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Revision as of 17:00, 26 May 2018 editRexxS (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers43,075 edits →top: they are also unproven in any other animal by MEDRS standards← Previous edit Revision as of 17:01, 26 May 2018 edit undoRexxS (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers43,075 edits →top: this section is about mice, not humansNext edit →
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Evidence from two large studies in 2017 showed that the transfusion of blood from younger donors to older people was either no different from, or led to worse outcomes than, blood from older donors.<ref name=sbm>{{cite news|last1=Novella|first1=Steven|title=Parabiosis – The Next Snakeoil|url=https://sciencebasedmedicine.org/parabiosis-the-next-snakeoil/|work=Science-Based Medicine|date=3 August 2016}}</ref><ref name=Garraud2017>{{cite journal|last1=Garraud|first1=O|title=Younger blood from older donors: Admitting ignorance and seeking stronger data and clinical trials?|journal=Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis|date=August 2017|volume=56|issue=4|pages=635-636|doi=10.1016/j.transci.2017.07.002|pmid=28780993}}</ref> Research on blood transfusion outcomes has been complicated by the lack of careful characterization of the transfusion products that have been used in clinical trials; studies had focused on how storage methods and duration might affect blood, but not on the differences among lots of blood themselves.<ref>{{cite journal|last1=Ning|first1=S|last2=Heddle|first2=NM|last3=Acker|first3=JP|title=Exploring donor and product factors and their impact on red cell post-transfusion outcomes.|journal=Transfusion medicine reviews|date=January 2018|volume=32|issue=1|pages=28-35|doi=10.1016/j.tmrv.2017.07.006|pmid=28988603}}</ref> Evidence from two large studies in 2017 showed that the transfusion of blood from younger donors to older people was either no different from, or led to worse outcomes than, blood from older donors.<ref name=sbm>{{cite news|last1=Novella|first1=Steven|title=Parabiosis – The Next Snakeoil|url=https://sciencebasedmedicine.org/parabiosis-the-next-snakeoil/|work=Science-Based Medicine|date=3 August 2016}}</ref><ref name=Garraud2017>{{cite journal|last1=Garraud|first1=O|title=Younger blood from older donors: Admitting ignorance and seeking stronger data and clinical trials?|journal=Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis|date=August 2017|volume=56|issue=4|pages=635-636|doi=10.1016/j.transci.2017.07.002|pmid=28780993}}</ref> Research on blood transfusion outcomes has been complicated by the lack of careful characterization of the transfusion products that have been used in clinical trials; studies had focused on how storage methods and duration might affect blood, but not on the differences among lots of blood themselves.<ref>{{cite journal|last1=Ning|first1=S|last2=Heddle|first2=NM|last3=Acker|first3=JP|title=Exploring donor and product factors and their impact on red cell post-transfusion outcomes.|journal=Transfusion medicine reviews|date=January 2018|volume=32|issue=1|pages=28-35|doi=10.1016/j.tmrv.2017.07.006|pmid=28988603}}</ref>


== Mice ==
The evidence suggesting the treatment could be beneficial was based on research done on rodents at ] in which blood transfused from young mice seemed to invigorate older mice;<ref name=Garraud2017/> the circulatory systems of the mice were connected which put them in a state of ].<ref name=sbm/> In experiments like this, researchers found that some of these mice died quickly (11 out of 69 in one experiment) for reasons the scientists couldn't explain, but described as possibly some form of rejection.<ref name=sbm/> The evidence suggesting the treatment could be beneficial was based on research done on rodents at ] in which blood transfused from young mice seemed to invigorate older mice;<ref name=Garraud2017/> the circulatory systems of the mice were connected which put them in a state of ].<ref name=sbm/> In experiments like this, researchers found that some of these mice died quickly (11 out of 69 in one experiment) for reasons the scientists couldn't explain, but described as possibly some form of rejection.<ref name=sbm/>


Revision as of 17:01, 26 May 2018

Young blood transfusion refers to transfusing blood specifically from a young person into an older one with the intention of creating a medicinal benefit. The scientific community currently views the practice as little more than snake oil. Health claims are unproven

Evidence from two large studies in 2017 showed that the transfusion of blood from younger donors to older people was either no different from, or led to worse outcomes than, blood from older donors. Research on blood transfusion outcomes has been complicated by the lack of careful characterization of the transfusion products that have been used in clinical trials; studies had focused on how storage methods and duration might affect blood, but not on the differences among lots of blood themselves.

Mice

The evidence suggesting the treatment could be beneficial was based on research done on rodents at Stanford University in which blood transfused from young mice seemed to invigorate older mice; the circulatory systems of the mice were connected which put them in a state of parabiosis. In experiments like this, researchers found that some of these mice died quickly (11 out of 69 in one experiment) for reasons the scientists couldn't explain, but described as possibly some form of rejection.

Availability

A startup company, Ambrosia, has been selling "young blood transfusions" for $8,000 since 2017 under the guise of running a clinical trial, to see if such transfusions lead to changes in the blood of recipients. The startup was started by Jesse Karmazin an MD with out a license to practice medicine. Physician David Wright is involved with doing intravenous treatments of vitamins and antibiotics for "non traditional" purposes. A bioethicist from McGill suggests that Ambrosia is running this trial as they would be unable to get FDA approval to sell this treatment otherwise.

A company, Alkahest, was spun out of Stanford based on that work, and as of 2017 was collaborating with European pharmaceutical company Grifols to create a blood plasma-based experimental biologic drug, which they propose to test on people with Alzheimer's. Human trials are reported to be underway in China and Korea but with very little detail about what is actually involved.

References

  1. ^ Novella, Steven (3 August 2016). "Parabiosis – The Next Snakeoil". Science-Based Medicine.
  2. Robbins, Rebecca. "Young-Blood Transfusions Are on the Menu at Society Gala". Scientific American. Retrieved 26 May 2018.
  3. ^ Garraud, O (August 2017). "Younger blood from older donors: Admitting ignorance and seeking stronger data and clinical trials?". Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 56 (4): 635–636. doi:10.1016/j.transci.2017.07.002. PMID 28780993.
  4. Ning, S; Heddle, NM; Acker, JP (January 2018). "Exploring donor and product factors and their impact on red cell post-transfusion outcomes". Transfusion medicine reviews. 32 (1): 28–35. doi:10.1016/j.tmrv.2017.07.006. PMID 28988603.
  5. ^ de Magalhães, JP; Stevens, M; Thornton, D (November 2017). "The Business of Anti-Aging Science". Trends in biotechnology. 35 (11): 1062–1073. doi:10.1016/j.tibtech.2017.07.004. PMID 28778607. Open access icon
  6. Haynes, Gavin (21 August 2017). "Ambrosia: the startup harvesting the blood of the young". The Guardian. Retrieved 23 May 2018.
  7. ^ Maxmen, Amy. "This startup takes cash from aging adults in exchange for young people's blood". MIT Technology Review. Retrieved 26 May 2018.
  8. Drew, L (27 September 2017). "Neuroscience: The power of plasma". Nature. 549 (7673): S26 – S27. doi:10.1038/549S26a. PMID 28953857.
  9. Bercovici, Jeff. "Peter Thiel Is Very, Very Interested In Young People's Blood". Inc. Retrieved 5 May 2018.


Further reading

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