Misplaced Pages

Noradrenergic and specific serotonergic antidepressant: Difference between revisions

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively← Previous editNext edit →Content deleted Content addedVisualWikitext
Revision as of 16:23, 20 February 2016 editVaccinationist (talk | contribs)Extended confirmed users4,732 editsm →List of NaSSAs← Previous edit Revision as of 19:53, 21 February 2016 edit undoAfterwriting (talk | contribs)Extended confirmed users, Pending changes reviewers33,718 edits →List of NaSSAs: When was "recently"?Next edit →
Line 15: Line 15:
Notably, all of these compounds are ] and are also classified as ]s (TeCAs) based on their ]s. Notably, all of these compounds are ] and are also classified as ]s (TeCAs) based on their ]s.


Recently, ], a structurally novel NaSSA with an improved ] profile (e.g., no ] effects, etc.), has been developed.<ref name="pmid22178752">{{cite journal |vauthors=Millan MJ, Mannoury la Cour C, Chanrion B, etal | title = S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 340 | issue = 3 | pages = 750–64 |date=March 2012 | pmid = 22178752 | doi = 10.1124/jpet.111.187468 | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=22178752}}</ref><ref name="pmid22178753">{{cite journal |vauthors=Dekeyne A, Brocco M, Loiseau F, etal | title = S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 340 | issue = 3 | pages = 765–80 |date=March 2012 | pmid = 22178753 | doi = 10.1124/jpet.111.187534 | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=22178753}}</ref> It has completed preliminary ] and may go on to undergo ]s. Recently,{{when}} ], a structurally novel NaSSA with an improved ] profile (e.g., no ] effects, etc.), has been developed.<ref name="pmid22178752">{{cite journal |vauthors=Millan MJ, Mannoury la Cour C, Chanrion B, etal | title = S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 340 | issue = 3 | pages = 750–64 |date=March 2012 | pmid = 22178752 | doi = 10.1124/jpet.111.187468 | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=22178752}}</ref><ref name="pmid22178753">{{cite journal |vauthors=Dekeyne A, Brocco M, Loiseau F, etal | title = S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 340 | issue = 3 | pages = 765–80 |date=March 2012 | pmid = 22178753 | doi = 10.1124/jpet.111.187534 | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=22178753}}</ref> It has completed preliminary ] and may go on to undergo ]s.


==See also== ==See also==

Revision as of 19:53, 21 February 2016

"Nassa" redirects here. For the sea snail genus, see Nassa (gastropod).
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron).

Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. They act by antagonizing the α2-adrenergic receptor and certain serotonin receptors such as 5-HT2A and 5-HT2C, but also 5-HT3, 5-HT6, and/or 5-HT7 in some cases. By blocking α2-adrenergic autoreceptors and heteroreceptors, NaSSAs enhance adrenergic and serotonergic neurotransmission in the brain involved in mood regulation, notably 5-HT1A-mediated transmission. In addition, due to their blockade of certain serotonin receptors, serotonergic neurotransmission is not facilitated in unwanted areas, which prevents the incidence of many side effects often associated with selective serotonin reuptake inhibitor (SSRI) antidepressants; hence, in part, the "specific serotonergic" label of NaSSAs.

List of NaSSAs

The NaSSAs include the following agents:

Notably, all of these compounds are analogues and are also classified as tetracyclic antidepressants (TeCAs) based on their chemical structures.

Recently, S32212, a structurally novel NaSSA with an improved selectivity profile (e.g., no antihistamine effects, etc.), has been developed. It has completed preliminary preclinical research and may go on to undergo clinical trials.

See also

References

  1. ^ Robert M. Julien (17 September 2004). A Primer Of Drug Action: A Comprehensive Guide To The Actions, Uses, And Side Effects Of Psychoactive Drugs. Macmillan. p. 286. ISBN 978-0-7167-0615-1. Retrieved 23 April 2012.
  2. ^ Robert E. Hales; Narriman C. Shahrokh; Alan F. Schatzberg; Charles B. Nemeroff (28 April 2009). Study Guide to Psychopharmacology: A Companion to the American Psychiatric Publishing Textbook of Psychopharmacology, Fourth Edition. American Psychiatric Pub. p. 202. ISBN 978-1-58562-354-9. Retrieved 23 April 2012.
  3. Bentham Science Publishers (August 1998). Current Pharmaceutical Design. Bentham Science Publishers. p. 298. Retrieved 23 April 2012.
  4. ^ Roland A. Carlstedt (14 December 2009). Handbook of Integrative Clinical Psychology, Psychiatry, and Behavioral Medicine: Perspectives, Practices, and Research. Springer Publishing Company. p. 290. ISBN 978-0-8261-1094-7. Retrieved 23 April 2012.
  5. Millan MJ, Mannoury la Cour C, Chanrion B, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization". The Journal of Pharmacology and Experimental Therapeutics. 340 (3): 750–64. doi:10.1124/jpet.111.187468. PMID 22178752.
  6. Dekeyne A, Brocco M, Loiseau F, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization". The Journal of Pharmacology and Experimental Therapeutics. 340 (3): 765–80. doi:10.1124/jpet.111.187534. PMID 22178753.

Further reading


Antidepressants (N06A)
Specific reuptake inhibitors and/or receptor modulators
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
Tricyclic and tetracyclic antidepressants
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Monoamine oxidase inhibitors
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Adjunctive therapies
Miscellaneous
Adrenergic receptor modulators
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
Serotonin receptor modulators
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Categories: