flushes
in the menopause.
Double blind clinical trial of
Borax and Candida in the
treatment of vaginal
discharge.
Therapeutic demonstrations in
homeopathy: treatment of
breast tension and mastodynia
in premenstrual syndrome.
Experimental study of the
action of Caulophyllum in
false labour.
Preparation for childbirth with
homeopathy: a double-blind
placebo-controlled trial.
Super placebo or pharmacolo-
gical action? A double-blind
randomised trial with a
homeopathic drug
(Caulophyllum thalictroides)
during labour.
The use of Transfactor 11 in
HPV infections (160 cases).
Universit
é
de
Bordeaux (Thesis),
1983
.
Comm. Br. Hom.
Res. Grp.,
1986
March:12-14.
Rev. Fr. Gynecol.
Obst
é
t.
,
1995
,
90: 94-95.
Universit
é
de
Limoges (Thesis)
,
1981
.
Cahiers de
Bioth
é
rapie
,
1987
, 94: 77- 81.
Proc. V Congr.
O.M.H.I., Paris,
1994
.
La Medicina
Biologica
,
2000
,
4; 95: 100.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
AUTHORS
Gynaecology and obstetrics
7 placebo-controlled clinical trials of a homeopathic medicine
45
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Diabetes mellitus
Diabetic
retinopathy
Obesity
Complications of
haemodialysis
Complications of
haemodialysis
Fabbro V.,
Gargiulo P.,
Minelli E.
Zicari D.,
Ricciotti F.,
Vingolo E.M.,
Zicari N.
Werke W.,
Lehmann M.,
Galland F.
Hariveau E.
Saruggia M.,
Corghi E.
Multicentric study of the
action of the homeopathic
complex R40 in the treatment
of hyperglycaemia.
Evaluation of the
angioprotective action of
arnica preparations in the
treatment of diabetic
retinopathy.
Comparative controlled trial
of the efficacy of the plant-
based homeopathic medicine
Heliantus tuberosus D1 in the
complementary treatment of
overweight patients.
Clinical research at the Boiron
Institute.
Effects of homeopathic
dilutions of China rubra on
intradialytic symptomatology
in patients treated with
Omeopatia Oggi,
1994
, 5 (10):
1-16.
Boll. Oculist
.,
1992
, 71:
841-848.
Therapiewoche
,
1994
, 44: 34-39.
Hom
é
opathie
,
1987
/5; 55-8.
Br. Hom. J
.,
1992
,
81: 86-88.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
Metabolism
5 clinical trials of a homeopathic medicine vs placebo
ORIGINAL/TRANSLATED
DISORDER
PUBLICATION EFFECT
Functional infertility
Toxaemia in
pregnancy
Lai G.
Stukalova E.N.
Homotoxicological treatment
of female functional infertility:
clinical trial.
Efficacy of homotoxicological
treatment in early toxaemia of
pregnancy.
La Medicina
Biologica,
2000
,
4:81-86.
BT
,
2000
, 4
(Ukrainian edition)
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
AUTHORS
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
KEY: BT = Biomedical Therapy
2 clinical trials of a homeopathic medicine
vs the corresponding allopathic reference drug
46
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Dental neuralgia
Kinetosis
(motion sickness)
Kinetosis
(motion sickness)
Aphasia
Migraine
Head injury
Migraine
Albertini H.,
Godberg W.
Ponti M.
Dexpert M.
Master F.J.
Brigo B.,
Serpelloni G.
Chapman E.H.,
Weintraub R.J.,
Milburn H.A.,
Pirozzi T.O.,
Woo E.
Straumsheim P.,
Borchgrevink C.,
Mowinckel P.,
Kierulf H.,
Hafslund D.
Homeopathic treatment of
dental neuralgia using Arnica
and hypericum: a summary of
60 observations.
Evaluation of homeopathic
treatment of motion sickness;
results of 93 observations.
Prevention of motion sickness
with Cocculine.
Scope of homeopathic drugs
in the treatment of Broca
s
aphasia.
Homeopathic treatment of
migraines: a randomized
double-blind controlled study
of sixty cases.
Homeopathic treatment of
mild traumatic brain injury:
a randomized, double blind
placebo-controlled clinical
trial.
Homeopathic treatment of
migraine: a double blind,
placebo controlled trial of 68
patients.
Hom
é
opathie
Fran
ç
aise,
1984
,
71: 47-49.
In: Recherches
Hom
é
opathiques
(Boiron J., Belon
P., Hariveau E.,
eds.). Fondation
Fran
ç
aise pour la
Recherche en
Hom
é
opathie
,
1986
. Lyon:
71-74.
Hom
é
opathie
Franc.
,
1987
, 75:
353-355.
Proc. 42nd Congr.
LMHI
,
1987
,
Arlington, USA:
330-334.
Berl. J. Res. Hom.
,
1991
, 1 (2):
98-106.
J. Head Trauma
Rehabil.
,
1999
Dec; 14 (6):
521-42.
Br. Homeopath. J.
,
2000
Jan; 89 (1)
4-7.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
Neurology
7 clinical trials of a homeopathic medicine vs placebo
47
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER
PUBLICATION EFFECT
Vertigo
Vertigo
Weiser M.
Wolschner U.,
Str
ö
sser W.,
Weiser M.,
Klein P.
Homeopathic vs conventional
treatment of vertigo.
Vertigo therapy:
Cocculus -heel
®
versus
Dimenhydrinate.
Arch. Of
Otolaryngology.
Head and Neck
Surgery,
1998
,
August.
BM,
2001
, 4.
Pubblicato in
italiano (2)
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
AUTHORS
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
KEY: BM = Biologische Medizin
2 clinical trials of a homeopathic medicine
vs the corresponding allopathic reference drug
48
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Infections of the
upper airways
Infections of the
upper airways
Infections of the
upper airways
Infections of the
upper airways
Coryza
Otitis media
Otitis media
Glue ear
Sinusitis
Sinusitis
Influenza syndrome
Hourst P.
Lecoq P.L.
Bordes L.R.,
Dorfman P.
Casanova P.,
Gerard R.
Mossinger P.
Mossinger P.
Jacobs J.,
Springer D.A.,
Crothers D.
Harrison H.,
Fixsen A.,
Vickers A.
Wiesenauer M.,
Gaus W.,
Bohnacker U.,
Haussler S.
Weiser M.,
Clasen B.P.
Ferley J.P.,
Zmirou D.,
D
Adhemar D.,
Balducci F.
Acknowledgement of the
efficacy of homeopathy.
Therapeutic possibilities in the
treatment of influenza
syndromes.
Evaluation of the antitussive
action of Drosetux syrup;
double-blind placebo-
controlled clinical trial.
Results of three years of
randomised multicentric
studies with Oscillococcinum/
placebo.
Study of treatment of
rhinorrhoea with Euphorbium
D3.
The treatment of otitis media
with Pulsatilla.
Homeopathic treatment of
acute otitis media in children:
a preliminary randomised
placebo-controlled trial.
A randomised comparison of
homeopathic and standard
care for the treatment of glue
ear in children.
Study of the efficacy of
homeopathic compound pre-
parations in sinusitis. Results
of a double-blind randomised
out-patient study.
Controlled double-blind study
of a homeopathic sinusitis
medication.
A controlled evaluation of a
homeopathic preparation in
influenza-like syndromes.
Universit
é
P. et M.
Curie (Thesis)
.
Paris. France,
1981.
Cah. Bioth
é
r.
,
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Cahiers
d
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,
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Proposta
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Kinderarzt
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Br. J. Clin.
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,
27: 329-335.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
Respiratory apparatus,
common cold/influenza syndrome and ENT
15 placebo-controlled clinical trials of a homeopathic medicine
49
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Influenza syndrome
Influenza syndrome
Influenza syndrome
Bronchial asthma
Saruggia M.
Heilmann A.
Saruggia M.
Matusiewicz R.
Influenza and viral respiratory
infections.
A combination injection
preparation as a prophylactic
for flu and common colds.
The preventive effect of
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like syndromes. Results of a
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The efficacy of Engystol in
cases of bronchial asthma
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Medicina
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,
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,
7: 249-253.
Medicina
Naturale
,
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La Medicina
Biologica
,
1996
,
1; 3-8.
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
AUTHORS
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Infections of the
upper airways
Infections of the
upper airways
Common cold
Common cold
Otitis media
Arrighi A.
Riley D.,
Fisher M.,
Singh B.,
Haidvogl M.,
Heger M.
Gassinger C.A.,
Wunstel G.
Maiwald L.,
Weinfurtner T.,
Mau J.,
Connert W.D.
Kruse K.
Evaluation of clinical efficacy in a
homotoxicologic protocol for
prevention of recurrent respiratory
infections in pediatrics.
Homeopathy and
Conventional Medicine: an
outcome study comparing
effectiveness in a primary care
setting.
A controlled clinical trial for
testing the efficacy of the
homeopathic drug Eupatorium
perfoliatum D2 in the
treatment of common cold.
The therapy of the common
cold with a combination
homeopathic preparation,
compared with treatment with
acetylsalicylic acid: a
controlled randomized, single-
blind study.
Subject reported in the
volume.
La Medicina
Biologica
,
2000
,
3: 13-21.
The Journal of
Alternative and
Complementary
Medicine
,
2001
,
Vol 7, N
°
2; 149-
159.
Arzheim
Forsch./Drug Res.
,
1981
, 31:
732-736.
Arzheim
Forsch./Drug Res.
,
1988
/4.
Edition Forsch.
Hippokrates
Verlag, Stuttgart,
The homeopathic
medicine was not
therapeutically inferior
to the allopathic
reference drug
The homeopathic
medicine was not
therapeutically inferior
to the allopathic
reference drug
The homeopathic
medicine was not
therapeutically inferior
to the allopathic
reference drug
The homeopathic
medicine was not
therapeutically inferior
to the allopathic
reference drug
The homeopathic
medicine was not
therapeutically inferior
to the allopathic
reference drug
AUTHORS
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
5 clinical trials of a homeopathic medicine
vs the corresponding allopathic reference drug
50
Homeopathy: overview of human clinical trials
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
HIV infection
Rastogi D.P.,
Singh V.P.,
Singh V.,
Dey S.K.,
Rao K.
Homeopathy in HIV infection:
a trial report of double-blind
placebo-controlled study.
Br. Homeopath. J.,
1999
Apr; 88 (2):
49-57.
The homeopathic
medicine proved
therapeutically
superior
AUTHORS
Sundry
1 placebo-controlled clinical trial of a homeopathic medicine
The term
NOT INFERIOR
means EQUAL or SUPERIOR TO.
KEY: BM = Biologische Medizin
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Conjunctivitis
K
ü
stermann
R.W.,
Weiser M.,
Klein P.
Antihomotoxic treatment of
conjunctivitis. Results of a
prospective, controlled,
cohort study.
BM,
2001
,
3. The homeopathic
medicine was not
therapeutically
inferior to the
allopathic reference
drug
AUTHORS
1 clinical trial of a homeopathic medicine
vs the corresponding allopathic reference drug
Homeopathy: overview of human clinical trials
51
ORIGINAL/TRANSLATED
DISORDER PUBLICATION EFFECT
Dynamic ileus
Dynamic ileus
Dynamic ileus
Post-operative
infections
Post-operative
psychomotor
agitation
Post-extraction
complications
(dental cases)
Valero E.
Chevrel J.P.,
Saglier J.,
Destable M.D.
Aulagnier G.
Valero E.
Alibeu J.P.,
Jobert J.
Michaud J.
Study of the preventive action
of Raphanus sativus 7CH on
the post-operative recovery
time of intestinal transit (80
cases); and of Pyrogenium
7CH on post-operative
infections (128 cases).
Recovery of intestinal transit
in digestive surgery.
Homeopathic action of
opium.
The action of post-operative
homeopathic treatment.
Study of the preventive action
of Raphanus sativus 7CH on
the post-operative recovery
time of intestinal transit (80
cases); and of Pyrogenium
7CH on post-operative infec-
tions (128 cases).
Aconite in homeopathic relief
of post-operative pain and
agitation in children.
The action of Apis mellifica
and Arnica montana in
preventing post-operative
oedema in maxillofacial
surgery in a clinical trial
involving 60 cases.
Universit
é
de
Grenoble (Thesis)
,
1981
.
Press Med.
,
1984
,
13: 833.
Hom
é
opathie
,
1985
, 6: 42-45.
Universit
é
de
Grenoble (Thesis)
,
1981
.
P
é
diatrie
,
1990
,
45: 465-466.
Universit
é
de
Nantes (Thesis)
,
1981
.
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically
superior
The homeopathic
medicine proved
therapeutically superior
The homeopathic
medicine proved
therapeutically
superior

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Some common points of argument are addressed in the FAQ below, which represents the consensus of editors here. Please remember that this page is only for discussing Misplaced Pages's encyclopedia article about Homeopathy.

To view an explanation to the answer, click the link to the right of the question. Q1: Should material critical of homeopathy be in the article? (Yes.) A1: Yes. Material critical of homeopathy must be included in the article. The articles on Misplaced Pages include information from all significant points of view. This is summarized in the policy pages which can be accessed from the Neutral point of view policy. This article strives to conform to Misplaced Pages policies, which dictate that a substantial fraction of articles in fringe areas be devoted to mainstream views of those topics. Q2: Should material critical of homeopathy be in the lead? (Yes.) A2: Yes. Material critical of homeopathy belongs in the lead section. The lead must contain a summary of all the material in the article, including the critical material. This is described further in the Lead section guideline. Q3: Is the negative material in the article NPOV? (Yes.) A3: Yes. Including negative material is part of achieving a neutral article. A neutral point of view does not necessarily equate to a sympathetic point of view. Neutrality is achieved by including all points of view – both positive and negative – in rough proportion to their prominence. Q4: Does Misplaced Pages consider homeopathy a fringe theory? (Yes.) A4: Yes. Homeopathy is described as a fringe medical system in sources reliable to make the distinction. This is defined by the Fringe theories guideline, which explains: We use the term fringe theory in a very broad sense to describe ideas that depart significantly from the prevailing or mainstream view in its particular field of study.

Since the collective weight of peer-reviewed studies does not support the efficacy of homeopathy, it departs significantly enough from the mainstream view of science to be considered a fringe theory.

References

  1. Jonas, WB; Ives, JA (February 2008). "Should we explore the clinical utility of hormesis". Human & Experimental Toxicology. 27 (2): 123–127. PMID 18480136.
Q5: Should studies that show that homeopathy does not work go into the article? (Yes.) A5: Yes. Studies that show that homeopathy does not work are part of a full treatment of the topic and should go into the article. Misplaced Pages is not the place to right great wrongs. Non-experts have suggested that all the studies that show homeopathy does not work are faulty studies and are biased, but this has not been borne out by the mainstream scientific community. Q6: Should another article called "Criticism of homeopathy" be created? (No.) A6: No. Another article called "Criticism of homeopathy" should not be created. This is called a "POV fork" and is discouraged. Q7: Should alleged proof that homeopathy works be included in the article? (No.) A7: No. Alleged proof that homeopathy works should not be included in the article. That is because no such proof has come from reliable sources. If you have found a reliable source, such as an academic study, that you think should be included, you can propose it for inclusion on the article’s talk page. Note that we do not have room for all material, both positive and negative. We try to sample some of each and report them according to their prominence. Note also that it is not the job of Misplaced Pages to convince those people who do not believe homeopathy works, nor to dissuade those who believe that it does work, but to accurately describe how many believe and how many do not believe and why. Q8: Should all references to material critical of homeopathy be put in a single section in the article? (No.) A8: No. Sources critical of homeopathy should be integrated normally in the course of presenting the topic and its reception, not shunted into a single criticism section. Such segregation is generally frowned upon as poor writing style on Misplaced Pages. Q9: Should the article mention that homeopathy might work by some as-yet undiscovered mechanism? (No.) A9: No. The article should not mention that homeopathy might work by some as-yet undiscovered mechanism. Misplaced Pages is not a place for original research or speculation. Q10: Is the article with its negative material biased? (No.) A10: No. The article with its negative material is not biased. The article must include both positive and negative views according to the policies of Misplaced Pages. Q11: Should the article characterize homeopathy as a blatant fraud and quackery? (No.) A11: No. Inflammatory language does not serve the purpose of an encyclopedia; it should only be done if essential to explain a specific point of view and must be supported from a reliable source. Misplaced Pages articles must be neutral and reflect information found in reliable sources. Misplaced Pages is an encyclopedia and not a consumer guide, so while scientific sources commonly characterise homeopathy as nonsense, fraud, pseudoscience and quackery - and the article should (and does) report this consensus - ultimately the reader should be allowed to draw his/her own conclusions.
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Pseodoscience

The article calls homeopathy a pseudoscience, but nowhere in wikipedia's guidelines does this seem to be allowed. Misplaced Pages:Fringe_theories There is no scientific consensus that homeopathy is pseudoscience, especially in Europe, therefore, it is classified as a questionable science. Klocek (talk) 12:11, 25 May 2014 (UTC)

It's not explicitly stated, in the Misplaced Pages guidelines that anything should be called anything. The thing is that there is nothing in the guidelines that says it shouldn't be - and anything that's not forbidden is OK. What we ARE required to do is to represent the world from a mainstream scientific perspective and to provide references for what we say.
The mainstream scientific view is that Homeopathy is a pseudoscience...and we have references to prove that. So there is no reason we shouldn't say so. More importantly, the WP:FRINGE guidelines make it clear that it would be a breach of the neutral position to allow the homeopathists to dominate the content of the article with their bogus (according to mainstream science - and therefore according to Misplaced Pages) position.
Aside from all of that - you may ask why poor old homeopathy is being called a pseudoscience in the first place? Some see this word as some kind of an insult. It's not, it's a straightforward classification of an idea or discipline. The definition of the word pseudoscience given in most dictionaries agrees with the one provided by Wiktionary, which I'll quote for you:
Any body of knowledge purported to be scientific or supported by science but which fails to comply with the scientific method.
Homeopathy undoubtedly purports to be scientific - it makes MANY claims to be able to produce certain results from certain practices based on scientific-sounding descriptions of some very odd properties of water.
The deciding factor is therefore whether or not homeopathy follows "The Scientific Method".
I suggest you read at least the introduction to our Scientific method article...but here is a summary of what this means:
Basically, the scientific method requires that you form an idea which you are not yet certain about. We call that a "hypothesis". A good hypothesis has to explain everything that we already know about the topic and then makes certain testable predictions about the universe. The next step is that you do some experiments to see if those predictions turn out to be true - and if they do, your hypothesis is a better explanation for how the universe works than the one we already have. So you write a paper describing your new hypothesis, what predictions you made, what experiments you did, what results you got and how you interpret those results to back up your hypothesis. This paper is then peer-reviewed for obvious mistakes and deceptions and to be sure that nobody else already showed it was true. That's by a bunch of other people who work in that field ("your peers") - and if it passes muster, it'll be published in some journal or other. If the hypothesis is reasonably compelling, other scientists will attempt to repeat your experiments to see if what you did really works as you claim and they may try to come up with alternative explanations for what you observed. They write more papers - perhaps devise more experiments to test your claims. Eventually, if enough of the other people who test this agree that your hypothesis is the best explanation for the experimental results, your hypothesis becomes accepted into the mainstream as a "theory". (Which is what used to be called a "law").
So - the burning question here is: Do homeopathists do this? The answer is a blindingly clear "NO!" - they most certainly do not. What they did is to come up with two basic hypotheses:
  1. Diluting something until there is none left 'imprints' the water in some permanent or at least long-lived fashion.
  2. Drinking imprinted water affects your health in some manner - possibly the reverse of the harm that would be caused by ingesting the original substance.
What experiments have been done to follow up on (1)? The answer is - none whatever. Not one single documented example of a homeopathist systematically testing whether water takes on this "imprint" has ever been performed! Where are the double-blind studies of (2)? Where is the statistical analysis of how many people were cured of their colds by very diluted raw duck liver?
That is why we call homeopathy a "pseudoscience" - it makes scientific claims - but never does the hard work to test them...instead they skip the basic science, skip the human trials and go straight to selling the stuff in little bottles in WalMart.
Misplaced Pages says that homeopathy is a pseudoscience because that is precisely, and undeniably what it is. This is the mainstream view of scientists - and it clearly follows the definition of the word and what is going on in the world of homeopathy.
We don't say that religions are pseudosciences because they tell people to take their wild and crazy claims on faith - and (with some exceptions) tend not to make scientific predictions or wrap themselves in the mantle of science. We don't say that quantum physics is pseudoscience because although quantum physicists make scientific claims, they really do follow the scientific method.
SteveBaker (talk) 12:54, 25 May 2014 (UTC)

Klocek (talk · contribs) - there is a scientific consensus that homoeopathy is pseudoscience, including "in Europe". Barney the barney barney (talk) 13:14, 25 May 2014 (UTC)

There is no consensus that homeopathy is pseudoscience --24.107.242.181 (talk) 02:40, 2 June 2014 (UTC)
Yes, there is. Homeopathy with astrology are the textbook case of obvious pseudoscience.--McSly (talk) 02:43, 2 June 2014 (UTC)
no - you are wrong - look what the best review for oscillo says — Preceding unsigned comment added by 24.107.242.181 (talk) 02:50, 2 June 2014 (UTC)
While SteveBaker provides an excellent explanation above, the real reason the article includes "Homeopathy is a pseudoscience" is the which (in the article) point to reliable sources that verify the statement. Anyone wanting to contest the statement needs to explain how the sources are incorrectly used, or provide other specific evidence to contradict the statement—bearing in mind that reliable sources are required. Johnuniq (talk) 04:16, 2 June 2014 (UTC)
Assuming that by "the best review for oscillo" you mean the Cochrane review, it doesn't say anything about whether or not homoeopathy is regarded as pseudoscience, so cannot be used as a source on this point. Brunton (talk) 07:15, 2 June 2014 (UTC)
Incidentally, if we need more sourcing for this, several of the essays in the book Philosophy of Pseudoscience (ed. Massimo Pigliucci and Maarten Boudry) recently published by the University of Chicago Press use homoeopathy as an example of pseudoscience, for example (p. 30), "Despite the lack of generally accepted demarcation criteria, we find remarkable agreement among virtually all philosophers and scientists that fields like astrology, creationism, homeopathy are either pseudosciences or at least lack the epistemic warrant to be taken seriously", or (p. 49), "homeopathy is a paradigmatic example of pseudoscience". Brunton (talk) 07:41, 2 June 2014 (UTC)

correcting misrepresentative opinion

The asertion of the UK House of Commons Scientific Select Committee is contentious with regard to the support garnered from within the committe, it noted that only three of those sitting actually voted and of those three none had any specilaist knowledge of the subject. No Health Care Trust at the time were invited to speak neither was representatives from Homeopathic association and not least no patient was afforded the same opportunity. As to the closing Paragraph remark that the government agrees is disingenous especial in light of Observations on the report Evidence Check 2: Homeopathy by the House Of Commons Science and Technology Committee, February 2010,which noted,these limitations make the Committee’s report an unreliable source of evidence about homeopathy. The jury must still be regarded as out on its efficacy and risk/ benefit ratio. Whether more research should be done, and of what kind, is another question. But there can be no ethical objection to it since the principal questions have not, as the Committee claimed, “been settled already”. Earl Baldwin of Bewdley. June 2010. Added to which 206 sitting MPs signed an early day motion expressing concerns over the report content and procedure — Preceding unsigned comment added by 80.2.37.152 (talk) 22:11, 11 June 2014 (UTC)

It is a direct quote from the report. If you want to have this modified or removed you will have to provide a WP:RS source of equal or greater weight which clearly contradicts the report. What you have provide so far is primarily WP:OR . --Daffydavid (talk) 00:17, 12 June 2014 (UTC)
That EDM was by David Tredinnick (politician). 'Nuff said. LeadSongDog come howl! 17:04, 15 June 2014 (UTC)

Better Source for Placebo Claim?

The lede makes the strong claim that "its remedies have been found to be no more effective than placebos" yet the cited source is much less committal in its interpretation:

Biases are present in placebo-controlled trials of both homoeopathy and conventional medicine. When account was taken for these biases in the analysis, there was weak evidence for a specific effect of homoeopathic remedies, but strong evidence for specific effects of conventional interventions. This finding is compatible with the notion that the clinical effects of homoeopathy are placebo effects.

Surely there is a better source, that more firmly supports the statement in the lede? I'd rather not back up an assertion that "homeopathic remedies have been found to be no more effective than placebos" with a finding that "there was weak evidence for a specific effect of homeopathic remedies." Most studies I've found online are meta-studies that are themselves based on analysis of earlier studies, many of which were conducted with the intention of proving that homeopathy works. So the meta-studies generally take the approach of finding flaws with the earlier studies, or cross-referencing effects to smooth out differences and reduce the significance of measured effects. I understand why they need to do this (nobody but homeopathy supporters tend to want to fund large-scale studies of homeopathy) but for something that is so widely accepted as pseudoscience among the mainstream medical community, surely there is some primary research with a less wishy-washy demonstration of the placebo claim?

Also, the same source is actually listed twice in the references. I'd try to fix it but the proper syntax for handling citations in Misplaced Pages is.. less than obvious to me. --Pyrrhoneia (talk) 05:36, 12 June 2014 (UTC)

Extremely high dilutions as basically only line of argument against homeopathy over several paragraphs?

Over several paragraphs in the "Evidence and Efficacy" section of the article, homeopathy is dismissed with the sole argument that extremely high dilutions (over D20/C10) statistically leave none of the original substance in the final product:
"The low concentration of homeopathic remedies, which often lack even a single molecule of the diluted substance..."
"The extreme dilutions used in homeopathic preparations often leave none of the original substance in the final product."
"The extremely high dilutions in homeopathy preclude a biologically plausible mechanism of action."
This, of course is statistically true for those extreme dilutions. However, this argumentation (and, I reiterate, this argumentation is basically used as the sole argument in those paragraphs) ignores that most homeopathic medications are usally administered at far lower dilutions (D3 to D12), which do not pose the need to argue with "water memory" or "quantum effects", as even a dilution as high as D12 (X12) still contains roughly 10 substance molecules per mol (14g/0.5oz) of water. I think pointing out the impossible "high" dilutions as the sole line of argumentation while completely ignoring the "lower" dilutions is a structural flaw of those paragraphs and should be adressed. -- megA (talk) 21:58, 12 June 2014 (UTC)

There is a section discussing high dilution, under the "Plausibility" sub-heading. But it is not by any means the "only line of argument", nor even the major one. There is more emphasis on the lack of reliable evidence for homeopathy's effectiveness. After all, as my grandmother used to say "the proof of the pudding is in the eating". --Gronk Oz (talk) 00:44, 13 June 2014 (UTC)

Gronk Oz, MegA is correct. While there are various other reasons to doubt the claims of homeopathy, they are nonetheless not adequately addressed in the specified paragraphs. MegA's point was about the article, not about homeopathy. This article actually does a pretty terrible job of providing references explaining why homeopathy is considered a pseudoscience. I came here looking for an easily accessible list of such references, but most of the cited sources are meta-studies that actually end up providing weak support for homeopathy rather than refuting it. I understand why that is (they're meta-studies based on primary studies that were attempting to prove homeopathy was effective) but there are good primary studies, if you dig deep enough. They're old and not all of them are online, though. I'm trying to locate them now, but help would be appreciated. --Pyrrhoneia (talk) 06:52, 13 June 2014 (UTC)

For your enjoyment

http://www.change.org/en-IN/petitions/wikipedia-call-to-action-to-update-homeopathy-at-wikipedia Be aware of online petitions! As a fun sidenote, this clearly demonstrate how homeopaths think how science works: By petition.^^Rka001 (talk) 11:36, 14 June 2014 (UTC)

Why are they calling for "a large number of people sign this petition"? Surely, the less people that sign it, the more effective it will be. ;) AndyTheGrump (talk) 14:46, 14 June 2014 (UTC)
I got a request to sign a petition from change.org to avoid the Homeopathic section's closure at the Bristol (or was it Glasgow?) Hospital which claimed that a petition for it's closure was signed by 2000 sceptics/critics of Homeopathy, while they have 24,000 signatures to avoid its closure and were looking to make it 25,000 signatures. However, are we at wikipedia going to put such trivia into this article? I hope not!—Khabboos (talk) 14:43, 18 June 2014 (UTC)

Positive studies and clinical trials

I will find good references like Lancet, Nature, JAMA etc. for these studies, but please let me know if we can insert these into this article:-

STUDIES OF THE ACTIVITY OF HOMEOPATHIC MEDICINES

ORIGINAL/TRANSLATED TITLE AUTHOR(S) PUBLICATION ACTIVITY STUDY

Inhibition of lymphoblast transformation test (LTT) in phytohaemagglutinin (PHA) with Phytolacca americana in homeopathic dilution

Colas H.,

Aubin M.,

Picard P.,

Lebecq J.C.

Ann. Homéopat.

Fr., 1975, 6: 1-11.

Inhibitory

Lymphoblast

transformation

Inquiry into the limits of biological effects of chemical compounds in tissue culture. I. Low dose effects of mercure chloride

Mansvelt J.D.,

van Amons E.

Z. Naturtorschung,

       

1975, 30:

643-649.

Inhibitory

Lymphocyte

growth

The effects of Belladonna and Ferrum phosphoricum on the chemoluminescence of human poly-morphonuclear neutrophils

Poitevin B.,

Aubin M.,

Royer J.F.

Ann. Homéop. Fr.,

       

1983, 3: 5-12.

Inhibitory

Radical release

Effect of aconitum and veratrum

on the isolated perfused heart of

the common eel (Anguilla anguilla)

Pennec J.P.,

Aubin M.

Comp. Biochem.

Physiol., 1984,

776: 367-369.

Protective Aconitine toxicity

Elements of homeopathic

pharmacology

Aubin M.

Homéopathie

Franç., 1984, 72:

231- 235

Protective Aconitine toxicity

The effect of homeopathic

preparations on the phagocyte

activity of granulocytes. In vitro

tests and double-blind controlled

trials

Wagner H.,

Jurcic K.,

Doenicke A.,

Rosenhuber E.,

Behrens N.

Arzneim.

Forsch./Drug Res.,

       

1986, 36:

1424-1425.

Stimulant Phagocytosis

Approach to quantitative analysis

of the effect of Apis mellifica on

the degranulation of human

basophils cultivated in vitro

Poitevin B.,

Aubin M.,

Benveniste J.

Innov. Tech. Biol.

Med., 1986, 7:

64-68.

Inhibitory

Basophil

degranulation

In vitro stimulation of human granulocytes and lymphocytes by pico- and femtogram quantities of cytostatic agents

Wagner H.,

Kreher B.,

Jurcic K.

Arzneim. Forsch./Drug Res., 1988, 38: 273-275.

Stimulant

Lymphocyte

growth

In vitro immunological

degranulation of human basophils

is modulated by lung histamine

and Apis mellifica

Poitevin B.,

Davenas E.,

Benveniste J.

Brit. J. Clin.

Pharmacol., 1988,

25: 439-444.

Inhibitory

Basophil

degranulation

Cytotoxic agents as

immunomodulators

Wagner H.,

Kreher B.

Proc. of the 3rd

GIRI meeting,

Paris, 1989, 31-

46.

Stimulant

Lymphocyte

growth

Contributions of fundamental

research in homeopathy

Boiron J.,

Belon P.

Berl. J. Res. Hom.,

       

1990, 1: 34-35.

Inhibitory

Basophil

degranulation

Synergism of action between

indoleacetic acid (IAA) and highly

diluted solutions of CaCO3 on the

growth of oat coleoptiles

Bornoroni C.

Berl. J. Res. Hom.,

       

1991, 1 (4/5):

275-278.

Stimulant

Growth of plant

cells

Study of the action of

Hahnemannian dilutions of

mercury chloride on the mitotic

index in animal cell cultures.

Boiron J.,

Abecassis J.,

Cotte J.,

Bernard A.M.

Ann. Homéop.

Fr., 1991, 23:

43-49.

Protective Hg toxicity

Dual effects of formylpeptides on

the adhesion of endotoxin-primed

human neutrophils

Bellavite P.,

Chirumbolo S.,

Lippi G.,

Andrioli G.,

Bonazzi L.,

Ferro I.

Cell. Biochem.

Funct., 1993, 11:

231-239.

Inhibitory

Cell adhesion

(bact. pept.

10-8-10-9)

Effects of homeopathic

preparations of organic acids and

of minerals on the oxidative

metabolism of human neutrophils

Chirumbolo S.,

Signorini A.,

Bianchi I.,

Lippi G.,

Bellavite P.

Br. Hom. J., 1993,

82: 227-244.

Inhibitory

Leucocyte

activation

(metabolism)

Platelets/endothelial cells

interactions in presence of

acetylsalicylic acid at ultra low

dose

Doutremepuich

C.,

Lalanne M.C.,

Ramboer I.,

Sertillanges

M.N.,

De Seze O.

Omeomed 92 (C.

Bornoroni, ed.),

       

1993, Editrice

Compositori,

Bologna:

109-115.

Inhibitory

Prostacyclin

release

Effect of high dilutions of epidermal

growth factor (EGF) on in vitro

       

proliferation of keratinocyte and

fibroblast cell lines

Fougeray S.,

Moubry K.,

Vallot N.,

Bastide M.

Br. Hom. J., 1993,

82: 124-125.

Inhibitory

Growth of

keratinocytes

Effects of different homeopathic

potencies of Lachesis on

lymphocyte cultures obtained

from rabbit blood

Enbergs H.,

Arndt G.

Biol. Tier., 1993,

4.

Stimulant

Mitotic and

immunostimulating

activity (bact. pept

10-5-10-6)

The effect of homeopathic

potencies of housedust mite on

the migration of house-dust sensitive

human leukocytes

Gibson S.L.,

Gibson R.G.

Complement.

Ther. Med., 1996,

4: 169-171.

Stimulant

Leucocyte

chemotaxis

The effects of Nux vomica

Homaccord and Atropinum comp.

on intestinal activity in vitro

Kanui T.I.,

Enbergs H.

Biol. Tier., 1996/1,

43-47.

Stimulant

Contraction of

intestinal muscles

Application of flow cytometry to

the analysis of the

immunosuppressive effect of

histamine dilutions on human

basophil action: effect of

cimetidine

Sainte-Laudy J.,

Belon P.

Inflamm. Res.,

       

1997, 46:

S27-S28.

Inhibitory

Basophil

degranulation

Effects of Podophillum pellatum

compounds in various

preparations and dilutions on

human neutrophil functions in

vitro

Chirumbolo S.,

Conforti A.,

Lussignoli S.,

Metelmann H.

et Al.

Br. Hom. J., 1997;

86-16.

Inhibitory

Release of

superoxides

In vivo and in vitro studies on the

efficiency of potentized and nonpotentized

substances

Harisch G.,

Dittmann J.

BT, 1997, 2;

40-46.

Difference between

potentised and

non-potentised

substances

In vivo and in

vitro study; basic

research

Experiments with the effects of

Ubichinon-Injeel and strong

Ubichinon-Injeel on an acellular

system

Harisch G.,

Dittmann J.

BM, 1997, 3;

99-104.

Different effects of

associations of

various potencies and

individual potencies

In vitro study;

basic research

Efficacy of the homeopathic drugs

Suis and Arnica comp.-Heel® on

lymphocyte and phagocyte

activity

Enbergs H.

BM, 1998, 1;

3-11.

Effect of

organotherapeutics

and Arnica comp. -

Heel® on immune

system cells

In vitro study;

basic research

Influence of dilutions and

potencies of cAMP on different

enzymatic systems

Harisch G.,

Dittmann J.

BM, 1998, 2;

55-62.

Effects of dilutions

and potencies of

cAMP on some

enzymatic activities

In vitro study;

basic research

Studies of the principles of

homeopathy; the changeover

from in vivo to in vitro

       

experimental research

Harisch G.,

Dittmann J.

BM, 1998, 3;

98-103.

Potentised and

non-potentised

dilutions are

equally effective,

but have different

actions

Basic research

Determination of the activity of acid phosphatase with cAMP at various potencies

Harisch G.,

Dittmann J.

BM, 1999, 1; 4-8.

Different effects on enzymatic activity

In vitro study;

basic research

Contribution to study of the

efficacy of homeopathic potencies

of phosphorus

Gomez J.C.

BT, 1999, 2;

53-57.

Effect of different

potencies of

phosphorus

Tests on guinea

pigs

Determination of the activity of

acid phosphatase in the presence

of Ubichinon comp.

Harisch G.,

Dittmann J.

BM, 1999, 4;

188-194.

Effect of enzymatic

activity of

homeopathic

medicine

Basic research

Biochemical efficacy of

homeopathic and electronic

preparations of D8 potassium

cyanate

Dittmann J.,

Kanapin H.,

Harisch G.

FKM, 1999, 6;

15-18.

Homeopathic

potentisation is

more effective than

electronic

potentisation

Basic research

Osteoporosis in vitro in rat tibiaderived

osteoblasts is promoted

by the homeopathic preparation,

FMS Calciumfluor

Palermo C.,

Filanti C.,

Poggi S.,

Manduca P.

Cell Biol Int, 1999,

23(1): 31-40.

Stimulant

Osteogenesis

(trial with

compound drug)

Thin-layer chromatography (TLC)

of homeopathic active

constituents

Schmolz M.

BM, 1999, 5;

248-250.

Constituents of Arnica comp.- Heel® ointment: electrophoresis accelerates their skin penetration.

Basic research
Effect of homeopathic
       constituents on enzymatic
activity.
Basic research

Efficacy of a potentised

homeopathic drug in reducing

cytotoxic effects produced by

arsenic trioxide in mice

Datta S.,

Mallick P.,

Bukhsh A.R.

Complement Ther

Med, 1999 Jan;

7 (8): 62-75 (a).

Protective

Arsenic trioxide

toxicity

Efficacy of a potentised

homeopathic drug in reducing

cytotoxic effects produced by

arsenic trioxide in mice

Datta S.,

Mallick P.,

Bukhsh A.R.

Complement Ther

Med, 1999 Sep;

7 (3): 156-63 (b).

Protective

Arsenic trioxide

toxicity

Non-cytotoxic antiviral action of a homeopathic drug

Heine H.

Ärzteitschrift für

Neturheilverfahre,

       

2000; 41: 542-7.

Stimulant

γ interferon

synthesis

Efficacy of a potentised

homeopathic drug in reducing

cytotoxic effects produced by

arsenic trioxide in mice

Kundu S.N.,

Mitra K.,

Khuda

Bukhsh A.R.

Complement Ther

Med , 2000 Sep;

1 (3): 157-65.

Protective

Arsenic trioxide

toxicity

Stimulatory effect of some plant

extracts used in homeopathy on

the phagocytosis induced

chemiluminescence of

polymorphonuclear leukocytes

Crocnan D.,

Greabu M.,

Olinescu R.

Rocz Akad Med

Biochemist, 2000;

45: 246-254.

Stimulant

Phagocytosis

Difference between the efficacy

of single potencies and chords

Dittmann J.,

Harisch G.

BM, 2000, 1;

18-23.

Potency chords are

more effective than

single potencies

Basic research

Influence of some homeopathic

drugs on the catalytic activity of

uricase, acid phosphatase and the

cytosol glutathion-S-transferase

Dittmann J.,

Kanapin H.,

Harisch G.

BM, 2000, 3;

125-131

Effect of D8

potencies on three

different enzymatic

systems

Basic research

Influence of some homeopathic

drugs on the catalytic activity of

cAMP-dependent protein kinases

Dittmann J.,

Kanapin H.,

Harisch G.

BM, 2000, 6;

289-296.

Effect of different

potencies of 5

substances on

enzymatic activity

Basic research

Neuroprotection from glutamate

toxicity with ultra-low dose

glutamate

Jonas W.,

Lin Y.,

Zortella F.

Neuroreport,

       

2001 Feb 92; 12

(2): 335-9.

Protective Glutamate toxicity

 

KEY: BT = Biomedical Therapy

BM = Biologische Medizin

FKM = Forschung Komplementär Medizin

A number of large-scale studies designed to evaluate the huge amount of homeo- pathic literature have been conducted, especially in the last 10 years. Organisations and institutes of great international prestige and importance have dealt with the issue of homeopathy. All of them have concluded that homeopathy possesses therapeutic efficacy. The characteristics of these studies are briefly summarised below. In 1991 , J. Kleijnen et al. in the Netherlands evaluated 107 homeopathic clinical trials on the basis of a number of evaluation criteria also used in allopathic clini- cal trials (Kleijnen J. et al. – Clinical trials in homeopathy. British Medical Journal, 1991

302
316-323)

. They selected 22 of these trials, which they judged to be of good quality (large number of patients recruited, type of randomisation, descrip- tion of patients and methods, double blinding, and stated parameters for evalua- tion of results). 15 of these 22 trials, in which patients treated with the homeo- pathic drug were compared with patients who were untreated or treated with a placebo, demonstrated the therapeutic efficacy of the homeopathic drug. Kleijnen’s meta-analysis was therefore mainly formulated on the basis of observa- tional studies. Globally, 81 of the 107 studies reviewed by Kleijnen et al. (76%) gave favourable results. In 1992 , in view of the increasingly widespread use of non-conventional medicine (among which homeopathy stands out for the quantity and quality of the basic research and controlled clinical trials) and increased interest by the public and the media, the US Congress instituted the Office of Complementary Alternative Medicine, which later became NICAM (the National Institute of Complementary Alternative Medicine) within the National Institute of Health. NICAM has an annu- al budget of US$ 100 million, and is responsible for laying down guidelines for 30 Homeopathy: overview of human clinical trials research into the validation of complementary medicines, formulating trial proto- cols and allocating funds for quality research. In May 1997 , a report entitled “ Overview of data from homeopathic medicine tri- als ” was published by experts (clinical physicians, university pharmacologists and researchers in the homeopathic field) forming the Homeopathic Medicine Research Group, Advisory Group 1, set up by the European Community. These experts identified 377 clinical trials, short-listed 220, and reviewed 184. Detailed research lasting several months was conducted on the best trials, to eval- uate their scientific value. The conclusions researched by the Advisory Group are unequivocal: the number of significant results cannot be attributed to chance. The analysis provided a ran- dom hypothesis value of p < 0.001. The Advisory Group remained very cautious, but expressly stated: “ The null hypothesis that homeopathy has no effect can be rejected with certainty; in other words, in at least one of the studies examined the patients treated with the home- opathic remedy received benefits compared with the control patients who received the placebo ” . In 1997, K. Linde et al. (Munich University) published the results of a meta-analy- sis of no less than 135 clinical trials which compared homeopathic drugs with a placebo in Lancet (Linde K. et Al. – Are the clinical effects of homeopathy place- bo effects? A meta-analysis of placebo-controlled trials. Lancet 1997

350
834-

843). The authors concluded that “... The results of this meta-analysis are not com- patible with the hypothesis that the clinical effects of homeopathy are completely due to placebo ” . Linde had already published the favourable results of basic research studies con- ducted with homeopathic drugs in 1994 (Linde K. et al. – Critical review and meta- analysis of serially agitated dilutions in experimental toxicology – Human Exp. Toxicol., 1994 , 13:481-492). In 1998 , E. Ernst and E.G. Hahn described the state of the art in homeopathy, drawing conclusions similar to those reached by Linde in his 1997 meta-analysis (Ernst E., Hahn E.G. – Homeopathy: a clinical appraisal. Oxford – Butterworth. Heinman, 1998 ). In 1998 , P. Bellavite , Associate Professor of General Pathology at Verona University, published a detailed review which collected, classified and analysed much of the available scientific literature that documents the effects of homeopathic remedies in clinical trials, together with studies conducted in the field of basic research. As regards clinical research, Bellavite reported on the most significant and methodologically reliable studies, drawing the conclusion that “ the common opin- 31 Homeopathy: overview of human clinical trials ion that scientific proof of the clinical efficacy of homeopathy does not exist must therefore be refuted ” . Basic research is also actively developing, and some high-quality in vitro and in vivo studies that demonstrate the efficacy of homeopathy have been published in internationally recognised journals. Another meta-analysis conducted in 2000 on 24 studies relating to controlled, ran- domised clinical trials concluded that “ There is some evidence that homeopathic treatments are more effective than placebo ” (M. Cucherat et al. – Evidence of clin- ical efficacy of homeopathy. A meta-analysis of clinical trials. Eur. J. Clin. Pharmacol., 2000

56
27-33).

SELECTED STUDIES GROUPED BY APPARATUS AND DISORDER Allergies 9 placebo-controlled clinical trials of a homeopathic medicine ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Rhinitis and oculorhinitis Rhinitis and oculorhinitis Rhinitis and oculorhinitis Rhinitis and oculorhinitis Rhinitis and oculorhinitis Rhinitis and oculorhinitis Rhinitis and oculorhinitis Allergic bronchial asthma Wiesenauer M., Haussler S., Gaus W. Wiesenauer M., Gaus W. Reilly D.T., Taylor M.A. Reilly D.T., Taylor M.A., McSharry C., Aitchinson T. Wiesenauer M., Gaus W., Haussler S. Wiesenauer M., Ludtke R. Taylor M.A., Reilly D., Llewellyn-Jones R.H., McSharry C., Aitchinson T.C. Campbell J.H., Taylor M.A., Beattie N., McSharry C., Aitchinson T., Carter R., Stevenson R.D., Reilly D.T. The treatment of pollinosis with Galphimia glauca. Double-blind trial comparing the effectiveness of the homeopathic preparation Galphimia potentisation D6, Galphimia dilution 10-6 and placebo on pollinosis. Potent placebo or potency? A proposed study model with its initial findings using homeopathically prepared pollens in hayfever. Is homeopathy a placebo response? Controlled trial of homeopathic potency, with pollen in hayfever as model. The treatment of pollinosis with Galphimia glauca - dou- ble-blind clinical trial. The treatment of pollinosis with Galphimia glauca D4 – a randomised placebo- controlled double-blind clinical trial. Randomized controlled trial of homeopathy versus placebo in perennial allergic rhinitis with overview of four trial series. Is homeopathy a placebo response? A controlled trial of homeopathic immunotherapy in atopic asthma. Fortsch. Med. , 1983 , 101: 811-814. Arzneim. Forsch./Drug Res. , 1985 , 33: 1745-1747. Br. Hom. J. , 1985 , 74: 65-75. Lancet , 1986 , 2: 881-886. Allergologie , 1990 , 13: 359-363. Phytomedicine , 1995 , 2: 3-6. British Medical Journal 2000 Aug, 19-26; 321 (7259): 471-6. Am. Rev. Resp. Dis. , 1990 , 141: A24. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS 38 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Allergic bronchial asthma Reilly D., Taylor M.A., Beattie N., Campbell J.H., McSharry C., Aitchinson T., Carter R., Stevenson R.D. Is evidence for homeopathy reproducible? Lancet , 1994 , 344: 1601-1606. The homeopathic medicine proved therapeutically superior AUTHORS ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Allergic rhinitis and oculorhinitis Allergic rhinitis and oculorhinitis Weiser M., Gegenheimer L.H., Klein P. Matusiewicz R. A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn- sodium spray in the treatment of seasonal allergic rhinitis. The efficacy of Engystol in cases of bronchial asthma treated with corticosteroids. Research in Complementary Medicine, 1999 /6. Biologische Medizin , 1995 , 5; 242-246. The homeopathic medicine was not therapeutically inferior* to the allopathic reference drug The homeopathic medicine was not therapeutically inferior* to the allopathic reference drug AUTHORS The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. 2 clinical trials of a homeopathic medicine vs the corresponding allopathic reference drug 39 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Muscle cramps (2 drugs vs. placebo Rheumatoid arthritis Rheumatoid arthritis Rheumatoid arthritis Tibiotarsal sprain (astragalus) Fibromyositis Trauma Haemarthrosis Mossinger P. Gibson R.G., Gibson S.L.M., Mc Neil A.D., Gray G.H., Carson W., Buchanan W.W. Gibson R.G., Gibson S.L.M., Mc Neil A.D, Buchanan W.W. Wiesenauer M., Gaus W. Zell J., Connert W.D., Mau J., Feuerstake G. Fisher P., Greenwood A., Huskisson E.C., Turner P., Belon P. Gibson J., Haslam Y., Laurenson L., Newman P., Pit R., Robins M. Thiel W., Borho B. Demonstrations of efficacy. Salicylates and homeopathy in rheumatoid arthritis: preliminary observations. Homeopathic therapy in rheumatoid arthritis: evaluation by double-blind clinical therapeutic trial. Demonstration of efficacy of a homeopathic medicine in chronic polyarthritis. Randomised double-blind trial. Treatment of acute sprains of the ankle: A controlled double-blind trial to test the effectiveness of a homeopathic ointment. Effect of homeopathic treatment on fibrositis (primary fibromyalgia). Double blind trial of Arnica in acute trauma patients. The treatment of recent traumatic blood effusions of the knee joint. Allg. Hom. Zeitung , 1976 , 221: 26-31. Br. J. Clin. Pharmac. , 1978

6: 391-395. Br. J. Clin. Pharmac. , 1980

9: 453-459. Akt Rheumatol. , 1991 , 16: 1-9. Forts. der Med. , 1988 96/62- 100/70. Brit. Med. J. , 1989 , 299: 365- 366. Homoeopathy , 1991 , 41: 54-55. Biol. Medizin , 1991 , 20: 506-515. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS Arthromyofascial apparatus 8 placebo-controlled clinical trials of a homeopathic medicine 40 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Osteoarthritis of the knee Osteoarthritis of the knee Osteoarthritis of the knee Backache Nahler G., Metelmann H., Sperber H. Maronna U., Weiser M., Klein P. Van Haselen R.A. Stam C., Bonnet M.S., Van Haselen R.A. Treating osteoarthritis of the knee with a homeopathic preparation – Results of a randomized, controlled, clinical trial in comparison to hyaluronic acid. Oral treatment of osteoarthritis of the knee with Zeel S tablets. A randomized controlled trial comparing topical piroxican gel with a homeopathic gel in osteoarthritis of the knee. The efficacy and safety of a homeopathic gel in the treatment of acute low back pain: a multi-centre, randomised, double-blind comparative clinical trial. Orthopädische Praxis , 1996 , 5. Orthop ä dische Praxis , 2000 , 5. Rheumatology (Oxford) , 2000 Jul,; 39 (7): 714-9. Br. Homeopath. J., 2001 Jan; 90(1): 21-8. The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug AUTHORS The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. 4 clinical trials of a homeopathic medicine vs the corresponding allopathic reference drug 41 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT AUTHORS Coagulation and circulatory disorders 5 placebo-controlled clinical trials of a homeopathic medicine ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Haemostasis Doutremepuich C., Pailley D., Anne M.C., De Seze O., Paccalin J., Quilichini R. Template bleeding time after ingestion of ultra low dosages of acetylsalicylic acid in healthy subjects. Preliminary study. Thrombosis Res., 1987 , 48: 501-504. The homeopathic medicine was not therapeutically inferior to the allopathic reference drug AUTHORS The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. 1 clinical trial of a homeopathic medicine vs the corresponding allopathic reference drug Haematoma Haematoma Varicose veins Filariasis Asymptomatic filariasis Bourgois J.C. Amodeo C., Dorfman P., Ricciotti F., Tetau M., Veroux P.F. Ernst E., Saradeth T., Resch K.L. Subramanyam V.R., Mishra N., Ray Y., Rakshit G., Pattnaik N.M. Kumar A., Mishra N. Protection of the venous system in patients with perfused breast cancer. Double-blind clinical trial. Evaluation of the action of Arnica 5CH on vein disorders after lengthy perfusion. Complementary treatment of varicose veins. A randomised, placebo-controlled, double- blind trial. Homeopathic treatment of filariasis. Experience in an Indian rural setting. Effect of homeopathic treatment of filariasis. A single-blind 69-months follow-up study in an endemic village in Orissa. Universit é Paris Nord (Thesis), 1983 . Cahiers Biother. , 1988 , 98: 77-82. Phlebology , 1990 , 5: 157-163. Br. Hom. J. , 1990 , 79: 157-160. Br. Hom. J. , 1994 , 83: 216-219. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior 42 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Skin lesions Skin lesions Pyodermitis Burns Dermatosis Plantar warts Paterson J. Balzarini A., Felisi E., Martini A., De Donno F. Mossinger P. Leaman A.M., Gorman D. Schwab G. Labrecque M., Audet D., Latulippe L.G., Drouin J. Report on Mustard Gas Experiment. Efficacy of homeopathic treatment of skin reaction during radiotherapy for breast cancer: a randomised, double-blind clinical trial. The therapeutic efficacy of Hepar sulfuris calcareum D4 in pyodermitis and boils. Cantharis in the early treatment of minor burns. Can the effect of homeopathic substances in high potencies be demonstrated experimentally? A controlled, cross-over double blind study in patients with skin conditions. Homeopathic treatment of plantar warts. J. Am. Inst. Homeopathy, 1944 , 37: 47-50, 88-92. Br. Homeopath. J. , 2000 Jan; 89 (1): 8-12. Allg. Hom. Zeitung , 1980 , 225: 22-28. Arch. Emerg. Med. , 1989 , 6: 259-261. Proc. 45th LMHI Congr., Barcelona, Spain , 1990 , 166-169. Ca. Med. Assoc. J. , 1992 , 146: 1749-1753. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS Dermatology 6 placebo-controlled clinical trials of a homeopathic medicine 43 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Pharyngitis Gastritis Irritable colon Cholecystitis Anal fissures Diarrhoea (paediatric cases) Diarrhoea (paediatric cases) Diarrhoea (paediatric cases) Mossinger P. Ritter H. Rahlfs V.W., Mossinger P. Mossinger P. Bignamini M., Saruggia M., Sansonetti G. Jacobs J., Jimenez L.M., Gloyd S.S., Carares F.E., Gaitan M.P., Crothers D. Jacobs J., Jimenez L.M., Gloyd S.S., Gale J.L., Crothers D. Jacobs J., Jimenez L.M., Malthouse S., Chapman E., Crothers D., Masuk M., Jonas W.B. The treatment of pharyngitis with Phytolacca. Double-blind homeotherapeutic study and the issues involved. Asa foetida in the treatment of irritable colon: double-blind clinical trial. Homeopathy and naturopathy. How to overcome conflicts. Homeopathic treatment of anal fissures using nitricum acidum. Homeopathic treatment of acute childhood diarrhoea. A randomised clinical trial in Nicaragua. Treatment of acute childhood diarrhoea. A randomised clinical trial in Nicaragua. Homeopathic treatment of acute childhood diarrhoea: results from a clinical trial in Nepal. Allg. Hom. Zeitung , 1973

218: 111-121. Hippokrates , 1966 , 12: 472-476. Dtsch. Med. Wschr. , 1979 , 104: 140-143. Hippokrates (Stuttgart) , 1984 , 165-169. Berl. J. Res. Hom. , 1991 , 1 (4/5): 286-287. Br. Hom. J. , 1993 , 82: 83-86. Pediatrics , 1994 , 93: 719-725. J. Altern. Complement. Med. , 2000 Apr; 6 (2): 131-9. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS Gastrointestinal apparatus 8 placebo-controlled clinical trials of a homeopathic medicine ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Vomiting Stukalova E.N. Efficacy of homotoxicological treatment in early toxaemia of pregnancy. B.T. , 2000 , 4 (Ukrainian edition) The homeopathic medicine was not therapeutically inferior to the allopathic reference drug AUTHORS The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. 1 clinical trial of a homeopathic medicine vs the corresponding allopathic reference drug 44 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Menopause Leucorrhoea Premenstrual syndrome Childbirth (pain) Childbirth (pain) Childbirth (labour) Florid condylomatosis Gauthier J.E. Carey H. Lepaisant C. Coudert M. Dorfman P., Lasserre M.N., Tetau M. Eid P., Felisi E., Sideri M. Destro Castaniti M. Comparative therapeutic study of the action of clonidine and Lachesis muta in the treatment of hot flushes in the menopause. Double blind clinical trial of Borax and Candida in the treatment of vaginal discharge. Therapeutic demonstrations in homeopathy: treatment of breast tension and mastodynia in premenstrual syndrome. Experimental study of the action of Caulophyllum in false labour. Preparation for childbirth with homeopathy: a double-blind placebo-controlled trial. Super placebo or pharmacolo- gical action? A double-blind randomised trial with a homeopathic drug (Caulophyllum thalictroides) during labour. The use of Transfactor 11 in HPV infections (160 cases). Universit é de Bordeaux (Thesis), 1983 . Comm. Br. Hom. Res. Grp., 1986 March:12-14. Rev. Fr. Gynecol. Obst é t. , 1995 , 90: 94-95. Universit é de Limoges (Thesis) , 1981 . Cahiers de Bioth é rapie , 1987 , 94: 77- 81. Proc. V Congr. O.M.H.I., Paris, 1994 . La Medicina Biologica , 2000 , 4; 95: 100. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS Gynaecology and obstetrics 7 placebo-controlled clinical trials of a homeopathic medicine 45 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Diabetes mellitus Diabetic retinopathy Obesity Complications of haemodialysis Complications of haemodialysis Fabbro V., Gargiulo P., Minelli E. Zicari D., Ricciotti F., Vingolo E.M., Zicari N. Werke W., Lehmann M., Galland F. Hariveau E. Saruggia M., Corghi E. Multicentric study of the action of the homeopathic complex R40 in the treatment of hyperglycaemia. Evaluation of the angioprotective action of arnica preparations in the treatment of diabetic retinopathy. Comparative controlled trial of the efficacy of the plant- based homeopathic medicine Heliantus tuberosus D1 in the complementary treatment of overweight patients. Clinical research at the Boiron Institute. Effects of homeopathic dilutions of China rubra on intradialytic symptomatology in patients treated with Omeopatia Oggi, 1994 , 5 (10): 1-16. Boll. Oculist ., 1992 , 71: 841-848. Therapiewoche , 1994 , 44: 34-39. Hom é opathie , 1987 /5; 55-8. Br. Hom. J ., 1992 , 81: 86-88. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS Metabolism 5 clinical trials of a homeopathic medicine vs placebo ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Functional infertility Toxaemia in pregnancy Lai G. Stukalova E.N. Homotoxicological treatment of female functional infertility: clinical trial. Efficacy of homotoxicological treatment in early toxaemia of pregnancy. La Medicina Biologica, 2000 , 4:81-86. BT , 2000 , 4 (Ukrainian edition) The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug AUTHORS The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. KEY: BT = Biomedical Therapy 2 clinical trials of a homeopathic medicine vs the corresponding allopathic reference drug 46 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Dental neuralgia Kinetosis (motion sickness) Kinetosis (motion sickness) Aphasia Migraine Head injury Migraine Albertini H., Godberg W. Ponti M. Dexpert M. Master F.J. Brigo B., Serpelloni G. Chapman E.H., Weintraub R.J., Milburn H.A., Pirozzi T.O., Woo E. Straumsheim P., Borchgrevink C., Mowinckel P., Kierulf H., Hafslund D. Homeopathic treatment of dental neuralgia using Arnica and hypericum: a summary of 60 observations. Evaluation of homeopathic treatment of motion sickness; results of 93 observations. Prevention of motion sickness with Cocculine. Scope of homeopathic drugs in the treatment of Broca ’ s aphasia. Homeopathic treatment of migraines: a randomized double-blind controlled study of sixty cases. Homeopathic treatment of mild traumatic brain injury: a randomized, double blind placebo-controlled clinical trial. Homeopathic treatment of migraine: a double blind, placebo controlled trial of 68 patients. Hom é opathie Fran ç aise, 1984 , 71: 47-49. In: Recherches Hom é opathiques (Boiron J., Belon P., Hariveau E., eds.). Fondation Fran ç aise pour la Recherche en Hom é opathie , 1986 . Lyon: 71-74. Hom é opathie Franc. , 1987 , 75: 353-355. Proc. 42nd Congr. LMHI , 1987 , Arlington, USA: 330-334. Berl. J. Res. Hom. , 1991 , 1 (2): 98-106. J. Head Trauma Rehabil. , 1999 Dec; 14 (6): 521-42. Br. Homeopath. J. , 2000 Jan; 89 (1) 4-7. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS Neurology 7 clinical trials of a homeopathic medicine vs placebo 47 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Vertigo Vertigo Weiser M. Wolschner U., Str ö sser W., Weiser M., Klein P. Homeopathic vs conventional treatment of vertigo. Vertigo therapy: Cocculus -heel ® versus Dimenhydrinate. Arch. Of Otolaryngology. Head and Neck Surgery, 1998 , August. BM, 2001 , 4. Pubblicato in italiano (2) The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug AUTHORS The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. KEY: BM = Biologische Medizin 2 clinical trials of a homeopathic medicine vs the corresponding allopathic reference drug 48 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Infections of the upper airways Infections of the upper airways Infections of the upper airways Infections of the upper airways Coryza Otitis media Otitis media Glue ear Sinusitis Sinusitis Influenza syndrome Hourst P. Lecoq P.L. Bordes L.R., Dorfman P. Casanova P., Gerard R. Mossinger P. Mossinger P. Jacobs J., Springer D.A., Crothers D. Harrison H., Fixsen A., Vickers A. Wiesenauer M., Gaus W., Bohnacker U., Haussler S. Weiser M., Clasen B.P. Ferley J.P., Zmirou D., D ’ Adhemar D., Balducci F. Acknowledgement of the efficacy of homeopathy. Therapeutic possibilities in the treatment of influenza syndromes. Evaluation of the antitussive action of Drosetux syrup; double-blind placebo- controlled clinical trial. Results of three years of randomised multicentric studies with Oscillococcinum/ placebo. Study of treatment of rhinorrhoea with Euphorbium D3. The treatment of otitis media with Pulsatilla. Homeopathic treatment of acute otitis media in children: a preliminary randomised placebo-controlled trial. A randomised comparison of homeopathic and standard care for the treatment of glue ear in children. Study of the efficacy of homeopathic compound pre- parations in sinusitis. Results of a double-blind randomised out-patient study. Controlled double-blind study of a homeopathic sinusitis medication. A controlled evaluation of a homeopathic preparation in influenza-like syndromes. Universit é P. et M. Curie (Thesis) . Paris. France, 1981. Cah. Bioth é r. , 1985 , 87: 65-73. Cahiers d ’ Otorhinolaryngo- logie , 1986 , 21: 731-734. Proposta Omeopatica 3 , Anno IV, ottobre 1988 . Allg. Hom. Zeitung , 1982 , 227: 89-95. Kinderarzt , 1985 , 16: 581-582. Pediatr. Infect. Dis. J. , 2001 Feb; 20 (2): 177-83. Complemen. Ther. Med. , 1999 , Sept; 7 (3): 132-5. Arzneim. Forsch./Drug Res. , 1989 , 39: 620-625. Biol. Ther. , 1994 , 13: 4-11. Br. J. Clin. Pharmac. , 1989 , 27: 329-335. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS Respiratory apparatus, common cold/influenza syndrome and ENT 15 placebo-controlled clinical trials of a homeopathic medicine 49 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Influenza syndrome Influenza syndrome Influenza syndrome Bronchial asthma Saruggia M. Heilmann A. Saruggia M. Matusiewicz R. Influenza and viral respiratory infections. A combination injection preparation as a prophylactic for flu and common colds. The preventive effect of Oscillococcinum in influenza- like syndromes. Results of a multicentric study. The efficacy of Engystol in cases of bronchial asthma treated with corticosteroids. Medicina Naturale , 1994 /6. Biol. Ther. , 1994 , 7: 249-253. Medicina Naturale , 1995 /6. La Medicina Biologica , 1996 , 1; 3-8. The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior AUTHORS ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Infections of the upper airways Infections of the upper airways Common cold Common cold Otitis media Arrighi A. Riley D., Fisher M., Singh B., Haidvogl M., Heger M. Gassinger C.A., Wunstel G. Maiwald L., Weinfurtner T., Mau J., Connert W.D. Kruse K. Evaluation of clinical efficacy in a homotoxicologic protocol for prevention of recurrent respiratory infections in pediatrics. Homeopathy and Conventional Medicine: an outcome study comparing effectiveness in a primary care setting. A controlled clinical trial for testing the efficacy of the homeopathic drug Eupatorium perfoliatum D2 in the treatment of common cold. The therapy of the common cold with a combination homeopathic preparation, compared with treatment with acetylsalicylic acid: a controlled randomized, single- blind study. Subject reported in the volume. La Medicina Biologica , 2000 , 3: 13-21. The Journal of Alternative and Complementary Medicine , 2001 , Vol 7, N ° 2; 149- 159. Arzheim Forsch./Drug Res. , 1981 , 31: 732-736. Arzheim Forsch./Drug Res. , 1988 /4. Edition Forsch. Hippokrates Verlag, Stuttgart, The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug The homeopathic medicine was not therapeutically inferior to the allopathic reference drug AUTHORS The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. 5 clinical trials of a homeopathic medicine vs the corresponding allopathic reference drug 50 Homeopathy: overview of human clinical trials ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT HIV infection Rastogi D.P., Singh V.P., Singh V., Dey S.K., Rao K. Homeopathy in HIV infection: a trial report of double-blind placebo-controlled study. Br. Homeopath. J., 1999 Apr; 88 (2): 49-57. The homeopathic medicine proved therapeutically superior AUTHORS Sundry 1 placebo-controlled clinical trial of a homeopathic medicine The term “ NOT INFERIOR ” means EQUAL or SUPERIOR TO. KEY: BM = Biologische Medizin ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Conjunctivitis K ü stermann R.W., Weiser M., Klein P. Antihomotoxic treatment of conjunctivitis. Results of a prospective, controlled, cohort study. BM, 2001 , 3. The homeopathic medicine was not therapeutically inferior to the allopathic reference drug AUTHORS 1 clinical trial of a homeopathic medicine vs the corresponding allopathic reference drug Homeopathy: overview of human clinical trials 51 ORIGINAL/TRANSLATED DISORDER PUBLICATION EFFECT Dynamic ileus Dynamic ileus Dynamic ileus Post-operative infections Post-operative psychomotor agitation Post-extraction complications (dental cases) Valero E. Chevrel J.P., Saglier J., Destable M.D. Aulagnier G. Valero E. Alibeu J.P., Jobert J. Michaud J. Study of the preventive action of Raphanus sativus 7CH on the post-operative recovery time of intestinal transit (80 cases); and of Pyrogenium 7CH on post-operative infections (128 cases). Recovery of intestinal transit in digestive surgery. Homeopathic action of opium. The action of post-operative homeopathic treatment. Study of the preventive action of Raphanus sativus 7CH on the post-operative recovery time of intestinal transit (80 cases); and of Pyrogenium 7CH on post-operative infec- tions (128 cases). Aconite in homeopathic relief of post-operative pain and agitation in children. The action of Apis mellifica and Arnica montana in preventing post-operative oedema in maxillofacial surgery in a clinical trial involving 60 cases. Universit é de Grenoble (Thesis) , 1981 . Press Med. , 1984 , 13: 833. Hom é opathie , 1985 , 6: 42-45. Universit é de Grenoble (Thesis) , 1981 . P é diatrie , 1990 , 45: 465-466. Universit é de Nantes (Thesis) , 1981 . The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior The homeopathic medicine proved therapeutically superior

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