| Revision as of 02:01, 11 July 2015 editDoc James (talk | contribs)Administrators312,255 edits →Gabor B. Racz← Previous edit | Revision as of 02:05, 11 July 2015 edit undoAtsme (talk | contribs)Autopatrolled, Extended confirmed users, Page movers, New page reviewers, Pending changes reviewers, Rollbackers42,803 edits →Gabor B. Racz: dupe detectorNext edit → | ||
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| ::::It is getting better but still issues. I have fixed some more. | ::::It is getting better but still issues. I have fixed some more. | ||
| ::::There was a large number of copyright issues ] (] · ] · ]) 01:57, 11 July 2015 (UTC) | ::::There was a large number of copyright issues ] (] · ] · ]) 01:57, 11 July 2015 (UTC) | ||
| ::::::The duplication detector tool isn't working? Or are you talking about the credentials list? Doc, I don't want to get all mushy and everything, but you actually brought me to tears because I would have considered it an honor to collaborate on an article with you. It appeared to me that you believed all the nonsense about me being a pusher of quackery and all that other BS that laid on me when it wasn't true at all. And neither were the allegations or what happened to me at COIN. I'm here just trying to go some good, help other editors with copy editing, especially those editors who have trouble with English because it's not their 1st language. And the things you called puffery and what I call puffery are simply differences of opinion. When I used "pioneered" it was (1) because the source said so, and (2) it was innovative. He invented it. Perhaps in medicine it's called "developed". It's not that I'm a bad editor and that I'm trying to promote anything - it's simply a choice of terminology. <font style="text-shadow:#F8F8FF 0.2em 0.2em 0.4em,#F4BBFF -0.2em -0.3em 0.6em,#BFFF00 0.8em 0.8em 0.6em;color:#A2006D">]</font><sup>]]</sup> 02:05, 11 July 2015 (UTC) | |||
| == quackguru/question == | == quackguru/question == | ||
Revision as of 02:05, 11 July 2015
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Cochrane Collaboration meeting in Vienna, October 1stHi Doc James, I 've heard you might be able to visit the Cochrane Collaboration meeting in Vienna. Somebody (User:FloNight?) reserved some time for a wikipedian pre-colloquium . We've skyped with FloNight about this recently, and several people would like to attend, but we need some details. Are you, or ia FloNight planning to give a speech, a workshop, or anything else? Do you want us to prepare something? What will be our objective? Please answer on our wikiproject's subpage, English is OK. - Or, if I'm completely wrong, please forward this to whom it may concern. Regards, --MBq (talk) 08:56, 30 June 2015 (UTC)
AOK on the further reading, after referencesWill follow your advice/guidance on med articles, though in cases outside your bailiwick, I may still slip in alternate ordering—in particular when the appearing references are uniformly bad, and the Further reading is serving as a basis for properly formatted, well-chosen and well-formatted future article sources. As a waypoint, an analogy (if you sail). Cheers. LeP. 71.201.62.200 (talk) 04:52, 1 July 2015 (UTC) ADHDHi James, I left a reply for you on my talk page. I don't know if you see those automatically so I am noting it here. Thanks! Ehaugsjaa (talk) 23:07, 2 July 2015 (UTC) HypoglycemiaHello Doc James, I suffer from congenital adrenal hyperplasia and one of the main symptoms I have when my cortisol levels are too low is hypoglycemia. During an adrenal crisis one suffers from seriously low blood sugar and also eleoctrolyte imbalances (low sodium/high potassium). In this article you have mentioned very briefly that cortisol should be checked in patients presenting with hypoglycemia but you never state explicitly anywhere that one of the causes of hypoglycemia could be Addison's disease, or other types of adrenal insufficiency - I think this is a serious oversight that should really be corrected. It is such a problem that often, those of us with Adrenal insufficiency who go to the emergency room because we are having a crisis get brushed off, or accused of being on drugs or alcoholics because even medical professionals don't think that it could be low cortisol - even if we are wearing medical jewelry stating that we have adrenal insufficiency. A friend of mine changed hers to read "Give Solu-cortef or watch me die" because she was left vomiting on an ER floor for 3 hours having an adrenal crisis. Please do what you can to help people be aware of this serious condition by including it where relevant in your wikipedia entries! Thank you for your time, Lahoma J. Howard, M.A. PhD student/Instructor of Sociology - Colorado State University 75.70.67.202 (talk) 12:03, 3 July 2015 (UTC)
Moving Text within Misplaced Pagesuser:Doc James how do I know where the content was moved from for this edit ? Is there a way to track that? The edit history simply says "moving." How is the original wiki attributed in this case (move versus copy) and does it need to be? — Preceding unsigned comment added by Lucas559 (talk • contribs) 19:40, 3 July 2015 (UTC)
The Signpost: 01 July 2015
July 2015
What is "MEDMOS"?Just asking, what is "MEDMOS"? Clubjustin (talk) 03:50, 4 July 2015 (UTC) PubMed up for you?Hey, just wondering, is Pubmed accessible? It seems to be down for me right now. Cheers doc. -- Aronzak (talk) 07:09, 4 July 2015 (UTC)
German pilot study for Roscovitine's effects on Glioblastoma cell linesHello Sir, I was wondering if you've seen the Roscotivine abstact published July 3 by Spadidos Publications. It's a European pilot study which appears to have seen some sucess. I can send you a link to the article if you'd like. I'd love to hear your thoughts on it. Please let me know if I can email or direct message (Twitter) the link to you. Thanks for your time, Gary Hudson garyhudson4557@sbcglobal.net Twitter @Gary Hudsn4557 — Preceding unsigned comment added by 70.139.35.13 (talk) 18:07, 4 July 2015 (UTC)
CopyrightI believe you are in error. I did not add copyrighted material. My article that was published in the American Journal of Public Health is copyrighted, but the reference to the journal article is not copyrighted per se. The correction I made was to the entry for Impacted Wisdom Teeth. The reference No. 8 lists my last name and the title of the article but it does not list the name and issue of the journal, which is standard for such references. There was no copyright violation in my entry. Reference no 8 should read: Friedman JW "The prophylactic extraction of third molars: a public health hazard." Am J Public Health 2007;97(9):1554-1559. Jay W Friedman Jay W Friedman (talk) 02:50, 5 July 2015 (UTC)
Which specialty: RAS?I recall this concern was raised when this paramater was in discussion. Might be seen by dentist, General (family) practitioner, oral and maxillofacial surgeon, paediatric physician, dermatologist, ENT, etc. Most commonly this problem would be dealt with in primary care by non specialists imo. Matthew Ferguson (talk) 08:24, 5 July 2015 (UTC)
Gabor RaczYou know, Doc - a BLP isn't a journal entry. It's a biography. Why do you want it to read like a science paper? It's one thing to create dry scientific articles about drugs and such, but this is a BLP. FA criteria clearly states: "its prose is engaging, even brilliant, and of a professional standard;" That doesn't mean dry and scientific. Your addition of the template with an edit summary that reads, "this article has serious issues" isn't very helpful. Why don't you point out the issues instead of templating a GA article? Your the medical professional or is there a reason you are refraining from editing and trying to improve this BLP? Atsme 17:12, 5 July 2015 (UTC)
Interesting ReseachThis research is actually quite promising for extrinsically motivated editors. I was under a bleaker impression of their quality and copyvio issues. --Lucas559 (talk) 18:08, 5 July 2015 (UTC)
PBCYou made some recent edits reverting compromise changes I made to the use of "cholangitis" or "PBC" rather than "cirrhosis". I had previously reverted much more major changes and established a section on the Talk:Primary_biliary_cirrhosis page to discuss this renaming. The patient groups have won almost universal support for this change in name which have been referenced. As I understand it, there will soon be publications in the scientific literature supporting this and will cite these when it has occurred. Thanks for watching these pages and please feel free to contribute to the Talk page! Jrfw51 (talk) 14:15, 6 July 2015 (UTC)
Misplaced Pages ReviewDear Doc James, I've again reviewed the vitamin D and cancer topic in Misplaced Pages and found that the section still remains somewhat scant. The first reference is to a popular press article about sales of vitamins in general. The remainder seems to trivialize the 35 years or so of active scientific research in this topic area. Rather than citing any original articles, it relies on a single tendentious review. Since students use Misplaced Pages to learn about the progression of scientific investigations as well as the latest findings on a topic, I wondered if we might consider rewriting this section together to reflect both the historical advancements in the understanding of vitamin D and cancer, as well as results of the latest laboratory, observational, and large cohort studies. I would like to suggest that we set-up an editorial board of subject matter experts who would then together revise this section. We would then submit a final draft to you as the Misplaced Pages editor. I have several colleagues listed below that I think would likely be very interested and willing to undertake this project. If you are amendable to this suggestion, please respond to my office email. We can then begin circulating revisions to this section. Many thanks. Very respectfully, Ed Edward Gorham, MPH, PhD Adjunct Professor Department of Family Medicine and Public Health School of Medicine University of California, San Diego (619) 990-3848 Email: edward.d.gorham2.civ@mail.mil Dr UVB (talk) 14:51, 6 July 2015 (UTC)
Thank you, Jytdog and Jrfw51, Site specific cancer studies would, in my view, be an important addition to this section. Many dietary and serum studies have been carried out for both colon (1) and breast cancer (2), and for cancers of other sites. Nested case-control serum studies have certain advantages over dietary studies of vitamin D since it doesn't matter whether the vitamin D is dietary or sun-derived. 25(OH)D is relatively stable and an optimal biomarker for vitamin D status. Results from large cohort studies should not be discounted, such as the prospective EPIC study of serum 25 (OH)D and colon cancer in countries across Europe (1). These are important primary sources, and deserve their own citation. In vitro cell studies of antineoplastic effects of 25(OH)D and 1,25(OH)D in several tumor lines should at least be mentioned. These potent vitamin D metabolites act as hormones and influence tight junctions between cells, promote apoptosis, and down-regulate oncogenes. Vitamin D is not simply another nutrient when it comes to cancer. The review of supplement sales is overly broad, not particularly relevant to this section, and should be considered for deletion. The role of most nutrients in disease causation has been contentious since they were first identified (3). This should not discourage us from their study or fair reporting of results of these investigations. Very respectfully, Professor Gorham 1) Jenab M, Bueno-de-Mesquita HB, Ferrari P, van Duijnhoven FJ, Norat T, Pischon T, Jansen EH, et al. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case–control study. BMJ 340:b5500, 2011. PMID 20093284 2) Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss EJ, Flesch-Janys D, Chang-Claude J. Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer: results of a large case-control study. Carcinogenesis. 2008;29:93–9 PMID 17974532 3) Heaney RP. Nutrients, endpoints, and the problem of proof. J Nutr. 2008 Sep;138(9):1591-5. PMID 18716155 Dr UVB (talk) 18:27, 8 July 2015 (UTC)
Thank you again, Jytdog, for your thoughtful response. Controversy is an inevitable part of scientific progress. EV McCollum himself, who first isolated vitamin D, was widely derided for the idea that it might prevent rickets. The proof of vitamin D in rickets prevention was based on observational and animal studies. Dr. Taylor's commentary represents a certain point of view, but there are many others who would not be so quick to dismiss the importance of vitamin D in public health. I'm attaching a link to another commentary, just for interest. There is incidentally a randomized controlled trial by Lappe et al that meets this highest level of medical evidence which is unfortunately omitted in Dr. Taylor's commentary, but included below. The temporal sequence, consistency across study designs, strength of association, and the dose-response findings each help address the causality issues you question. These factors should be noted in Misplaced Pages. The important thing in my view is to establish a balanced panel of subject matter experts who could improve this section of Misplaced Pages, as I've suggested above. Very respectfully, Professor Gorham Dr UVB (talk) 00:10, 9 July 2015 (UTC)
Incidentally, a randomized controlled trail does exist (abstract also provided below) which found exactly the level of evidence you are seeking. In fact, these investigators observed a 60% reduction in incidence of cancers of all sites in the vitamin D and calcium treatment arm of this trial. These and many similar results are overlooked in the review by Taylor, et al. This is a drawback of relying solely on reviews. Elevation of this section of Misplaced Pages to an external panel of experts, such as those suggested above, could, in my opinion, improve this section of Misplaced Pages substantially. By almost any objective measure, it is currently lacking, both scientifically and factually. If you will not approve, may I request that we elevate to a higher echelon in the Misplaced Pages review process. Sincerely yours, Prof. Gorham Lancet. 1989 Nov 18;2(8673):1176-8. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, Gorham ED. Abstract Blood samples taken in 1974 in Washington County, Maryland, from 25 620 volunteers were used to investigate the relation of serum 25-hydroxyvitamin D (25-OHD) with subsequent risk of getting colon cancer. 34 cases of colon cancer diagnosed between August, 1975, and January, 1983, were matched to 67 controls by age, race, sex, and month blood was taken. Risk of colon cancer was reduced by 75% in the third quintile (27-32 ng/ml) and by 80% in the fourth quintile (33-41 ng/ml) of serum 25-OHD. Risk of getting colon cancer decreased three-fold in people with a serum 25-OHD concentration of 20 ng/ml or more. The results are consistent with a protective effect of serum 25-OHD on colon cancer.
Abstract Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking. The purpose of this analysis was to determine the efficacy of calcium alone and calcium plus vitamin D in reducing incident cancer risk of all types. This was a 4-y, population-based, double-blind, randomized placebo-controlled trial. The primary outcome was fracture incidence, and the principal secondary outcome was cancer incidence. The subjects were 1179 community-dwelling women randomly selected from the population of healthy postmenopausal women aged >55 y in a 9-county rural area of Nebraska centered at latitude 41.4 degrees N. Subjects were randomly assigned to receive 1400-1500 mg supplemental calcium/d alone (Ca-only), supplemental calcium plus 1100 IU vitamin D3/d (Ca + D), or placebo. When analyzed by intention to treat, cancer incidence was lower in the Ca + D women than in the placebo control subjects (P < 0.03). With the use of logistic regression, the unadjusted relative risks (RR) of incident cancer in the Ca + D and Ca-only groups were 0.402 (P = 0.01) and 0.532 (P = 0.06), respectively. When analysis was confined to cancers diagnosed after the first 12 mo, RR for the Ca + D group fell to 0.232 (CI: 0.09, 0.60; P < 0.005) but did not change significantly for the Ca-only group. In multiple logistic regression models, both treatment and serum 25-hydroxyvitamin D concentrations were significant, independent predictors of cancer risk. Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00352170. Dr UVB (talk) 20:58, 9 July 2015 (UTC)
Cochrane excludes all observational epidemiologic studies including prospective cohort studies, nested case-control studies, and of course, case-control studies, and ecological studies. I don't want to turn this into a discussion of Cochrane, but public health advances linking cigarettes to lung cancer, lack of sunlight and vitamin D to rickets, passive smoking to heart disease, and numerous other medical advances would never have occurred if held to Cochrane criteria. John Snow, to his undying credit, did not randomly allocate people to drink or not drink cholera-tainted water from London's Broad Street pump. We have an opportunity to improve this section of Misplaced Pages substantially by admitting much published, peer-reviewed evidence approved medical journal editors and excluded by Cochrane. Koch's postulates of causality don't depend on Cochrane. If Cochrane is the current Wiki standard, the result will be to arbitrarily exclude all the lines of epidemiologic evidence described above. I would respectfully request an appeal of that decision, and a repeal of that standard. To whom should I address this request? V/r, Prof. Gorham Dr UVB (talk) 22:20, 9 July 2015 (UTC)
By the way here are the IOP's conclusions "For extraskeletal outcomes, including cancer, cardiovascular disease, diabetes, and autoimmune disorders, the evidence was inconsistent, inconclusive as to causality, and insufficient to inform nutritional requirements." Doc James (talk · contribs · email) 22:37, 9 July 2015 (UTC)
Excellent! So observational epidemiologic studies including prospective cohort studies, nested case-control studies, and of course, case-control studies, and ecological studies are admissible. Our panel will review and submit these for inclusion. Thank you, Dr. James. We'll get started on this right away. I'm not sure I completely follow your statements regarding toxicity. It is rarely an issue in vitamin D until serum levels of 25(OH)D exceed at least 100 ng/ml. This would be the approximate equivalent of a daily oral intake of 10,000 IU per day for several weeks. 50,000 IU per week is the prescribed replenishment dose for treating deficiency, or approximately 7,000 IU per day. I hope this is helpful. V/r, Prof. Gorham Dr UVB (talk) 22:52, 9 July 2015 (UTC)
Okay, so I am not talking about vitamin D for treatment, although there is evidence that vitamin D is an effective adjuvant in cancer treatment. Vitamin D is a nutrient with important hormonal metabolites that have critical endocrine and autocrine functions. There is much epidemiological evidence suggesting that vitamin D (as a nutrient, not a treatment) is important in chronic disease prevention. Are you restricting this page to prevention trials? If so, this page in Misplaced Pages will not represent the current level of understanding of the role of vitamin D in cancer prevention. It will remain lacking both scientifically and factually. Is that your decision? If so, how may I appeal it? V/r, Prof Gorham Dr UVB (talk) 23:17, 9 July 2015 (UTC)
an aggressive chroinc infection of the sweat glandsYDear doctor james I would like to thank you for this amazing description of the disease(Hidradenitis suppurativa)my name yasmina ahmed and i My father suffers from the disease for about 15 years but now the case has spread widely and the lesions became aggressive under arm and in the region of the thigh. Now he can't tolerate the pain and this makes him suffering from depression. He has undergone several treatment modalities such as intra lesional steroids injection but this treatment has masked the manifestation of the disease for a while and then the case got worsen to end by abscess and has suppressed the immune system .. My dad is also suffering from diabetes mellitus , hypertension and also he has undergone the surgery of cardiac catherization from 3 months ago and now he is taking anticoagulant therapyaand the doctors refused to do any surgery unless after 6 months to allow him to stop the anticoagulant therapy.. Also my dad has taken some medications such as several types of antibiotics and Netlook but now it is kinda don't give benefits.. I need for your help to rtell me the suitable treatment for my dad and can you also tell me the most suitable country in the treatment of this disease.. — Preceding unsigned comment added by Doc yasmina madkour (talk • contribs) 21:35, 7 July 2015 (UTC)
Fistula in ano. Missing " perfact technique"Hi doc James Last week I just read about fistula in ano and I found the latest technique " perfact" by dr. Pankarg garg from India , however I read wiki again and now this technique did not show up on page , why ? — Preceding unsigned comment added by 27.55.34.24 (talk) 04:20, 8 July 2015 (UTC)
Removal of ADAWhy? Anmccaff (talk) 16:08, 9 July 2015 (UTC)
Gabor B. RaczDoc, are you acting in your capacity as an admin at the Racz article? Atsme 17:59, 9 July 2015 (UTC)
It's easy to list general statements that point to nothing. An accomplished reviewer and writer of numerous GAs and FAs disagreed with you twice and you refuse to drop the stick.
I am really disappointed to see such behavior. What you're doing is trying to create instability and cause the article to be delisted. That is downright shameful. This is retaliatory, nothing more. A lot of editors are aware of it, too. Atsme 19:38, 9 July 2015 (UTC)
quackguru/questionhi,,,i was going to answer a question posted by an editor just yesterday on the main talk page but its not there any more?--Ozzie10aaaa (talk) 18:44, 10 July 2015 (UTC)
Introducing the new WikiProject Cannabis!Greetings!  I am happy to introduce you to the new WikiProject Cannabis! The newly designed WikiProject features automatically updated work lists, article quality class predictions, and a feed that tracks discussions on the 559 talk pages tagged by the WikiProject. Our hope is that these new tools will help you as a Misplaced Pages editor interested in the subject of cannabis.
Hope to see you join! Harej (talk) 20:57, 10 July 2015 (UTC)
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