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| IUPAC name Ethyl N-(aminoiminomethyl)-N-methylglycine | |
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| Properties | |
| Chemical formula | C6H13N3O2 |
| Molar mass | 159.19 g/mol |
| Acidity (pKa) | 2.67, 11.2, 6 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
 N verify (what is ?)
Infobox references
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Creatine ethyl ester, also known as creatine ester, cre-ester and CEE, is a substance sold as an aid for athletic performance and for muscle development in bodybuilding. It is an ethyl ester derivative of creatine, from which it is made. In the body, CEE is converted back into creatine. CEE is said to have a much better absorption rate and a longer half-life in the body than regular creatine monohydrate, because it is slightly more lipophilic. It is also proposed to bypass the creatine transporter, thereby increasing skeletal muscle uptake of creatine and leading to an increased ability to regenerate ATP. However, in a published study comparing the two, CEE was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power.
Research published in 2013 found that creatine ethyl ester is likely to be no better than taking Creatine. This report has been misconstrued, due to the fact that it measured the amount of creatine produced by the body after consumption. Physiological aspects have to be taken into account also, as different people can have different levels of the substance in their system. It found that the levels of Creatine found after consumption of CEE than that of taking standard creatine was actually the same. The report does not mention the benefits of CEE in comparison though, such as it takes far lower doses to create those levels, is absorbed quicker and lasts longer in the system than that of standard Creatine powders and pills.
As a supplement, the compound was developed, patented and licensed through UNeMed, the technology transfer entity of the University of Nebraska Medical Center, and is sold under numerous brand names.
See also
References
- Spillane, Mike; Schoch, Ryan; Cooke, Matt; Harvey, Travis; Greenwood, Mike; Kreider, Richard; Willoughby, Darryn S (2009). "The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels". Journal of the International Society of Sports Nutrition. 6: 6. doi:10.1186/1550-2783-6-6. PMC 2649889. PMID 19228401.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Katseres, Nicholas S.; Reading, David W.; Shayya, Luay; Dicesare, John C.; Purser, Gordon H. (2009). "Non-enzymatic hydrolysis of creatine ethyl ester". Biochemical and Biophysical Research Communications. 386 (2): 363–7. doi:10.1016/j.bbrc.2009.06.037. PMID 19524547.
- "Analysis of Creatine Ethyl Ester: TU researchers bust myth on popular nutritional supplement". University of Tulsa.