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Revision as of 03:25, 7 April 2004 by 68.170.182.174 (talk)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)Paroxetine (paroxetine hydrochloride) is the formal name for Paxil® (in the United States), Seroxat® (in the UK) or Aropax® (in Australia). It was released onto the market in 1992 by the pharmaceutical company GlaxoSmithKline and has since become one of the most successful anti-depressants on the market. It is the second most prescribed anti-depressant in the UK.
Chemically identified as Aropax 20, Seroxat, paroxetine, Paxil, and (Immediate-Release Tablets / Oral Suspension:) (-)-trans-4R-(4'-fluorophenyl)-3S- piperidine hydrochloride hemihydrate and (Controlled-Release Tablets:) (-) - (3S,4R)-4-methyl]piperidine hydrochloride hemihydrate, its empirical formula is:
C19H20FNO3
with a molecular weight of 374.8 (329.3703 as free base).
Paroxetine is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) of which Prozac is probably the most well known.
Like some other antidepressants, it also can be used in the treating of anxiety disorders. It was the first (and as of 2002, the only) antidepressant formally approved in the United States for the treatment of social phobia, causing it to be sometimes referred to (although inaccurately) as an anti-shyness drug.
Although the drug has proved to be extremely helpful in the majority of cases it is used, there is a growing body of anecdotal evidence that have raised concerns about some of its side effects.
Compared to other SSRIs, Paxil has a very short "half-life" and leaves the body quickly. This can lead to extreme side effects if the drug is stopped suddenly.
Although the manufacturers say there is no reliable clinical evidence that the drug can cause any violence or aggression, the company was sued in the US after Donald Schell had killed his wife, daughter and grandchild after two days on the drug. During the investigation of the clinical records it was reported that although effective most of the time, in a minority of cases the drug could cause unpredictable side effects.
- Wild mood swings/Suicidal thoughts when first starting on the drug
- Withdrawal effects making it hard to stop taking the drug.
The manufacturers claim it is impossible to get addicted. Other campaigners disagree. Generally it is accepted that withdrawal symptoms are not enough to make a drug addictive, it has to leave the user needing more and more in order to gain the same desired effect. That's not the case with Paroxetine, as the body does not become tolerant to Parexotine's positive effects. Note however, that addiction is generally also an extremely debated issue, although no drug is known to be addictive that does not have both these characteristics; withdrawal symptoms and tolerance.
Recent studies have found that the drug is relatively ineffective in children, and that they are prone to becoming suicidal when first given it.
Side effects
Common side effects include:
- drowsiness
- sleepiness
- nausea
- upset stomach
- dry mouth
- constipation
- diarrhea
- decrease of sexual desire
- delayed orgasm or anorgasmia
- rash
- itch
- changes in urination
If you experience any of the following symptoms, call your doctor immediately
- jaw, neck, and back muscle spasms
- fever, chills, sore throat, or flu-like symptoms
- yellowing of the skin or eyes