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| Clinical data | |
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| ATC code | |
| Identifiers | |
IUPAC name
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.006.832  |
| Chemical and physical data | |
| Formula | C21H25NO5 |
| Molar mass | 371.43 g/mol g·mol |
| 3D model (JSmol) | |
SMILES
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InChI
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Demecolcine is a drug used in chemotherapy.It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl.
During cell division Demecolcine inhibits mitosis at metaphase by inhibiting spindle formation. Medically Demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle.
In animal cloning procedures Demecolcine makes an ovum eject its nucleus, creating space for insertion of a new nucleus.
References
- Brit med J., 1965, 1, 495 – 496
- Reprod Nutr Dev. 2006 Mar-Apr;46(2):219-26
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