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E-liquid, or e-juice is the solution used in vapor products including Electronic Cigarettes. E-Liquids come in many variations, including different nicotine strengths and many different flavors. The main ingredients are propylene glycol,vegetable glycerin, glycerin, water, and flavorings; and most often, nicotine in liquid form. The liquid typically contains 95% propylene glycol and vegetable glycerin. The nicotine in e-liquid may be manufactured using a United States Pharmacopeia-grade nicotine, however zero-nicotine options are also commonly made. Most e-cigarette liquids contain nicotine, but the level of nicotine varies depending on user-preference and manufacturers. E-liquid without nicotine is also available. Although some e-juice is nicotine-free, surveys demonstrate that 97% of e-cigarette users use products that contain nicotine. A 2015 review suggests that 1% of users use liquid without nicotine.

The solution is often sold in bottles or pre-filled disposable cartridges, or as a kit for consumers to make their own e-juices. E-liquids made at home are common. Components are also available to modify or boost their flavor or nicotine strength. Pre-made e-liquids are made with various tobacco, fruit, and other flavors, as well as variable nicotine concentrations (including nicotine-free versions). The standard notation "mg/ml" is often used on labels to denote nicotine concentration, and is sometimes shortened to "mg". In surveys of regular e-cigarette users, the most popular e-liquids have a nicotine content of 18 mg/ml, and the preferred flavors were largely tobacco, mint and fruit. A cartridge may contain 0 to 20 mg of nicotine. EU regulations cap the concentration of nicotine in e-liquid at a maximum of 20mg/mL. A refill bottle can contain up to 1 g of nicotine. Refill liquids are often sold in the size range from 15 to 30 mL. One cartridge may typically last as long as one pack of cigarettes. Some liquids without flavoring is also sold. The flavorings may be natural or artificial. About 8,000 flavors exist as of 2014. A user does not normally consume a whole cartridge in a single session. Most e-liquids are produced by a few manufacturers in China, the US and Europe.

Manufacturing

E-Liquids are manufactured by many producers, both in the United States and across the world. First tier manufacturers use lab suits, gloves, hair covers, inside of certified clean rooms with air filtration similar to pharmaceutical-grade production areas

Standards

Standards for E-Liquid manufacturing have been created by American E-liquid Manufacturing Standards Association (AEMSA), which is trade association dedicated to creating responsible and sustainable standards for the safe manufacturing of e-liquids used in vapor products. AEMSA has published a comprehensive list standards and best known methods, which are openly available for use by any manufacturer of E-Liquids. The AEMSA standards cover Nicotine, Ingredients, Sanitary manufacturing rooms, Safety packaging, Age Restrictions, and Labeling.

Regulation

There are no current governmental or FDA manufacturing standards for E-Liquid. The FDA has sought to regulate E-Liquid through use of the Tobacco Control Act, passed into law in 2009. In April of 2014, the FDA issued it's "Deeming" proposals for public comment, which would cover E-Liquids manufacturing. The Final Rule, (in final form) giving the FDA authority to regulate E-Liquids is anticipated to be released in late 2015, or early 2016.

References

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