Misplaced Pages

Talk:Pneumonia

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

This is an old revision of this page, as edited by Editor3456123123 (talk | contribs) at 00:26, 11 May 2022 (→Semi-protected edit request on 10 May 2022: new section). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 00:26, 11 May 2022 by Editor3456123123 (talk | contribs) (→Semi-protected edit request on 10 May 2022: new section)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
Skip to table of contents
This is the talk page for discussing improvements to the Pneumonia article.
Article policies
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL
Archives: 1Auto-archiving period: 12 months 

Template:Vital article

          Other talk page banners
Former featured articlePneumonia is a former featured article. Please see the links under Article milestones below for its original nomination page (for older articles, check the nomination archive) and why it was removed.
Good articlePneumonia has been listed as one of the Natural sciences good articles under the good article criteria. If you can improve it further, please do so. If it no longer meets these criteria, you can reassess it.
Main Page trophyThis article appeared on Misplaced Pages's Main Page as Today's featured article on December 4, 2005.
Article milestones
DateProcessResult
September 19, 2005Peer reviewReviewed
November 9, 2005Peer reviewReviewed
November 19, 2005Featured article candidatePromoted
August 17, 2009Featured article reviewDemoted
November 25, 2012Good article nomineeListed
Current status: Former featured article, current good article
This article is substantially duplicated by a piece in an external publication. Since the external publication copied Misplaced Pages rather than the reverse, please do not flag this article as a copyright violation of the following source:
Additional comments
Extensive copy and pastes of large sections of Misplaced Pages without appropriate attribution or release under the appropriate license.
This article has not yet been rated on Misplaced Pages's content assessment scale.
It is of interest to the following WikiProjects:
Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.
WikiProject iconMedicine: Translation / Pulmonology Top‑importance
WikiProject iconThis article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Misplaced Pages talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine
TopThis article has been rated as Top-importance on the project's importance scale.
Taskforce icon
This article is supported by the Translation task force (assessed as Top-importance).
Taskforce icon
This article is supported by the Pulmonology task force (assessed as Top-importance).
Note icon
This article was selected on the Medicine portal as one of Misplaced Pages's best articles related to Medicine.
Note icon
This article is currently the Medicine Collaboration of the Month.
Template:WP1.0
Ideal sources for Misplaced Pages's health content are defined in the guideline Misplaced Pages:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Pneumonia.


Archives

1


This page has archives. Sections older than 365 days may be automatically archived by Lowercase sigmabot III when more than 10 sections are present.

Links about Coronavirus as cause

at link 11 https://pubmed.ncbi.nlm.nih.gov/21435708/

It says that infections comes together bacterial and viral. But on virus infection, it gives feel like, viruses can cause pneumonia.

"Dual viral infections are common, and a third of children have evidence of viral-bacterial co-infection. In adults, viruses are the putative causative agents in a third of cases of community-acquired pneumonia, in particular influenza viruses, rhinoviruses, and coronaviruses. Bacteria continue to have a predominant role in adults with pneumonia."

On page, there are no clear understanding of a thing. The last sentence says, the bacterial infections are dominant.

Nowdays, because of "corona pandemic" maybe not. I tend not to believe for governments, because of lack pictures of the virus in public domain. Today EM microscopes can easily make resolution of 0.1 nm, what about some virus that 100 nm?

It should be checked twice links. — Preceding unsigned comment added by 2A00:A040:198:313F:9495:E07C:68C3:D47D (talk) 02:14, 13 April 2020 (UTC)

I'm not entirely sure what you are asking, but bacteria are the most common cause of Pneumonia in general. In infants and toddlers, RSV is generally the most common cause. The link you provided isn't contradicting itself. Dual infections often happen with viral infections leading to a bacterial infection as well. I'm not sure if that is what you are confused about? Battykin (talk) 23:00, 5 May 2020 (UTC)

"Necrotizing pneumonia" listed at Redirects for discussion

An editor has asked for a discussion to address the redirect Necrotizing pneumonia. Please participate in the redirect discussion if you wish to do so.  — Mr. Guye (talk) (contribs)  01:42, 29 April 2020 (UTC)

Limitations on diagnosis

Mikalra added the Jain 2015 NEJM study which showed the limitations of advanced diagnostics in determining the aetiology of CAP (doi:10.1056/NEJMoa1500245). This study, while groundbreaking, does not comply with WP:MEDRS. Currently the observation on this problem is cited in the body of the article to a source called EBMED05, which is now 15 years old and should be updated in line with MEDRS.

Oddly the updated ATS guideline does not discuss the poor yield of investigations, but the Jain study is cited in doi:10.1097/MCP.0000000000000671. I'm sure this would be a good alternative to EBMED05 for this information as well as some other bits. JFW | T@lk 14:47, 1 September 2020 (UTC)

This study didn't use 'advanced diagnostics,' but routine laboratory diagnostics such as PCR and urinary antigen testing. You're right that "the observation on this problem is cited in the body of the article to a source called EBMED05;" the Jain study is an example of that problem and is a large and relatively recent report in institutions equipped to address the question.Mikalra (talk) 15:54, 1 September 2020 (UTC)

For many healthcare settings, the diagnostics used in Jain2015 were definitely "advanced". In the UK the viral PCR panel in pneumonia only includes influenza and RSV unless the host is immunocompromised. JFW | T@lk 15:01, 2 September 2020 (UTC)

@Mikalra: The Jain 2015 reference is not an appropriate source, so it has been removed again. Please review WP:MEDRS for explanation. JFW | T@lk 11:13, 3 September 2020 (UTC)

Semi-protected edit request on 21 November 2020

This edit request has been answered. Set the |answered= or |ans= parameter to no to reactivate your request.

I would like to enhance this page's coverage of the robustly established relationship between SARS-CoV-2 and pneumonia.

Change "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also result in pneumonia."

to

"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also result in pneumonia. The virus infects and destroys the cells of the alveoli, both those that are ciliated and those that produce mucus and surfactant . Because the cilia cannot function properly, fluid and cellular debris accumulate in the alveoli, which can cause pneumonia . Teddymhill (talk) 02:06, 21 November 2020 (UTC)

This can only be supported with very high quality references. A newspaper article would not be sufficient, nor an animal study. The pathogenesis is probably more complicated than you have indicated: there is diffuse alveolar damage and immunothrombosis. Hence not supporting this addition at this time. JFW | T@lk 21:27, 21 November 2020 (UTC)

References

  1. https://www.seattletimes.com/seattle-news/health/facts-about-novel-coronavirus-and-how-to-prevent-covid-19/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373339/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431901/

Please harmonize the internal contradiction about the cause of pneumonia

In the Cause section you cite #28 Jain 2015, a paper which puts viruses well ahead of bacteria in causing pneumonia. Later, in the Bacteria section you state that "Bacteria are the most common cause" with a different reference (#35 Sharma 2007), putting a direct contradiction into this article, just a few lines

PS: Just as in the telephone game the numbers have been misquoted. It says "20% haemophilus" but it was 20 cases or 7% in the original paper!

Good catch here @JS. I can help make this edit. As for the review article, this is one of differences between medical writing on Misplaced Pages and writing for a peer-reviewed medical journal- the use of the WP:MEDRS guideline preferring high-quality secondary sources to primary research sources. It is not always perfect- i.e.- susceptibilty to the 'telephone game' errors, however, some feel that there are strengths as well to this approach given that anyone can edit these articles. I will not have time to review the citations for a few days, but will try to circle back soon. Citations to consider: Primary source, presently ref # 28 Jain et al 2015. . Outdated secondary source (does not meet WP:MEDDATE): JenOttawa (talk) 16:39, 22 November 2021 (UTC)
P.S- if anyone wants to beat me to this improvement please do go ahead!!! There are a lot of outdated references in the aforementioned sections. JenOttawa (talk) 16:46, 22 November 2021 (UTC)

References

  1. Jain, Seema; Self, Wesley H.; Wunderink, Richard G.; Fakhran, Sherene; Balk, Robert; Bramley, Anna M.; Reed, Carrie; Grijalva, Carlos G.; Anderson, Evan J.; Courtney, D. Mark; Chappell, James D. (2015-07-30). "Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults". The New England Journal of Medicine. 373 (5): 415–427. doi:10.1056/NEJMoa1500245. ISSN 1533-4406. PMC 4728150. PMID 26172429.
  2. Sharma, Sat; Maycher, Bruce; Eschun, Gregg (May, 2007). "Radiological imaging in pneumonia: recent innovations". Current Opinion in Pulmonary Medicine. 13 (3): 159–169. doi:10.1097/MCP.0b013e3280f3bff4. ISSN 1070-5287. PMID 17414122. {{cite journal}}: Check date values in: |date= (help)

Keiko died from this! This is for real!!!

Here is the whale Keiko of the free willy movie, it DOES exist as a disease in wild animals! "Killer whale Keiko dies of pneumonia.." The Free Library. 2003 The Register Guard 19 Mar. 2022 https://www.thefreelibrary.com/Killer+whale+Keiko+dies+of+pneumonia.-a0112803638 --82.207.238.166 (talk) 11:50, 19 March 2022 (UTC)

Semi-protected edit request on 10 May 2022

It is requested that an edit be made to the semi-protected article at Pneumonia. (edit · history · last · links · protection log)

This template must be followed by a complete and specific description of the request, that is, specify what text should be removed and a verbatim copy of the text that should replace it. "Please change X" is not acceptable and will be rejected; the request must be of the form "please change X to Y".

The edit may be made by any autoconfirmed user. Remember to change the |answered=no parameter to "yes" when the request has been accepted, rejected or on hold awaiting user input. This is so that inactive or completed requests don't needlessly fill up the edit requests category. You may also wish to use the {{ESp}} template in the response. To request that a page be protected or unprotected, make a protection request.

Genetics of Pneumonia

It has been found that vulnerability to Pneumonia and its severity may be linked to underlying genetic mechanisms. These mechanisms, such as the CYP1A1 gene (CYP1A1) regulating inflammatory responses and sepsis, can influence the efficacy of the immune system which can either be detrimental or beneficial in combating Pneumonia.

Individuals with certain genetic variants can be at risk for a higher susceptibility to Pneumonia. For example, individuals with mutations in Bruton’s tyrosine kinase (BTK). These mutations lead to the development of a disease called X-linked agammaglobulinemia which inhibits the formation of white blood cells and mature B cells. Without functional BTK, the development cycle of B lymphocytes is stopped at the pre-B cell stage which results in the loss of mature lymphocytes in the bone marrow and lymphatic system. In BTK, the mutation of arg525 to gln was particularly responsible for the lowered functionality of BTK. Due to decreased white blood cell count, this immune deficiency increases one’s susceptibility to Pneumonia greatly.

A broad mapping study aimed at identifying loci associated with pulmonary function and Pneumonia in humans mapped 137 loci of interest. 116 of the 137 loci were found to be responsible for both pulmonary function and susceptibility to Pneumonia. Furthermore, 336/340 SNPs were shared between Pneumonia and pulmonary function . Genes that are responsible for pulmonary function play an integral role in overall lung development and inflammation pathways that are key to an immune response. Individuals with an impaired pulmonary function due to certain predisposed developmental, inflammatory, or cardiovascular traits were found to be at a higher risk for Pneumonia. This high degree of overlap of genes and the correlation between pulmonary function traits and susceptibility to Pneumonia could mean that there is a major genetic factor.

There are nine disease genes currently known to increase susceptibility to idiopathic interstitial Pneumonia. Three of the disease genes are responsible for the production of surfactant by alveoli in the lungs: Surfactant protein C (SFTPC), Surfactant protein A2 (SFTPA2), and Adenosine triphosphate-binding cassette subfamily A member 3 (ABCA3). Surfactant is a mixture of proteins and fats that helps keep the alveoli from collapsing when a person exhales and also protects lung cells from infection. Mutations at these loci have age-dependent effects, however, it is not yet possible to predict which family members will develop Pneumonia at what age. The other six disease genes are associated with telomeres: Telomerase reverse transcriptase , Telomerase RNA component , Dyskerin , Telomere repeat binding factor 1-interacting nuclear factor 2 , Regulator of telomere elongation helicase , Poly(A)-specific ribonuclease . Mutations in these genes impede the ability of the body to repair damage in the telomeres of chromosomes and thus they become shorter, which can also increase the risk of developing Pneumonia, amongst many other diseases. Currently, doctors do offer genetic testing for these 9 disease genes in cases where two or more individuals in the same family have Pneumonia.

During the COVID-19 pandemic, patients infected with COVID-19 were found to have twice the risk of developing pneumonia. Doctors have developed a DNA test that uses multiple polymerase chain reactions to detect DNA and antibiotic resistance of streptococcus pneumoniae in a patient’s blood sample. This can be done in the span of four hours which is much quicker than the conventional method of growing bacterial cultures which is prone to false negatives due to patients receiving antibiotics before the sample is collected. The test expedites the treatment procedure with doctors being able to prescribe antibiotics at an earlier stage and making it more effective in the treatment of Pneumonia.

References

Chen, Shaw, Petty, North. (2020, December 11). Host genetic effects in Pneumonia. Cell. https://www.cell.com/ajhg/fulltext/S0002-9297(20)30446-8

Genetics in community-acquired Pneumonia : Current Opinion in Pulmonary Medicine. (2019). LWW. https://journals.lww.com/co-pulmonarymedicine/Abstract/2019/05000/Genetics_in_community_acquired_Pneumonia.17.aspx

ILD Colaborative. (2020). Genetics of Familial Idiopathic Interstitial Pneumonia. https://www.ildcollaborative.org/resources/genetics-of-familial-idiopathic-interstitial-Pneumonia

Khadzhieva, Kuzovlev, Salnikova. (2019, December). Pneumonia: host susceptibility and shared genetics with pulmonary function and other traits. PubMed. https://pubmed.ncbi.nlm.nih.gov/31487037/

Kropski, YOung, Cogan, Mitchell, Lancaster, Worrell, Markin, Liu. (2017, June 1). Genetic Evaluation and Testing of Patients and Families with Idiopathic Pulmonary Fibrosis. National Library of Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470751/

Waterer, Wunderink. (2010). Genetic susceptibility to Pneumonia. PubMed. https://pubmed.ncbi.nlm.nih.gov/15802163/

Guin, Debleena, et al. “Human Genetic Factors Associated with Pneumonia Susceptibility, a Cue for Covid-19 Mortality.” MedRxiv, Cold Spring Harbor Laboratory Press, 1 Jan. 2021, https://www.medrxiv.org/content/10.1101/2021.06.03.21258106v1.full.

“DNA Test Can Quickly Identify Pneumonia in Patients with Severe COVID-19, Aiding Faster Treatment.” ScienceDaily, ScienceDaily, 15 Jan. 2021, https://www.sciencedaily.com/releases/2021/01/210115091340.htm.

  1. Guin, Debleena, et al. “Human Genetic Factors Associated with Pneumonia Susceptibility, a Cue for Covid-19 Mortality.” MedRxiv, Cold Spring Harbor Laboratory Press, 1 Jan. 2021, https://www.medrxiv.org/content/10.1101/2021.06.03.21258106v1.full.
  2. Genetics in community-acquired Pneumonia : Current Opinion in Pulmonary Medicine. (2019). LWW. https://journals.lww.com/co-pulmonarymedicine/Abstract/2019/05000/Genetics_in_community_acquired_Pneumonia.17.aspx
  3. Chen, Shaw, Petty, North. (2020, December 11). Host genetic effects in Pneumonia. Cell. https://www.cell.com/ajhg/fulltext/S0002-9297(20)30446-8
  4. Khadzhieva, Kuzovlev, Salnikova. (2019, December). Pneumonia: host susceptibility and shared genetics with pulmonary function and other traits. PubMed. https://pubmed.ncbi.nlm.nih.gov/31487037/
  5. Khadzhieva, Kuzovlev, Salnikova. (2019, December). Pneumonia: host susceptibility and shared genetics with pulmonary function and other traits. PubMed. https://pubmed.ncbi.nlm.nih.gov/31487037/
  6. ILD Colaborative. (2020). Genetics of Familial Idiopathic Interstitial Pneumonia. https://www.ildcollaborative.org/resources/genetics-of-familial-idiopathic-interstitial-Pneumonia
  7. ILD Colaborative. (2020). Genetics of Familial Idiopathic Interstitial Pneumonia. https://www.ildcollaborative.org/resources/genetics-of-familial-idiopathic-interstitial-Pneumonia
  8. Kropski, YOung, Cogan, Mitchell, Lancaster, Worrell, Markin, Liu. (2017, June 1). Genetic Evaluation and Testing of Patients and Families with Idiopathic Pulmonary Fibrosis. National Library of Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470751/
  9. “DNA Test Can Quickly Identify Pneumonia in Patients with Severe COVID-19, Aiding Faster Treatment.” ScienceDaily, ScienceDaily, 15 Jan. 2021, https://www.sciencedaily.com/releases/2021/01/210115091340.htm.

Editor3456123123 (talk) 00:26, 11 May 2022 (UTC)

Categories: