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Homeopathy (also homœopathy or homoeopathy; from the Greek ὅμοιος, hómoios, "similar" + πάθος, páthos, "suffering" or "disease") is described by its practitioners as a complementary and alternative medicine. Homeopathy was created in the late 18th century by German physician Samuel Hahnemann and laid out in his textbook, The Organon of the Healing Art.

Homeopathic remedies are made from substances that, in undiluted form, cause symptoms similar to the disease they aim to treat. These substances are repeatedly diluted, with shaking at each stage. Homeopaths believe that this procedure removes side-effects, "adds to their power to stimulate a response", and "develops the special properties of the remedy", even for substances that are chemically inert or so greatly diluted that none of the original substance remains. The therapeutic applications of the remedies used in homeopathy are recorded in homeopathic materia medica, and practitioners select treatments according to a patient consultation that explores both the physical and psychological state of the patient. Some homeopaths, who are a minority in the medical field, contend that many studies and meta-analyses have demonstrated that homeopathy has an effect other than placebo, and that placebo-controlled, randomized, and blinded clinical trials are not the best research tool to test homeopathic effects.

The ideas of homeopathy are scientifically implausible and its "theory is diametrically opposed to modern pharmaceutical knowledge." Claims for its efficacy beyond placebo are unsupported by the collective weight of scientific and clinical studies and it is considered to be pseudoscientific. A lack of convincing scientific evidence supporting its efficacy, and its contradiction of basic scientific principles have caused homeopathy to be regarded, in the words of a recent medical review, as "placebo therapy at best and quackery at worst".

The legal status of homeopathy varies from country to country, but homeopathic remedies are generally not tested and regulated under the same laws as conventional drugs. Usage is also variable and ranges from only two percent of people in Britain and the United States using homeopathy in any one year, to India, where homeopathy now forms part of traditional medicine and is used by approximately 15 percent of the population.

History

18th century medicine

At the time of the inception of homeopathy, the late 1700s, mainstream medicine employed such measures as bloodletting and purging, the use of laxatives and enemas, and the administration of complex mixtures, such as theriac, which was made from 64 substances including opium, myrrh, and viper's flesh. Such measures often worsened symptoms and sometimes proved fatal. While the virtues of these treatments had been extolled for centuries, Hahnemann rejected such methods as irrational and unadvisable. Instead, he favored the use of single drugs at lower doses and promoted an immaterial, vitalistic view of how living organisms function, believing that diseases have spiritual, as well as physical causes. (At the time, vitalism was part of mainstream science; in the twentieth century, however, medicine discarded vitalism, with the development of microbiology, the germ theory of disease, and advances in chemistry.) Hahnemann also advocated various lifestyle improvements to his patients, including exercise, diet, and cleanliness.

Hahnemann's conception of homeopathy

Samuel Hahnemann conceived of homeopathy while translating a medical treatise by Scottish physician and chemist William Cullen into German. He was skeptical of Cullen’s explanation of cinchona bark’s mechanism of action in treating malaria, so he decided to test its effects by taking it himself. Upon ingesting the bark, he experienced fever, shivering and joint pain, symptoms similar to some of the early symptoms of malaria, the disease that the bark was ordinarily used to treat. From this, Hahnemann came to believe that all effective drugs produce symptoms in healthy individuals similar to those of the diseases that they can treat. This later became known as the "law of similars", the most important concept of homeopathy. The term "homeopathy" was coined by Hahnemann and first appeared in print in 1807, although he began outlining his theories of "medical similars" in a series of articles and monographs in 1796.

Hahnemann began to test what effects substances produced in humans, a procedure which would later become known as "proving". These time-consuming tests required subjects to clearly record all of their symptoms as well as the ancillary conditions under which they appeared. Hahnemann saw this data as a way of identifying substances suitable for the treatment of particular diseases. The first collection of provings was published in 1805 and a second collection of 65 remedies appeared in his book, Materia Medica Pura, in 1810. Hahnemann believed that large doses of drugs that caused similar symptoms would only aggravate illness, and so he advocated extreme dilutions of the substances; he devised a technique for making dilutions that he believed would preserve a substance's therapeutic properties while removing its harmful effects,, proposing that this process aroused and enhanced "spirit-like medicinal powers held within a drug". He gathered and published a complete overview of his new medical system in his 1810 book, The Organon of the Healing Art, whose 6th edition, published in 1921, is still used by homeopaths today.

Rise to popularity and early criticism

During the 19th century homeopathy grew in popularity. In 1830, the first homeopathic schools opened, and throughout the 19th century dozens of homeopathic institutions appeared in Europe and the United States. Because of mainstream medicine's reliance on blood-letting and untested, often dangerous medicines, patients of homeopaths often had better outcomes than those of mainstream doctors. Homeopathic treatments, even if ineffective, would almost surely cause no harm, making the users of homeopathic medicine less likely to be killed by the medicine that was supposed to be helping them. The relative success of homeopathy in the 18th century may have led to the abandonment of the ineffective and harmful treatments of bloodletting and purging and to have begun the move towards more effective, scientific medicine.

In the early 19th century, homeopathy began to be criticized. Sir John Forbes, physician to Queen Victoria, said the extremely small doses of homeopathy were regularly derided as useless, laughably ridiculous and "an outrage to human reason." Professor Sir James Young Simpson said of the highly diluted drugs: "no poison, however strong or powerful, the billionth or decillionth of which would in the least degree affect a man or harm a fly." Nineteenth century American physician and author Oliver Wendell Holmes, Sr. was also a vocal critic of homeopathy and published an essay in 1842 entitled Homœopathy, and its Kindred Delusions. The last school in the U.S. exclusively teaching homeopathy closed down in 1920.

General philosophy

Homeopathy is a vitalist philosophy in that it regards diseases and sickness to be caused by disturbances in a hypothetical vital force or life force in humans and that these disturbances manifest themselves as unique symptoms. Homeopathy contends that the vital force has the ability to react and adapt to internal and external causes, which homeopaths refer to as the "law of susceptibility". The law of susceptibility states that a negative state of mind can attract hypothetical disease entities called "miasms" to invade the body and produce symptoms of diseases, However, Hahnemann rejected the notion of a disease as a separate thing or invading entity and insisted that it was always part of the "living whole".

Law of similars

Hahnemann observed from his experiments with Cinchona bark, used as a treatment of malaria, that the side effects he experienced from the quinine in the Cinchona bark were similar to the symptoms of malaria. He reasoned that treatments for diseases must produce symptoms similar to those of disease being treated when taken by healthy individuals. From this Hahnemann conceived of the "law of similars", otherwise known as "like cures like" (Template:Lang-la). Hahnemann believed that by inducing artificial symptoms of a disease, the artificial symptoms would create another disturbance in the vital force thus pushing out the old disturbance and that the body would naturally recover from the artificially induced disturbance. The basic idea is that to cure a person suffering from an illness, one should administer a dilute dose of a substance that produces the same symptoms of the illness being treated in healthy individuals.

Miasms and disease

Hahnemann found as early as 1816 that his patients who he treated through homeopathy still suffered from chronic diseases that he was unable to cure. In 1828, he introduced the concept of miasms, which he regarded as underlying causes for many known diseases. A miasm is often defined by homeopaths as an imputed "peculiar morbid derangement of our vital force." Hahnemann associated each miasm with specific diseases, with each miasm seen as the root cause of several diseases. According to Hahnemann, initial exposure to miasms causes local symptoms, such as skin or venereal diseases, but if these symptoms are suppressed by medication, the cause goes deeper and begins to manifest itself as diseases of the internal organs. Homeopathy contends that treating diseases by directly opposing their symptoms, as is sometimes done in conventional medicine, is not so effective because all "disease can generally be traced to some latent, deep-seated, underlying chronic, or inherited tendency." The underlying imputed miasm still remains, and deep-seated ailments can only be corrected by removing the deeper disturbance of the vital force.

Hahnemann's miasm theory remains disputed and controversial within homeopathy even in modern times. In 1978, Anthony Campbell, then a consultant physician at The Royal London Homeopathic Hospital, criticized statements by George Vithoulkas claiming that syphilis, when treated with antibiotics, would develop into secondary and tertiary syphilis with involvement of the central nervous system. This conflicts with scientific studies, which indicate that penicillin treatment produces a complete cure of syphilis in more than 90% of cases. Campbell described this as "a thoroughly irresponsible statement which could mislead an unfortunate layman into refusing orthodox treatment" and said that it was not an isolated case, but part of a lengthy section arguing against conventional medicine. This echoes the idea in homeopathy that using medication to suppress the symptoms of a disease would only drive the underlying disease deeper into the body.

Originally Hahnemann presented only three miasms, of which the most important was "psora" (Greek for itch), described as being related to any itching diseases of the skin, supposed to be derived from suppressed scabies, and claimed to be the foundation of many further disease conditions. Hahnemann claimed psora to be the cause of such diseases as epilepsy, cancer, jaundice, deafness, and cataracts. Since Hahnemann's time, other miasms have been proposed, some replacing one or more of psora's proposed functions, including tubercular miasms and cancer miasms.

Preparation of remedies

Dilution and succussion

It has been suggested that Arsenicum album and Misplaced Pages:Articles for deletion/Arsenicum album be merged into this article. (Discuss) Proposed since February 2008.

In producing treatments for diseases, homeopaths use a process called "dynamization" or "potentization" where the remedy is diluted into alcohol or water and then vigorously shaken by ten hard strikes against an elastic body in a process called "succussion". Hahnemann thought that the use of remedies which present symptoms similar to those of disease in healthy individuals would only intensify the symptoms and exacerbate the condition, so he advocated the dilution of the remedies to the point the symptoms were no longer experienced. During the process of potentization, homeopaths believe that the vital energy of the diluted substance is activated and its energy released by vigorous shaking of the substance. For this purpose, Hahnemann had a saddle maker construct a special wooden striking board covered in leather on one side and stuffed with horsehair. Insoluble solids, such as quartz and oyster shell, are diluted by grinding them with lactose (trituration).

Three potency scales are in regular use in homeopathy. Hahnemann pioneered and always favored the centesimal or "C scale", diluting a substance 1 part in a 100 of diluent at each stage. A 2C dilution is one where a substance is diluted to one part in one hundred, then one part of that diluted solution is diluted to one part in one hundred. This works out to one part of the original solution to ten thousand parts (100x100) of diluent. A 6C dilution repeats the process six times, ending up with one part in 1,000,000,000,000. (100x100x100x100x100x100, or 100) Other dilutions follow the same pattern. In homeopathy, a solution is described as higher potency the more dilute it is. Higher potencies - i.e. more dilute substances - are considered to be stronger deep-acting remedies.

Hahnemann advocated 30C dilutions for most purposes (a dilution by a factor of 10) and a common homeopathic treatment for the flu is a 200C dilution of duck liver, called Oscillococcinum in homeopathy. Comparing these levels of dilution to the number of molecules present in the initial solution, a 12C solution contains on average only about one molecule of the original substance. The chances of a single molecule of the original substance remaining in a 15C dilution would be roughly 1 in 2 million, and less than one in a billion billion billion billion (10) for a 30C solution. For a perspective on these numbers, there are in the order of 10 molecules of water in an Olympic size swimming pool and if such a pool were filled with a 15C homeopathic remedy, to expect to get a single molecule from the original substance, one would need to swallow 1% of the volume of such a pool, or roughly 25 metric tons of water.

For more perspective, 1ml of a solution which has gone through a 30C dilution would have been diluted into a volume of water equal to that of a cube of 1,000,000,000,000,000,000 meters per side, or about 106 light years. Thus, homeopathic remedies of the standard dilutions contain, with overwhelming probability, only water (or alcohol). Practitioners of homeopathy believe that this water retains some 'essential property' of the original substance, due to the shaking after each dilution. Hahnemann believed that the dynamization or shaking of the solution caused a "spirit like" healing force to be released from within the substance. He thought that even after every molecule of the previous substance has been removed from the water, the spiritual healing force still remained.

Some homeopaths developed a decimal scale (D or X), diluting the substance to ten times its original volume each stage. The D or X scale dilution is therefore half that of the same value of the C scale; for example, "12x" is the same level of dilution as "6C". Hahnemann never used this scale but it was very popular throughout the 19th century and still is in Europe. This potency scale appears to have been introduced in the 1830s by the American homeopath, Dr. Constantine Hering. In the last ten years of his life Hahnemann also developed a quintamillesimal (Q) or LM scale diluting the drug 1 part in 50,000 parts of diluent. A Q scale dilution is 2.35 times that of a C scale one, for example "20Q" is the same potency as "47C".

Not all homeopaths advocate extremely high dilutions. Many of the early homeopaths were originally doctors and generally tended to use lower dilutions such as "3x" or "6x", rarely going beyond "12x". A good example of this approach is that of Dr. Richard Hughes, who dismissed the extremely high dilutions as unnecessary. This was the dominant pattern in Europe throughout the 1820s to 1930s, but in America many practitioners developed and preferred the higher dilutions. This trend became especially exemplified by James Tyler Kent and dominated US homeopathy from the 1850s until its demise in the 1940s. The split between lower and higher dilutions also followed ideological lines with the former stressing pathology and a strong link to conventional medicine, while the latter emphasized vital force, miasms and a spiritual take on sickness. From a modern regulatory viewpoint, any product that contains detectable levels of active ingredients cannot be classified as a homeopathic remedy.

Coverage in the mainstream press

The BBC's Horizon and American Broadcasting Company's (ABC) 20/20 broadcast programs describing scientific testing of homeopathic dilutions that were unable to differentiate these dilutions from water.

Provings

In order to determine which specific remedies could be used to treat which diseases, Hahnemann experimented on himself for several years as well as with patients. His experiments did not initially consist of giving remedies to the sick, because he thought that the most similar remedy, by virtue of its ability to induce symptoms similar to the disease itself, would make it impossible to determine which symptoms came from the remedy and which from the disease itself. Therefore, sick people were excluded from the provings. The method used for determining which remedies were suitable for specific diseases was called "proving". A homeopathic proving is the method by which the profile of a homeopathic remedy is determined. The word 'proving' derives from the German word 'Prüfung' meaning 'test'.

During the process of proving, Hahnemann used healthy volunteers who were given remedies, often in molecular doses, and the resulting symptoms were compiled by observers into a "Drug Picture". During the process the volunteers were observed for months at a time and were made to keep extensive journals detailing all of their symptoms at specific times during the day. During the tests volunteers were forbidden from consuming coffee, tea, spices, or wine. They were also not allowed to play chess, because Hahnemann considered it to be "too exciting", however they were allowed to drink beer and were encouraged to moderately exercise. After the experiments were over, Hahnemann made the volunteers offer their hands and take an oath swearing that what they reported in their journals was the truth, at which time he would interrogate them extensively concerning their symptoms.

Provings have been described as important in the development of the clinical trial, due to their early use of simple control groups, systematic and quantitative procedures, and some of the first application of statistics in medicine. The lengthy records of self-experimentation by homeopaths have occasionally proven useful in the development of modern drugs: For example, evidence nitroglycerin might be useful as a treatment for angina was discovered by looking through homeopathic provings, though homeopaths themselves never used it for that purpose at that time. The first recorded provings were published by Hahnemann in his 1796 Essay on a New Principle. His Fragmenta de viribus (1805) contained the results of 27 provings, and his 1810 Materia Medica Pura contained 65. 217 remedies underwent provings for James Tyler Kent's 1905 Lectures on Homoeopathic Materia Medica, and newer substances are continually added to contemporary versions.

Repertory

A compilation of reports of many homeopathic provings is known as a homeopathic materia medica. In practice the usefulness of such a compilation is limited because a practitioner does not need to look up the symptoms for a particular remedy, but rather to explore the remedies for a particular symptom. This need is filled by the homeopathic repertory, which is an index of symptoms, listing after each symptom those remedies that are associated with it. Repertories are often very extensive and may include data from clinical experience in addition to provings. There is often lively debate among the compilers of a repertory and interested practitioners over the veracity of a particular inclusion. The first symptomatic index of the homeopathic materia medica was arranged by Hahnemann. Soon after, one of his students Clemens von Bönninghausen, created the Therapautic Pocket Book, another homeopathic repertory. The first such Homeopathic Repertory was Dr. George Jahr's Repertory, published in 1835 in German and then again in 1838 in English and edited by Dr. Constantine Hering. This version was less focused on disease categories and would be the forerunner to Kent's later works. It consisted of three large volumes. Such repertories increased in size and detail as time progressed.

Treatments

Homeopathic treatments generally begin with a detailed examinations of their patients' histories, including questions regarding their physical, mental and emotional states, their one's life circumstances and any physical/emotional illnesses. The homeopath then translates this information into a complex formula of mental and physical symptoms, including likes, dislikes, innate predispositions and even body type. The goal is to develop a comprehensive representation of each individual's overall health. This information can then be compared with similar established data in the drug provings found in the homeopathic materia medica. Assisted by further dialogs with the patient, the homeopath then aims to find the one drug most closely matching the 'symptom totality' of the patient. There are many methods for determining the most-similar remedy (the simillimum), and homeopaths sometimes disagree. This is partly due to the complexity of the "totality of symptoms" concept. That is, homeopaths do not use all symptoms, but decide which are the most characteristic. This subjective evaluation of case analysis relies on knowledge and experience of the homeopath doing the diagnosis.

Some diversity in approaches to treatments exists among homeopaths. So called "classical" homeopathy generally involves detailed examinations of a patient's history and infrequent doses of a single remedy as the patient is monitored for improvements in symptoms. On the other hand, "clinical" homeopathy uses a range of approaches including combinations of remedies to "cover" the various symptoms of an illness, similar to conventional drug treatments.

Remedies

"Remedy" is a technical term used in homeopathy to refer to a substance prepared with a particular procedure and intended for treating patients. Homeopathic practitioners rely on two types of reference when prescribing remedies. The Homeopathic Materia Medicae which is comprised of alphabetical indexes of "drug pictures" organized by remedy and describe the symptom patterns associated with individual remedies. They also rely on homeopathic repertories which consist of indexes of symptoms of diseases and listing remedies associated with specific symptoms.

Homeopathy uses many animal, plant, mineral, and synthetic substances in its remedies. Examples include Natrum muriaticum (sodium chloride or table salt), Lachesis muta (the venom of the bushmaster snake), Opium, and Thyroidinum (thyroid hormone). Homeopaths also use treatments called nosodes (from the Greek nosos, disease) made from diseased or pathological products such as fecal, urinary, and respiratory discharges, blood, and tissue. Homeopathic remedy prepared from healthy specimens are called Sarcodes.

Some modern homeopaths have considered more esoteric substances, known as "imponderables" because they do not originate from a material but from electromagnetic energy presumed to have been "captured" by alcohol or lactose. Examples include X-rays, sunlight, and electricity. Recent ventures by homeopaths into even more esoteric substances include thunderstorms (prepared from collected rainwater). Today there are about 3,000 different remedies commonly used in homeopathy. Some homeopaths also use techniques that are regarded by other practitioners as controversial. These include paper remedies, where the substance and dilution are written on a piece of paper and either pinned to the patient's clothing, put in their pocket, or placed under a glass of water that is then given to the patient, as well as the use of radionics to prepare remedies. Such practices have been strongly criticized by classical homeopaths as unfounded, speculative and verging upon magic and superstition.

Isopathy

Isopathy is a therapy derived from homeopathy and was invented by Johann Joseph Wilhelm Lux in the 1830s. Isopathy differs from homeopathy in general in that the remedies are made up either from things that cause the disease, or from products of the disease, such as pus. Many so-called "homeopathic vaccines" are a form of isopathy.

Tautopathy

Tautopathy is a practice of alternative medicine that is similar to homeopathy in that it uses very diluted substances to treat illness. However, tautopathy does not rely on the "law of similars", as homeopathy does. According to practitioners of Tautopathy, dilute solutions of lead and arsenic can cause the body to secrete excess amounts of these toxic metals.

Flower remedies

Flower remedies are produced by placing flowers in water and exposing them to sunlight. The most famous of these are the Bach flower remedies, which were developed by the homeopath Edward Bach. The relationship between these remedies and homeopathy is controversial. On the one hand, the proponents of these remedies share homeopathy's vitalist world-view and the remedies are claimed to act through the same hypothetical vital force. However, although many of the same plants are used as in homeopathy, flower remedies are used undiluted. There is no convincing scientific or clinical evidence for flower remedies being effective.

Veterinary homeopathy

Veterinary homeopathy is the term used to describe the treatment of animals with homeopathy. The idea of using homeopathy as a treatment for other animals dates back to the inception of homeopathy as Hahnemann himself wrote and spoke of the use of homeopathy in animals other than humans. In the USA veterinary homeopathy is used by veterinarian members of the Academy for Veterinary Homeopathy and/or the American Holistic Veterinary Medical Association. In the UK, veterinary surgeons who use homeopathy belong to the Faculty of Homeopathy and/or to the British Association of Homeopathic Veterinary Surgeons. Animals may only be treated by qualified veterinary surgeons in the UK and some other countries. Internationally, the body that supports and represents homeopathic veterinarians is the International Association for Veterinary Homeopathy. The use of homeopathy in veterinary medicine is controversial, as there has been little scientific investigation and current research in the field is not of a high enough standard to provide reliable data. Other studies have also found that giving animals placebos can play active roles in influencing pet owners to believe in the effectiveness of the treatment when none exists.

Medical and scientific analysis

Homeopathy is unsupported by modern scientific research. The extreme dilutions used in homeopathic preparations usually leave none of the active ingredient (no atoms, ions or molecules) in the final product. The idea that any biological effects could be produced by these preparations is inconsistent with the observed dose-response relationships of conventional drugs. The proposed rationale for these extreme dilutions - that the water contains the "memory" or "vibration" from the diluted ingredient - is also counter to the laws of chemistry and physics. Thus critics contend that any positive results obtained from homeopathic remedies are purely due to the placebo effect, where the patient's subjective improvement of symptoms is based solely on the patient expecting that it will work. Critics cite the lack of viable scientific studies for the effectiveness of homeopathic remedies as evidence that they are not effective and that any positive effects are due to the placebo effect. Critics also contend that homeopathy is inherently dangerous, because homeopaths offer a false hope that may discourage or delay proper treatment.

High dilutions

The extremely high dilutions in homeopathy have been a main point of criticism. Homeopaths believe that the methodical dilution of a substance, beginning with a 10% or lower solution and working downwards, with shaking after each dilution, produces a therapeutically active "remedy", in contrast to therapeutically inert water. However, homeopathic remedies are usually diluted to the point where there are no molecules from the original solution left in a dose of the final remedy. Since even the longest-lived noncovalent structures in liquid water at room temperature are only stable for a few picoseconds, critics have concluded that any effect that might have been present from the original substance can no longer exist. Furthermore, since water will have been in contact with millions of different substances throughout its history, critics point out that any glass of water is therefore an extreme dilution of almost any conceivable substance, and so by drinking water one would, according to homeopathic principles, receive treatment for every imaginable condition. Proponents of homeopathy, including Rustum Roy, maintain that water has a memory effect beyond the presence of individual molecules of the dissolved substance but this is unsupported by experimental evidence.

Homeopathy contends that higher dilutions (fewer potential molecules in each dose) result in stronger medicinal effects. This idea is inconsistent with the observed dose-response relationships of conventional drugs, where the effects are dependent on the concentration of the active ingredient in the body. This dose-response relationship has been confirmed in thousands of experiments on organisms as diverse as nematodes, rats and humans.

Physicist Robert L. Park, former executive director of the American Physical Society, has noted that "since the least amount of a substance in a solution is one molecule, a 30C solution would have to have at least one molecule of the original substance dissolved in a minimum of 1,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 molecules of water. This would require a container more than 30,000,000,000 times the size of the Earth." Park has also noted that "to expect to get even one molecule of the "medicinal" substance allegedly present in 30X pills, it would be necessary to take some two billion of them, which would total about a thousand tons of lactose plus whatever impurities the lactose contained." The laws of chemistry state that there is a limit to the dilution that can be made without losing the original substance altogether. This limit, which is related to Avogadro's number, corresponds to homeopathic potencies of 12C or 24X (1 part in 1,000,000,000,000,000,000,000,000).

Research on medical effectiveness

The medical effectiveness of homeopathy has been a point of contention since its inception, and researchers have subjected the system to close scrutiny. One of the earliest studies concerning homeopathic medicine was sponsored by the British government during World War II in which volunteers tested the effectiveness of homeopathic remedies against diluted mustard gas burns. More recent controlled clinical trials on homeopathy have shown poor results, showing a slight to no difference between homeopathic remedies and placebo.

Meta-analyses, which analyze large groups of studies and draw conclusions based on the results as a whole, have been used to evaluate the effectiveness of homeopathy. Early meta-analyses investigating homeopathic remedies showed slightly positive results among the studies examined, however such studies have warned that it was impossible to draw conclusions due to low methodological quality and difficulty in controlling for publication bias in the studies reviewed,. One of the positive metaanalyses, by Linde, et al, was later corrected by the authors, who wrote:

The evidence of bias weakens the findings of our original meta-analysis. Since we completed our literature search in 1995, a considerable number of new homeopathy trials have been published. The fact that a number of the new high-quality trials... have negative results, and a recent update of our review for the most “original” subtype of homeopathy (classical or individualized homeopathy), seem to confirm the finding that more rigorous trials have less-promising results. It seems, therefore, likely that our meta-analysis at least overestimated the effects of homeopathic treatments.

A recent meta-analysis of clinical trials on the effectiveness of homeopathy has shown that earlier clinical trials showed signs of major weakness in methodology and reporting, and that homeopathy trials were less randomized and reported less on dropouts than other types of trials.

In 2005 The Lancet medical journal published a meta-analysis of 110 placebo-controlled homeopathy trials and 110 matched conventional-medicine trials based upon the Swiss government's Program for Evaluating Complementary Medicine, or PEK. The study concluded that its findings were compatible with the notion that the clinical effects of homeopathy are nothing more than placebo effects.

A 2006 meta-analysis of six trials evaluating homeopathic treatments to reduce cancer therapy side effects following radiotherapy and chemotherapy found "encouraging but not convincing" evidence in support of homeopathic treatment, however variability in the methodological quality of the six studies provided "insufficient evidence to support clinical efficacy of homeopathic therapy in cancer care."

Since homeopathic remedies at dilutions higher than about D23 (10) contain no ingredients apart from the diluent (water, alcohol or sugar), there is no chemical basis for them to have any medicinal action. Newer randomized, double-blind, placebo-controlled trials using highly-diluted homeopathic preparations also fail to find clinical effects of the substances.

The Cochrane Library found insufficient clinical evidence to evaluate the efficacy of homeopathic treatments for asthma or dementia, or recommend the use of homeopathy in induction of labor. Other researchers found no evidence that homeopathy is beneficial for osteoarthritis, migraines or delayed-onset muscle soreness.

Health organizations such as UK's National Health Service, the American Medical Association, and the FASEB have issued statements of their conclusion that there is no convincing scientific evidence to support the use of homeopathic treatments in medicine.

Clinical studies of the medical efficacy of homeopathy have been criticized by some homeopaths as being irrelevant because they do not test "classical homeopathy". There have, however been a number of clinical trials that have tested individualized homeopathy. A 1998 review found 32 trials that met their inclusion criteria, 19 of which were placebo-controlled and provided enough data for meta-analysis. These 19 studies showed a pooled odds ratio of 1.17 to 2.23 in favor of individualized homeopathy over the placebo, but no difference was seen when the analysis was restricted to the methodologically best trials. In conclusion, the evidence was described as suggestive but "not convincing because of methodological shortcomings and inconsistencies".

Dr. Jack Killen, acting deputy director of the National Center for Complementary and Alternative Medicine, says homeopathy "goes beyond current understanding of chemistry and physics." He adds: "There is, to my knowledge, no condition for which homeopathy has been proven to be an effective treatment."

Research on effects in other biological systems

While some articles have suggested that homeopathic solutions of high dilution can have statistically significant effects on organic processes including the growth of grain, histamine release by leukocytes, and enzyme reactions, such evidence is disputed since attempts to replicate them have failed.

In 1987, French immunologist Jacques Benveniste submitted a paper to the journal Nature while working at INSERM. The paper purported to have discovered that basophils released histamine when exposed to a homeopathic dilution of anti-immunoglobulin E, a type of white blood cell. The journal editors, skeptical of the results, requested that the study be replicated in a separate laboratory. Upon replication in four separate laboratories the study was published. Still skeptical of the findings, Nature assembled an independent investigative team to determine the accuracy of the research, consisting of Nature editor and physicist Sir John Maddox, American scientific fraud investigator and chemist Walter Stewart, and skeptic and magician James Randi. After investigating the findings and methodology of the experiment, the team found that the experiments were "statistically ill-controlled", "interpretation has been clouded by the exclusion of measurements in conflict with the claim", and concluded "We believe that experimental data have been uncritically assessed and their imperfections inadequately reported." James Randi stated that he doubted that there had been any conscious fraud, but that the researchers had allowed "wishful thinking" to influence their interpretation of the data.

Ethical and safety issues

As homeopathic remedies usually contain often only water and/or alcohol, they are thought to be generally safe. Only in rare cases are the original ingredients present at detectable levels. However, in one case, an unusually undiluted (1:100 or "2X") solution of zinc gluconate, marketed as Zicam Nasal Spray, allegedly caused a small percentage of users to lose their sense of smell. There were 340 cases settled out of court for 12 million U.S. dollars.

Homeopaths are also accused of giving 'false hope' to patients who might otherwise seek effective conventional treatments. Many homeopaths advise against standard medical procedures such as vaccination, and some homeopaths even advise against the use of anti-malarial drugs.

However, critics of homeopathy have cited other concerns over homeopathic remedies, most seriously, cases of patients of homeopathy failing to receive proper treatment for diseases that could be diagnosed or cured with modern medicine. Surveys have shown that homeopathic practitioners often advise their patients against receiving immunization for diseases. Modern homeopathic practitioners also use their own vaccines, which they refer to as "nosodes", created from dilutions of biological agents - including material such as vomit, feces or infected human tissues. While Hahnemann was opposed to such preparations, modern homeopaths often use them and there is no evidence to suggest they have any beneficial effects. Cases of homeopaths advising against the use of anti-malarial drugs have been identified. This puts visitors to the tropics who take this advice in severe danger, since homeopathic remedies are completely ineffective against the malaria parasite. Also, in one case in 2004, a homeopath instructed one of his patients to stop taking conventional medication for a heart condition, writing in his advice: "She just cannot take ANY drugs – I have suggested some homeopathic remedies. I feel confident that if she follows the advice she will regain her health." The patient suffered a fatal heart attack four months later, caused by this stoppage of her medication.

In 1978, Anthony Campbell, then a consultant physician at The Royal London Homeopathic Hospital, criticized statements made by George Vithoulkas to promote his homeopathic treatments. Vithoulkas stated that syphilis, when treated with antibiotics, would develop into secondary and tertiary syphilis with involvement of the central nervous system. Campbell described this as a thoroughly irresponsible statement which could mislead an unfortunate layman into refusing orthodox treatment. This claim echoes the idea that treating a disease with external medication used to treat the symptoms would only drive it deeper into the body and conflicts with scientific studies, which indicate that penicillin treatment produces a complete cure of syphilis in more than 90% of cases.

Critics also contend that it is inherently unethical to provide homeopathic remedies to patients when the effectiveness of homeopathy is clearly unproven. Critics also assert that all homeopathic patients or clients should be fully informed of the lack of convincing experimental support for the effectiveness of homeopathy, prior to being given the remedies. Critics also state that it is unethical to employ unsupported and unproven remedies such as homeopathy when modern alternatives are genuinely effective.

Prevalence and legal trends

Homeopathic medicine is fairly common in some countries while uncommon in others and is also highly regulated in some countries while fairly unregulated in others. Regulations vary in Europe depending on the country. In some countries, there are no specific legal regulations concerning the use of homeopathy, while in others, licenses or degrees in conventional medicine from accredited universities are required. In Austria and Germany, no specific regulations exist, while France and Denmark mandate licenses to diagnose any illness or dispense of any product whose purpose is to treat any illness. Some homeopathic treatment is covered by the national insurance coverage of several European countries, including France, the United Kingdom, Denmark, and Luxembourg. In other countries, such as Belgium, homeopathy is not covered. In Austria, public insurance requires scientific proof of effectiveness in order to reimburse medical treatments, but exceptions are made for homeopathy. Two countries which formerly offered homeopathy under their public health insurance schemes have withdrawn this privilege. At the start of 2004, homeopathic medications, with some exceptions, were no longer covered by German public health insurance, and in June 2005, the Swiss Government, after a 5-year trial, withdrew insurance coverage for homeopathy and four other complementary treatments, stating that they did not meet efficacy and cost-effectiveness criteria, though additional insurance can be bought to cover such treatments provided by a medical doctor.

Outline of past prevalence in Great Britain

In Britain homeopathy was first established by Dr. Frederick Quin around 1827, although two Italian homeopathic doctors (Drs Romani and Roberta) had been employed two years previously by the Earl of Shrewsbury based at Alton Towers in North Staffordshire. Homeopathy in Britain quickly became the preferred medical treatment of the upper classes, as well as the aristocracy and retained an elite clientele, including members of the royal family.

At its peak in the 1870s, Britain had numerous homeopathic dispensaries and small hospitals as well as large busy hospitals in Liverpool, Birmingham, Glasgow, London and Bristol.

Contemporary prevalence

The largest organization of homeopaths in Britain, the Society of Homeopaths, was founded in 1978 and the Faculty of Homeopathy, which is based in London, has over 1,400 members and was incorporated by an Act of Parliament in 1950. According to a 2006 study, forty nine percent of Scottish medical practices prescribed homeopathic remedies. During the study period, 0.22% of patients were prescribed at least one homeopathic remedy, with children making up 16 percent of the population prescribed homeopathic remedies (0.22% of the total registered patients at that age). The study concluded that critical review of Homeopathy's role in the Scottish branch of the national health care system was needed. The NHS currently operates five homeopathic hospitals.

In Australia, according to one study, about 4.4% of Australian adults have used homeopathic remedies at least once in their lives and only about 1.2% sought help exclusively from homeopathic practitioners. In Canada, a study detailing the use of alternative medicines by children in Quebec found that 11% of the sample of 1911 children used alternative medicines and 25% of those who did use alternative medicines used homeopathy. The study also pointed out that homeopathy is more commonly used in children in Canada than in adults, 19% of whom used alternative medicine used homeopathy. Homeopathy is not officially recognized by Federal Food and Drug Act in Canada and physicians who choose to use alternative medicines such as Homeopathy must follow guidelines set by their province's College of Physicians and Surgeons. Provincial health care generally doesn't cover homeopathy.

Some countries in South America, such as Argentina, allow only professional doctors who are qualified and have graduated from a recognized medical school to practice homeopathy. Homeopathy has been regulated in other South American countries, such as Colombia, since the beginning of the 20th century. In Brazil, Homeopathy is included in the national health system and since 1991, physicians who want to practice homeopathy must complete 2,300 hours of education prior to receiving the proper licenses. In Mexico, Homeopathy is currently integrated into the national health care system. In 1985, a presidential decree established the first homeopathic school as well as regulations specifying training requirements for homeopathic doctors. In Mexico, of the individuals who use complementary alternative medicines, over 26% use Homeopathy.

In the United States homeopathy is much less common, where the percentage of people seeking homeopathic treatment declined from 3.4% in 1997 to 1.7% in 2002. Homeopathy was first established in the United States by Dr Hans Burch Gram in 1825 and rapidly gained popularity, partly because conventional medicine of the time was inherently dangerous and risky. The height of its influence was the end of the 19th century where hardly any city with over 50,000 people was without a homeopathic hospital. In 1890 there were 93 regular schools, 14 of them were fully homeopathic and 8 of them were eclectic and in 1900 there were 121 regular schools and 22 of them were homeopathic and 10 eclectic. The use of homeopathy in the United States among adults is about 0.3%. According to one study, in 1990, 0.7% of individuals used homeopathy in the past year of being questioned; in 1997, 3.4% had used homeopathy at least once in the previous year. According to the same study, of those who used homeopathy, 31.7% had seen a homeopathic practitioner in the past year in 1990 and the number dropped to 16.5 by 1997.

In the United States, homeopathic remedies, like all health-care products, are regulated by the Food and Drug Administration. However, the FDA treats homeopathic remedies very differently than conventional medicines. Homeopathic products do not need FDA approval before sale; they do have to be proven safe since the Dietary Supplement Health and Education Act of 1994, any products prior to 1994 may or may not have been tested for safety, but they do not have to prove efficacy; they do not have to be labeled with an expiration date; and they do not have to undergo finished product testing to verify contents and strength, all of these are voluntary actions done by the manufacturer. The manufacturer is required to have all ingredients on the label; however, it might not specify which ones are active. In the USA, only homeopathic medicines that claim to treat self-limiting conditions may be sold over the counter; homeopathic medicines that claim to treat a serious disease can be sold only by prescription. A memorandum, written in 1985 by attorneys for the American Association of Homeopathic Manufacturers, describes a meeting between the AAHP attorneys and high-ranking FDA officials to discuss whether homeopathic products must be proven effective to remain legally marketable. Such negotiations led to the issuance in 1988 (revised in 1995) of an FDA Compliance Policy Guide that permits homeopathic products "intended solely for self-limiting disease conditions amenable to self-diagnosis (of symptoms) and treatment" to be marketed as nonprescription drugs. In 2001, the FDA published a comprehensive review of mercury compounds in homeopathic drugs. This report indicated that nearly all examined compounds derived from the use of mercury. However, due to the extreme dilution of materials, the presence of mercury in the finished product would be minimal. At present the FDA Health Fraud Division only pursues claims which may cause direct harm to consumers through their use. Homeopathic drugs, largely regarded as equivalent to placebos, are not considered under these guidelines. Due to the significant dilution of the products, the agents become practically immeasurable: the harmful effects of homeopathic drugs is more likely to be that patients avoid conventional treatments.

In Asia, the use of homeopathic treatments is increasing, especially in India. Homeopathy arrived in India with Dr John Martin Honigberger in Lahore, in 1829–1830. India has the largest homeopathic infrastructure in the world, with low estimates at about 64,000, but going as high as 300,000 practicing homeopaths. In addition, there are 180 colleges teaching courses, and 7500 government clinics and 307 hospitals which dispense homeopathic remedies. In Malaysia, homeopathy was introduced during World War II and was brought by Indians via the British army. There is no legislation governing homeopathy in Malaysia and only a few medical doctors are involved in homeopathic treatments. In South Africa, homeopathy is regulated by the Associated Health Service Professions Act of 1982, which was set up to provide a registration and licensing framework for health professions. During the 1960s, all homeopathic colleges were closed by the South African Medical Council. However, conventional medical doctors retained the right to use homeopathic treatments.

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External links

• Homeopathy: Real Medicine or Empty Promises? – Food and Drug Administration report
• HomeoWatch: A Guide to Homeopathic History, Theories, and Current Practices – Stephen Barrett
• The Scientific Evidence on Homeopathy – Article from the American Council on Science and Health
• Homeopathy Explained – Video (14 min 34 sec) – Portion of James Randi's 2001 Princeton lecture. (Complete 2 hr 10 min 43 sec lecture.)
• Wilhelm Ameke, History of Homœopathy, with an appendix on the present state of University medicine, translated by A. E. Drysdale, edited by R. E. Dudgeon, London: E. Gould & Son, 1885

• Articles with dead external links from December 2007
• Misplaced Pages neutral point of view disputes from February 2008
• Articles to be merged from February 2008
• Misplaced Pages articles needing factual verification from January 2008
• Alternative medical systems
• Alternative medicine
• Pseudoscience
• Homeopathy
• Fringe science